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Search results 2401 to 2500 out of 2733 for C6

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Type Details Score
Protein Domain
IPR002540 | Pept_S30_P1_potyvir
Type: Domain
Description: Proteolytic enzymes that exploit serine in their catalytic activity are ubiquitous, being found in viruses, bacteria and eukaryotes []. They include a wide range of peptidase activity, including exopeptidase, endopeptidase, oligopeptidase and omega-peptidase activity. Many families of serine protease have been identified, these being grouped into clans on the basis of structural similarity and other functional evidence []. Structures are known for members of the clans and the structures indicate that some appear to be totally unrelated, suggesting different evolutionary origins for the serine peptidases [].Not withstanding their different evolutionary origins, there are similarities in the reaction mechanisms of several peptidases. Chymotrypsin, subtilisin and carboxypeptidase C have a catalytic triad of serine, aspartate and histidine in common: serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base []. The geometric orientations of the catalytic residues are similar between families, despite different protein folds []. The linear arrangements of the catalytic residues commonly reflect clan relationships. For example the catalytic triad in the chymotrypsin clan (PA) is ordered HDS, but is ordered DHS in the subtilisin clan (SB) and SDH in the carboxypeptidase clan (SC) [, ].The potyviridae are a family of positive strand RNA viruses, members of which include Zucchini yellow mosaic virus, and Turnip mosaic virus (strain Japanese) which cause considerable losses of crops worldwide.This entry represents a C-terminal region from various plant potyvirus P1 proteins (found at the N terminus of the polyprotein). The C terminus of P1 is a serine peptidase belonging to MEROPS peptidase family S30 (clan PA(S)). It is the protease responsible for autocatalytic cleavage between P1 and the helper component protease, which is a cysteine peptidase belonging to MEROPS peptidase family C6 [, ]. The P1 protein may be involved in virus-host interactions [], and evasion of immune responses [].
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Protein Domain
IPR042308 | HC_PRO_CPD_sf
Type: Homologous_superfamily
Description: Potyviruses form one of the most numerous groups of plant viruses and are a major cause of crop loss worldwide. The helper-component proteinase (HC-Pro) is an indispensable, multifunctional protein of members of the genus Potyvirus and other viruses of the family Potyviridae. It is directly involved in diverse steps of viral infection, such as aphid plant-to-plant transmission, polyprotein processing, and suppression of host antiviral RNA silencing. HC-Pro is generally divided into three functional domains: a N-terminal domain, a central region, and a cysteine protease domain (CPD) in the C-terminal region. The HC-Pro CPD domain has a protease activity that autocatalytically cleaves a Gly-Gly dipeptide at its own C terminus to release HC-Pro from the rest of the viral polyprotein. Cysteine and histidine residues form the catalytic dyad at the active site. The HC-Pro CPD domain constitutes the peptidase family C6 of the CA clan [].The HC-Pro CPD domain adopts a compact oval-shaped alpha/beta fold. The secondary structure elements include four α-helices (alpha1-alpha4) and two short β-strands (beta1 and beta2) arranged in the order alpha1-alpha2-alpha3-beta1-beta2-alpha4. In addition, two 3(10) helices are located between alpha3 and beta1 and downstream of alpha4. The four helices form a helix bundle packed against one face of a short β-hairpin formed by strands beta1 and beta2. The catalytic residue Cys is located at the N terminus of helix alpha1, and the other catalytic residue His is located on strand beta2. The substrate binding cleft is lined by the loop connecting helices alpha2 and alpha3 and the N-terminal region of helix alpha1 on one side and by strand beta2 on the other side [].This superfamily represents the CPD domain of the HC-Pro protein.
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Protein Domain
IPR031159 | HC_PRO_CPD_dom
Type: Domain
Description: This entry represents the CPD domain of the HC-Pro protein. Potyviruses form one of the most numerous groups of plant viruses and are a major cause of crop loss worldwide. The helper-component proteinase (HC-Pro) is an indispensable, multifunctional protein of members of the genus Potyvirus and other viruses of the family Potyviridae. It is directly involved in diverse steps of viral infection, such as aphid plant-to-plant transmission, polyprotein processing, and suppression of host antiviral RNA silencing. HC-Pro is generally divided into three functional domains: a N-terminal domain, a central region, and a cysteine protease domain (CPD) in the C-terminal region. The HC-Pro CPD domain has a protease activity that autocatalytically cleaves a Gly-Gly dipeptide at its own C terminus to release HC-Pro from the rest of the viral polyprotein. Cysteine and histidine residues form the catalytic dyad at the active site. The HC-Pro CPD domain constitutes the peptidase family C6 of the CA clan [].The HC-Pro CPD domain adopts a compact oval-shaped alpha/beta fold. The secondary structure elements include four α-helices (alpha1-alpha4) and two short β-strands (beta1 and beta2) arranged in the order alpha1-alpha2-alpha3-beta1-beta2-alpha4. In addition, two 3(10) helices are located between alpha3 and beta1 and downstream of alpha4. The four helices form a helix bundle packed against one face of a short β-hairpin formed by strands beta1 and beta2. The catalytic residue Cys is located at the N terminus of helix alpha1, and the other catalytic residue His is located on strand beta2. The substrate binding cleft is lined by the loop connecting helices alpha2 and alpha3 and the N-terminal region of helix alpha1 on one side and by strand beta2 on the other side [].
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Protein
Q8VCH5
Organism: Mus musculus/domesticus
Length: 380  
Fragment?: false
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Protein
Q8VEM9
Organism: Mus musculus/domesticus
Length: 382  
Fragment?: false
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Protein
A2AH59
Organism: Mus musculus/domesticus
Length: 446  
Fragment?: false
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Protein
A2AUF7
Organism: Mus musculus/domesticus
Length: 321  
Fragment?: false
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Protein
B0R0S4
Organism: Mus musculus/domesticus
Length: 372  
Fragment?: false
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Protein
Q8K3B7
Organism: Mus musculus/domesticus
Length: 430  
Fragment?: false
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Protein
A0A3B2WB53
Organism: Mus musculus/domesticus
Length: 373  
Fragment?: false
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Protein
A0A0R4J0W0
Organism: Mus musculus/domesticus
Length: 382  
Fragment?: false
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Publication
8453663 | -
First Author: Xue F
Year: 1993
Journal: Cell
Title: kelch encodes a component of intercellular bridges in Drosophila egg chambers.
Volume: 72
Issue: 5
Pages: 681-93
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Publication
7822422 | -
First Author: Way M
Year: 1995
Journal: J Cell Biol
Title: Sequence and domain organization of scruin, an actin-cross-linking protein in the acrosomal process of Limulus sperm.
Volume: 128
Issue: 1-2
Pages: 51-60
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Publication
8182749 | -
First Author: Ito N
Year: 1994
Journal: J Mol Biol
Title: Crystal structure of a free radical enzyme, galactose oxidase.
Volume: 238
Issue: 5
Pages: 794-814
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Publication
2002850 | -
First Author: Ito N
Year: 1991
Journal: Nature
Title: Novel thioether bond revealed by a 1.7 A crystal structure of galactose oxidase.
Volume: 350
Issue: 6313
Pages: 87-90
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Publication
2899893 | J:9272
First Author: Schughart K
Year: 1988
Journal: Proc Natl Acad Sci U S A
Title: Structure and expression of Hox-2.2, a murine homeobox-containing gene.
Volume: 85
Issue: 15
Pages: 5582-6
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Publication
31754028 | J:301455
First Author: Gulati GS
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Neogenin-1 distinguishes between myeloid-biased and balanced Hoxb5 + mouse long-term hematopoietic stem cells.
Volume: 116
Issue: 50
Pages: 25115-25125
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Publication
1683482 | J:1777
First Author: Ura K
Year: 1991
Journal: Nucleic Acids Res
Title: Possible role of DNA topoisomerase II on transcription of the homeobox gene Hox-2.1 in F9 embryonal carcinoma cells.
Volume: 19
Issue: 22
Pages: 6087-92
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Publication
2875852 | J:8424
First Author: Münke M
Year: 1986
Journal: Cytogenet Cell Genet
Title: The murine Hox-2 cluster of homeo box containing genes maps distal on chromosome 11 near the tail-short (Ts) locus.
Volume: 42
Issue: 4
Pages: 236-40
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Publication
2881353 | J:32907
First Author: Utset MF
Year: 1987
Journal: Science
Title: Region-specific expression of two mouse homeo box genes.
Volume: 235
Issue: 4794
Pages: 1379-82
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Publication
9174240 | J:40362
First Author: Safaei R
Year: 1997
Journal: Brain Res Dev Brain Res
Title: A target of the HoxB5 gene from the mouse nervous system.
Volume: 100
Issue: 1
Pages: 5-12
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Publication
12527197 | J:81714
First Author: Hershko AY
Year: 2003
Journal: Gene
Title: Methylation of HoxA5 and HoxB5 and its relevance to expression during mouse development.
Volume: 302
Issue: 1-2
Pages: 65-72
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Publication
2458220 | J:290828
First Author: Holland PW
Year: 1988
Journal: Development
Title: Spatially restricted patterns of expression of the homeobox-containing gene Hox 2.1. during mouse embryogenesis.
Volume: 102
Issue: 1
Pages: 159-74
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Publication
17114649 | J:187362
First Author: Munton RP
Year: 2007
Journal: Mol Cell Proteomics
Title: Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.
Volume: 6
Issue: 2
Pages: 283-93
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Publication
23260145 | J:193325
First Author: Boj SF
Year: 2012
Journal: Cell
Title: Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand.
Volume: 151
Issue: 7
Pages: 1595-607
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Publication
26450967 | J:239872
First Author: Larsen BM
Year: 2015
Journal: Development
Title: Mesenchymal Hox6 function is required for mouse pancreatic endocrine cell differentiation.
Volume: 142
Issue: 22
Pages: 3859-68
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Publication
35315772 | J:322321
   
First Author: Catela C
Year: 2022
Journal: Elife
Title: Control of spinal motor neuron terminal differentiation through sustained Hoxc8 gene activity.
Volume: 11
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Publication
27568519 | J:253351
First Author: Hanley O
Year: 2016
Journal: Neuron
Title: Parallel Pbx-Dependent Pathways Govern the Coalescence and Fate of Motor Columns.
Volume: 91
Issue: 5
Pages: 1005-1020
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Publication
11208732 | J:66998
First Author: Lammert F
Year: 2001
Journal: Gastroenterology
Title: Chromosomal organization of candidate genes involved in cholesterol gallstone formation: a murine gallstone map.
Volume: 120
Issue: 1
Pages: 221-38
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Protein
Q9CR40
Organism: Mus musculus/domesticus
Length: 571  
Fragment?: false
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Protein
Q8BZM0
Organism: Mus musculus/domesticus
Length: 568  
Fragment?: false
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Protein
O89050
Organism: Mus musculus/domesticus
Length: 735  
Fragment?: false
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Protein
P10820
Organism: Mus musculus/domesticus
Length: 554  
Fragment?: false
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Protein
Q6PDJ6
Organism: Mus musculus/domesticus
Length: 717  
Fragment?: false
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Protein
Q3TBJ0
Organism: Mus musculus/domesticus
Length: 613  
Fragment?: true
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Protein
Q3TNG8
Organism: Mus musculus/domesticus
Length: 705  
Fragment?: false
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Protein
Q3UA61
Organism: Mus musculus/domesticus
Length: 705  
Fragment?: false
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Protein
Q3TDH0
Organism: Mus musculus/domesticus
Length: 717  
Fragment?: false
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Protein
Q9CUQ2
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: true
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Protein
Q9CUA2
Organism: Mus musculus/domesticus
Length: 204  
Fragment?: true
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Protein
Q3UBU7
Organism: Mus musculus/domesticus
Length: 705  
Fragment?: false
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Protein
F6W0Q8
Organism: Mus musculus/domesticus
Length: 146  
Fragment?: true
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Protein
A2RSY7
Organism: Mus musculus/domesticus
Length: 554  
Fragment?: false
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Publication
3248729 | -
First Author: Pósfai J
Year: 1988
Journal: Gene
Title: Sequence motifs specific for cytosine methyltransferases.
Volume: 74
Issue: 1
Pages: 261-5
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Publication
2716049 | -
First Author: Lauster R
Year: 1989
Journal: J Mol Biol
Title: Cytosine-specific type II DNA methyltransferases. A conserved enzyme core with variable target-recognizing domains.
Volume: 206
Issue: 2
Pages: 305-12
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Publication
4075393 | J:32355
First Author: Hauser CA
Year: 1985
Journal: Cell
Title: Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos.
Volume: 43
Issue: 1
Pages: 19-28
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Publication
1983472 | J:73
First Author: Frohman MA
Year: 1990
Journal: Development
Title: Isolation of the mouse Hox-2.9 gene; analysis of embryonic expression suggests that positional information along the anterior-posterior axis is specified by mesoderm.
Volume: 110
Issue: 2
Pages: 589-607
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Publication
10419695 | J:56681
First Author: Yamauchi Y
Year: 1999
Journal: Dev Biol
Title: A novel transgenic technique that allows specific marking of the neural crest cell lineage in mice.
Volume: 212
Issue: 1
Pages: 191-203
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Publication
12897140 | J:84798
First Author: Wu Y
Year: 2003
Journal: Mol Cell Biol
Title: HoxB5 is an upstream transcriptional switch for differentiation of the vascular endothelium from precursor cells.
Volume: 23
Issue: 16
Pages: 5680-91
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Publication
9450632 | J:45249
First Author: Volpe MV
Year: 1997
Journal: Histochem Cell Biol
Title: Hoxb-5 expression in the developing mouse lung suggests a role in branching morphogenesis and epithelial cell fate.
Volume: 108
Issue: 6
Pages: 495-504
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Publication
12505043 | J:81585
First Author: Chinoy MR
Year: 2002
Journal: J Surg Res
Title: Mesenchymal nuclear transcription factors in nitrofen-induced hypoplastic lung.
Volume: 108
Issue: 2
Pages: 203-11
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Protein
Q499E0
Organism: Mus musculus/domesticus
Length: 766  
Fragment?: false
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Protein
Q8C828
Organism: Mus musculus/domesticus
Length: 458  
Fragment?: false
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Protein
Q9JI74
Organism: Mus musculus/domesticus
Length: 751  
Fragment?: false
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Protein
Q9CQ33
Organism: Mus musculus/domesticus
Length: 837  
Fragment?: false
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Protein
Q8BNW9
Organism: Mus musculus/domesticus
Length: 633  
Fragment?: false
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Protein
Q80T74
Organism: Mus musculus/domesticus
Length: 875  
Fragment?: false
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Protein
Q8CE33
Organism: Mus musculus/domesticus
Length: 709  
Fragment?: false
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Protein
Q8BFQ9
Organism: Mus musculus/domesticus
Length: 493  
Fragment?: false
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Protein
Q8CDE2
Organism: Mus musculus/domesticus
Length: 588  
Fragment?: false
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Protein
Q3V0X6
Organism: Mus musculus/domesticus
Length: 752  
Fragment?: false
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Protein
B1AZQ9
Organism: Mus musculus/domesticus
Length: 711  
Fragment?: false
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Protein
Q8BXL1
Organism: Mus musculus/domesticus
Length: 420  
Fragment?: false
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Protein
B2KFS7
Organism: Mus musculus/domesticus
Length: 493  
Fragment?: false
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Protein
Q8R1W9
Organism: Mus musculus/domesticus
Length: 469  
Fragment?: false
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Protein
Q3V184
Organism: Mus musculus/domesticus
Length: 302  
Fragment?: true
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Protein
Q3USQ6
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: true
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Protein
Q8CCY1
Organism: Mus musculus/domesticus
Length: 751  
Fragment?: false
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Protein
Q3UWI4
Organism: Mus musculus/domesticus
Length: 393  
Fragment?: true
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Protein
A0A338P6P0
Organism: Mus musculus/domesticus
Length: 818  
Fragment?: false
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Protein
A2ARU0
Organism: Mus musculus/domesticus
Length: 441  
Fragment?: false
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Protein
A2AH60
Organism: Mus musculus/domesticus
Length: 553  
Fragment?: false
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Protein
B7ZNG7
Organism: Mus musculus/domesticus
Length: 844  
Fragment?: true
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Protein
B1AZR0
Organism: Mus musculus/domesticus
Length: 717  
Fragment?: false
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Protein
Q6PDF5
Organism: Mus musculus/domesticus
Length: 107  
Fragment?: false
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Protein
Q5DTX3
Organism: Mus musculus/domesticus
Length: 758  
Fragment?: true
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Protein
F6T0G2
Organism: Mus musculus/domesticus
Length: 145  
Fragment?: true
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Protein
A0A1W2P6N5
Organism: Mus musculus/domesticus
Length: 814  
Fragment?: false
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Protein
Q14DU1
Organism: Mus musculus/domesticus
Length: 709  
Fragment?: false
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Protein
A0A804C8S9
Organism: Mus musculus/domesticus
Length: 131  
Fragment?: true
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Protein
Q99NM2
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: true
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Protein
B2RX51
Organism: Mus musculus/domesticus
Length: 588  
Fragment?: false
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Publication
16971476 | J:119560
First Author: Choi MY
Year: 2006
Journal: Development
Title: A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development.
Volume: 133
Issue: 20
Pages: 4119-29
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Publication
21529712 | J:173414
First Author: Kondrashov N
Year: 2011
Journal: Cell
Title: Ribosome-mediated specificity in Hox mRNA translation and vertebrate tissue patterning.
Volume: 145
Issue: 3
Pages: 383-397
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Publication
11180952 | J:67747
First Author: Thut CJ
Year: 2001
Journal: Dev Biol
Title: A large-scale in situ screen provides molecular evidence for the induction of eye anterior segment structures by the developing lens.
Volume: 231
Issue: 1
Pages: 63-76
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Protein
Q6TDP3
Organism: Mus musculus/domesticus
Length: 640  
Fragment?: false
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Protein
Q8VCK5
Organism: Mus musculus/domesticus
Length: 604  
Fragment?: false
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Protein
Q3TCA1
Organism: Mus musculus/domesticus
Length: 640  
Fragment?: false
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Protein
B2RTE7
Organism: Mus musculus/domesticus
Length: 640  
Fragment?: false
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Publication
1701153 | J:22691
First Author: Lussier M
Year: 1990
Journal: Gene
Title: The mouse keratin 19-encoding gene: sequence, structure and chromosomal assignment.
Volume: 95
Issue: 2
Pages: 203-13
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Publication
25220476 | J:216286
 
First Author: Kam MK
Year: 2014
Journal: Int J Biochem Cell Biol
Title: Homeobox b5 (Hoxb5) regulates the expression of Forkhead box D3 gene (Foxd3) in neural crest.
Volume: 55
Pages: 144-52
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Publication
2882472 | J:8643
First Author: Mock B
Year: 1987
Journal: Nucleic Acids Res
Title: A TaqI restriction fragment length polymorphism at the Hox-2.1 locus cosegregates with the Dlb-1 locus on mouse chromosome 11.
Volume: 15
Issue: 5
Pages: 2397
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Publication
9501100 | J:46991
First Author: Sharpe J
Year: 1998
Journal: EMBO J
Title: Selectivity, sharing and competitive interactions in the regulation of Hoxb genes.
Volume: 17
Issue: 6
Pages: 1788-98
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Protein
Q8BYR1
Organism: Mus musculus/domesticus
Length: 686  
Fragment?: false
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Protein
A0A338P6Y5
Organism: Mus musculus/domesticus
Length: 529  
Fragment?: true
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Protein
G3UZG8
Organism: Mus musculus/domesticus
Length: 107  
Fragment?: true
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Protein
A0A2I3BQ98
Organism: Mus musculus/domesticus
Length: 486  
Fragment?: false
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Protein
Q0VDW2
Organism: Mus musculus/domesticus
Length: 197  
Fragment?: true
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Protein
P21784
Organism: Mus musculus/domesticus
Length: 527  
Fragment?: false
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Protein
P28575
Organism: Mus musculus/domesticus
Length: 584  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom