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Search results 2401 to 2500 out of 2532 for Arnt

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0.033s

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Type Details Score
Publication
26215100 | -
 
First Author: Oshida K
Year: 2015
Journal: Toxicology
Title: Screening a mouse liver gene expression compendium identifies modulators of the aryl hydrocarbon receptor (AhR).
Volume: 336
Pages: 99-112
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Publication
26475489 | -
First Author: Tarnow P
Year: 2016
Journal: Arch Toxicol
Title: G protein-coupled receptor 30 ligand G-1 increases aryl hydrocarbon receptor signalling by inhibition of tubulin assembly and cell cycle arrest in human MCF-7 cells.
Volume: 90
Issue: 8
Pages: 1939-48
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Protein Domain
IPR033348 | AHR
Type: Family
Description: Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the biological and toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), dioxin-like compounds (DLC), as well as some drugs and endogenous tryptophan metabolites []. Without ligands, AHR is part of the Hsp90/XAP2 (heat shock protein 90/hepatitis B virus X-associated protein) multi-chaperone protein complex. Upon ligand binding, the receptor dissociates from the chaperone complex and translocates into the nucleus where it heterodimerises with ARNT (AHR nuclear translocator). The respective heterodimeric complex then modulates the cell's transcriptional activity by binding to specific xenobiotic response elements (XREs) in the promoters of AHR target genes [, ].
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Publication
14645221 | J:207820
First Author: Curtis AM
Year: 2004
Journal: J Biol Chem
Title: Histone acetyltransferase-dependent chromatin remodeling and the vascular clock.
Volume: 279
Issue: 8
Pages: 7091-7
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Publication
16291793 | J:104419
First Author: Marion JF
Year: 2005
Journal: Development
Title: Sim1 and Sim2 are required for the correct targeting of mammillary body axons.
Volume: 132
Issue: 24
Pages: 5527-37
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Publication
12024206 | J:76640
First Author: Cheng MY
Year: 2002
Journal: Nature
Title: Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus.
Volume: 417
Issue: 6887
Pages: 405-10
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Publication
20159955 | J:156994
First Author: Schmutz I
Year: 2010
Journal: Genes Dev
Title: The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors.
Volume: 24
Issue: 4
Pages: 345-57
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Publication
21680841 | J:173532
First Author: Duong HA
Year: 2011
Journal: Science
Title: A molecular mechanism for circadian clock negative feedback.
Volume: 332
Issue: 6036
Pages: 1436-9
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Publication
26232227 | J:223990
First Author: Parsons MJ
Year: 2015
Journal: Cell
Title: The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis.
Volume: 162
Issue: 3
Pages: 607-21
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Genotype
Genotype
Symbol: Bmal1/Bmal1 Hif1a/Hif1a Speer6-ps1/Speer6-ps1<+>
Background: involves: 129 * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Publication
1314586 | J:477
First Author: Ema M
Year: 1992
Journal: Biochem Biophys Res Commun
Title: cDNA cloning and structure of mouse putative Ah receptor.
Volume: 184
Issue: 1
Pages: 246-53
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Publication
9887096 | J:52189
First Author: Mimura J
Year: 1999
Journal: Genes Dev
Title: Identification of a novel mechanism of regulation of Ah (dioxin) receptor function.
Volume: 13
Issue: 1
Pages: 20-5
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Publication
15741322 | J:96328
First Author: Warnecke M
Year: 2005
Journal: Genes Dev
Title: Abnormal development of the locus coeruleus in Ear2(Nr2f6)-deficient mice impairs the functionality of the forebrain clock and affects nociception.
Volume: 19
Issue: 5
Pages: 614-25
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Publication
36213234 | J:329949
 
First Author: Yuan H
Year: 2022
Journal: Front Physiol
Title: A potential role of p75NTR in the regulation of circadian rhythm and incremental growth lines during tooth development.
Volume: 13
Pages: 981311
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Genotype
Genotype
Symbol: Arnt/Arnt Hprt1/? Vhl/Vhl
Background: involves: 129 * BALB/c * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Arnt/Arnt Vhl/Vhl Speer6-ps1/Speer6-ps1<+>
Background: involves: 129 * BALB/c * C57BL/6 * DBA
Zygosity: cn
Has Mutant Allele: true
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Protein
F7C9F6
Organism: Mus musculus/domesticus
Length: 126  
Fragment?: true
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Publication
1325649 | J:2256
First Author: Burbach KM
Year: 1992
Journal: Proc Natl Acad Sci U S A
Title: Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor.
Volume: 89
Issue: 17
Pages: 8185-9
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Publication
15272135 | J:103476
First Author: Tan Z
Year: 2004
Journal: Toxicol Sci
Title: A critical role for MAP kinases in the control of Ah receptor complex activity.
Volume: 82
Issue: 1
Pages: 80-7
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Publication
31594926 | J:281963
First Author: Liang C
Year: 2019
Journal: Nat Commun
Title: HIF1α inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis.
Volume: 10
Issue: 1
Pages: 4579
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Publication
31801086 | J:296789
First Author: Funahashi Y
Year: 2019
Journal: Cell Rep
Title: Phosphorylation of Npas4 by MAPK Regulates Reward-Related Gene Expression and Behaviors.
Volume: 29
Issue: 10
Pages: 3235-3252.e9
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Publication
8786149 | J:33863
First Author: Semenza GL
Year: 1996
Journal: Genomics
Title: Assignment of the hypoxia-inducible factor 1alpha gene to a region of conserved synteny on mouse chromosome 12 and human chromosome 14q.
Volume: 34
Issue: 3
Pages: 437-9
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Publication
9498548 | J:44972
First Author: Sogawa K
Year: 1997
Journal: J Biochem
Title: Ah receptor, a novel ligand-activated transcription factor.
Volume: 122
Issue: 6
Pages: 1075-9
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Publication
12642624 | J:82549
First Author: Aitola M
Year: 2003
Journal: J Histochem Cytochem
Title: Aint/Tacc3 is highly expressed in proliferating mouse tissues during development, spermatogenesis, and oogenesis.
Volume: 51
Issue: 4
Pages: 455-69
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Protein Coding Gene
MGI:2384308 | Pdk3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
A0A0R4J1D3
Organism: Mus musculus/domesticus
Length: 573  
Fragment?: false
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Publication
9199934 | J:41129
First Author: Chrast R
Year: 1997
Journal: Genome Res
Title: Cloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome chromosomal region.
Volume: 7
Issue: 6
Pages: 615-24
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Protein
Q56DJ6
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: true
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Publication
7756254 | -
First Author: Borgstahl GE
Year: 1995
Journal: Biochemistry
Title: 1.4 A structure of photoactive yellow protein, a cytosolic photoreceptor: unusual fold, active site, and chromophore.
Volume: 34
Issue: 19
Pages: 6278-87
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Publication
11091086 | -
First Author: Coumailleau P
Year: 2000
Journal: Mech Dev
Title: Characterization and developmental expression of xSim, a Xenopus bHLH/PAS gene related to the Drosophila neurogenic master gene single-minded.
Volume: 99
Issue: 1-2
Pages: 163-6
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Protein Domain
IPR010578 | SIM_C
Type: Domain
Description: In Drosophila, single-minded (sim) is a transcription factor that acts as the master regulator of neurogenesis. Two mammalian homologues of Sim which have been identified, Sim1 and Sim2, are novel heterodimerisation partners for ARNT in vitro, and may function both as positive and negative transcriptional regulators in vivo, during embryogenesis and in the adult organism []. SIM2 is thought to contribute to some specific Down syndrome phenotypes []. There is a high level of homology among mammalian and Drosophila sim proteins in their amino-terminal half where the conserved bHLH, PAS () and PAC motifs are present (). The PAC region occurs C-terminal to the PAS domains and are proposed to contribute to the PAS domain fold [, , ]. In contrast, the carboxy-terminal parts are only conserved in vertebrates []. The Sim1 C terminus contains a Ser-rich region, whereas the Sim2 C terminus both contain Ser/Thr-rich regions, Pro/Ser-rich regions, Pro/Ala-rich regions, and positively charged regions. Sim2s, a splice variant of Sim2, still contains the Ser/Thr- and Pro/Ser-rich regions shown to harbor repressive activities, but is missing the Pro/Ala-rich repressor region [, , ].
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Publication
18070924 | J:132655
First Author: Yamashita T
Year: 2008
Journal: Mol Cell Biol
Title: Abnormal heart development and lung remodeling in mice lacking the hypoxia-inducible factor-related basic helix-loop-helix PAS protein NEPAS.
Volume: 28
Issue: 4
Pages: 1285-97
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Publication
18359762 | J:138497
First Author: Fritz WA
Year: 2008
Journal: Carcinogenesis
Title: The aryl hydrocarbon receptor (AhR) inhibits vanadate-induced vascular endothelial growth factor (VEGF) production in TRAMP prostates.
Volume: 29
Issue: 5
Pages: 1077-82
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Publication
21507987 | J:175001
First Author: Kang HJ
Year: 2011
Journal: Toxicol Sci
Title: Detoxification: a novel function of BRCA1 in tumor suppression?
Volume: 122
Issue: 1
Pages: 26-37
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Publication
10408444 | J:56167
First Author: Zheng B
Year: 1999
Journal: Nature
Title: The mPer2 gene encodes a functional component of the mammalian circadian clock.
Volume: 400
Issue: 6740
Pages: 169-73
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Publication
17413038 | J:134911
First Author: Ichihara S
Year: 2007
Journal: Arterioscler Thromb Vasc Biol
Title: A role for the aryl hydrocarbon receptor in regulation of ischemia-induced angiogenesis.
Volume: 27
Issue: 6
Pages: 1297-304
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Publication
23800876 | J:206693
First Author: Wang L
Year: 2013
Journal: Arch Biochem Biophys
Title: The aryl hydrocarbon receptor interacts with nuclear factor erythroid 2-related factor 2 to mediate induction of NAD(P)H:quinoneoxidoreductase 1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Volume: 537
Issue: 1
Pages: 31-8
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Publication
22442665 | J:187039
First Author: Do KN
Year: 2012
Journal: PLoS One
Title: TLR2 controls intestinal carcinogen detoxication by CYP1A1.
Volume: 7
Issue: 3
Pages: e32309
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Publication
19850893 | J:155350
First Author: Heliövaara E
Year: 2009
Journal: Am J Pathol
Title: The expression of AIP-related molecules in elucidation of cellular pathways in pituitary adenomas.
Volume: 175
Issue: 6
Pages: 2501-7
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Publication
11401485 | J:68636
First Author: Hsu HJ
Year: 2001
Journal: Biochem Biophys Res Commun
Title: Ectopic expression of negative ARNT2 factor disrupts fish development.
Volume: 282
Issue: 2
Pages: 487-92
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Publication
11835227 | J:73615
First Author: Fujita H
Year: 2002
Journal: Teratology
Title: Characterization of the aryl hydrocarbon receptor repressor gene and association of its Pro185Ala polymorphism with micropenis.
Volume: 65
Issue: 1
Pages: 10-8
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Publication
10630574 | J:60062
First Author: Seidel SD
Year: 1999
Journal: Toxicol Sci
Title: Differential gene expression in wild-type and arnt-defective mouse hepatoma (Hepa1c1c7) cells.
Volume: 52
Issue: 2
Pages: 217-25
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Publication
8287061 | J:16256
First Author: Swanson HI
Year: 1993
Journal: Pharmacogenetics
Title: The AH-receptor: genetics, structure and function.
Volume: 3
Issue: 5
Pages: 213-30
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Publication
9027741 | J:38769
First Author: Gassmann M
Year: 1997
Journal: Kidney Int
Title: Oxygen- and dioxin-regulated gene expression in mouse hepatoma cells.
Volume: 51
Issue: 2
Pages: 567-74
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Publication
9211913 | J:41723
First Author: Eguchi H
Year: 1997
Journal: J Biol Chem
Title: A nuclear localization signal of human aryl hydrocarbon receptor nuclear translocator/hypoxia-inducible factor 1beta is a novel bipartite type recognized by the two components of nuclear pore-targeting complex.
Volume: 272
Issue: 28
Pages: 17640-7
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Publication
9759704 | J:50424
First Author: Kashani M
Year: 1998
Journal: Prostate
Title: Expression of the aryl hydrocarbon receptor (AhR) and the aryl hydrocarbon receptor nuclear translocator (ARNT) in fetal, benign hyperplastic, and malignant prostate.
Volume: 37
Issue: 2
Pages: 98-108
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Publication
16954219 | J:117390
First Author: Teh CH
Year: 2006
Journal: J Biol Chem
Title: Neuronal PAS domain protein 1 is a transcriptional repressor and requires arylhydrocarbon nuclear translocator for its nuclear localization.
Volume: 281
Issue: 45
Pages: 34617-29
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Publication
20450880 | J:164268
First Author: Mukai R
Year: 2010
Journal: Arch Biochem Biophys
Title: Suppression mechanisms of flavonoids on aryl hydrocarbon receptor-mediated signal transduction.
Volume: 501
Issue: 1
Pages: 134-41
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Publication
25652407 | J:222444
First Author: Lidral AC
Year: 2015
Journal: Hum Mol Genet
Title: A single nucleotide polymorphism associated with isolated cleft lip and palate, thyroid cancer and hypothyroidism alters the activity of an oral epithelium and thyroid enhancer near FOXE1.
Volume: 24
Issue: 14
Pages: 3895-907
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Publication
28602625 | J:260915
First Author: Zheng X
Year: 2017
Journal: Exp Cell Res
Title: A Notch-independent mechanism contributes to the induction of Hes1 gene expression in response to hypoxia in P19 cells.
Volume: 358
Issue: 2
Pages: 129-139
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Publication
20935161 | J:284558
First Author: Nukaya M
Year: 2010
Journal: Toxicol Sci
Title: Aryl hydrocarbon receptor nuclear translocator in hepatocytes is required for aryl hydrocarbon receptor-mediated adaptive and toxic responses in liver.
Volume: 118
Issue: 2
Pages: 554-63
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Publication
34851661 | J:316473
First Author: Tampakakis E
Year: 2021
Journal: Sci Adv
Title: Heart neurons use clock genes to control myocyte proliferation.
Volume: 7
Issue: 49
Pages: eabh4181
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Protein Coding Gene
MGI:1926119 | Pdk1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
8927054 | J:35345
First Author: Ema M
Year: 1996
Journal: Mol Cell Biol
Title: Two new members of the murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis.
Volume: 16
Issue: 10
Pages: 5865-75
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Publication
12215665 | J:113951
First Author: Laiosa MD
Year: 2002
Journal: Toxicol Sci
Title: 2,3,7,8-tetrachlorodibenzo-p-dioxin causes alterations in lymphocyte development and thymic atrophy in hemopoietic chimeras generated from mice deficient in ARNT2.
Volume: 69
Issue: 1
Pages: 117-24
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Publication
11318878 | J:74118
First Author: Hosoya T
Year: 2001
Journal: Genes Cells
Title: Defective development of secretory neurones in the hypothalamus of Arnt2-knockout mice.
Volume: 6
Issue: 4
Pages: 361-74
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Publication
7942273 | J:21984
 
First Author: Hankinson O
Year: 1994
Journal: Adv Enzyme Regul
Title: A genetic analysis of processes regulating cytochrome P4501A1 expression.
Volume: 34
Pages: 159-71
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Publication
9382818 | -
First Author: Ponting CP
Year: 1997
Journal: Curr Biol
Title: PAS: a multifunctional domain family comes to light.
Volume: 7
Issue: 11
Pages: R674-7
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Protein
Q8BRU1
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: true
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Protein
A0A0G2YKU1
Organism: Mus musculus/domesticus
Length: 138  
Fragment?: true
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Protein
A0A140LIL3
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: true
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Protein
A0A140LHH4
Organism: Mus musculus/domesticus
Length: 167  
Fragment?: true
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Protein
A0A0G2YDK5
Organism: Mus musculus/domesticus
Length: 176  
Fragment?: true
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Protein
Q68HB9
Organism: Mus musculus/domesticus
Length: 229  
Fragment?: false
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Protein
A0A0G2YJ29
Organism: Mus musculus/domesticus
Length: 153  
Fragment?: true
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Protein
A0A140LID4
Organism: Mus musculus/domesticus
Length: 91  
Fragment?: true
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Protein
Q6F6D5
Organism: Mus musculus/domesticus
Length: 222  
Fragment?: false
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Protein Coding Gene
MGI:88574 | Cybb
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
A0A0B4J1L1
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: false
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Publication
19501082 | J:152865
First Author: Georgas K
Year: 2009
Journal: Dev Biol
Title: Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment.
Volume: 332
Issue: 2
Pages: 273-86
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Protein
A0A338P771
Organism: Mus musculus/domesticus
Length: 406  
Fragment?: false
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Protein Coding Gene
MGI:103223 | Vhl
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
19741146 | J:152838
First Author: Fu H
Year: 2009
Journal: J Neurosci
Title: A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development.
Volume: 29
Issue: 36
Pages: 11399-408
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Protein
P30561
Organism: Mus musculus/domesticus
Length: 848  
Fragment?: false
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Protein
Q8R4S5
Organism: Mus musculus/domesticus
Length: 883  
Fragment?: false
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Protein
Q2VPD4
Organism: Mus musculus/domesticus
Length: 579  
Fragment?: false
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Protein
Q3U1U7
Organism: Mus musculus/domesticus
Length: 701  
Fragment?: false
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Protein
Q8R4S6
Organism: Mus musculus/domesticus
Length: 848  
Fragment?: false
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Protein
P97460
Organism: Mus musculus/domesticus
Length: 816  
Fragment?: false
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Protein
Q9WTL8
Organism: Mus musculus/domesticus
Length: 632  
Fragment?: false
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Protein
O08785
Organism: Mus musculus/domesticus
Length: 855  
Fragment?: false
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Protein
Q6F6D7
Organism: Mus musculus/domesticus
Length: 633  
Fragment?: false
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Protein
G3X9B7
Organism: Mus musculus/domesticus
Length: 816  
Fragment?: false
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Protein
A0A140LHY4
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: true
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Protein
Q8CEC2
Organism: Mus musculus/domesticus
Length: 760  
Fragment?: false
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Protein
Q1A3C9
Organism: Mus musculus/domesticus
Length: 570  
Fragment?: false
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Protein
A0A0J9YU61
Organism: Mus musculus/domesticus
Length: 854  
Fragment?: false
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Protein
E9Q993
Organism: Mus musculus/domesticus
Length: 569  
Fragment?: false
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Protein
Q3U7X2
Organism: Mus musculus/domesticus
Length: 791  
Fragment?: false
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Protein
Q3URM6
Organism: Mus musculus/domesticus
Length: 585  
Fragment?: false
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Protein
Q1A532
Organism: Mus musculus/domesticus
Length: 569  
Fragment?: false
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Protein
A0A1B0GS77
Organism: Mus musculus/domesticus
Length: 633  
Fragment?: false
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Protein
Q3U2B1
Organism: Mus musculus/domesticus
Length: 848  
Fragment?: false
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Protein
Q6DLX1
Organism: Mus musculus/domesticus
Length: 420  
Fragment?: true
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Protein
Q6DLX4
Organism: Mus musculus/domesticus
Length: 420  
Fragment?: true
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Protein
E9QLT6
Organism: Mus musculus/domesticus
Length: 771  
Fragment?: false
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Protein
Q5DTR2
Organism: Mus musculus/domesticus
Length: 721  
Fragment?: true
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Protein
Q8C9W6
Organism: Mus musculus/domesticus
Length: 272  
Fragment?: true
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Protein
Q32ME6
Organism: Mus musculus/domesticus
Length: 816  
Fragment?: false
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Protein
Q6ZQD6
Organism: Mus musculus/domesticus
Length: 857  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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