|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 2401 to 2500 out of 4449 for Apc

0.036s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
First Author: Shepherd DM
Year: 1999
Journal: J Immunol
Title: Disruption of CD154:CD40 blocks generation of allograft immunity without affecting APC activation.
Volume: 163
Issue: 5
Pages: 2470-7
Publication
First Author: Ma C
Year: 1999
Journal: J Immunol
Title: Role of APC in the selection of immunodominant T cell epitopes.
Volume: 163
Issue: 12
Pages: 6413-23
Publication
First Author: Lau T
Year: 2013
Journal: Cancer Res
Title: A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth.
Volume: 73
Issue: 10
Pages: 3132-44
Publication
First Author: Chiasson V
Year: 2019
Journal: J Am Heart Assoc
Title: Deficiency of MicroRNA miR-1954 Promotes Cardiac Remodeling and Fibrosis.
Volume: 8
Issue: 21
Pages: e012880
Publication
First Author: Rosenits K
Year: 2010
Journal: Eur J Immunol
Title: T cells acquire cell surface determinants of APC via in vivo trogocytosis during viral infections.
Volume: 40
Issue: 12
Pages: 3450-7
Publication
First Author: Sonoda KH
Year: 2002
Journal: Eur J Immunol
Title: CD1d on antigen-transporting APC and splenic marginal zone B cells promotes NKT cell-dependent tolerance.
Volume: 32
Issue: 3
Pages: 848-57
Publication  
First Author: Lane SI
Year: 2014
Journal: Nat Commun
Title: Non-canonical function of spindle assembly checkpoint proteins after APC activation reduces aneuploidy in mouse oocytes.
Volume: 5
Pages: 3444
Publication
First Author: Hülsken J
Year: 1994
Journal: J Cell Biol
Title: E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.
Volume: 127
Issue: 6 Pt 2
Pages: 2061-9
Publication
First Author: Mitin N
Year: 2007
Journal: Nat Struct Mol Biol
Title: Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression.
Volume: 14
Issue: 9
Pages: 814-23
Publication
First Author: Oshima M
Year: 1995
Journal: Cancer Res
Title: Evidence against dominant negative mechanisms of intestinal polyp formation by Apc gene mutations.
Volume: 55
Issue: 13
Pages: 2719-22
Publication
First Author: Pace L
Year: 2010
Journal: J Immunol
Title: APC activation by IFN-alpha decreases regulatory T cell and enhances Th cell functions.
Volume: 184
Issue: 11
Pages: 5969-79
Publication
First Author: Schreiner B
Year: 2008
Journal: Eur J Immunol
Title: PD-1 ligands expressed on myeloid-derived APC in the CNS regulate T-cell responses in EAE.
Volume: 38
Issue: 10
Pages: 2706-17
Publication
First Author: Lee DJ
Year: 2011
Journal: Invest Ophthalmol Vis Sci
Title: Following EAU recovery there is an associated MC5r-dependent APC induction of regulatory immunity in the spleen.
Volume: 52
Issue: 12
Pages: 8862-7
Publication
First Author: Evans DE
Year: 2000
Journal: J Immunol
Title: Resting B lymphocytes as APC for naive T lymphocytes: dependence on CD40 ligand/CD40.
Volume: 164
Issue: 2
Pages: 688-97
Publication
First Author: Marleau AM
Year: 2008
Journal: J Immunol
Title: Differential contributions of APC subsets to T cell activation in nonobese diabetic mice.
Volume: 180
Issue: 8
Pages: 5235-49
Publication
First Author: Breitman M
Year: 2008
Journal: Biochim Biophys Acta
Title: The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family members.
Volume: 1783
Issue: 10
Pages: 1792-802
Publication
First Author: Ekman M
Year: 2012
Journal: Mol Biol Cell
Title: APC and Smad7 link TGFβ type I receptors to the microtubule system to promote cell migration.
Volume: 23
Issue: 11
Pages: 2109-21
Publication
First Author: Lesko AC
Year: 2015
Journal: Biochim Biophys Acta
Title: The APC tumor suppressor is required for epithelial cell polarization and three-dimensional morphogenesis.
Volume: 1853
Issue: 3
Pages: 711-23
Publication
First Author: Wildhagen KC
Year: 2014
Journal: PLoS One
Title: Effects of exogenous recombinant APC in mouse models of ischemia reperfusion injury and of atherosclerosis.
Volume: 9
Issue: 7
Pages: e101446
Publication
First Author: Seah MK
Year: 2012
Journal: J Cell Sci
Title: The APC activator fizzy-related-1 (FZR1) is needed for preimplantation mouse embryo development.
Volume: 125
Issue: Pt 24
Pages: 6030-7
Publication
First Author: Yue SC
Year: 2010
Journal: J Immunol
Title: Direct CD1d-mediated stimulation of APC IL-12 production and protective immune response to virus infection in vivo.
Volume: 184
Issue: 1
Pages: 268-76
Publication
First Author: Young MA
Year: 2018
Journal: Stem Cells
Title: Subtle Deregulation of the Wnt-Signaling Pathway Through Loss of Apc2 Reduces the Fitness of Intestinal Stem Cells.
Volume: 36
Issue: 1
Pages: 114-122
Publication
First Author: Khanna KM
Year: 2010
Journal: J Immunol
Title: T cell and APC dynamics in situ control the outcome of vaccination.
Volume: 185
Issue: 1
Pages: 239-52
Publication
First Author: Smith RM
Year: 1994
Journal: Immunology
Title: Anti-class II MHC antibodies prevent and treat EAE without APC depletion.
Volume: 83
Issue: 1
Pages: 1-8
Publication  
First Author: Taketo MM
Year: 1999
Journal: Prog Exp Tumor Res
Title: Apc gene knockout mice as a model for familial adenomatous polyposis.
Volume: 35
Pages: 109-19
Publication
First Author: Zhu P
Year: 2004
Journal: Cancer Cell
Title: Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis.
Volume: 5
Issue: 5
Pages: 455-63
Publication
First Author: Jiang Y
Year: 2024
Journal: iScience
Title: Mapping and tracing Grem1(+) stromal cells in an Apc (Min/+) mouse utilizing cryopreserved intestinal sections prepared via modified Swiss-roll technique.
Volume: 27
Issue: 11
Pages: 111173
Publication      
First Author: He Z
Year: 2012
Journal: MGI Direct Data Submission
Title: Direct Data Submission 2012/01/09
Allele    
Name: APC regulator of WNT signaling pathway 2; wild type
Allele
Name: suppressor APC domain containing 2; targeted mutation 1, Shinichi Aizawa
Allele Type: Targeted
Attribute String: Null/knockout
Allele  
Name: APC membrane recruitment 1; gene trap OST46524, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: suppressor APC domain containing 1; gene trap OST269747, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: suppressor APC domain containing 1; gene trap OST297272, Lexicon Genetics
Allele Type: Gene trapped
Allele
Name: suppressor APC domain containing 1; targeted mutation 1, Velocigene
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Allele
Name: suppressor APC domain containing 2; targeted mutation 1, Velocigene
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Allele
Name: APC membrane recruitment 2; targeted mutation 1, Velocigene
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Allele
Name: APC membrane recruitment 1; targeted mutation 1.1, Nabeel Bardeesy
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
Allele
Name: APC membrane recruitment 1; targeted mutation 1.2, Nabeel Bardeesy
Allele Type: Targeted
Attribute String: Null/knockout
Allele
Name: suppressor APC domain containing 1; targeted mutation 1.1, Velocigene
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Allele
Name: APC membrane recruitment 1; targeted mutation 1.1, Andreas Schedl
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
Allele
Name: APC membrane recruitment 1; targeted mutation 1.2, Andreas Schedl
Allele Type: Targeted
Attribute String: Null/knockout
Allele
Name: APC membrane recruitment 1; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Allele
Name: APC membrane recruitment 2; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Allele
Name: APC membrane recruitment 3; endonuclease-mediated mutation 2, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Publication
First Author: Mukhopadhyay S
Year: 1999
Journal: J Immunol
Title: Delayed clearance of filarial infection and enhanced Th1 immunity due to modulation of macrophage APC functions in xid mice.
Volume: 163
Issue: 2
Pages: 875-83
Publication
First Author: Brahmakshatriya V
Year: 2017
Journal: J Immunol
Title: IL-6 Production by TLR-Activated APC Broadly Enhances Aged Cognate CD4 Helper and B Cell Antibody Responses In Vivo.
Volume: 198
Issue: 7
Pages: 2819-2833
Publication
First Author: Chougnet C
Year: 2001
Journal: J Immunol
Title: In vivo CD40-CD154 (CD40 ligand) interaction induces integrated HIV expression by APC in an HIV-1-transgenic mouse model.
Volume: 166
Issue: 5
Pages: 3210-7
Publication
First Author: Molnarfi N
Year: 2013
Journal: J Exp Med
Title: MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies.
Volume: 210
Issue: 13
Pages: 2921-37
Publication
First Author: Thomas PG
Year: 2005
Journal: J Immunol
Title: A helminth glycan induces APC maturation via alternative NF-kappa B activation independent of I kappa B alpha degradation.
Volume: 175
Issue: 4
Pages: 2082-90
Publication
First Author: Karmaus PW
Year: 2011
Journal: J Leukoc Biol
Title: Deletion of cannabinoid receptors 1 and 2 exacerbates APC function to increase inflammation and cellular immunity during influenza infection.
Volume: 90
Issue: 5
Pages: 983-95
Publication
First Author: Morris S
Year: 2011
Journal: J Immunol
Title: Autophagy-mediated dendritic cell activation is essential for innate cytokine production and APC function with respiratory syncytial virus responses.
Volume: 187
Issue: 8
Pages: 3953-61
Publication
First Author: Markova M
Year: 2005
Journal: Oncogene
Title: Diversity in secreted PLA2-IIA activity among inbred mouse strains that are resistant or susceptible to Apc Min/+ tumorigenesis.
Volume: 24
Issue: 42
Pages: 6450-8
Publication
First Author: Shintani T
Year: 2012
Journal: J Neurosci
Title: Directional neuronal migration is impaired in mice lacking adenomatous polyposis coli 2.
Volume: 32
Issue: 19
Pages: 6468-84
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1778728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692577
Age: postnatal adult
Image: JAX_1126035
Specimen Label: JAX_1126035
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5701424
Assay Type: RNA in situ
Annotation Date: 2016-01-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716319
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:5701443
Age: embryonic day 11.5-12.0
Specimen Label: 3
Detected: true
Specimen Num: 1
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692577
Age: postnatal adult
Image: JAX_1126037
Specimen Label: JAX_1126037
Detected: true
Specimen Num: 3
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1881228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692577
Age: postnatal adult
Image: JAX_1126033
Specimen Label: JAX_1126033
Detected: true
Specimen Num: 1
Allele
Name: APC, WNT signaling pathway regulator; targeted mutation 1, Khashayarsha Khazaie
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
Publication
First Author: Prizant H
Year: 2021
Journal: Cell Rep
Title: CXCL10+ peripheral activation niches couple preferred sites of Th1 entry with optimal APC encounter.
Volume: 36
Issue: 6
Pages: 109523
Publication
First Author: Jones MC
Year: 2023
Journal: J Immunol
Title: CD4 Effector TCR Avidity for Peptide on APC Determines the Level of Memory Generated.
Volume: 210
Issue: 12
Pages: 1950-1961
Publication
First Author: Ahlmann M
Year: 2009
Journal: J Immunol
Title: The cyclic AMP response element modulator {alpha} suppresses CD86 expression and APC function.
Volume: 182
Issue: 7
Pages: 4167-74
Publication  
First Author: Feau S
Year: 2012
Journal: Nat Commun
Title: The CD4⁺ T-cell help signal is transmitted from APC to CD8⁺ T-cells via CD27-CD70 interactions.
Volume: 3
Pages: 948
Publication
First Author: Lagarrigue F
Year: 2017
Journal: J Immunol
Title: Cutting Edge: Loss of T Cell RIAM Precludes Conjugate Formation with APC and Prevents Immune-Mediated Diabetes.
Volume: 198
Issue: 9
Pages: 3410-3415
Publication
First Author: Warnecke G
Year: 2010
Journal: Am J Pathol
Title: CD4+ regulatory T cells generated in vitro with IFN-{gamma} and allogeneic APC inhibit transplant arteriosclerosis.
Volume: 177
Issue: 1
Pages: 464-72
Publication
First Author: Markey KA
Year: 2009
Journal: Blood
Title: Conventional dendritic cells are the critical donor APC presenting alloantigen after experimental bone marrow transplantation.
Volume: 113
Issue: 22
Pages: 5644-9
Publication
First Author: Salvadori S
Year: 1998
Journal: Cell Immunol
Title: Antigen presentation by B7-nonprofessional APC does not prevent responses to solid tumor cells.
Volume: 183
Issue: 1
Pages: 52-9
Interaction Experiment
Description: APC inhibits ERK pathway activation and cellular proliferation induced by RAS.
Interaction Experiment
Description: Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes.
Interaction Experiment
Description: Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2).
Interaction Experiment
Description: Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas.
Interaction Experiment
Description: Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation.
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory