|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 2301 to 2400 out of 4141 for Mtor

<< First    < Previous  |  Next >    Last >>
0.024s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
28462079 | J:275931
First Author: Caron A
Year: 2017
Journal: Mol Metab
Title: Loss of hepatic DEPTOR alters the metabolic transition to fasting.
Volume: 6
Issue: 5
Pages: 447-458
•
•
•
•
•
Publication
37200193 | J:341014
First Author: Xu W
Year: 2023
Journal: Cell Rep
Title: Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells.
Volume: 42
Issue: 5
Pages: 112529
•
•
•
•
•
Publication
19046572 | J:143748
First Author: Bentzinger CF
Year: 2008
Journal: Cell Metab
Title: Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy.
Volume: 8
Issue: 5
Pages: 411-24
•
•
•
•
•
Publication
35881440 | J:327593
   
First Author: Kosillo P
Year: 2022
Journal: Elife
Title: Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2.
Volume: 11
•
•
•
•
•
Publication
33660780 | J:304858
First Author: Olthof AM
Year: 2021
Journal: Nucleic Acids Res
Title: Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns.
Volume: 49
Issue: 6
Pages: 3524-3545
•
•
•
•
•
Publication
19654316 | -
First Author: Hoshino D
Year: 2009
Journal: J Biol Chem
Title: A novel protein associated with membrane-type 1 matrix metalloproteinase binds p27(kip1) and regulates RhoA activation, actin remodeling, and matrigel invasion.
Volume: 284
Issue: 40
Pages: 27315-26
•
•
•
•
•
Publication
20544018 | -
First Author: Guillaumot P
Year: 2010
Journal: PLoS One
Title: Pdro, a protein associated with late endosomes and lysosomes and implicated in cellular cholesterol homeostasis.
Volume: 5
Issue: 6
Pages: e10977
•
•
•
•
•
Publication
22424774 | -
First Author: Bonfils G
Year: 2012
Journal: Mol Cell
Title: Leucyl-tRNA synthetase controls TORC1 via the EGO complex.
Volume: 46
Issue: 1
Pages: 105-10
•
•
•
•
•
Publication
22493244 | -
First Author: Kim S
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Drosophila Golgi membrane protein Ema promotes autophagosomal growth and function.
Volume: 109
Issue: 18
Pages: E1072-81
•
•
•
•
•
Publication
20194640 | -
First Author: Kim S
Year: 2010
Journal: J Cell Biol
Title: The novel endosomal membrane protein Ema interacts with the class C Vps-HOPS complex to promote endosomal maturation.
Volume: 188
Issue: 5
Pages: 717-34
•
•
•
•
•
Protein Domain
IPR028209 | LAMTOR1/MEH1
Type: Family
Description: LAMTOR1 is a family of eukaryotic proteins that have otherwise been referred to as Lipid raft adaptor protein p18, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1, and Protein associated with DRMs and endosomes.LAMTOR1 regulates the mTOR (mammalian target of rapamycin) pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. LAMTOR1 is part of the Ragulator complex, recruits the Rag GTPases and the mTORC1 complex to lysosomes, a key step in activation of the TOR signaling cascade by amino acids []. LAMTOR1 is responsible for anchoring the Ragulator complex to membranes. It may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes []. It may be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. It may also play a role in RHOA activation [, ].This family also includes Saccharomyces cerevisiae MEH1 (Ego1), a component of the EGO complex. The EGO complex and the Rag-Ragulator complex are structurally related []. The yeast EGO complex consists of Gtr1, Gtr2, Ego1, and Ego3, localises to the endosomal and vacuolar membranes, and plays a crucial role in cell growth and autophagy regulation through amino acid signals that activate TORC1 []. MEH1 (GSE2) is also a component of the GSE complex, which is required for proper sorting of amino acid permease Gap1 [].
•
•
•
•
•
Publication
28877476 | J:254940
First Author: Oh MH
Year: 2017
Journal: Cell Rep
Title: mTORC2 Signaling Selectively Regulates the Generation and Function of Tissue-Resident Peritoneal Macrophages.
Volume: 20
Issue: 10
Pages: 2439-2454
•
•
•
•
•
Publication
37694145 | J:341110
First Author: Cortada M
Year: 2023
Journal: iScience
Title: mTORC2 regulates auditory hair cell structure and function.
Volume: 26
Issue: 9
Pages: 107687
•
•
•
•
•
Publication
29531165 | J:260960
First Author: Raybuck AL
Year: 2018
Journal: J Immunol
Title: B Cell-Intrinsic mTORC1 Promotes Germinal Center-Defining Transcription Factor Gene Expression, Somatic Hypermutation, and Memory B Cell Generation in Humoral Immunity.
Volume: 200
Issue: 8
Pages: 2627-2639
•
•
•
•
•
Publication
24072782 | J:206625
First Author: Lamming DW
Year: 2014
Journal: FASEB J
Title: Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2).
Volume: 28
Issue: 1
Pages: 300-15
•
•
•
•
•
Publication
25404366 | J:230703
First Author: Prevot N
Year: 2015
Journal: J Immunol
Title: Mammalian target of rapamycin complex 2 regulates invariant NKT cell development and function independent of promyelocytic leukemia zinc-finger.
Volume: 194
Issue: 1
Pages: 223-30
•
•
•
•
•
Publication
27262777 | J:235510
 
First Author: Liu DM
Year: 2016
Journal: Bone
Title: Rictor/mTORC2 loss in osteoblasts impairs bone mass and strength.
Volume: 90
Pages: 50-8
•
•
•
•
•
Publication
27043284 | J:234958
First Author: Grahammer F
Year: 2016
Journal: J Clin Invest
Title: mTORC2 critically regulates renal potassium handling.
Volume: 126
Issue: 5
Pages: 1773-82
•
•
•
•
•
Publication
30318117 | J:270384
First Author: Onufer EJ
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Intestinal epithelial cell-specific Raptor is essential for high fat diet-induced weight gain in mice.
Volume: 505
Issue: 4
Pages: 1174-1179
•
•
•
•
•
Publication
32154868 | J:301181
 
First Author: Brooks DL
Year: 2020
Journal: Endocrinology
Title: mTORC1 Deficiency Modifies Volume Homeostatic Responses to Dietary Sodium in a Sex-Specific Manner.
Volume: 161
Issue: 5
•
•
•
•
•
Publication
22622041 | J:190434
First Author: Hoshii T
Year: 2012
Journal: J Clin Invest
Title: mTORC1 is essential for leukemia propagation but not stem cell self-renewal.
Volume: 122
Issue: 6
Pages: 2114-29
•
•
•
•
•
Publication
17967879 | J:128916
First Author: Kumar A
Year: 2008
Journal: Mol Cell Biol
Title: Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity.
Volume: 28
Issue: 1
Pages: 61-70
•
•
•
•
•
Publication
29106387 | J:281408
First Author: Bozadjieva N
Year: 2017
Journal: J Clin Invest
Title: Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion.
Volume: 127
Issue: 12
Pages: 4379-4393
•
•
•
•
•
Publication
38761065 | J:359274
First Author: Guo D
Year: 2024
Journal: Epilepsia
Title: A role of dentate gyrus mechanistic target of rapamycin activation in epileptogenesis in a mouse model of posttraumatic epilepsy.
Volume: 65
Issue: 7
Pages: 2127-2137
•
•
•
•
•
Publication
27677248 | J:359141
First Author: Chen LL
Year: 2016
Journal: CNS Neurosci Ther
Title: Neural Progenitor Cells Rptor Ablation Impairs Development but Benefits to Seizure-Induced Behavioral Abnormalities.
Volume: 22
Issue: 12
Pages: 1000-1008
•
•
•
•
•
Publication
34866316 | J:359135
First Author: Xu X
Year: 2022
Journal: EMBO Rep
Title: The mTORC1-eIF4F axis controls paused pluripotency.
Volume: 23
Issue: 2
Pages: e53081
•
•
•
•
•
Publication
25582201 | J:224291
First Author: Wang S
Year: 2015
Journal: Mol Cell Biol
Title: Regulation of endothelial cell proliferation and vascular assembly through distinct mTORC2 signaling pathways.
Volume: 35
Issue: 7
Pages: 1299-313
•
•
•
•
•
Publication
35618880 | J:352377
First Author: Godale CM
Year: 2022
Journal: J Mol Neurosci
Title: Impact of Raptor and Rictor Deletion on Hippocampal Pathology Following Status Epilepticus.
Volume: 72
Issue: 6
Pages: 1243-1258
•
•
•
•
•
Publication
38307148 | J:359144
 
First Author: Zheng Z
Year: 2024
Journal: Behav Brain Res
Title: Selective disruption of mTORC1 and mTORC2 in VTA astrocytes induces depression and anxiety-like behaviors in mice.
Volume: 463
Pages: 114888
•
•
•
•
•
Publication
23092880 | J:219062
First Author: Le Bacquer O
Year: 2013
Journal: J Endocrinol
Title: mTORC1 and mTORC2 regulate insulin secretion through Akt in INS-1 cells.
Volume: 216
Issue: 1
Pages: 21-9
•
•
•
•
•
Publication
30887444 | J:359266
First Author: Li T
Year: 2019
Journal: Protein Cell
Title: PKM2 coordinates glycolysis with mitochondrial fusion and oxidative phosphorylation.
Volume: 10
Issue: 8
Pages: 583-594
•
•
•
•
•
Protein Coding Gene
MGI:2384784 | Eif4g1
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:95305 | Eif4e
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:98159 | Rps6
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein
Q6NZJ6
Organism: Mus musculus/domesticus
Length: 1600  
Fragment?: false
•
•
•
•
•
Protein
P63073
Organism: Mus musculus/domesticus
Length: 217  
Fragment?: false
•
•
•
•
•
Protein
P62754
Organism: Mus musculus/domesticus
Length: 249  
Fragment?: false
•
•
•
•
•
HT Experiment
GSE252252 | TFEB safeguards trophoblast syncytialization in humans and mice (mouse RNA-Seq)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
•
•
•
•
•
HT Experiment
E-GEOD-43575 | A Prader-Willi locus lncRNA cloud modulates diurnal genes and energy expenditure
Series Id: GSE43575
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
•
•
•
•
•
HT Experiment
E-GEOD-54417 | mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress
Series Id: GSE54417
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
•
•
•
•
•
HT Experiment
GSE213202 | mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
•
•
•
•
•
HT Experiment
GSE77941 | RNA sequencing of WT and Uhrf1 KO iNKT cells
Series Id: E-GEOD-77941
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
•
•
•
•
•
Publication
34496251 | J:327012
First Author: Bai X
Year: 2021
Journal: Cell Rep
Title: Diurnal regulation of oxidative phosphorylation restricts hepatocyte proliferation and inflammation.
Volume: 36
Issue: 10
Pages: 109659
•
•
•
•
•
Publication
35945201 | J:334140
First Author: Karalis V
Year: 2022
Journal: Nat Commun
Title: Raptor downregulation rescues neuronal phenotypes in mouse models of Tuberous Sclerosis Complex.
Volume: 13
Issue: 1
Pages: 4665
•
•
•
•
•
Publication
22504639 | J:188676
First Author: Ohtani M
Year: 2012
Journal: J Immunol
Title: Cutting edge: mTORC1 in intestinal CD11c+ CD11b+ dendritic cells regulates intestinal homeostasis by promoting IL-10 production.
Volume: 188
Issue: 10
Pages: 4736-40
•
•
•
•
•
Publication
25639470 | J:219960
First Author: Ye P
Year: 2015
Journal: Mol Cell
Title: An mTORC1-Mdm2-Drosha axis for miRNA biogenesis in response to glucose- and amino acid-deprivation.
Volume: 57
Issue: 4
Pages: 708-20
•
•
•
•
•
Publication
21765414 | J:176473
First Author: Yang K
Year: 2011
Journal: Nat Immunol
Title: The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function.
Volume: 12
Issue: 9
Pages: 888-97
•
•
•
•
•
Publication
22883231 | J:187378
First Author: Laplante M
Year: 2012
Journal: Cell Metab
Title: DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity.
Volume: 16
Issue: 2
Pages: 202-12
•
•
•
•
•
Publication
24671993 | J:210456
First Author: Bercury KK
Year: 2014
Journal: J Neurosci
Title: Conditional ablation of raptor or rictor has differential impact on oligodendrocyte differentiation and CNS myelination.
Volume: 34
Issue: 13
Pages: 4466-80
•
•
•
•
•
Publication
25759015 | J:219922
First Author: Moses MA
Year: 2015
Journal: Cancer Cell
Title: The GLU that holds cancer together: targeting GLUtamine transporters in breast cancer.
Volume: 27
Issue: 3
Pages: 317-9
•
•
•
•
•
Publication
26977873 | J:231768
First Author: Malumbres M
Year: 2016
Journal: Cancer Cell
Title: CDK4/6 Inhibitors resTORe Therapeutic Sensitivity in HER²⁺ Breast Cancer.
Volume: 29
Issue: 3
Pages: 243-4
•
•
•
•
•
Publication
36323257 | J:333428
First Author: Tariq K
Year: 2022
Journal: Cell Rep
Title: Disruption of mTORC1 rescues neuronal overgrowth and synapse function dysregulated by Pten loss.
Volume: 41
Issue: 5
Pages: 111574
•
•
•
•
•
Publication
28699639 | J:250382
 
First Author: Blandino-Rosano M
Year: 2017
Journal: Nat Commun
Title: Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing.
Volume: 8
Pages: 16014
•
•
•
•
•
Publication
25201874 | J:217934
 
First Author: Knight ZA
Year: 2014
Journal: Elife
Title: A critical role for mTORC1 in erythropoiesis and anemia.
Volume: 3
Pages: e01913
•
•
•
•
•
Publication
29035283 | J:255468
First Author: Quinn WJ 3rd
Year: 2017
Journal: J Clin Invest
Title: mTORC1 stimulates phosphatidylcholine synthesis to promote triglyceride secretion.
Volume: 127
Issue: 11
Pages: 4207-4215
•
•
•
•
•
Publication
20832730 | J:163988
First Author: Gao D
Year: 2010
Journal: Mol Cell
Title: Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.
Volume: 39
Issue: 5
Pages: 797-808
•
•
•
•
•
Publication
30154443 | J:302784
First Author: Zhu Y
Year: 2019
Journal: Cell Death Differ
Title: Superhero Rictor promotes cellular differentiation of mouse embryonic stem cells.
Volume: 26
Issue: 5
Pages: 958-968
•
•
•
•
•
Publication
31619583 | J:309000
 
First Author: Katholnig K
Year: 2019
Journal: JCI Insight
Title: Inactivation of mTORC2 in macrophages is a signature of colorectal cancer that promotes tumorigenesis.
Volume: 4
Issue: 20
•
•
•
•
•
Publication
30665937 | J:272905
First Author: Ding C
Year: 2019
Journal: J Immunol
Title: Tumor Microenvironment Modulates Immunological Outcomes of Myeloid Cells with mTORC1 Disruption.
Volume: 202
Issue: 5
Pages: 1623-1634
•
•
•
•
•
Publication
30539788 | J:295038
First Author: Liu W
Year: 2019
Journal: Cell Mol Gastroenterol Hepatol
Title: Macrophage Raptor Deficiency-Induced Lysosome Dysfunction Exacerbates Nonalcoholic Steatohepatitis.
Volume: 7
Issue: 1
Pages: 211-231
•
•
•
•
•
Publication
31533002 | J:298719
First Author: Raybuck AL
Year: 2019
Journal: FASEB J
Title: mTORC1 as a cell-intrinsic rheostat that shapes development, preimmune repertoire, and function of B lymphocytes.
Volume: 33
Issue: 12
Pages: 13202-13215
•
•
•
•
•
Publication
23958952 | J:203260
First Author: Lee K
Year: 2013
Journal: Blood
Title: Requirement for Rictor in homeostasis and function of mature B lymphoid cells.
Volume: 122
Issue: 14
Pages: 2369-79
•
•
•
•
•
Publication
35579957 | J:327151
 
First Author: Wong C
Year: 2022
Journal: J Clin Invest
Title: mTORC2 mediates structural plasticity in distal nociceptive endings that contributes to pain hypersensitivity following inflammation.
Volume: 132
Issue: 15
•
•
•
•
•
Publication
29161318 | J:251217
First Author: Grier MD
Year: 2017
Journal: PLoS One
Title: Loss of mTORC2 signaling in oligodendrocyte precursor cells delays myelination.
Volume: 12
Issue: 11
Pages: e0188417
•
•
•
•
•
Publication
29670094 | J:265006
First Author: Wang C
Year: 2018
Journal: Cell Death Dis
Title: Loss of DEPTOR in renal tubules protects against cisplatin-induced acute kidney injury.
Volume: 9
Issue: 5
Pages: 441
•
•
•
•
•
Publication
23030823 | J:190940
First Author: Najafov A
Year: 2012
Journal: Biochem J
Title: Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P3-dependent mechanisms leading to resistance to PDK1 inhibitors.
Volume: 448
Issue: 2
Pages: 285-95
•
•
•
•
•
Publication
33307020 | J:302126
First Author: Inomata M
Year: 2021
Journal: Exp Cell Res
Title: Rictor-targeting exosomal microRNA-16 ameliorates lung fibrosis by inhibiting the mTORC2-SPARC axis.
Volume: 398
Issue: 2
Pages: 112416
•
•
•
•
•
Publication
28106162 | J:323752
 
First Author: Chen WY
Year: 2017
Journal: Sci Rep
Title: Heterogeneous nuclear ribonucleoprotein M associates with mTORC2 and regulates muscle differentiation.
Volume: 7
Pages: 41159
•
•
•
•
•
Publication
29518209 | J:333233
First Author: Bai S
Year: 2018
Journal: Mol Hum Reprod
Title: A germline-specific role for the mTORC2 component Rictor in maintaining spermatogonial differentiation and intercellular adhesion in mouse testis.
Volume: 24
Issue: 5
Pages: 244-259
•
•
•
•
•
Publication
36460463 | J:348340
First Author: Dahl KD
Year: 2023
Journal: J Neurosci
Title: mTORC2 Loss in Oligodendrocyte Progenitor Cells Results in Regional Hypomyelination in the Central Nervous System.
Volume: 43
Issue: 4
Pages: 540-558
•
•
•
•
•
Protein
Q8VH52
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: true
•
•
•
•
•
Publication
18076573 | -
First Author: Hayashi T
Year: 2007
Journal: Genes Cells
Title: Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits.
Volume: 12
Issue: 12
Pages: 1357-70
•
•
•
•
•
Protein Domain
IPR037588 | MLST8
Type: Family
Description: This entry represents target of rapamycin complex subunit LST8 (MLST8 or GbetaL), a component of both mTORC1 and mTORC2, complexes that regulate cell growth in response to nutrients. The mTORC1 complex consists of MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. The mTORC2 complex contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR []. In mTORC1, MLST8 interacts directly with MTOR and enhances its kinase activity [].This entry also includes the target of rapamycin complex subunit wat1 (pop3 or wat1) from Schizosaccharomyces pombe, which is also a component of yeast TORC1 and TORC2 complexes. The subunits of TORC1 in fission yeasts are known as mip1, pop3/wat1, tco89, toc1 and tor2; and the subunits of the TORC2 complex are bit61, pop3/wat1, sin1, ste20 and tor1 [].
•
•
•
•
•
Publication
31167146 | J:284459
First Author: Cai Y
Year: 2019
Journal: Cell Rep
Title: Differential Roles of the mTOR-STAT3 Signaling in Dermal γδ T Cell Effector Function in Skin Inflammation.
Volume: 27
Issue: 10
Pages: 3034-3048.e5
•
•
•
•
•
Publication
24948799 | J:212082
First Author: Lebrun-Julien F
Year: 2014
Journal: J Neurosci
Title: Balanced mTORC1 activity in oligodendrocytes is required for accurate CNS myelination.
Volume: 34
Issue: 25
Pages: 8432-48
•
•
•
•
•
Publication
31384057 | J:305614
First Author: Charbonnier LM
Year: 2019
Journal: Nat Immunol
Title: Functional reprogramming of regulatory T cells in the absence of Foxp3.
Volume: 20
Issue: 9
Pages: 1208-1219
•
•
•
•
•
Publication
37386153 | J:355689
First Author: Martinez-Lopez N
Year: 2023
Journal: Nat Cell Biol
Title: mTORC2-NDRG1-CDC42 axis couples fasting to mitochondrial fission.
Volume: 25
Issue: 7
Pages: 989-1003
•
•
•
•
•
HT Experiment
E-GEOD-55177 | Ataxin-2 adapts ribosomal mRNA levels and S6 phosphorylation to nutrient availability, with effects on protein synthesis and growth
Series Id: GSE55177
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
•
•
•
•
•
HT Experiment
GSE147191 | Single Cell Transcriptomics Reveals Dysregulated Cellular and Molecular Networks in a Fragile X Syndrome Model
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
•
•
•
•
•
HT Experiment
GSE252364 | Effect of methionine/choline deficient diet on liver and suprachiasmatic nucleus circadian transcriptome.
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
•
•
•
•
•
HT Experiment
GSE67120 | Tracing the Formation of Haematopoietic Stem Cells in Mouse Embryos by Single-cell Functional and RNA-Seq Analyses [single-cell]
Series Id: E-GEOD-67120
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
•
•
•
•
•
Publication
31263418 | J:281845
 
First Author: Hiraiwa M
Year: 2019
Journal: Front Pharmacol
Title: mTORC1 Activation in Osteoclasts Prevents Bone Loss in a Mouse Model of Osteoporosis.
Volume: 10
Pages: 684
•
•
•
•
•
Publication
34031386 | J:337333
First Author: Deng J
Year: 2021
Journal: Nat Commun
Title: The metabolic hormone leptin promotes the function of T(FH) cells and supports vaccine responses.
Volume: 12
Issue: 1
Pages: 3073
•
•
•
•
•
Publication
30830877 | J:292166
First Author: Han Y
Year: 2019
Journal: J Clin Invest
Title: Lkb1 deletion in periosteal mesenchymal progenitors induces osteogenic tumors through mTORC1 activation.
Volume: 129
Issue: 5
Pages: 1895-1909
•
•
•
•
•
Publication
30201994 | J:282504
First Author: Sato R
Year: 2018
Journal: Nat Immunol
Title: Combating herpesvirus encephalitis by potentiating a TLR3-mTORC2 axis.
Volume: 19
Issue: 10
Pages: 1071-1082
•
•
•
•
•
Publication
31296736 | J:359134
First Author: Di Luccia B
Year: 2019
Journal: J Exp Med
Title: ILC3s integrate glycolysis and mitochondrial production of reactive oxygen species to fulfill activation demands.
Volume: 216
Issue: 10
Pages: 2231-2241
•
•
•
•
•
Publication
37775560 | J:343230
First Author: Malik N
Year: 2023
Journal: Leukemia
Title: mTORC1-selective activation of translation elongation promotes disease progression in chronic lymphocytic leukemia.
Volume: 37
Issue: 12
Pages: 2414-2425
•
•
•
•
•
Publication
28319048 | J:243675
First Author: Kalaitzidis D
Year: 2017
Journal: J Clin Invest
Title: Amino acid-insensitive mTORC1 regulation enables nutritional stress resilience in hematopoietic stem cells.
Volume: 127
Issue: 4
Pages: 1405-1413
•
•
•
•
•
Publication
25431931 | J:218793
First Author: Lopez RJ
Year: 2015
Journal: Biochem J
Title: Raptor ablation in skeletal muscle decreases Cav1.1 expression and affects the function of the excitation-contraction coupling supramolecular complex.
Volume: 466
Issue: 1
Pages: 123-35
•
•
•
•
•
Publication
26889835 | J:231363
First Author: Wang HX
Year: 2016
Journal: PLoS Biol
Title: mTORC1 in Thymic Epithelial Cells Is Critical for Thymopoiesis, T-Cell Generation, and Temporal Control of γδT17 Development and TCRγ/δ Recombination.
Volume: 14
Issue: 2
Pages: e1002370
•
•
•
•
•
Publication
29969188 | J:306489
First Author: Wedel J
Year: 2019
Journal: Am J Transplant
Title: DEPTOR modulates activation responses in CD4+ T cells and enhances immunoregulation following transplantation.
Volume: 19
Issue: 1
Pages: 77-88
•
•
•
•
•
Publication
28557002 | J:246184
First Author: Li B
Year: 2017
Journal: Immunology
Title: Mammalian target of rapamycin complex 1 signalling is essential for germinal centre reaction.
Volume: 152
Issue: 2
Pages: 276-286
•
•
•
•
•
Publication
32029223 | J:329617
 
First Author: Paolella LM
Year: 2020
Journal: Mol Metab
Title: mTORC1 restrains adipocyte lipolysis to prevent systemic hyperlipidemia.
Volume: 32
Pages: 136-147
•
•
•
•
•
Publication
30224697 | J:281763
First Author: Lian WS
Year: 2018
Journal: Cell Death Dis
Title: Chaperonin 60 sustains osteoblast autophagy and counteracts glucocorticoid aggravation of osteoporosis by chaperoning RPTOR.
Volume: 9
Issue: 10
Pages: 938
•
•
•
•
•
Publication
22057724 | J:321353
First Author: Zhang Z
Year: 2012
Journal: Mol Cell Biochem
Title: mTOR-rictor is the Ser473 kinase for AKT1 in mouse one-cell stage embryos.
Volume: 361
Issue: 1-2
Pages: 249-57
•
•
•
•
•
Publication
25120095 | J:234896
First Author: Jiang H
Year: 2014
Journal: Diabetologia
Title: Macrophage mTORC1 disruption reduces inflammation and insulin resistance in obese mice.
Volume: 57
Issue: 11
Pages: 2393-404
•
•
•
•
•
Publication
36535626 | J:336790
 
First Author: Colas C
Year: 2023
Journal: Mol Metab
Title: DEPTOR loss impairs brown adipocyte development in vitro but has limited impacts in mice.
Volume: 67
Pages: 101660
•
•
•
•
•
Publication
35715811 | J:358759
First Author: Khlaifia A
Year: 2022
Journal: Mol Brain
Title: mTORC1 function in hippocampal parvalbumin interneurons: regulation of firing and long-term potentiation of intrinsic excitability but not long-term contextual fear memory and context discrimination.
Volume: 15
Issue: 1
Pages: 56
•
•
•
•
•
Publication
29103956 | J:253967
First Author: Wu CC
Year: 2017
Journal: Dev Cell
Title: mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma.
Volume: 43
Issue: 6
Pages: 673-688.e5
•
•
•
•
•
Publication
28930662 | J:258657
First Author: Xu L
Year: 2017
Journal: Immunity
Title: The Kinase mTORC1 Promotes the Generation and Suppressive Function of Follicular Regulatory T Cells.
Volume: 47
Issue: 3
Pages: 538-551.e5
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom