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Search results 2301 to 2400 out of 2972 for Ca2

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Hits by Strain

Type Details Score
Protein
Q5HZI2
Organism: Mus musculus/domesticus
Length: 419  
Fragment?: false
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Protein
P0CG09
Organism: Mus musculus/domesticus
Length: 341  
Fragment?: false
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Publication
8884281 | J:35528
First Author: Omeis IA
Year: 1996
Journal: Genomics
Title: Mouse and human neuronal pentraxin 1 (NPTX1): conservation, genomic structure, and chromosomal localization.
Volume: 36
Issue: 3
Pages: 543-5
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Protein
Q3UYE4
Organism: Mus musculus/domesticus
Length: 286  
Fragment?: true
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Protein
A0A0A6YX56
Organism: Mus musculus/domesticus
Length: 225  
Fragment?: false
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Protein
A0A1Y7VJP1
Organism: Mus musculus/domesticus
Length: 1028  
Fragment?: true
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Protein
Q9CTH3
Organism: Mus musculus/domesticus
Length: 225  
Fragment?: true
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Protein
J3QPE5
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: false
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Publication
9514915 | -
First Author: Li XA
Year: 1998
Journal: Biochem Biophys Res Commun
Title: Serum amyloid P component associates with high density lipoprotein as well as very low density lipoprotein but not with low density lipoprotein.
Volume: 244
Issue: 1
Pages: 249-52
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Publication
9614930 | -
First Author: Romero IR
Year: 1998
Journal: Clin Immunol Immunopathol
Title: Inflammatory potential of C-reactive protein complexes compared to immune complexes.
Volume: 87
Issue: 2
Pages: 155-62
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Publication
8114934 | -
First Author: Emsley J
Year: 1994
Journal: Nature
Title: Structure of pentameric human serum amyloid P component.
Volume: 367
Issue: 6461
Pages: 338-45
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Publication
9583999 | -
First Author: Coe JE
Year: 1997
Journal: Scand J Immunol
Title: Electrophoretic polymorphism of a hamster pentraxin, female protein (amyloid P component).
Volume: 46
Issue: 2
Pages: 180-6
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Publication
7881902 | -
First Author: Srinivasan N
Year: 1994
Journal: Structure
Title: Comparative analyses of pentraxins: implications for protomer assembly and ligand binding.
Volume: 2
Issue: 11
Pages: 1017-27
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Publication
8899296 | -
First Author: Goodman AR
Year: 1996
Journal: Cytokine Growth Factor Rev
Title: Long pentraxins: an emerging group of proteins with diverse functions.
Volume: 7
Issue: 2
Pages: 191-202
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Publication
10748068 | J:62756
First Author: Kirkpatrick LL
Year: 2000
Journal: J Biol Chem
Title: Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2.
Volume: 275
Issue: 23
Pages: 17786-92
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Publication
31587896 | -
First Author: McCarthy AE
Year: 2019
Journal: Cell
Title: Full-Length P2X7 Structures Reveal How Palmitoylation Prevents Channel Desensitization.
Volume: 179
Issue: 3
Pages: 659-670.e13
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Protein Domain
IPR046815 | P2RX7_C
Type: Domain
Description: P2X purinoceptors are cell membrane ion channels, gated by adenosine 5'-triphosphate (ATP) and other nucleotides; they have been found to be widely expressed on mammalian cells, and, by means of their functional properties, can be differentiated into three sub-groups. The first group is almost equally well activated by ATP and its analogue alpha,betamethylene-ATP, whereas, the second group is not activated by the latter compound. A third type of receptor (also called P2Z) is distinguished by the fact that repeated or prolonged agonist application leads to the opening of much larger pores, allowing large molecules to traverse the cell membrane. This increased permeability rapidly leads to cell death, and lysis.Molecular cloning studies have identified seven P2X receptor subtypes, designated P2XR1-P2XR7, however, P2X1R, P2X2R, P2X3R, P2X4R, and P2X7R are functional []. These receptors are proteins that share 35-48% amino acid identity, and possess two putative transmembrane (TM) domains, separated by a long (~270 residues) intervening sequence, which is thought to form an extracellular loop. Around 1/4 of the residues within the loop are invariant between the cloned subtypes, including 10 characteristic cysteines.Studies of the functional properties of heterologously expressed P2X receptors, together with the examination of their distribution in native tissues, suggests they likely occur as both homo- and hetero multimers in vivo [, ]. Stimulation of these receptors induces changes in intracellular ion homeostasis leading to multiple key responses crucial for initiation, propagation, and resolution of inflammation []. The P2X7 subtype has an important role in the activation of lymphocyte, granulocyte, macrophage and dendritic cell responses and, therefor, it may be a promising target for anti-inflammatory therapies.This entry represents the intracellular domain found at the C-terminal domain of P2X7 (also known as P2Z receptor). P2X7 receptor has different functional properties from those of P2X1-P2X6. Key properties of the current produced are little rectification or desensitisation, and strong potentiation of responses when the concentration of extracellular Ca2 and/or Mg2 are reduced. It is also found to be relatively insensitive to ATP. In certain studies, prolonged activation of expressed P2X7 receptors causes cell permeabilization, and lysis. This domain is critical for the receptor to initiate apoptosis and not undergo desensitization. It shows a globular structure and is shaped like a wedge with three β-strands forming an antiparallel β-sheet followed by eight α-helices separated by loops that form a helical bundle [].
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Protein Domain
IPR001759 | Pentraxin-related
Type: Family
Description: This entry represents Pentaxins and its related proteins such as CRP (C-reactive protein) and SAP (serum amyloid P component protein) []. This entry also includes adhesion G-protein coupled receptors D2 and G6 from humans.Pentraxins (or pentaxins) [, ]are a family of proteins which show, under electron microscopy, a discoid arrangement of five noncovalently bound subunits. Proteins of the pentraxin family are involved in acute immunological responses []. Three of the principal members of the pentraxin family are serum proteins and Ca2 dependent: namely, C-reactive protein (CRP) [], serum amyloid P component protein (SAP) [], and female protein (FP) []. CRP binds to ligands containing phosphocholine, SAP binds to amyloid fibrils, DNA, chromatin, fibronectin, C4-binding proteins and glycosaminoglycans.CRP is expressed during acute phase response to tissue injury or inflammation in mammals. The protein resembles antibody and performs several functions associated with host defence: it promotes agglutination, bacterial capsular swelling and phagocytosis, and activates the classical complement pathway through its calcium-dependent binding to phosphocholine. CRPs have also been sequenced in an invertebrate, Limulus polyphemus (Atlantic horseshoe crab), where they are a normal constituent of the hemolymph [].SAP is a vertebrate protein that is a precursor of amyloid component P. It is found in all types of amyloid deposits, in glomerular basement menbrane and in elastic fibres in blood vessels. SAP binds to various lipoprotein ligands in a calcium-dependent manner, and it has been suggested that, in mammals, this may have important implications in atherosclerosis and amyloidosis [].FP is a SAP homologue found in Mesocricetus auratus (golden hamster). The concentration of this plasma protein is altered by sex steroids and stimuli that elicit an acute phase response."Long"pentraxins have N-terminal extensions to the common pentraxin domain []; one group, the neuronal pentraxins, may be involved in synapse formation and remodeling, and they may also be able to form heteromultimers []. Pentraxin proteins expressed in the nervous system are neural pentraxin I (NPI) and II (NPII) []. NPI and NPII are homologous and can exist within one species. It is suggested that both proteins mediate the uptake of synaptic macromolecules and play a role in synaptic plasticity. Apexin, a sperm acrosomal protein, is a homologue of NPII found in Cavia porcellus (Guinea pig) [].PTX3 is a long pentraxin that provides defence against infectious agents and plays several functions in tissue repair and regulation of cancer-related inflammation [].
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Protein
P41209
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: false
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Protein
P14211
Organism: Mus musculus/domesticus
Length: 416  
Fragment?: false
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Protein
Q9R1K9
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: false
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Protein
Q9JLK4
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: false
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Protein
Q9JJG7
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
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Protein
Q9CQ35
Organism: Mus musculus/domesticus
Length: 332  
Fragment?: false
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Protein
Q8VBV8
Organism: Mus musculus/domesticus
Length: 201  
Fragment?: false
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Protein
P43081
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: false
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Protein
P32848
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: false
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Protein
P51879
Organism: Mus musculus/domesticus
Length: 109  
Fragment?: false
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Protein
Q9D9Q6
Organism: Mus musculus/domesticus
Length: 380  
Fragment?: false
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Protein
Q9CYL5
Organism: Mus musculus/domesticus
Length: 154  
Fragment?: false
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Protein
A2A5I3
Organism: Mus musculus/domesticus
Length: 253  
Fragment?: false
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Protein
Q91WD9
Organism: Mus musculus/domesticus
Length: 276  
Fragment?: false
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Protein
Q91ZM8
Organism: Mus musculus/domesticus
Length: 215  
Fragment?: false
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Protein
Q6GQS1
Organism: Mus musculus/domesticus
Length: 467  
Fragment?: false
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Protein
Q9ET66
Organism: Mus musculus/domesticus
Length: 498  
Fragment?: false
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Protein
Q8BMD8
Organism: Mus musculus/domesticus
Length: 475  
Fragment?: false
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Protein
Q6S5I3
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: false
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Protein
Q8BG58
Organism: Mus musculus/domesticus
Length: 503  
Fragment?: false
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Protein
O54916
Organism: Mus musculus/domesticus
Length: 795  
Fragment?: false
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Protein
Q9D708
Organism: Mus musculus/domesticus
Length: 124  
Fragment?: false
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Protein
P50114
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: false
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Protein
P56565
Organism: Mus musculus/domesticus
Length: 94  
Fragment?: false
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Protein
Q8BH59
Organism: Mus musculus/domesticus
Length: 677  
Fragment?: false
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Protein
P62761
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: false
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Protein
Q8BS03
Organism: Mus musculus/domesticus
Length: 258  
Fragment?: false
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Protein
Q80XA6
Organism: Mus musculus/domesticus
Length: 647  
Fragment?: false
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Protein
P27005
Organism: Mus musculus/domesticus
Length: 89  
Fragment?: false
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Protein
P50543
Organism: Mus musculus/domesticus
Length: 98  
Fragment?: false
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Protein
Q69ZZ9
Organism: Mus musculus/domesticus
Length: 3305  
Fragment?: false
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Protein
Q8BG18
Organism: Mus musculus/domesticus
Length: 352  
Fragment?: false
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Protein
Q91ZP9
Organism: Mus musculus/domesticus
Length: 389  
Fragment?: false
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Protein
Q9D6J4
Organism: Mus musculus/domesticus
Length: 353  
Fragment?: false
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Protein
F6YT69
Organism: Mus musculus/domesticus
Length: 210  
Fragment?: true
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Protein
A0A1D5RLS1
Organism: Mus musculus/domesticus
Length: 599  
Fragment?: false
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Protein
Q4QQN2
Organism: Mus musculus/domesticus
Length: 455  
Fragment?: true
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Protein
Q3TSN3
Organism: Mus musculus/domesticus
Length: 282  
Fragment?: false
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Protein
Q542R1
Organism: Mus musculus/domesticus
Length: 219  
Fragment?: false
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Protein
Q5NCJ7
Organism: Mus musculus/domesticus
Length: 215  
Fragment?: false
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Protein
B9EI38
Organism: Mus musculus/domesticus
Length: 648  
Fragment?: false
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Protein
Q6NZJ5
Organism: Mus musculus/domesticus
Length: 621  
Fragment?: false
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Protein
Q3UY00
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: false
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Protein
Q4W4C9
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: false
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Protein
Q53X15
Organism: Mus musculus/domesticus
Length: 89  
Fragment?: false
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Protein
B9EJL3
Organism: Mus musculus/domesticus
Length: 99  
Fragment?: false
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Protein
Q5JC28
Organism: Mus musculus/domesticus
Length: 793  
Fragment?: false
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Protein
Q8BYR9
Organism: Mus musculus/domesticus
Length: 398  
Fragment?: false
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Protein
Q8R0V6
Organism: Mus musculus/domesticus
Length: 296  
Fragment?: true
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Protein
D3Z6P4
Organism: Mus musculus/domesticus
Length: 359  
Fragment?: true
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Protein
A0A1W2P7G8
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: true
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Protein
G3XA16
Organism: Mus musculus/domesticus
Length: 168  
Fragment?: false
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Protein
Q8BXP8
Organism: Mus musculus/domesticus
Length: 402  
Fragment?: true
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Protein
E9PWU1
Organism: Mus musculus/domesticus
Length: 230  
Fragment?: false
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Protein
Q9D5G5
Organism: Mus musculus/domesticus
Length: 473  
Fragment?: false
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Protein
B2L107
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: false
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Protein
D3YVW8
Organism: Mus musculus/domesticus
Length: 101  
Fragment?: true
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Protein
Q8CJ43
Organism: Mus musculus/domesticus
Length: 164  
Fragment?: true
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Protein
B1Q2L7
Organism: Mus musculus/domesticus
Length: 380  
Fragment?: false
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Protein
E9PWI3
Organism: Mus musculus/domesticus
Length: 1003  
Fragment?: false
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Protein
G5E8W3
Organism: Mus musculus/domesticus
Length: 203  
Fragment?: false
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Protein
E0CYY0
Organism: Mus musculus/domesticus
Length: 163  
Fragment?: true
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Protein
D3Z2E3
Organism: Mus musculus/domesticus
Length: 705  
Fragment?: false
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Protein
F7AB82
Organism: Mus musculus/domesticus
Length: 240  
Fragment?: true
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Protein
Q3TYI8
Organism: Mus musculus/domesticus
Length: 808  
Fragment?: true
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Protein
Q7M092
Organism: Mus musculus/domesticus
Length: 77  
Fragment?: false
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Protein
Q80ZZ3
Organism: Mus musculus/domesticus
Length: 542  
Fragment?: true
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Protein
Q9CYG3
Organism: Mus musculus/domesticus
Length: 393  
Fragment?: false
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Protein
D3YZ25
Organism: Mus musculus/domesticus
Length: 76  
Fragment?: true
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Protein
E0CXZ2
Organism: Mus musculus/domesticus
Length: 103  
Fragment?: true
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Protein
S4R2A8
Organism: Mus musculus/domesticus
Length: 262  
Fragment?: true
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Protein
G3UYI2
Organism: Mus musculus/domesticus
Length: 98  
Fragment?: true
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Protein
Q99LJ3
Organism: Mus musculus/domesticus
Length: 400  
Fragment?: true
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Protein
A0A338P6L8
Organism: Mus musculus/domesticus
Length: 131  
Fragment?: true
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Protein
D3Z7D9
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: true
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Protein
S4R2C6
Organism: Mus musculus/domesticus
Length: 259  
Fragment?: true
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Protein
Q3UWP8
Organism: Mus musculus/domesticus
Length: 368  
Fragment?: true
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Protein
Q8CJ62
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: true
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Protein
A0A0R4J126
Organism: Mus musculus/domesticus
Length: 269  
Fragment?: false
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Protein
G5CPP0
Organism: Mus musculus/domesticus
Length: 439  
Fragment?: false
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Protein
Q8BUN1
Organism: Mus musculus/domesticus
Length: 435  
Fragment?: false
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Protein
Q80TZ5
Organism: Mus musculus/domesticus
Length: 1485  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom