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Search results 2301 to 2400 out of 2589 for Pcna

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Type Details Score
Publication
14762204 | J:87789
First Author: Wang X
Year: 2004
Journal: Nucleic Acids Res
Title: Involvement of Hus1 in the chain elongation step of DNA replication after exposure to camptothecin or ionizing radiation.
Volume: 32
Issue: 2
Pages: 767-75
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Publication
7910606 | J:113822
First Author: Zeng XR
Year: 1994
Journal: J Biol Chem
Title: DNA polymerase delta is involved in the cellular response to UV damage in human cells.
Volume: 269
Issue: 19
Pages: 13748-51
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Publication
16982685 | J:118069
First Author: Guo C
Year: 2006
Journal: Mol Cell Biol
Title: Ubiquitin-binding motifs in REV1 protein are required for its role in the tolerance of DNA damage.
Volume: 26
Issue: 23
Pages: 8892-900
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Publication
10211316 | J:51413
First Author: Uehara M
Year: 1999
Journal: Oral Oncol
Title: Cell kinetics of mouse tumour subjected to photodynamic therapy--evaluation by proliferating cell nuclear antigen immunohistochemistry.
Volume: 35
Issue: 1
Pages: 93-7
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Publication
18951892 | J:144877
First Author: Capanni C
Year: 2008
Journal: Exp Cell Res
Title: Prelamin A is involved in early steps of muscle differentiation.
Volume: 314
Issue: 20
Pages: 3628-37
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Publication
19228710 | J:173037
First Author: Watanabe K
Year: 2009
Journal: Nucleic Acids Res
Title: RAD18 promotes DNA double-strand break repair during G1 phase through chromatin retention of 53BP1.
Volume: 37
Issue: 7
Pages: 2176-93
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Publication
27377895 | J:240783
 
First Author: Gao Y
Year: 2016
Journal: Nat Commun
Title: A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis.
Volume: 7
Pages: 12105
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Publication
28854357 | J:255266
First Author: Zhou J
Year: 2017
Journal: Cell Rep
Title: NEIL3 Repairs Telomere Damage during S Phase to Secure Chromosome Segregation at Mitosis.
Volume: 20
Issue: 9
Pages: 2044-2056
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Publication
29673590 | J:273345
First Author: Qin J
Year: 2018
Journal: Biochem Biophys Res Commun
Title: The cross roles of sphingosine kinase 1/2 and ceramide glucosyltransferase in cell growth and death.
Volume: 500
Issue: 3
Pages: 597-602
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Publication
32454192 | J:296878
 
First Author: Marinho TS
Year: 2020
Journal: Mol Cell Endocrinol
Title: Browning of the subcutaneous adipocytes in diet-induced obese mouse submitted to intermittent fasting.
Volume: 513
Pages: 110872
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Publication
38175749 | J:344367
First Author: Marple T
Year: 2024
Journal: Cell Rep
Title: TREX2 deficiency suppresses spontaneous and genotoxin-associated mutagenesis.
Volume: 43
Issue: 1
Pages: 113637
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Protein Coding Gene
MGI:1919357 | Dscc1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2146571 | Rfc4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1919401 | Rfc5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1341868 | Rfc2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q6IRT3
Organism: Mus musculus/domesticus
Length: 573  
Fragment?: false
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Protein
Q8BQY8
Organism: Mus musculus/domesticus
Length: 280  
Fragment?: false
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Protein
Q8K572
Organism: Mus musculus/domesticus
Length: 276  
Fragment?: false
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Protein
A0A0R4J0G5
Organism: Mus musculus/domesticus
Length: 573  
Fragment?: false
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Protein
F6VRS2
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: true
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Protein
A0A0N4SVN6
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: true
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Protein
A0A494BAY5
Organism: Mus musculus/domesticus
Length: 144  
Fragment?: true
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Protein
A0A494BAL0
Organism: Mus musculus/domesticus
Length: 73  
Fragment?: false
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Protein
Q3UPY0
Organism: Mus musculus/domesticus
Length: 255  
Fragment?: true
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Protein
Q3UXB7
Organism: Mus musculus/domesticus
Length: 365  
Fragment?: true
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Protein
D3Z515
Organism: Mus musculus/domesticus
Length: 64  
Fragment?: true
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Protein
A0A494B9R8
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
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Protein
Q8QZZ4
Organism: Mus musculus/domesticus
Length: 122  
Fragment?: true
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Protein
Q059L7
Organism: Mus musculus/domesticus
Length: 276  
Fragment?: false
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Protein Domain
IPR007268 | Rad9/Ddc1
Type: Family
Description: This entry represents the DNA damage checkpoint protein Rad9 and its homologue in budding yeast, Ddc1. Rad9 forms a complex with Hus1 and Rad1 (called 9-1-1 complex). Ddc1 forms a similar complex with Mec1 and Rad17. Structurally, the 9-1-1 / Ddc1-Mec3-Rad17 complex is similar to the PCNA complex, which forms trimeric ring-shaped clamps. The 9-1-1 / Ddc1-Mec3-Rad17 complex plays a role in checkpoint activation that permits DNA-repair pathways to prevent cell cycle progression in response to DNA damage and replication stress [, ].In humans, 9-1-1 binds to TopBP1 and activates the ATR-Chk1 checkpoint pathway []. Besides its function in the 9-1-1 complex, Rad9 can also act as a transcriptional factor and participate in immunoglobulin class switch recombination []. It also shows 3'-5' exonuclease activity []. Aberrant Rad9 expression has been associated with prostate, breast, lung, skin, thyroid, and gastric cancers [].In budding yeast, Ddc1 can activate Mec1 (the principal checkpoint protein kinase, human ATR homologue) in G1 phase. In G2 phase, Ddc1 can either activate Mec1 directly or recruit Dpb11 (the orthologue of human TopBP1) and subsequently activate Mec1 []. Ddc1 does not have DNA exonuclease function [].It is worth noting that the Rad9 proteins referred to in this entry are the mammalian and fission yeast homologues of budding yeast Ddc1. Members of this family do not share the sequence homology another DNA damage-dependent checkpoint protein from budding yeast, confusingly also called Rad9.
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Protein Domain
IPR038437 | GINS_Psf3_sf
Type: Homologous_superfamily
Description: DNA replication in eukaryotes results from a highly coordinated interaction between proteins, often as part of protein complexes, and the DNA template. One of the key early steps leading to DNA replication is formation of the pre-replication complex, or pre-RC. The pre-RC is formed by the sequential binding of the origin recognition complex (ORC), Cdc6 and Cdt1 proteins, and the MCM complex. Activation of the pre-RC into the initiation complex (IC) is achieved via the action of S-phase kinases, eventually leading to the loading of the replication machinery.Recently, a novel replication complex, GINS (for Go, Ichi, Nii, and San; five, one, two, and three in Japanese), has been identified [, ]. The precise function of GINS is not known. However, genetic and two-hybrid interactions indicate that it mediates the loading of the enzymatic replication machinery at a step after the action of the S-phase kinases []. Furthermore, GINS may be a part of the replication machinery itself, since it is found associated with replicating DNA [, ]. Electron microscopy of GINS shows that it forms a ring-like structure [], reminiscent of the structure of PCNA [], the DNA polymerase delta replication clamp. This observation, coupled with the observed interactions for GINS, indicates that the complex may represent the replication clamp for DNA polymerase epsilon [].The GINS complex is essential for initiation of DNA replication in Xenopus egg extracts []. This 100kDa stable complex includes Sld5, Psf1, Psf2, and Psf3. Homologues of these components are found also in other eukaryotes. This superfamily represents the Psf3 component.
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Protein Domain
IPR010492 | GINS_Psf3
Type: Family
Description: DNA replication in eukaryotes results from a highly coordinated interaction between proteins, often as part of protein complexes, and the DNA template. One of the key early steps leading to DNA replication is formation of the pre-replication complex, or pre-RC. The pre-RC is formed by the sequential binding of the origin recognition complex (ORC), Cdc6 and Cdt1 proteins, and the MCM complex. Activation of the pre-RC into the initiation complex (IC) is achieved via the action of S-phase kinases, eventually leading to the loading of the replication machinery.Recently, a novel replication complex, GINS (for Go, Ichi, Nii, and San; five, one, two, and three in Japanese), has been identified [, ]. The precise function of GINS is not known. However, genetic and two-hybrid interactions indicate that it mediates the loading of the enzymatic replication machinery at a step after the action of the S-phase kinases []. Furthermore, GINS may be a part of the replication machinery itself, since it is found associated with replicating DNA [, ]. Electron microscopy of GINS shows that it forms a ring-like structure [], reminiscent of the structure of PCNA [], the DNA polymerase delta replication clamp. This observation, coupled with the observed interactions for GINS, indicates that the complex may represent the replication clamp for DNA polymerase epsilon [].The GINS complex is essential for initiation of DNA replication in Xenopusegg extracts []. This 100kDa stable complex includes Sld5, Psf1, Psf2, and Psf3. Homologues of these components are found also in other eukaryotes. This family of proteins represents the Psf3 component.
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Protein Domain
IPR007257 | GINS_Psf2
Type: Family
Description: DNA replication in eukaryotes results from a highly coordinated interaction between proteins, often as part of protein complexes, and the DNA template. One of the key early steps leading to DNA replication is formation of the prereplication complex, or pre-RC. The pre-RC is formed by the sequential binding of the origin recognition complex (ORC), Cdc6 and Cdt1 proteins, and the MCM complex. Activation of the pre-RC into the initiation complex (IC) is achieved via the action of S-phase kinases, eventually leading to the loading of the replication machinery.Recently, a novel replication complex, GINS (for Go, Ichi, Nii, and San; five, one, two, and three in Japanese), has been identified [, ]. The precise function of GINS is not known. However, genetic and two-hybrid interactions indicate that it mediates the loading of the enzymatic replication machinery at a step after the action of the S-phase kinases []. Furthermore, GINS may be a part of the replication machinery itself, since it is found associated with replicating DNA [, ]. Electron microscopy of GINS shows that it forms a ring-like structure [], reminiscent of the structure of PCNA [], the DNA polymerase delta replication clamp.This observation, coupled with the observed interactions for GINS, indicates that the complex may represent the replication clamp for DNA polymerase epsilon [].The GINS complex is essential for initiation of DNA replication in Xenopus egg extracts []. This 100kDa stable complex includes Sld5, Psf1, Psf2, and Psf3. Homologues of these components are found also in other eukaryotes. This family of proteins represents the Psf2 component.
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Protein Domain
IPR029091 | CAF1_p150_N
Type: Domain
Description: Chromatin assembly factor 1 (CAF-1) consists of three evolutionary conserved subunits, p150, p60, and p48 (yeast homologues Cac1, cac2 and cac3 respectively), and mediates the assembly of nucleosomes onto newly replicated DNA. The p150 subunit (CAF-1_p150, also known as subunit A) is the core component of the CAF-1 histone chaperone complex, which functions in depositing newly synthesised and acetylated histones H3/H4 into chromatin during DNA replication and repair [, ], being essential for cell viability and efficient DNA replication. The p150 subunit contains the interaction regions with proliferating cell nuclear antigen (PCNA), heterochromatin protein 1 (HP1), the CAF-1 p60 subunit among others proteins []. It is thought that the DNA association with two histone-bound CAF-1 complexes may promote the formation of the (H3-H4)2 tetramer on DNA [].This entry represents the N-terminal region of the CAF-1 subunit p150 that contains one of the PCNA (proliferating cell nuclear antigen) binding sites, designated PIP1 and the heterochromatin protein 1 (HP1) interacting domain MIR []. These domains are dispensable for p150 role in nucleosome assembly and it is thought that this N-terminal region of CAF-1 might act as a regulatory domain contributing to CAF-1-PCNA interaction stability or mediate other functions during DNA repair or heterochromatin maintenance [].
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Protein Domain
IPR005339 | GINS_Psf1
Type: Family
Description: DNA replication in eukaryotes results from a highly coordinated interaction between proteins, often as part of protein complexes, and the DNA template. One of the key early steps leading to DNA replication is formation of the prereplication complex, or pre-RC. The pre-RC is formed by the sequential binding of the origin recognition complex (ORC), Cdc6 and Cdt1 proteins, and the MCM complex. Activation of the pre-RC into the initiation complex (IC) is achieved via the action of S-phase kinases, eventually leading to the loading of the replication machinery.Recently, a novel replication complex, GINS (for Go, Ichi, Nii, and San; five, one, two, and three in Japanese), has been identified [, ]. The precise function of GINS is not known. However, genetic and two-hybrid interactions indicate that it mediates the loading of the enzymatic replication machinery at a step after the action of the S-phase kinases []. Furthermore, GINS may be a part of the replication machinery itself, since it is found associated with replicating DNA [, ]. Electron microscopy of GINS shows that it forms a ring-like structure [], reminiscent of the structure of PCNA [], the DNA polymerase delta replication clamp.This observation, coupled with the observed interactions for GINS, indicates that the complex may represent the replication clamp for DNA polymerase epsilon [].This family of proteins represents the PSF1 component (for partner of SLD five) of the GINS complex.
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Publication
12730133 | -
First Author: Kubota Y
Year: 2003
Journal: Genes Dev
Title: A novel ring-like complex of Xenopus proteins essential for the initiation of DNA replication.
Volume: 17
Issue: 9
Pages: 1141-52
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Publication
12730134 | -
First Author: Takayama Y
Year: 2003
Journal: Genes Dev
Title: GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast.
Volume: 17
Issue: 9
Pages: 1153-65
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Publication
10984098 | J:342936
First Author: Uemura T
Year: 2000
Journal: Cell Struct Funct
Title: Temporal and spatial localization of novel nuclear protein NP95 in mitotic and meiotic cells.
Volume: 25
Issue: 3
Pages: 149-59
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Publication
16782882 | J:110331
First Author: Haegebarth A
Year: 2006
Journal: Mol Cell Biol
Title: Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestine.
Volume: 26
Issue: 13
Pages: 4949-57
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Publication
15585571 | J:94693
First Author: Coverley D
Year: 2005
Journal: J Cell Sci
Title: Ciz1 promotes mammalian DNA replication.
Volume: 118
Issue: Pt 1
Pages: 101-12
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Publication
12522211 | J:82586
First Author: Liu L
Year: 2003
Journal: J Biol Chem
Title: Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen.
Volume: 278
Issue: 12
Pages: 10041-7
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Publication
11595739 | J:282617
First Author: Ducoux M
Year: 2001
Journal: J Biol Chem
Title: Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta.
Volume: 276
Issue: 52
Pages: 49258-66
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Publication
19845771 | J:158320
First Author: Negishi M
Year: 2009
Journal: Genes Cells
Title: Dmap1 plays an essential role in the maintenance of genome integrity through the DNA repair process.
Volume: 14
Issue: 11
Pages: 1347-57
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Publication
23589330 | J:204494
First Author: Cataldo F
Year: 2013
Journal: Mol Cell Biol
Title: CAPNS1 regulates USP1 stability and maintenance of genome integrity.
Volume: 33
Issue: 12
Pages: 2485-96
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Publication
25377875 | J:246322
First Author: Lin Y
Year: 2015
Journal: Diabetes
Title: In vivo pancreatic β-cell-specific expression of antiaging gene Klotho: a novel approach for preserving β-cells in type 2 diabetes.
Volume: 64
Issue: 4
Pages: 1444-58
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Publication
30292635 | J:270162
First Author: Howe C
Year: 2018
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Differential expression of tumor-associated genes and altered gut microbiome with decreased Akkermansia muciniphila confer a tumor-preventive microenvironment in intestinal epithelial Pten-deficient mice.
Volume: 1864
Issue: 12
Pages: 3746-3758
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Publication
26791485 | J:232640
First Author: Qingjuan L
Year: 2016
Journal: Am J Physiol Cell Physiol
Title: miR-148a-3p overexpression contributes to glomerular cell proliferation by targeting PTEN in lupus nephritis.
Volume: 310
Issue: 6
Pages: C470-8
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Publication
14985319 | J:109731
First Author: Zeiss CJ
Year: 2004
Journal: Invest Ophthalmol Vis Sci
Title: Proliferation of microglia, but not photoreceptors, in the outer nuclear layer of the rd-1 mouse.
Volume: 45
Issue: 3
Pages: 971-6
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Publication
15044451 | J:90334
First Author: Williams TM
Year: 2004
Journal: J Biol Chem
Title: Combined loss of INK4a and caveolin-1 synergistically enhances cell proliferation and oncogene-induced tumorigenesis: role of INK4a/CAV-1 in mammary epithelial cell hyperplasia.
Volume: 279
Issue: 23
Pages: 24745-56
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Publication
15585573 | J:94692
First Author: Gittens JE
Year: 2005
Journal: J Cell Sci
Title: Interplay between paracrine signaling and gap junctional communication in ovarian follicles.
Volume: 118
Issue: Pt 1
Pages: 113-22
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Publication
25586993 | J:325813
 
First Author: Tsiperson V
Year: 2015
Journal: ASN Neuro
Title: Brain-derived neurotrophic factor deficiency restricts proliferation of oligodendrocyte progenitors following cuprizone-induced demyelination.
Volume: 7
Issue: 1
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Publication
30639531 | J:270928
 
First Author: Liu K
Year: 2019
Journal: Cancer Lett
Title: Defective CFTR promotes intestinal proliferation via inhibition of the hedgehog pathway during cystic fibrosis.
Volume: 446
Pages: 15-24
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Publication
20203062 | J:159243
First Author: von Montfort C
Year: 2010
Journal: Am J Physiol Gastrointest Liver Physiol
Title: PAI-1 plays a protective role in CCl4-induced hepatic fibrosis in mice: role of hepatocyte division.
Volume: 298
Issue: 5
Pages: G657-66
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Publication
20724593 | J:165340
First Author: Lin L
Year: 2010
Journal: Am J Pathol
Title: tPA activates LDL receptor-related protein 1-mediated mitogenic signaling involving the p90RSK and GSK3beta pathway.
Volume: 177
Issue: 4
Pages: 1687-96
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Publication
8536852 | J:31369
First Author: Fox JG
Year: 1996
Journal: Gastroenterology
Title: Hypertrophic gastropathy in Helicobacter felis-infected wild-type C57BL/6 mice and p53 hemizygous transgenic mice.
Volume: 110
Issue: 1
Pages: 155-66
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Publication
9707425 | J:49422
First Author: Venkatachalam S
Year: 1998
Journal: EMBO J
Title: Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation.
Volume: 17
Issue: 16
Pages: 4657-67
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Publication
11532341 | J:109332
First Author: Uberti D
Year: 2001
Journal: Brain Res Mol Brain Res
Title: p53 is dispensable for apoptosis but controls neurogenesis of mouse dentate gyrus cells following gamma-irradiation.
Volume: 93
Issue: 1
Pages: 81-9
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Publication
15790956 | J:108534
First Author: Kip SN
Year: 2005
Journal: Circ Res
Title: [Ca2+]i reduction increases cellular proliferation and apoptosis in vascular smooth muscle cells: relevance to the ADPKD phenotype.
Volume: 96
Issue: 8
Pages: 873-80
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Publication
16012758 | J:107612
First Author: Kase S
Year: 2005
Journal: Int J Mol Med
Title: Phosphorylation of p27(KIP1) in the developing retina and retinoblastoma.
Volume: 16
Issue: 2
Pages: 257-62
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Publication
18824542 | J:143318
First Author: Liu R
Year: 2008
Journal: Mol Cell Biol
Title: Laforin negatively regulates cell cycle progression through glycogen synthase kinase 3beta-dependent mechanisms.
Volume: 28
Issue: 23
Pages: 7236-44
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Publication
25942471 | J:235353
First Author: Chinzei N
Year: 2015
Journal: PLoS One
Title: P21 deficiency delays regeneration of skeletal muscular tissue.
Volume: 10
Issue: 5
Pages: e0125765
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Publication
16723699 | J:109129
First Author: Vitiello PF
Year: 2006
Journal: Am J Pathol
Title: p21Cip1 protection against hyperoxia requires Bcl-XL and is uncoupled from its ability to suppress growth.
Volume: 168
Issue: 6
Pages: 1838-47
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Publication
15138611 | J:94059
First Author: Nagata J
Year: 2004
Journal: Int J Mol Med
Title: Helicobacter pylori induces chronic active gastritis in p53-knockout mice.
Volume: 13
Issue: 6
Pages: 773-7
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Publication
24632830 | J:215113
First Author: Chaves LD
Year: 2014
Journal: PLoS One
Title: Loss of CD11b exacerbates murine complement-mediated tubulointerstitial nephritis.
Volume: 9
Issue: 3
Pages: e92051
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Publication
15917306 | J:101710
First Author: Maeda T
Year: 2005
Journal: Carcinogenesis
Title: Loss of p21WAF1/Cip1 in Gadd45-deficient keratinocytes restores DNA repair capacity.
Volume: 26
Issue: 10
Pages: 1804-10
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Publication
16799078 | J:125777
First Author: Lucattelli M
Year: 2006
Journal: Am J Respir Crit Care Med
Title: Neurokinin-1 receptor blockade and murine lung tumorigenesis.
Volume: 174
Issue: 6
Pages: 674-83
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Publication
17332475 | J:123695
First Author: Apte U
Year: 2007
Journal: Am J Physiol Gastrointest Liver Physiol
Title: beta-Catenin is critical for early postnatal liver growth.
Volume: 292
Issue: 6
Pages: G1578-85
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Publication
16159896 | J:104674
First Author: Sun J
Year: 2006
Journal: Am J Physiol Renal Physiol
Title: Compensatory kidney growth in estrogen receptor-alpha null mice.
Volume: 290
Issue: 2
Pages: F319-23
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Publication
15955696 | J:100292
First Author: Tekmal RR
Year: 2005
Journal: J Steroid Biochem Mol Biol
Title: Estrogen receptor alpha is required for mammary development and the induction of mammary hyperplasia and epigenetic alterations in the aromatase transgenic mice.
Volume: 95
Issue: 1-5
Pages: 9-15
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Publication
16006154 | J:117908
First Author: Wadhwa S
Year: 2005
Journal: Osteoarthritis Cartilage
Title: Accelerated osteoarthritis in the temporomandibular joint of biglycan/fibromodulin double-deficient mice.
Volume: 13
Issue: 9
Pages: 817-27
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Publication
25445542 | J:234218
First Author: Schaefer FM
Year: 2015
Journal: Biochim Biophys Acta
Title: Bone marrow-derived c-jun N-terminal kinase-1 (JNK1) mediates liver regeneration.
Volume: 1852
Issue: 1
Pages: 137-45
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Publication
9551401 | J:48005
First Author: Ma J
Year: 1998
Journal: Kidney Int
Title: Accelerated fibrosis and collagen deposition develop in the renal interstitium of angiotensin type 2 receptor null mutant mice during ureteral obstruction.
Volume: 53
Issue: 4
Pages: 937-44
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Publication
11554311 | J:172932
 
First Author: Krokan HE
Year: 2001
Journal: Prog Nucleic Acid Res Mol Biol
Title: Properties and functions of human uracil-DNA glycosylase from the UNG gene.
Volume: 68
Pages: 365-86
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Publication
25169977 | J:227753
First Author: Graf A
Year: 2014
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Knockout of histidine decarboxylase decreases bile duct ligation-induced biliary hyperplasia via downregulation of the histidine decarboxylase/VEGF axis through PKA-ERK1/2 signaling.
Volume: 307
Issue: 8
Pages: G813-23
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Publication
18955732 | J:149090
First Author: Ikeda H
Year: 2009
Journal: J Lipid Res
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