| Type |
Details |
Score |
| Strain |
| Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 2, David D Ginty |
| Allele Type: |
Targeted |
| Attribute String: |
Inducible, Recombinase |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Ret/Ret |
| Background: |
involves: 129S1/Sv * 129X1/SvJ * FVB/N |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor. |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; wild type |
| Allele Type: |
Not Specified |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bonnefont J |
| Year: |
2008 |
| Journal: |
Am J Hum Genet |
| Title: |
Evolutionary forces shape the human RFPL1,2,3 genes toward a role in neocortex development. |
| Volume: |
83 |
| Issue: |
2 |
| Pages: |
208-18 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Volakakis N |
| Year: |
2015 |
| Journal: |
J Neurosci |
| Title: |
Nurr1 and Retinoid X Receptor Ligands Stimulate Ret Signaling in Dopamine Neurons and Can Alleviate α-Synuclein Disrupted Gene Expression. |
| Volume: |
35 |
| Issue: |
42 |
| Pages: |
14370-85 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wills MK |
| Year: |
2017 |
| Journal: |
J Biol Chem |
| Title: |
Signaling adaptor ShcD suppresses extracellular signal-regulated kinase (Erk) phosphorylation distal to the Ret and Trk neurotrophic receptors. |
| Volume: |
292 |
| Issue: |
14 |
| Pages: |
5748-5759 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jmaeff S |
| Year: |
2020 |
| Journal: |
J Biol Chem |
| Title: |
Small-molecule agonists of the RET receptor tyrosine kinase activate biased trophic signals that are influenced by the presence of GFRa1 co-receptors. |
| Volume: |
295 |
| Issue: |
19 |
| Pages: |
6532-6542 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li Y |
| Year: |
2015 |
| Journal: |
Hum Mol Genet |
| Title: |
SRY interference of normal regulation of the RET gene suggests a potential role of the Y-chromosome gene in sexual dimorphism in Hirschsprung disease. |
| Volume: |
24 |
| Issue: |
3 |
| Pages: |
685-97 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Ret/Ret<+> |
| Background: |
involves: 129S1/Sv * C57BL/6J * FVB/N |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Regulatory Region |
| Type: |
enhancer |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Michiels FM |
| Year: |
1997 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Development of medullary thyroid carcinoma in transgenic mice expressing the RET protooncogene altered by a multiple endocrine neoplasia type 2A mutation. |
| Volume: |
94 |
| Issue: |
7 |
| Pages: |
3330-5 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Ret/Ret<+> |
| Background: |
involves: C57BL/6 |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Goodman KM |
| Year: |
2014 |
| Journal: |
Cell Rep |
| Title: |
RET recognition of GDNF-GFRα1 ligand by a composite binding site promotes membrane-proximal self-association. |
| Volume: |
8 |
| Issue: |
6 |
| Pages: |
1894-1904 |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells. |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 1, Frank Costantini |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 2, Frank Costantini |
| Allele Type: |
Targeted |
| Attribute String: |
Humanized sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 1, Vassilis Pachnis |
| Allele Type: |
Targeted |
| Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 2, Vassilis Pachnis |
| Allele Type: |
Targeted |
| Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret finger protein-like 4; wild type |
|
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 1, Jeffrey Milbrandt |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 1, Masahide Takahashi |
| Allele Type: |
Targeted |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 2, Jeffrey Milbrandt |
| Allele Type: |
Targeted |
| Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 3.1, Jeffrey Milbrandt |
| Allele Type: |
Targeted |
| Attribute String: |
Dominant negative |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 3, Jeffrey Milbrandt |
| Allele Type: |
Targeted |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 3, Vassilis Pachnis |
| Allele Type: |
Targeted |
| Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 4, Vassilis Pachnis |
| Allele Type: |
Targeted |
| Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 5, Vassilis Pachnis |
| Allele Type: |
Targeted |
| Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 4, Jeffrey Milbrandt |
| Allele Type: |
Targeted |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 5, Jeffrey Milbrandt |
| Allele Type: |
Targeted |
| Attribute String: |
Humanized sequence, Inserted expressed sequence, Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 6, Jeffrey Milbrandt |
| Allele Type: |
Targeted |
| Attribute String: |
Humanized sequence, Inserted expressed sequence, Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 7, Jeffrey Milbrandt |
| Allele Type: |
Targeted |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 8, Jeffrey Milbrandt |
| Allele Type: |
Targeted |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 9, Jeffrey Milbrandt |
| Allele Type: |
Targeted |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 10, Jeffrey Milbrandt |
| Allele Type: |
Targeted |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 11, Jeffrey Milbrandt |
| Allele Type: |
Targeted |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 12, Jeffrey Milbrandt |
| Allele Type: |
Targeted |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 1, Cristiana Carniti |
| Allele Type: |
Targeted |
| Attribute String: |
Humanized sequence, Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 1.1, Rudiger Klein |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 1, Rudiger Klein |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 13, Jeffrey Milbrandt |
| Allele Type: |
Targeted |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 3, Frank Costantini |
| Allele Type: |
Targeted |
| Attribute String: |
Not Specified |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 14, Jeffrey Milbrandt |
| Allele Type: |
Targeted |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 1, Hideki Enomoto |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 1, Giovanni Romeo |
| Allele Type: |
Targeted |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ret finger protein-like 4B; wild type |
| Allele Type: |
Not Specified |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 1.1, Patrik Ernfors |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 1.2, Patrik Ernfors |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 3.1, Hideki Enomoto |
| Allele Type: |
Targeted |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 6.1, Vassilis Pachnis |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 6.2, Vassilis Pachnis |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 1.1, Velocigene |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; endonuclease-mediated mutation 2, Hideki Enomoto |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Humanized sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; endonuclease-mediated mutation 3, Hideki Enomoto |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Humanized sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; endonuclease-mediated mutation 4, Hideki Enomoto |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Humanized sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; endonuclease-mediated mutation 1, Cyagen Biosciences |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7471444 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2023-05-15 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1666828 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:7481265 |
| Age: |
postnatal day 14 |
|
| Note: |
Segregation of neurons expressing TrkA from those expressing Ret nearly complete. |
| Specimen Label: |
1A P14 |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7471446 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2023-05-15 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1666828 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:7481268 |
| Age: |
postnatal day 14 |
|
| Note: |
Weak expression in Gfra2 expressing neurons. Overlap with Ret expression in 18.2% of cells. |
| Specimen Label: |
1B |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7471447 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2023-05-15 |
| Strength: |
Strong |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1666828 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:7481271 |
| Age: |
postnatal day 14 |
|
| Note: |
Strong expression in Gfra2 expressing neurons. Overlap with Ret expression in 61.4% of cells. |
| Specimen Label: |
1C |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7471448 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2023-05-15 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1666828 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:7481274 |
| Age: |
postnatal day 14 |
|
| Note: |
Weak expression in Gfra2 expressing neurons. Overlap with Ret expression in 13.9% of cells. |
| Specimen Label: |
1D |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7471447 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2023-05-15 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1666827 |
| Pattern: |
Regionally restricted |
| Stage: |
TS27 |
| Assay Id: |
MGI:7481273 |
| Age: |
postnatal day 2 |
|
| Note: |
Weak expression in Gfra2 expressing neurons. Overlap with Ret expression in 13.9% of cells. |
| Specimen Label: |
S6D |
| Detected: |
true |
| Specimen Num: |
10 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Ret/Ret<+> |
| Background: |
involves: 129/Sv * C57BL/6 |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
457
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
306
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
331
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
325
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Itier JM |
| Year: |
1998 |
| Journal: |
Nature |
| Title: |
Imprinted gene in postnatal growth role. |
| Volume: |
393 |
| Issue: |
6681 |
| Pages: |
125-6 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
513
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tezel G |
| Year: |
1999 |
| Journal: |
Pathol Int |
| Title: |
Different nuclear/cytoplasmic distributions of RET finger protein in different cell types. |
| Volume: |
49 |
| Issue: |
10 |
| Pages: |
881-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tezel G |
| Year: |
2002 |
| Journal: |
Pathol Int |
| Title: |
Differential expression of RET finger protein in testicular germ cell tumors. |
| Volume: |
52 |
| Issue: |
10 |
| Pages: |
623-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Horio M |
| Year: |
2012 |
| Journal: |
Cancer Med |
| Title: |
Expression of RET finger protein predicts chemoresistance in epithelial ovarian cancer. |
| Volume: |
1 |
| Issue: |
2 |
| Pages: |
218-29 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Ret/Ret<+> |
| Background: |
Not Specified |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Ret/Ret |
| Background: |
involves: 129S/Sv * C57BL/6 * FVB/N |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Ret/Ret<+> |
| Background: |
involves: 129 * C57BL/6 |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vargiolu M |
| Year: |
2009 |
| Journal: |
J Clin Endocrinol Metab |
| Title: |
The tyrosine kinase receptor RET interacts in vivo with aryl hydrocarbon receptor-interacting protein to alter survivin availability. |
| Volume: |
94 |
| Issue: |
7 |
| Pages: |
2571-8 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Transgene |
| Type: |
transgene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
targeted mutation, mutant strain |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
targeted mutation, mutant strain, congenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, congenic, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
Not specified |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
Not specified |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
targeted mutation, mutant strain, congenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
targeted mutation, mutant stock |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, targeted mutation |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 1, David D Ginty |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, Null/knockout, Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; targeted mutation 1.2, David D Ginty |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret finger protein-like 4B; endonuclease-mediated mutation 12, GemPharmatech Co., Ltd |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Allele |
| Name: |
ret proto-oncogene; endonuclease-mediated mutation 2, GemPharmatech Co., Ltd |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|