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Search results 2301 to 2400 out of 2634 for Lef1

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Type Details Score
Publication
32439755 | J:290855
 
First Author: Yu W
Year: 2020
Journal: Development
Title: Pitx2-Sox2-Lef1 interactions specify progenitor oral/dental epithelial cell signaling centers.
Volume: 147
Issue: 11
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Publication
20142103 | J:158620
First Author: Guo J
Year: 2010
Journal: Cell Metab
Title: Suppression of Wnt signaling by Dkk1 attenuates PTH-mediated stromal cell response and new bone formation.
Volume: 11
Issue: 2
Pages: 161-71
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Publication
27102016 | J:240219
First Author: Guimarães-Young A
Year: 2016
Journal: Dev Biol
Title: Conditional deletion of Sox17 reveals complex effects on uterine adenogenesis and function.
Volume: 414
Issue: 2
Pages: 219-27
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Publication
34648327 | J:314931
First Author: Conner JM
Year: 2021
Journal: Science
Title: Modulation of tactile feedback for the execution of dexterous movement.
Volume: 374
Issue: 6565
Pages: 316-323
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Publication
27058938 | J:235192
First Author: Wang H
Year: 2016
Journal: Cell Stem Cell
Title: SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt Signaling.
Volume: 18
Issue: 4
Pages: 495-507
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Publication
30053582 | J:273319
 
First Author: Zhao L
Year: 2018
Journal: Mol Cell Endocrinol
Title: Transcriptomic analysis of mRNA expression and alternative splicing during mouse sex determination.
Volume: 478
Pages: 84-96
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Publication
39738217 | J:361386
First Author: Li X
Year: 2024
Journal: Sci Rep
Title: Prader-Willi syndrome protein necdin regulates the nucleocytoplasmic distribution and dopaminergic neuron development.
Volume: 14
Issue: 1
Pages: 31605
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Publication
18281466 | J:303056
First Author: Rendl M
Year: 2008
Journal: Genes Dev
Title: BMP signaling in dermal papilla cells is required for their hair follicle-inductive properties.
Volume: 22
Issue: 4
Pages: 543-57
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Publication
34342114 | J:312412
First Author: Geueke A
Year: 2021
Journal: EMBO Rep
Title: The anti-apoptotic Bcl-2 protein regulates hair follicle stem cell function.
Volume: 22
Issue: 10
Pages: e52301
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Publication
27009580 | J:234868
First Author: Rezza A
Year: 2016
Journal: Cell Rep
Title: Signaling Networks among Stem Cell Precursors, Transit-Amplifying Progenitors, and their Niche in Developing Hair Follicles.
Volume: 14
Issue: 12
Pages: 3001-18
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Publication
28693719 | J:257154
   
First Author: Watanabe M
Year: 2017
Journal: Elife
Title: Type XVII collagen coordinates proliferation in the interfollicular epidermis.
Volume: 6
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Publication
23153495 | J:191082
First Author: Clavel C
Year: 2012
Journal: Dev Cell
Title: Sox2 in the dermal papilla niche controls hair growth by fine-tuning BMP signaling in differentiating hair shaft progenitors.
Volume: 23
Issue: 5
Pages: 981-94
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Publication
20940224 | J:165557
First Author: Ambler CA
Year: 2010
Journal: Development
Title: Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1.
Volume: 137
Issue: 21
Pages: 3569-79
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Publication
31272105 | J:298784
First Author: Kennedy JC
Year: 2019
Journal: Hum Mol Genet
Title: Loss of FLCN inhibits canonical WNT signaling via TFE3.
Volume: 28
Issue: 19
Pages: 3270-3281
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Publication
19340312 | J:148508
First Author: Amleh A
Year: 2009
Journal: PLoS One
Title: Mouse cofactor of BRCA1 (Cobra1) is required for early embryogenesis.
Volume: 4
Issue: 4
Pages: e5034
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Publication
20194509 | J:163054
First Author: Li M
Year: 2010
Journal: J Biol Chem
Title: TAB2 scaffolds TAK1 and NLK in repressing canonical Wnt signaling.
Volume: 285
Issue: 18
Pages: 13397-404
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Publication
27086928 | J:309340
First Author: Lu C
Year: 2016
Journal: Oncogene
Title: Intestinal knockout of Nedd4 enhances growth of Apcmin tumors.
Volume: 35
Issue: 45
Pages: 5839-5849
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Publication
30814306 | J:274339
First Author: Millan AJ
Year: 2019
Journal: J Immunol
Title: Sostdc1 Regulates NK Cell Maturation and Cytotoxicity.
Volume: 202
Issue: 8
Pages: 2296-2306
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Publication
21663736 | J:175466
First Author: von Gise A
Year: 2011
Journal: Dev Biol
Title: WT1 regulates epicardial epithelial to mesenchymal transition through β-catenin and retinoic acid signaling pathways.
Volume: 356
Issue: 2
Pages: 421-31
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Publication
28811640 | J:323522
First Author: Choi H
Year: 2017
Journal: Sci Rep
Title: A Reciprocal Interaction between β-Catenin and Osterix in Cementogenesis.
Volume: 7
Issue: 1
Pages: 8160
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Publication
23257686 | J:241832
First Author: Choe Y
Year: 2012
Journal: Dev Neurosci
Title: Wnt signaling regulates intermediate precursor production in the postnatal dentate gyrus by regulating CXCR4 expression.
Volume: 34
Issue: 6
Pages: 502-14
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Publication
23185135 | J:193968
First Author: Tiemessen MM
Year: 2012
Journal: PLoS Biol
Title: The nuclear effector of Wnt-signaling, Tcf1, functions as a T-cell-specific tumor suppressor for development of lymphomas.
Volume: 10
Issue: 11
Pages: e1001430
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Publication
37589076 | J:341493
First Author: Brown M
Year: 2023
Journal: EMBO Mol Med
Title: Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis.
Volume: 15
Issue: 10
Pages: e17094
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Publication
28099467 | J:246742
First Author: Barnes L
Year: 2017
Journal: PLoS One
Title: Senescent Atrophic Epidermis Retains Lrig1+ Stem Cells and Loses Wnt Signaling, a Phenotype Shared with CD44KO Mice.
Volume: 12
Issue: 1
Pages: e0169452
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Publication
19850024 | J:168283
First Author: Abu-Elmagd M
Year: 2010
Journal: Dev Biol
Title: Wnt/Lef1 signaling acts via Pitx2 to regulate somite myogenesis.
Volume: 337
Issue: 2
Pages: 211-9
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Publication
17553962 | J:142940
First Author: Kobielak K
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling.
Volume: 104
Issue: 24
Pages: 10063-8
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Publication
15102710 | J:91054
First Author: Andl T
Year: 2004
Journal: Development
Title: Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development.
Volume: 131
Issue: 10
Pages: 2257-68
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Publication
35227671 | J:324926
 
First Author: Chalmers FE
Year: 2022
Journal: Dev Biol
Title: Targeted deletion of TGFβ1 in basal keratinocytes causes profound defects in stratified squamous epithelia and aberrant melanocyte migration.
Volume: 485
Pages: 9-23
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Publication
20729551 | J:166785
First Author: Plasari G
Year: 2010
Journal: J Biol Chem
Title: Nuclear factor I-C regulates TGF-{beta}-dependent hair follicle cycling.
Volume: 285
Issue: 44
Pages: 34115-25
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Publication
35129866 | J:329885
First Author: Bélanger C
Year: 2022
Journal: FASEB J
Title: CHARGE syndrome-associated proteins FAM172A and CHD7 influence male sex determination and differentiation through transcriptional and alternative splicing mechanisms.
Volume: 36
Issue: 3
Pages: e22176
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Publication
28201653 | J:246900
First Author: Subramaniam M
Year: 2017
Journal: Nucleic Acids Res
Title: TIEG1 modulates β-catenin sub-cellular localization and enhances Wnt signaling in bone.
Volume: 45
Issue: 9
Pages: 5170-5182
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Publication
25088803 | J:302800
First Author: Revollo L
Year: 2015
Journal: J Bone Miner Res
Title: N-cadherin restrains PTH activation of Lrp6/β-catenin signaling and osteoanabolic action.
Volume: 30
Issue: 2
Pages: 274-85
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Publication
29180475 | J:256301
First Author: Abbas HA
Year: 2018
Journal: Cancer Res
Title: Distinct TP63 Isoform-Driven Transcriptional Signatures Predict Tumor Progression and Clinical Outcomes.
Volume: 78
Issue: 2
Pages: 451-462
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Publication
32985581 | J:296253
First Author: Tan Y
Year: 2020
Journal: Sci Rep
Title: Wnt signaling mediates oncogenic synergy between Akt and Dlx5 in T-cell lymphomagenesis by enhancing cholesterol synthesis.
Volume: 10
Issue: 1
Pages: 15837
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Publication
11856745 | J:76366
First Author: Petropoulos H
Year: 2002
Journal: J Biol Chem
Title: Beta-catenin is essential and sufficient for skeletal myogenesis in P19 cells.
Volume: 277
Issue: 18
Pages: 15393-9
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Publication
9419974 | J:44935
First Author: Porfiri E
Year: 1997
Journal: Oncogene
Title: Induction of a beta-catenin-LEF-1 complex by wnt-1 and transforming mutants of beta-catenin.
Volume: 15
Issue: 23
Pages: 2833-9
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Publication
17397822 | J:121612
First Author: Bazzi H
Year: 2007
Journal: Dev Biol
Title: The Wnt inhibitor, Dickkopf 4, is induced by canonical Wnt signaling during ectodermal appendage morphogenesis.
Volume: 305
Issue: 2
Pages: 498-507
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Publication
17517646 | J:122302
First Author: Cianferotti L
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Vitamin D receptor is essential for normal keratinocyte stem cell function.
Volume: 104
Issue: 22
Pages: 9428-33
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Publication
18851995 | J:147248
First Author: Liu Z
Year: 2009
Journal: Biochim Biophys Acta
Title: WNT signaling promotes Nkx2.5 expression and early cardiomyogenesis via downregulation of Hdac1.
Volume: 1793
Issue: 2
Pages: 300-11
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Publication
21879290 | J:177568
First Author: Cai J
Year: 2011
Journal: Cell Tissue Res
Title: Wnt5a plays a crucial role in determining tooth size during murine tooth development.
Volume: 345
Issue: 3
Pages: 367-77
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Publication
23417899 | J:196874
First Author: Li Y
Year: 2013
Journal: Stem Cells
Title: Brief report: Oct4 and canonical Wnt signaling regulate the cardiac lineage factor Mesp1 through a Tcf/Lef-Oct4 composite element.
Volume: 31
Issue: 6
Pages: 1213-7
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Publication
24928892 | J:215682
First Author: Schneider AJ
Year: 2014
Journal: Toxicol Sci
Title: In utero exposure to TCDD alters Wnt signaling during mouse prostate development: linking ventral prostate agenesis to downregulated β-catenin signaling.
Volume: 141
Issue: 1
Pages: 176-87
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Publication
27421576 | J:236015
 
First Author: Uematsu Y
Year: 2016
Journal: Toxicol Appl Pharmacol
Title: MicroRNA-mediated Th2 bias in methimazole-induced acute liver injury in mice.
Volume: 307
Pages: 1-9
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Publication
27484482 | J:250352
First Author: Shy BR
Year: 2016
Journal: Nucleic Acids Res
Title: Co-incident insertion enables high efficiency genome engineering in mouse embryonic stem cells.
Volume: 44
Issue: 16
Pages: 7997-8010
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Publication
32722078 | J:293956
 
First Author: Neupane S
Year: 2020
Journal: Int J Mol Sci
Title: Signaling Modulations of miR-206-3p in Tooth Morphogenesis.
Volume: 21
Issue: 15
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Publication
32839237 | J:301518
First Author: Daams R
Year: 2020
Journal: J Immunol
Title: Deletion of Nemo-like Kinase in T Cells Reduces Single-Positive CD8+ Thymocyte Population.
Volume: 205
Issue: 7
Pages: 1830-1841
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Protein
F6RKH8
Organism: Mus musculus/domesticus
Length: 71  
Fragment?: true
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Publication
12631292 | -
First Author: Dahle Ø
Year: 2003
Journal: Eur J Biochem
Title: Transactivation properties of c-Myb are critically dependent on two SUMO-1 acceptor sites that are conjugated in a PIASy enhanced manner.
Volume: 270
Issue: 6
Pages: 1338-48
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Publication
12727872 | -
First Author: Yamamoto H
Year: 2003
Journal: EMBO J
Title: Sumoylation is involved in beta-catenin-dependent activation of Tcf-4.
Volume: 22
Issue: 9
Pages: 2047-59
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Publication
12511558 | J:262364
First Author: Subramanian L
Year: 2003
Journal: J Biol Chem
Title: A synergy control motif within the attenuator domain of CCAAT/enhancer-binding protein alpha inhibits transcriptional synergy through its PIASy-enhanced modification by SUMO-1 or SUMO-3.
Volume: 278
Issue: 11
Pages: 9134-41
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Publication
15831457 | -
First Author: Ihara M
Year: 2005
Journal: Mol Cell Biol
Title: SUMO-1 modification of PIASy, an E3 ligase, is necessary for PIASy-dependent activation of Tcf-4.
Volume: 25
Issue: 9
Pages: 3506-18
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Publication
22508508 | -
First Author: Danielsen JR
Year: 2012
Journal: J Cell Biol
Title: DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger.
Volume: 197
Issue: 2
Pages: 179-87
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Protein Domain
IPR009071 | HMG_box_dom
Type: Domain
Description: High mobility group (HMG) box domains are involved in binding DNA, and may be involved in protein-protein interactions as well. The structure of the HMG-box domain consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. Many of these proteins are regulators of gene expression. HMG-box proteins are found in a variety of eukaryotic organisms, and can be broadly divided into two groups, based on sequence-dependent and sequence-independent DNA recognition; the former usually contain one HMG-box motif, while the latter can contain multiple HMG-box motifs.HMG-box domains can be found in single or multiple copies in the following protein classes: HMG1 and HMG2 non-histone components of chromatin; SRY (sex determining region Y protein) involved in differential gonadogenesis; the SOX family of transcription factors []; sequence-specific LEF1 (lymphoid enhancer binding factor 1) and TCF-1 (T-cell factor 1) involved in regulation of organogenesis and thymocyte differentiation []; structure-specific recognition protein SSRP involved in transcription and replication; MTF1 mitochondrial transcription factor; nucleolar transcription factors UBF 1/2 (upstream binding factor) involved in transcription by RNA polymerase I; Abf2 yeast ARS-binding factor []; yeast transcription factors lxr1, Rox1, Nhp6b and Spp41; mating type proteins (MAT) involved in the sexual reproduction of fungi []; and the YABBY plant-specific transcription factors.
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Protein Domain
IPR036910 | HMG_box_dom_sf
Type: Homologous_superfamily
Description: High mobility group (HMG) box domains are involved in binding DNA, and may be involved in protein-protein interactions as well. The structure of the HMG-box domain consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. Many of these proteins are regulators of gene expression. HMG-box proteins are found in a variety of eukaryotic organisms, and can be broadly divided into two groups, based on sequence-dependent and sequence-independent DNA recognition; the former usually contain one HMG-box motif, while the latter can contain multiple HMG-box motifs.HMG-box domains can be found in single or multiple copies in the following protein classes: HMG1 and HMG2 non-histone components of chromatin; SRY (sex determining region Y protein) involved in differential gonadogenesis; the SOX family of transcription factors []; sequence-specific LEF1 (lymphoid enhancer binding factor 1) and TCF-1 (T-cell factor 1) involved in regulation of organogenesis and thymocyte differentiation []; structure-specific recognition protein SSRP involved in transcription and replication; MTF1 mitochondrial transcription factor; nucleolar transcription factors UBF 1/2 (upstream binding factor) involved in transcription by RNA polymerase I; Abf2 yeast ARS-binding factor []; yeast transcription factors lxr1, Rox1, Nhp6b and Spp41; mating type proteins (MAT) involved in the sexual reproduction of fungi []; and the YABBY plant-specific transcription factors. Structurally, the HMG box domain is composed of three helices.
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Protein Domain
IPR027224 | PIAS4
Type: Family
Description: SUMO proteins are ubiquitin like proteins that are covalently attached to and detached from other proteins in cells to modify their function. SUMO is first activated in an ATP-dependent reaction by formation of a thioester bond with an E1 (SUMO-activating) enzyme and then transferred to the SUMO conjugating (E2) enzyme Ubc9. Ubc9 catalyses the formation of an isopeptide bond between the C-terminal of SUMO and the amino group of lysine in the target protein. Sumoylated proteins can be targeted for different cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability []. PIAS4 is an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilising the interaction between Ubc9 and the substrate, and is a SUMO-tethering factor []. It plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. It mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations [, , , , ].
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Publication
25849774 | J:226377
First Author: Mesa KR
Year: 2015
Journal: Nature
Title: Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool.
Volume: 522
Issue: 7554
Pages: 94-7
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Publication
24653033 | J:209582
First Author: Deschene ER
Year: 2014
Journal: Science
Title: β-Catenin activation regulates tissue growth non-cell autonomously in the hair stem cell niche.
Volume: 343
Issue: 6177
Pages: 1353-6
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Publication
33972551 | J:321715
First Author: Tsutsui K
Year: 2021
Journal: Nat Commun
Title: Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions.
Volume: 12
Issue: 1
Pages: 2577
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Publication
17035290 | J:115280
First Author: Estrach S
Year: 2006
Journal: Development
Title: Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis.
Volume: 133
Issue: 22
Pages: 4427-38
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Publication
31857493 | J:285185
First Author: Heitman N
Year: 2020
Journal: Science
Title: Dermal sheath contraction powers stem cell niche relocation during hair cycle regression.
Volume: 367
Issue: 6474
Pages: 161-166
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Publication
28413068 | J:241508
First Author: Yang H
Year: 2017
Journal: Cell
Title: Epithelial-Mesenchymal Micro-niches Govern Stem Cell Lineage Choices.
Volume: 169
Issue: 3
Pages: 483-496.e13
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Publication
30532694 | J:310331
 
First Author: Han X
Year: 2018
Journal: Front Cell Neurosci
Title: FoxG1 Directly Represses Dentate Granule Cell Fate During Forebrain Development.
Volume: 12
Pages: 452
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Publication
25917236 | J:350759
First Author: Wang L
Year: 2015
Journal: J Bone Miner Res
Title: Loss of Gi G-Protein-Coupled Receptor Signaling in Osteoblasts Accelerates Bone Fracture Healing.
Volume: 30
Issue: 10
Pages: 1896-904
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Publication
25880808 | J:233487
First Author: Costa M
Year: 2015
Journal: PLoS One
Title: Lymphocyte gene expression signatures from patients and mouse models of hereditary hemochromatosis reveal a function of HFE as a negative regulator of CD8+ T-lymphocyte activation and differentiation in vivo.
Volume: 10
Issue: 4
Pages: e0124246
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Publication
12490564 | J:163140
First Author: Kubo F
Year: 2003
Journal: Development
Title: Wnt2b controls retinal cell differentiation at the ciliary marginal zone.
Volume: 130
Issue: 3
Pages: 587-98
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Protein
Q8BVN9
Organism: Mus musculus/domesticus
Length: 434  
Fragment?: false
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Protein
Q9DC33
Organism: Mus musculus/domesticus
Length: 346  
Fragment?: false
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Protein
Q8VBW5
Organism: Mus musculus/domesticus
Length: 907  
Fragment?: false
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Protein
Q9Z104
Organism: Mus musculus/domesticus
Length: 317  
Fragment?: false
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Protein
P43680
Organism: Mus musculus/domesticus
Length: 377  
Fragment?: false
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Protein
Q04887
Organism: Mus musculus/domesticus
Length: 507  
Fragment?: false
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Protein
Q6P8W9
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: false
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Protein
Q62249
Organism: Mus musculus/domesticus
Length: 55  
Fragment?: true
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Protein
Q62247
Organism: Mus musculus/domesticus
Length: 57  
Fragment?: true
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Protein
P53784
Organism: Mus musculus/domesticus
Length: 375  
Fragment?: false
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Protein
Q04891
Organism: Mus musculus/domesticus
Length: 613  
Fragment?: false
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Protein
Q04888
Organism: Mus musculus/domesticus
Length: 466  
Fragment?: false
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Protein
Q04892
Organism: Mus musculus/domesticus
Length: 240  
Fragment?: false
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Protein
Q04886
Organism: Mus musculus/domesticus
Length: 464  
Fragment?: false
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Protein
Q06831
Organism: Mus musculus/domesticus
Length: 440  
Fragment?: false
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Protein
P53783
Organism: Mus musculus/domesticus
Length: 391  
Fragment?: false
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Protein
Q924A2
Organism: Mus musculus/domesticus
Length: 2510  
Fragment?: false
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Protein
Q3USZ2
Organism: Mus musculus/domesticus
Length: 394  
Fragment?: false
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Protein
Q61473
Organism: Mus musculus/domesticus
Length: 419  
Fragment?: false
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Protein
P48432
Organism: Mus musculus/domesticus
Length: 319  
Fragment?: false
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Protein
Q811W0
Organism: Mus musculus/domesticus
Length: 276  
Fragment?: false
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Protein
Q66JW3
Organism: Mus musculus/domesticus
Length: 526  
Fragment?: false
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Protein
P43267
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: false
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Protein
Q8CGW4
Organism: Mus musculus/domesticus
Length: 782  
Fragment?: false
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Protein
P40645
Organism: Mus musculus/domesticus
Length: 827  
Fragment?: false
•
•
•
•
•
Protein
Q80W03
Organism: Mus musculus/domesticus
Length: 575  
Fragment?: false
•
•
•
•
•
Protein
O54941
Organism: Mus musculus/domesticus
Length: 411  
Fragment?: false
•
•
•
•
•
Protein
P35710
Organism: Mus musculus/domesticus
Length: 763  
Fragment?: false
•
•
•
•
•
Protein
P40646
Organism: Mus musculus/domesticus
Length: 380  
Fragment?: false
•
•
•
•
•
Protein
P40630
Organism: Mus musculus/domesticus
Length: 243  
Fragment?: false
•
•
•
•
•
Protein
Q8BU11
Organism: Mus musculus/domesticus
Length: 619  
Fragment?: false
•
•
•
•
•
Protein
P25976
Organism: Mus musculus/domesticus
Length: 765  
Fragment?: false
•
•
•
•
•
Protein
Q3TSW9
Organism: Mus musculus/domesticus
Length: 243  
Fragment?: false
•
•
•
•
•
Protein
C0IMX3
Organism: Mus musculus/domesticus
Length: 98  
Fragment?: true
•
•
•
•
•
Protein
B2KFM4
Organism: Mus musculus/domesticus
Length: 679  
Fragment?: false
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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