| Type |
Details |
Score |
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
246
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cullen ER |
| Year: |
2023 |
| Journal: |
J Neurosci |
| Title: |
mTORC2 Inhibition Improves Morphological Effects of PTEN Loss, But Does Not Correct Synaptic Dysfunction or Prevent Seizures. |
| Volume: |
43 |
| Issue: |
5 |
| Pages: |
827-845 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gantois I |
| Year: |
2017 |
| Journal: |
Nat Med |
| Title: |
Metformin ameliorates core deficits in a mouse model of fragile X syndrome. |
| Volume: |
23 |
| Issue: |
6 |
| Pages: |
674-677 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lin F |
| Year: |
2014 |
| Journal: |
Autophagy |
| Title: |
Seeing is believing: dynamic changes in renal epithelial autophagy during injury and repair. |
| Volume: |
10 |
| Issue: |
4 |
| Pages: |
691-3 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Resnick-Silverman L |
| Year: |
2015 |
| Journal: |
Cancer Discov |
| Title: |
Two Faces of SIVA. |
| Volume: |
5 |
| Issue: |
6 |
| Pages: |
581-3 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jung SM |
| Year: |
2019 |
| Journal: |
Mol Cell |
| Title: |
Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1. |
| Volume: |
75 |
| Issue: |
4 |
| Pages: |
807-822.e8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Castro W |
| Year: |
2018 |
| Journal: |
Nat Immunol |
| Title: |
The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity. |
| Volume: |
19 |
| Issue: |
8 |
| Pages: |
809-820 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Huang WC |
| Year: |
2016 |
| Journal: |
Nat Commun |
| Title: |
Hyperconnectivity of prefrontal cortex to amygdala projections in a mouse model of macrocephaly/autism syndrome. |
| Volume: |
7 |
|
| Pages: |
13421 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pollizzi KN |
| Year: |
2015 |
| Journal: |
J Clin Invest |
| Title: |
mTORC1 and mTORC2 selectively regulate CD8⁺ T cell differentiation. |
| Volume: |
125 |
| Issue: |
5 |
| Pages: |
2090-108 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gong L |
| Year: |
2021 |
| Journal: |
Cancer Lett |
| Title: |
DEPTOR inhibits lung tumorigenesis by inactivating the EGFR-mTOR signals. |
| Volume: |
519 |
|
| Pages: |
263-276 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen J |
| Year: |
2015 |
| Journal: |
J Bone Miner Res |
| Title: |
mTORC2 signaling promotes skeletal growth and bone formation in mice. |
| Volume: |
30 |
| Issue: |
2 |
| Pages: |
369-78 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhao X |
| Year: |
2014 |
| Journal: |
Mol Cell Biol |
| Title: |
Phosphoinositide-dependent kinase 1 and mTORC2 synergistically maintain postnatal heart growth and heart function in mice. |
| Volume: |
34 |
| Issue: |
11 |
| Pages: |
1966-75 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Andrade ML |
| Year: |
2021 |
| Journal: |
Biochim Biophys Acta Mol Cell Biol Lipids |
| Title: |
PPARγ-induced upregulation of subcutaneous fat adiponectin secretion, glyceroneogenesis and BCAA oxidation requires mTORC1 activity. |
| Volume: |
1866 |
| Issue: |
8 |
| Pages: |
158967 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shende P |
| Year: |
2011 |
| Journal: |
Circulation |
| Title: |
Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice. |
| Volume: |
123 |
| Issue: |
10 |
| Pages: |
1073-82 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen H |
| Year: |
2018 |
| Journal: |
Hepatology |
| Title: |
DEP domain-containing mTOR-interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute-on-chronic liver injury in alcoholic liver disease. |
| Volume: |
68 |
| Issue: |
2 |
| Pages: |
496-514 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
796
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Angelini MM |
| Year: |
2013 |
| Journal: |
mBio |
| Title: |
Severe acute respiratory syndrome coronavirus nonstructural proteins 3, 4, and 6 induce double-membrane vesicles. |
| Volume: |
4 |
| Issue: |
4 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Navarro G |
| Year: |
2018 |
| Journal: |
JCI Insight |
| Title: |
Androgen excess in pancreatic β cells and neurons predisposes female mice to type 2 diabetes. |
| Volume: |
3 |
| Issue: |
12 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xu S |
| Year: |
2021 |
| Journal: |
J Bone Miner Res |
| Title: |
Rictor Is a Novel Regulator of TRAF6/TRAF3 in Osteoclasts. |
| Volume: |
36 |
| Issue: |
10 |
| Pages: |
2053-2064 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Loewith R |
| Year: |
2002 |
| Journal: |
Mol Cell |
| Title: |
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. |
| Volume: |
10 |
| Issue: |
3 |
| Pages: |
457-68 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gao M |
| Year: |
2006 |
| Journal: |
Nat Cell Biol |
| Title: |
A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast. |
| Volume: |
8 |
| Issue: |
7 |
| Pages: |
657-67 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dubouloz F |
| Year: |
2005 |
| Journal: |
Mol Cell |
| Title: |
The TOR and EGO protein complexes orchestrate microautophagy in yeast. |
| Volume: |
19 |
| Issue: |
1 |
| Pages: |
15-26 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Inoki K |
| Year: |
2011 |
| Journal: |
J Clin Invest |
| Title: |
mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice. |
| Volume: |
121 |
| Issue: |
6 |
| Pages: |
2181-96 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lai Y |
| Year: |
2020 |
| Journal: |
EMBO Rep |
| Title: |
DOCK5 regulates energy balance and hepatic insulin sensitivity by targeting mTORC1 signaling. |
| Volume: |
21 |
| Issue: |
2 |
| Pages: |
e49473 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang Y |
| Year: |
2017 |
| Journal: |
J Bone Miner Res |
| Title: |
mTORC1 Inhibits NF-κB/NFATc1 Signaling and Prevents Osteoclast Precursor Differentiation, In Vitro and In Mice. |
| Volume: |
32 |
| Issue: |
9 |
| Pages: |
1829-1840 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang Y |
| Year: |
2013 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells. |
| Volume: |
110 |
| Issue: |
50 |
| Pages: |
E4894-903 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu P |
| Year: |
2017 |
| Journal: |
Oncotarget |
| Title: |
Central role of mTORC1 downstream of YAP/TAZ in hepatoblastoma development. |
| Volume: |
8 |
| Issue: |
43 |
| Pages: |
73433-73447 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hu S |
| Year: |
2023 |
| Journal: |
Hepatology |
| Title: |
Hepatocyte β-catenin loss is compensated by Insulin-mTORC1 activation to promote liver regeneration. |
| Volume: |
77 |
| Issue: |
5 |
| Pages: |
1593-1611 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1157
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mieulet V |
| Year: |
2007 |
| Journal: |
Am J Physiol Cell Physiol |
| Title: |
S6 kinase inactivation impairs growth and translational target phosphorylation in muscle cells maintaining proper regulation of protein turnover. |
| Volume: |
293 |
| Issue: |
2 |
| Pages: |
C712-22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Burnett PE |
| Year: |
1998 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeleton. |
| Volume: |
95 |
| Issue: |
14 |
| Pages: |
8351-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ruvinsky I |
| Year: |
2006 |
| Journal: |
Trends Biochem Sci |
| Title: |
Ribosomal protein S6 phosphorylation: from protein synthesis to cell size. |
| Volume: |
31 |
| Issue: |
6 |
| Pages: |
342-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lucchesi PA |
| Year: |
2004 |
| Journal: |
Am J Physiol Cell Physiol |
| Title: |
Rapamycin plays a new role as differentiator of vascular smooth muscle phenotype. focus on "The mTOR/p70 S6K1 pathway regulates vascular smooth muscle differentiation". |
| Volume: |
286 |
| Issue: |
3 |
| Pages: |
C480-1 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Thomas G |
| Year: |
2002 |
| Journal: |
Biol Res |
| Title: |
The S6 kinase signaling pathway in the control of development and growth. |
| Volume: |
35 |
| Issue: |
2 |
| Pages: |
305-13 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hasumi H |
| Year: |
2008 |
| Journal: |
Gene |
| Title: |
Identification and characterization of a novel folliculin-interacting protein FNIP2. |
| Volume: |
415 |
| Issue: |
1-2 |
| Pages: |
60-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kus BM |
| Year: |
2004 |
| Journal: |
Proteins |
| Title: |
Functional interaction of 13 yeast SCF complexes with a set of yeast E2 enzymes in vitro. |
| Volume: |
54 |
| Issue: |
3 |
| Pages: |
455-67 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fernández-Sáiz V |
| Year: |
2013 |
| Journal: |
Nat Cell Biol |
| Title: |
SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma. |
| Volume: |
15 |
| Issue: |
1 |
| Pages: |
72-81 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This family consists of Raptor (regulatory associated protein of TOR) and its orthologs which includes Kog1p of Saccharomyces cerevisiae (Baker's yeast), a highly conserved 150kDa TOR-binding protein [, , ]. The target-of-rapamycin (TOR) proteins are protein kinases that were first identified in S. cerevisiae through mutants that conferred resistance to growth inhibition induced by the immunosuppressive macrolide rapamycin [].All Raptor orthologs contain a unique conserved region in their N-terminal half (raptor N-terminal conserved, also called the RNC domain) followed by three HEAT (huntingtin, elongation factor 3, A subunit of protein phosphatase 2A and TOR1) repeats and seven WD-40 repeats near the C terminus. Research on mammalian Raptor suggests that its association with mTOR promotes the phosphorylation of downstream effectors in nutrient-stimulated cells [, ]. In concordance with these observations, the binding of TOR to Raptor or to Kog1p []is necessary for TOR signalling in vivo in Caenorhabditis elegans and S. cerevisiae [, ].The RNC domain consists of 3 blocks with at least 67 to 79% sequence similarity and is predicted to have a high propensity to form alpha helices. The RNC domain is characterised by the presence of invariant catalytic Cys-His dyad, which is structurally and evolutionarily related to known caspases, suggesting that the raptor proteins may have protease activity []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This entry represents the non-structural protein 6 (NSP6) from betacoronavirus. Recently, it was reported that SARS-CoV-2 NSP6 binds TANK binding kinase 1 (TBK1) to suppress interferon regulatory factor 3 (IRF3) phosphorylation which suppresses IFN-I signalling and production more efficiently than SARS-CoV and MERS-CoV [].Coronaviruses (CoV) redirect and rearrange host cell membranes as part of the viral genome replication and transcription machinery; they induce the formation of double-membrane vesicles in infected cells. CoV non-structural protein 6 (NSP6), a transmembrane-containing protein, together with NSP3 and NSP4, have the ability to induce double-membrane vesicles that are similar to those observed in severe acute respiratory syndrome (SARS) coronavirus-infected cells []. By itself, NSP6 can generate autophagosomes from the endoplasmic reticulum. Autophagosomes are normally generated as a cellular response to starvation to carry cellular organelles and long-lived proteins to lysosomes for degradation. Degradation through autophagy may provide an innate defense against virus infection, or conversely, autophagosomes can promote infection by facilitating the assembly of replicase proteins []. In additionto initiating autophagosome formation, NSP6 also limits autophagosome expansion regardless of how they were induced, i.e. whether they were induced directly by NSP6, or indirectly by starvation or chemical inhibition of MTOR signalling. This may favour coronavirus infection by compromising the ability of autophagosomes to deliver viral components to lysosomes for degradation []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This entry represents the non-structural protein 6 (NSP6) from gammacoronavirus.Coronaviruses (CoV) redirect and rearrange host cell membranes as part of the viral genome replication and transcription machinery; they induce the formation of double-membrane vesicles in infected cells. CoV non-structural protein 6 (NSP6), a transmembrane-containing protein, together with NSP3 and NSP4, have the ability to induce double-membrane vesicles that are similar to those observed in severe acute respiratory syndrome (SARS) coronavirus-infected cells []. By itself, NSP6 can generate autophagosomes from the endoplasmic reticulum. Autophagosomes are normally generated as a cellular response to starvation to carry cellular organelles and long-lived proteins to lysosomes for degradation. Degradation through autophagy may provide an innate defense against virus infection, or conversely, autophagosomes can promote infection by facilitating the assembly of replicase proteins []. In addition to initiating autophagosome formation, NSP6 also limits autophagosome expansion regardless of how they were induced, i.e. whether they were induced directly by NSP6, or indirectly by starvation or chemical inhibition of MTOR signalling. This may favour coronavirus infection by compromising the ability of autophagosomes to deliver viral components to lysosomes for degradation []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This entry represents the non-structural protein 6 (NSP6) from alphacoronavirus.Coronaviruses (CoV) redirect and rearrange host cell membranes as part of the viral genome replication and transcription machinery; they induce the formation of double-membrane vesicles in infected cells. CoV non-structural protein 6 (NSP6), a transmembrane-containing protein, together with NSP3 and NSP4, have the ability to induce double-membrane vesicles that are similar to those observed in severe acute respiratory syndrome (SARS) coronavirus-infected cells []. By itself, NSP6 can generate autophagosomes from the endoplasmic reticulum. Autophagosomes are normally generated as a cellular response to starvation to carry cellular organelles and long-lived proteins to lysosomes for degradation. Degradation through autophagy may provide an innate defense against virus infection, or conversely, autophagosomes can promote infection by facilitating the assembly of replicase proteins []. In addition to initiating autophagosome formation, NSP6 also limits autophagosome expansion regardless of how they were induced, i.e. whether they were induced directly by NSP6, or indirectly by starvation or chemical inhibition of MTOR signalling. This may favour coronavirus infection by compromising the ability of autophagosomes to deliver viral components to lysosomes for degradation []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry represents ribosomal protein S6 kinase (or p70S6K). S6 kinase is a serine/threonine kinase (STK) that catalyses the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. It contains only one catalytic kinase domain, unlike p90 ribosomal S6 kinases (RSKs). S6 kinase is part of the mammalian target of rapamycin (mTOR) pathway, which is a key regulator of cell growth via the regulation of protein synthesis. Both S6 kinase and eukaryotic initiation factor 4E-binding protein 1 (4EBP-1) are key mTOR effectors of cell growth [, , , ]. S6 kinase specifically phosphorylates ribosomal protein S6 in response to insulin or several classes of mitogens. S6 kinase is activated by serine/threonine phosphorylation and protein kinase C, and is inactivated by type 2A phosphatase []. S6 kinase interacts with PPP1R9A/neurabin-1 []. S6 kinase also plays a pivotal role glucose homeostasis. Its targets include the insulin receptor substrate IRS-1, among others. Mammals contain two isoforms of S6 kinase, named S6K1 and S6K2 (or S6K-beta). S6 kinase is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Birt-Hogg-Dube' syndrome, a disorder characterised by benign tumours of the hair follicle, lung cysts and renal neoplasia, is caused by germline mutations in the BHD(FLCN) gene; this encodes a tumour suppressor protein, folliculin (FLCN), of unknown function []. The folliculin- interacting protein, FNIP1, has also been identified and shown to interact with 5' AMP-activated protein kinase (AMPK), which plays a vital role in energy sensing []. Together, then, it is thought that folliculin (mutated in Birt-Hogg-Dube' syndrome) and its interaction partner, FNIP1, may be involved in energy and/or nutrient sensing via the AMPK and mTOR signalling pathways.FNIP1 has a homologue, FNIP2, which also interacts with FLCN and AMPK. C-terminally-deleted FLCN mutants, like those produced by germline mutations in BHD patients, do not bind FNIP2, suggesting that FLCN tumour-suppressor function may be facilitated by interactions with both FNIP1 and FNIP2 via its C terminus []. FNIP1 and FNIP2 are able to form homo- or heteromeric multimers, and may hence function either independently or cooperatively with FLCN [].This entry represents the FNIP family, including FNIP1 and FNIP2. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu Q |
| Year: |
2022 |
| Journal: |
Cell Death Dis |
| Title: |
IL-1β-activated mTORC2 promotes accumulation of IFN-γ+ γδ T cells by upregulating CXCR3 to restrict hepatic fibrosis. |
| Volume: |
13 |
| Issue: |
4 |
| Pages: |
289 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zeng H |
| Year: |
2013 |
| Journal: |
Nature |
| Title: |
mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function. |
| Volume: |
499 |
| Issue: |
7459 |
| Pages: |
485-90 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
481
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
So EY |
| Year: |
2013 |
| Journal: |
J Cancer Biol Res |
| Title: |
The Potential Role of BRCA1-Associated ATM Activator-1 (BRAT1) in Regulation of mTOR. |
| Volume: |
1 |
| Issue: |
1 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nardella C |
| Year: |
2008 |
| Journal: |
Genes Dev |
| Title: |
Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events. |
| Volume: |
22 |
| Issue: |
16 |
| Pages: |
2172-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Obayashi Y |
| Year: |
2013 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Impaired lipid accumulation in the liver of Tsc2-heterozygous mice during liver regeneration. |
| Volume: |
437 |
| Issue: |
1 |
| Pages: |
146-50 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Anisimov VN |
| Year: |
2010 |
| Journal: |
Am J Pathol |
| Title: |
Rapamycin extends maximal lifespan in cancer-prone mice. |
| Volume: |
176 |
| Issue: |
5 |
| Pages: |
2092-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhou X |
| Year: |
2021 |
| Journal: |
Cell Rep |
| Title: |
Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity. |
| Volume: |
34 |
| Issue: |
1 |
| Pages: |
108601 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chae YC |
| Year: |
2012 |
| Journal: |
Cancer Cell |
| Title: |
Control of tumor bioenergetics and survival stress signaling by mitochondrial HSP90s. |
| Volume: |
22 |
| Issue: |
3 |
| Pages: |
331-44 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Goorden SM |
| Year: |
2011 |
| Journal: |
Mol Cell Biol |
| Title: |
Rheb is essential for murine development. |
| Volume: |
31 |
| Issue: |
8 |
| Pages: |
1672-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kaul A |
| Year: |
2012 |
| Journal: |
Genes Dev |
| Title: |
Pediatric glioma-associated KIAA1549:BRAF expression regulates neuroglial cell growth in a cell type-specific and mTOR-dependent manner. |
| Volume: |
26 |
| Issue: |
23 |
| Pages: |
2561-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Andrade-Talavera Y |
| Year: |
2015 |
| Journal: |
Neurobiol Dis |
| Title: |
Rapamycin restores BDNF-LTP and the persistence of long-term memory in a model of Down's syndrome. |
| Volume: |
82 |
|
| Pages: |
516-525 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Badodi S |
| Year: |
2021 |
| Journal: |
Nat Commun |
| Title: |
Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation. |
| Volume: |
12 |
| Issue: |
1 |
| Pages: |
2148 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li J |
| Year: |
2014 |
| Journal: |
Cell Metab |
| Title: |
Rapamycin: one drug, many effects. |
| Volume: |
19 |
| Issue: |
3 |
| Pages: |
373-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Witkowski S |
| Year: |
2010 |
| Journal: |
FEBS Lett |
| Title: |
High-frequency electrically stimulated skeletal muscle contractions increase p70s6k phosphorylation independent of known IGF-I sensitive signaling pathways. |
| Volume: |
584 |
| Issue: |
13 |
| Pages: |
2891-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang Y |
| Year: |
2012 |
| Journal: |
Elife |
| Title: |
The starvation hormone, fibroblast growth factor-21, extends lifespan in mice. |
| Volume: |
1 |
|
| Pages: |
e00065 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Uhrbom L |
| Year: |
2004 |
| Journal: |
Nat Med |
| Title: |
Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model. |
| Volume: |
10 |
| Issue: |
11 |
| Pages: |
1257-60 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hay N |
| Year: |
2005 |
| Journal: |
Cancer Cell |
| Title: |
The Akt-mTOR tango and its relevance to cancer. |
| Volume: |
8 |
| Issue: |
3 |
| Pages: |
179-83 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bobrovnikova-Marjon E |
| Year: |
2012 |
| Journal: |
Mol Cell Biol |
| Title: |
PERK utilizes intrinsic lipid kinase activity to generate phosphatidic acid, mediate Akt activation, and promote adipocyte differentiation. |
| Volume: |
32 |
| Issue: |
12 |
| Pages: |
2268-78 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stead RL |
| Year: |
2013 |
| Journal: |
FEBS Lett |
| Title: |
Rapamycin enhances eIF4E phosphorylation by activating MAP kinase-interacting kinase 2a (Mnk2a). |
| Volume: |
587 |
| Issue: |
16 |
| Pages: |
2623-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang K |
| Year: |
2022 |
| Journal: |
Nat Commun |
| Title: |
mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity. |
| Volume: |
13 |
| Issue: |
1 |
| Pages: |
7252 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang Q |
| Year: |
2018 |
| Journal: |
Cancer Res |
| Title: |
Deptor Is a Novel Target of Wnt/β-Catenin/c-Myc and Contributes to Colorectal Cancer Cell Growth. |
| Volume: |
78 |
| Issue: |
12 |
| Pages: |
3163-3175 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ramírez JA |
| Year: |
2019 |
| Journal: |
J Immunol |
| Title: |
Folliculin Interacting Protein 1 Maintains Metabolic Homeostasis during B Cell Development by Modulating AMPK, mTORC1, and TFE3. |
| Volume: |
203 |
| Issue: |
11 |
| Pages: |
2899-2908 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen J |
| Year: |
2015 |
| Journal: |
PLoS One |
| Title: |
mTORC1 Signaling Promotes Osteoblast Differentiation from Preosteoblasts. |
| Volume: |
10 |
| Issue: |
6 |
| Pages: |
e0130627 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhao Y |
| Year: |
2021 |
| Journal: |
Gastroenterology |
| Title: |
mTORC1 and mTORC2 Converge on the Arp2/3 Complex to Promote KrasG12D-Induced Acinar-to-Ductal Metaplasia and Early Pancreatic Carcinogenesis. |
| Volume: |
160 |
| Issue: |
5 |
| Pages: |
1755-1770.e17 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Caron A |
| Year: |
2016 |
| Journal: |
Am J Physiol Regul Integr Comp Physiol |
| Title: |
DEPTOR in POMC neurons affects liver metabolism but is dispensable for the regulation of energy balance. |
| Volume: |
310 |
| Issue: |
11 |
| Pages: |
R1322-31 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ouyang Z |
| Year: |
2022 |
| Journal: |
Biomed Pharmacother |
| Title: |
DEPTOR exacerbates bone-fat imbalance in osteoporosis by transcriptionally modulating BMSC differentiation. |
| Volume: |
151 |
|
| Pages: |
113164 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7596429 |
| Assay Type: |
Western blot |
| Annotation Date: |
2024-02-23 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672826 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:7596446 |
| Age: |
embryonic day 18.5 |
| Image: |
7 |
|
| Specimen Label: |
1 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7596429 |
| Assay Type: |
Western blot |
| Annotation Date: |
2024-02-23 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672826 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:7596446 |
| Age: |
embryonic day 18.5 |
| Image: |
7 |
|
| Specimen Label: |
2 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7596429 |
| Assay Type: |
Western blot |
| Annotation Date: |
2024-02-23 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672826 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:7596446 |
| Age: |
embryonic day 18.5 |
| Image: |
7 |
|
| Specimen Label: |
3 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7596429 |
| Assay Type: |
Western blot |
| Annotation Date: |
2024-02-23 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672826 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:7596446 |
| Age: |
embryonic day 18.5 |
| Image: |
7 |
|
| Specimen Label: |
4 |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7596429 |
| Assay Type: |
Western blot |
| Annotation Date: |
2024-02-23 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672826 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:7596446 |
| Age: |
embryonic day 18.5 |
| Image: |
7 |
|
| Specimen Label: |
5 |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7596429 |
| Assay Type: |
Western blot |
| Annotation Date: |
2024-02-23 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672826 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:7596446 |
| Age: |
embryonic day 18.5 |
| Image: |
7 |
|
| Specimen Label: |
6 |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7596429 |
| Assay Type: |
Western blot |
| Annotation Date: |
2024-02-23 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672826 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:7596446 |
| Age: |
embryonic day 18.5 |
| Image: |
7 |
|
| Specimen Label: |
7 |
| Detected: |
true |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7596429 |
| Assay Type: |
Western blot |
| Annotation Date: |
2024-02-23 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672826 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:7596446 |
| Age: |
embryonic day 18.5 |
| Image: |
7 |
|
| Specimen Label: |
8 |
| Detected: |
true |
| Specimen Num: |
8 |
|
•
•
•
•
•
|