|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 2401 to 2500 out of 3085 for Myd88

<< First    < Previous  |  Next >    Last >>
0.032s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
24603458 | J:210996
First Author: Aviello G
Year: 2014
Journal: Am J Physiol Gastrointest Liver Physiol
Title: MyD88 adaptor-like (Mal) regulates intestinal homeostasis and colitis-associated colorectal cancer in mice.
Volume: 306
Issue: 9
Pages: G769-78
•
•
•
•
•
Publication
28404732 | J:242239
First Author: Strickson S
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling.
Volume: 114
Issue: 17
Pages: E3481-E3489
•
•
•
•
•
Publication
19717524 | J:152393
First Author: Kenny EF
Year: 2009
Journal: J Immunol
Title: MyD88 adaptor-like is not essential for TLR2 signaling and inhibits signaling by TLR3.
Volume: 183
Issue: 6
Pages: 3642-51
•
•
•
•
•
Publication
26712311 | J:231176
 
First Author: Xie L
Year: 2016
Journal: J Natl Cancer Inst
Title: Targeting of MyD88 Homodimerization by Novel Synthetic Inhibitor TJ-M2010-5 in Preventing Colitis-Associated Colorectal Cancer.
Volume: 108
Issue: 4
•
•
•
•
•
Publication
20714353 | J:167929
First Author: Bosschaerts T
Year: 2010
Journal: PLoS Pathog
Title: Tip-DC development during parasitic infection is regulated by IL-10 and requires CCL2/CCR2, IFN-gamma and MyD88 signaling.
Volume: 6
Issue: 8
Pages: e1001045
•
•
•
•
•
Publication
23612054 | J:318825
First Author: Corr SC
Year: 2014
Journal: Mucosal Immunol
Title: MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C.
Volume: 7
Issue: 1
Pages: 57-67
•
•
•
•
•
Interaction Experiment
Shi CS (2008)
Description: MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages.
•
•
•
•
•
Interaction Experiment
Li Q (2020)
Description: SPOP promotes ubiquitination and degradation of MyD88 to suppress the innate immune response.
•
•
•
•
•
Publication
22095710 | J:180379
First Author: Popovic ZV
Year: 2011
Journal: J Immunol
Title: The proteoglycan biglycan enhances antigen-specific T cell activation potentially via MyD88 and TRIF pathways and triggers autoimmune perimyocarditis.
Volume: 187
Issue: 12
Pages: 6217-26
•
•
•
•
•
Publication
18292575 | J:131568
First Author: Semaan N
Year: 2008
Journal: J Immunol
Title: Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways.
Volume: 180
Issue: 5
Pages: 3485-91
•
•
•
•
•
Protein
Q99JY1
Organism: Mus musculus/domesticus
Length: 241  
Fragment?: false
•
•
•
•
•
Publication
31406379 | J:291812
First Author: Guillamot M
Year: 2019
Journal: Nat Immunol
Title: The E3 ubiquitin ligase SPOP controls resolution of systemic inflammation by triggering MYD88 degradation.
Volume: 20
Issue: 9
Pages: 1196-1207
•
•
•
•
•
Publication
34570998 | J:337225
First Author: Lopez Kostka S
Year: 2022
Journal: J Invest Dermatol
Title: Exclusive Expression of MyD88 on Dendritic Cells Is Sufficient to Induce Protection against Experimental Leishmaniasis.
Volume: 142
Issue: 4
Pages: 1230-1233
•
•
•
•
•
Publication
12217523 | -
First Author: Janssens S
Year: 2002
Journal: Trends Biochem Sci
Title: A universal role for MyD88 in TLR/IL-1R-mediated signaling.
Volume: 27
Issue: 9
Pages: 474-82
•
•
•
•
•
Protein
A0A1S5WLF0
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: false
•
•
•
•
•
Publication
29395066 | J:257326
First Author: Zhao Y
Year: 2018
Journal: Mol Cell
Title: OTUD4 Is a Phospho-Activated K63 Deubiquitinase that Regulates MyD88-Dependent Signaling.
Volume: 69
Issue: 3
Pages: 505-516.e5
•
•
•
•
•
Pathway
R-MMU-975155 | MyD88 dependent cascade initiated on endosome
•
•
•
•
•
Pathway
R-MMU-975871 | MyD88 cascade initiated on plasma membrane
•
•
•
•
•
Interaction Experiment
Han C (2010)
Description: Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b.
•
•
•
•
•
Publication
20802145 | J:164217
First Author: Lysakova-Devine T
Year: 2010
Journal: J Immunol
Title: Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule.
Volume: 185
Issue: 7
Pages: 4261-71
•
•
•
•
•
Publication
27646001 | J:357944
First Author: Gravina HD
Year: 2016
Journal: J Biol Chem
Title: MyD88 Adapter-like (Mal)/TIRAP Is Required for Cytokine Production by Splenic Ly6CloTLR2hi but Not by Ly6ChiTLR2hi Monocytes during Trypanosoma cruzi Infection.
Volume: 291
Issue: 45
Pages: 23832-23841
•
•
•
•
•
GO Term
GO:0035665 | TIRAP-dependent toll-like receptor 4 signaling pathway
•
•
•
•
•
GO Term
GO:0035664 | TIRAP-dependent toll-like receptor signaling pathway
•
•
•
•
•
Publication
11909531 | -
First Author: Janssens S
Year: 2002
Journal: Curr Biol
Title: Regulation of interleukin-1- and lipopolysaccharide-induced NF-kappaB activation by alternative splicing of MyD88.
Volume: 12
Issue: 6
Pages: 467-71
•
•
•
•
•
HT Experiment
E-GEOD-17438 | Transcriptional profiling of intestinal tissue samples from germ-free and conventionally raised mice which are either wild-type or Myd88-/-
Series Id: GSE17438
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
•
•
•
•
•
Publication
29703722 | J:262309
First Author: Yu X
Year: 2018
Journal: Cancer Res
Title: MYD88 L265P Mutation in Lymphoid Malignancies.
Volume: 78
Issue: 10
Pages: 2457-2462
•
•
•
•
•
Publication
9374458 | -
First Author: Muzio M
Year: 1997
Journal: Science
Title: IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling.
Volume: 278
Issue: 5343
Pages: 1612-5
•
•
•
•
•
Allele
Myd88<em2Smoc> | MGI:7291206
Name: myeloid differentiation primary response gene 88; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
•
•
•
•
•
Publication
18772134 | -
First Author: Shi CS
Year: 2008
Journal: J Biol Chem
Title: MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages.
Volume: 283
Issue: 48
Pages: 33175-82
•
•
•
•
•
Publication
32365080 | -
First Author: Li Q
Year: 2020
Journal: PLoS Pathog
Title: SPOP promotes ubiquitination and degradation of MyD88 to suppress the innate immune response.
Volume: 16
Issue: 5
Pages: e1008188
•
•
•
•
•
GO Term
GO:0002755 | MyD88-dependent toll-like receptor signaling pathway
•
•
•
•
•
GO Term
GO:0002756 | MyD88-independent toll-like receptor signaling pathway
•
•
•
•
•
GO Term
GO:0035660 | MyD88-dependent toll-like receptor 4 signaling pathway
•
•
•
•
•
Allele
Myd88<em1Smoc> | MGI:7291205
Name: myeloid differentiation primary response gene 88; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
•
•
•
•
•
Strain
MGI:6355035 | C57BL/6JSmoc-Myd88<em2Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
•
•
•
•
•
DO Term
DOID:0081066 | MCD diffuse large B-cell lymphoma
•
•
•
•
•
Publication
17548806 | -
First Author: Loiarro M
Year: 2007
Journal: J Leukoc Biol
Title: Pivotal Advance: Inhibition of MyD88 dimerization and recruitment of IRAK1 and IRAK4 by a novel peptidomimetic compound.
Volume: 82
Issue: 4
Pages: 801-10
•
•
•
•
•
GO Term
GO:0035661 | MyD88-dependent toll-like receptor 2 signaling pathway
•
•
•
•
•
Ontology Term
- | Inhibition of host TLR pathway by virus
•
•
•
•
•
Publication
16951688 | -
First Author: Choi KC
Year: 2006
Journal: Nat Immunol
Title: Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1.
Volume: 7
Issue: 10
Pages: 1057-65
•
•
•
•
•
Protein Coding Gene
MGI:1918518 | Lrrfip2
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Allele
Tg(Defa2-Myd88)1Lvh | MGI:4941629
Name: transgene insertion 1, Lora Hooper
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
•
•
•
•
•
Strain
MGI:6475844 | C57BL/6JSmoc-Myd88<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
•
•
•
•
•
Publication
23918981 | J:205798
First Author: Pauls E
Year: 2013
Journal: J Immunol
Title: Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice.
Volume: 191
Issue: 5
Pages: 2717-30
•
•
•
•
•
Protein
Q8CFA1
Organism: Mus musculus/domesticus
Length: 622  
Fragment?: false
•
•
•
•
•
Allele
Myd88<tm1Defr> | MGI:3809600
Name: myeloid differentiation primary response gene 88; targeted mutation 1, Anthony L DeFranco
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
•
•
•
•
•
Strain
MGI:4941785 | C57BL/6-Tg(Defa2-Myd88)1Lvh/J
Attribute String: coisogenic, mutant strain, transgenic
•
•
•
•
•
Publication
18250417 | J:131922
First Author: Gantier MP
Year: 2008
Journal: J Immunol
Title: TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages.
Volume: 180
Issue: 4
Pages: 2117-24
•
•
•
•
•
Publication
12091878 | J:95726
First Author: Alexopoulou L
Year: 2002
Journal: Nat Med
Title: Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice.
Volume: 8
Issue: 8
Pages: 878-84
•
•
•
•
•
Protein Domain
IPR026880 | TLR7
Type: Family
Description: Toll-like receptor 7 (TLR7) is a key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR, which is activated by single-stranded RNA, acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response [, ].
•
•
•
•
•
Protein Domain
IPR027190 | TLR1
Type: Family
Description: Toll-like receptor 1 (TLR1) participates in the innate immune response to microbial agents. TLR1 cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides [, ]. It acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
•
•
•
•
•
Protein Coding Gene
MGI:2147032 | Ticam1
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:3041165 | Tnip3
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Strain
MGI:7615054 | NOD.Cg-Myd88<tm1Defr> H2<b>/JkraJ
Attribute String: major histocompatibility congenic, congenic, mutant strain, spontaneous mutation, targeted mutation
•
•
•
•
•
Strain
MGI:4867253 | CBy.129P2(B6)-Myd88<tm1Defr>/J
Attribute String: targeted mutation, mutant strain, congenic
•
•
•
•
•
Strain
MGI:5008380 | NOD.Cg-Myd88<tm1Defr>/J
Attribute String: targeted mutation, mutant strain, congenic
•
•
•
•
•
Strain
MGI:3829502 | B6.129P2(SJL)-Myd88<tm1Defr>/J
Attribute String: congenic, targeted mutation
•
•
•
•
•
Genotype
Genotype
Symbol: Myd88/Myd88
Background: B6.129P2(SJL)-Myd88/J
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Publication
12077222 | J:103395
First Author: Takeuchi O
Year: 2002
Journal: J Immunol
Title: Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins.
Volume: 169
Issue: 1
Pages: 10-4
•
•
•
•
•
Publication
22429337 | -
First Author: Ferrao R
Year: 2012
Journal: Curr Opin Struct Biol
Title: Helical assembly in the death domain (DD) superfamily.
Volume: 22
Issue: 2
Pages: 241-7
•
•
•
•
•
Protein Domain
IPR034249 | MyD88_Death
Type: Domain
Description: This entry represents the Death Domain (DD) of Myeloid Differentiation primary response protein 88 (MyD88). MyD88 is an adaptor protein involved in interleukin-1 receptor (IL-1R)- and Toll-like receptor (TLR)-induced activation of nuclear factor-kappaB (NF-kB) and mitogen activated protein kinase pathways that lead to the induction of proinflammatory cytokines []. It is a key component in the signaling pathway of pathogen recognition in the innate immune system. MyD88 contains an N-terminal DD and a C-terminal Toll/IL-1 Receptor (TIR) homology domain that mediates interaction with TLRs and IL-1R [].In general, DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including CARD (Caspase activation and recruitment domain), DED (Death Effector Domain), and PYRIN []. They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes [].
•
•
•
•
•
Publication
11470918 | -
First Author: Bauer S
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition.
Volume: 98
Issue: 16
Pages: 9237-42
•
•
•
•
•
Publication
11867692 | J:68228
First Author: Chuang TH
Year: 2002
Journal: J Leukoc Biol
Title: Toll-like receptor 9 mediates CpG-DNA signaling.
Volume: 71
Issue: 3
Pages: 538-44
•
•
•
•
•
Publication
17474149 | J:123483
First Author: Anderson AE
Year: 2007
Journal: Eur J Immunol
Title: TLR9 polymorphisms determine murine lymphocyte responses to Helicobacter: results from a genome-wide scan.
Volume: 37
Issue: 6
Pages: 1548-61
•
•
•
•
•
Publication
11564765 | -
First Author: Takeshita F
Year: 2001
Journal: J Immunol
Title: Cutting edge: Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells.
Volume: 167
Issue: 7
Pages: 3555-8
•
•
•
•
•
Publication
20560798 | -
First Author: Huang X
Year: 2010
Journal: Expert Opin Ther Targets
Title: Targeting the TLR9-MyD88 pathway in the regulation of adaptive immune responses.
Volume: 14
Issue: 8
Pages: 787-96
•
•
•
•
•
Publication
18332149 | -
First Author: Nyman T
Year: 2008
Journal: J Biol Chem
Title: The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer.
Volume: 283
Issue: 18
Pages: 11861-5
•
•
•
•
•
Publication
15728506 | -
First Author: Hasan U
Year: 2005
Journal: J Immunol
Title: Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88.
Volume: 174
Issue: 5
Pages: 2942-50
•
•
•
•
•
Protein Domain
IPR027182 | TLR10
Type: Family
Description: Toll-like receptor 10 (TLR10) participates in the innate immune response to microbial agents. The human TLR family consist of numerous members, which recognise a wide variety of pathogen-associated molecular patterns. No ligand has yet been reported for TLR10, thus it remains the only orphanfamily member []. It acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. TLR10 has been shown to form homodimers and to interact with TLRs 1 and 2 [].
•
•
•
•
•
Protein Domain
IPR027181 | TLR9
Type: Family
Description: Toll-like receptor 9 (TLR9) is a key component of innate and adaptive immunity [, ]. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides, which is more abundant in bacterial genomes or viral DNA compared to the vertebrate genomes [, , , ]. It acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. TLR9 controls lymphocyte response to Helicobacter infection [].
•
•
•
•
•
Protein Domain
IPR033611 | IRAK2
Type: Family
Description: Interleukin-1 receptor-associated kinase-like 2 (IRAK2) is a critical mediator of TLR/IL1-R signalling [, ]. It is required for production of pro-inflammatory cytokines [, ].All IRAKs are multidomain proteins, consisting of a conserved N-terminal death domain (DD) and a central kinase domain (KD). The DD is a protein interaction motif implicated in binding to the adaptor protein MyD88 []. IRAK2 lacks an active kinase domain, as a critical residue in the kinase domain has changed [].
•
•
•
•
•
HT Experiment
E-GEOD-17344 | Analysis of spatial mRNA expression differences in the skin of Casp-8F/-K5-Cre or Casp-8F/+K5-Cre mice
Series Id: GSE17344
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
•
•
•
•
•
Protein Coding Gene
MGI:96824 | Tlr4
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:1346872 | Map3k1
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:1891445 | Peli2
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:1924963 | Peli3
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:1859212 | Irf7
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:1349469 | Ecsit
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein
Q9QZH6
Organism: Mus musculus/domesticus
Length: 435  
Fragment?: false
•
•
•
•
•
Protein
P70434
Organism: Mus musculus/domesticus
Length: 457  
Fragment?: false
•
•
•
•
•
Protein
P53349
Organism: Mus musculus/domesticus
Length: 1493  
Fragment?: false
•
•
•
•
•
Protein
Q8BXR6
Organism: Mus musculus/domesticus
Length: 445  
Fragment?: false
•
•
•
•
•
Protein
Q8BST6
Organism: Mus musculus/domesticus
Length: 419  
Fragment?: false
•
•
•
•
•
Publication
21949866 | -
First Author: Govindaraj RG
Year: 2011
Journal: PLoS One
Title: Comparative analysis of species-specific ligand recognition in Toll-like receptor 8 signaling: a hypothesis.
Volume: 6
Issue: 9
Pages: e25118
•
•
•
•
•
Publication
16123302 | -
First Author: Peng G
Year: 2005
Journal: Science
Title: Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function.
Volume: 309
Issue: 5739
Pages: 1380-4
•
•
•
•
•
Publication
12032557 | J:114769
First Author: Jurk M
Year: 2002
Journal: Nat Immunol
Title: Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848.
Volume: 3
Issue: 6
Pages: 499
•
•
•
•
•
Publication
16188996 | -
First Author: Melchjorsen J
Year: 2005
Journal: J Virol
Title: Activation of innate defense against a paramyxovirus is mediated by RIG-I and TLR7 and TLR8 in a cell-type-specific manner.
Volume: 79
Issue: 20
Pages: 12944-51
•
•
•
•
•
Publication
12610729 | -
First Author: Droemann D
Year: 2003
Journal: Histochem Cell Biol
Title: Toll-like receptor 2 is expressed by alveolar epithelial cells type II and macrophages in the human lung.
Volume: 119
Issue: 2
Pages: 103-8
•
•
•
•
•
Publication
17449723 | -
First Author: Sheedy FJ
Year: 2007
Journal: J Leukoc Biol
Title: The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling.
Volume: 82
Issue: 2
Pages: 196-203
•
•
•
•
•
Publication
18177245 | -
First Author: Bochud PY
Year: 2008
Journal: J Infect Dis
Title: Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosy.
Volume: 197
Issue: 2
Pages: 253-61
•
•
•
•
•
Publication
10426996 | -
First Author: Aliprantis AO
Year: 1999
Journal: Science
Title: Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2.
Volume: 285
Issue: 5428
Pages: 736-9
•
•
•
•
•
Publication
11431423 | J:70578
First Author: Takeuchi O
Year: 2001
Journal: Int Immunol
Title: Discrimination of bacterial lipoproteins by Toll-like receptor 6.
Volume: 13
Issue: 7
Pages: 933-40
•
•
•
•
•
Publication
12646604 | -
First Author: Bochud PY
Year: 2003
Journal: J Immunol
Title: Cutting edge: a Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling.
Volume: 170
Issue: 7
Pages: 3451-4
•
•
•
•
•
Publication
12594207 | -
First Author: Schröder NW
Year: 2003
Journal: J Biol Chem
Title: Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved.
Volume: 278
Issue: 18
Pages: 15587-94
•
•
•
•
•
Publication
11680785 | -
First Author: Kirschning CJ
Year: 2001
Journal: Int J Med Microbiol
Title: Toll-like receptors: cellular signal transducers for exogenous molecular patterns causing immune responses.
Volume: 291
Issue: 4
Pages: 251-60
•
•
•
•
•
Publication
11441107 | J:114041
First Author: Bulut Y
Year: 2001
Journal: J Immunol
Title: Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling.
Volume: 167
Issue: 2
Pages: 987-94
•
•
•
•
•
Publication
12697090 | -
First Author: Takeda K
Year: 2002
Journal: J Endotoxin Res
Title: Recognition of lipopeptides by Toll-like receptors.
Volume: 8
Issue: 6
Pages: 459-63
•
•
•
•
•
Protein Domain
IPR027187 | TLR6
Type: Family
Description: Toll-like receptor 6 (TLR6) participates in the innate immune response to Gram-positive bacteria and fungi. TLRs recognize specific molecular patterns present only in micro-organisms. TLR1 and TLR6 are involved in the discrimination of a subtle difference between triacyl and diacyl lipopeptides through interaction with TLR2 []. Cooperatively with TLR2, TLR6 recognises mycoplasmal macrophage-activating lipopeptide-2 (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and Borrelia burgdorferi outer surface protein A lipoprotein (OspA-L) []. TLR6 acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response [].
•
•
•
•
•
Protein Domain
IPR027185 | TLR2
Type: Family
Description: Toll-like receptor 2 (TLR2) is a member of the Toll-like receptor (TLR) family, which plays a role in activation of innate immunity and pathogen recognition []. It helps mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components, acting via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response [, , , ]. TLR2 in association with TLR1 or TLR6 is essential for recognising bacterial lipoproteins and lipopeptides [, ]. It also promotes apoptosis in response to lipoproteins [].Genetic variations in TLR2 are associated with susceptibility to leprosy, a chronic disease associated with depressed cellular (but not humoral) immunity [, ].
•
•
•
•
•
Protein Domain
IPR027175 | TLR8
Type: Family
Description: Toll-like receptor 8 (TLR8) is a key component of innate and adaptive immunity [, , ]. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. It acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response []. TLR8 has been shown to recognise different types of ligands such as viral or bacterial ssRNA, as well as small synthetic molecules. Activation by ligands is species-specific, varying among non-rodents and rodents [, ].
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom