| Type |
Details |
Score |
| Publication |
| First Author: |
Shimizu T |
| Year: |
2017 |
| Journal: |
DNA Repair (Amst) |
| Title: |
Somatic hypermutation of immunoglobulin genes in Rad18 knockout mice. |
| Volume: |
50 |
|
| Pages: |
54-60 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schenk LK |
| Year: |
2018 |
| Journal: |
Am J Physiol Renal Physiol |
| Title: |
Nephron-specific knockout of TMEM16A leads to reduced number of glomeruli and albuminuria. |
| Volume: |
315 |
| Issue: |
6 |
| Pages: |
F1777-F1786 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hossain MI |
| Year: |
2018 |
| Journal: |
Neurochem Res |
| Title: |
Reduced Proliferation of Oligodendrocyte Progenitor Cells in the Postnatal Brain of Dystonia Musculorum Mice. |
| Volume: |
43 |
| Issue: |
1 |
| Pages: |
92-100 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Singh A |
| Year: |
2017 |
| Journal: |
Sci Rep |
| Title: |
NADPH oxidase 4 modulates hepatic responses to lipopolysaccharide mediated by Toll-like receptor-4. |
| Volume: |
7 |
| Issue: |
1 |
| Pages: |
14346 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jung YS |
| Year: |
2011 |
| Journal: |
Mol Cell Biol |
| Title: |
Pirh2 E3 ubiquitin ligase monoubiquitinates DNA polymerase eta to suppress translesion DNA synthesis. |
| Volume: |
31 |
| Issue: |
19 |
| Pages: |
3997-4006 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Heo SH |
| Year: |
2015 |
| Journal: |
Oncol Rep |
| Title: |
Krüppel-like factor 10 null mice exhibit lower tumor incidence and suppressed cellular proliferation activity following chemically induced liver tumorigenesis. |
| Volume: |
33 |
| Issue: |
4 |
| Pages: |
2037-44 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
El Zowalaty AE |
| Year: |
2018 |
| Journal: |
Biol Reprod |
| Title: |
Seipin deficiency leads to increased endoplasmic reticulum stress and apoptosis in mammary gland alveolar epithelial cells during lactation. |
| Volume: |
98 |
| Issue: |
4 |
| Pages: |
570-578 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zou ZG |
| Year: |
2020 |
| Journal: |
Clin Sci (Lond) |
| Title: |
Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates vascular smooth muscle cell function. |
| Volume: |
134 |
| Issue: |
15 |
| Pages: |
2019-2035 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen L |
| Year: |
2014 |
| Journal: |
Oncol Rep |
| Title: |
Enhancement of DEN-induced liver tumourigenesis in hepatocyte-specific Lass2-knockout mice coincident with upregulation of the TGF-β1-Smad4-PAI-1 axis. |
| Volume: |
31 |
| Issue: |
2 |
| Pages: |
885-93 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jin H |
| Year: |
2017 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Liver-specific deletion of LASS2 delayed regeneration of mouse liver after partial hepatectomy. |
| Volume: |
493 |
| Issue: |
3 |
| Pages: |
1176-1183 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Leng X |
| Year: |
2024 |
| Journal: |
Reprod Fertil Dev |
| Title: |
Mouse Tspyl5 promotes spermatogonia proliferation through enhancing Pcna-mediated DNA replication. |
| Volume: |
36 |
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kohno H |
| Year: |
2001 |
| Journal: |
Cancer Lett |
| Title: |
Inhibitory effect of mandarin juice rich in beta-cryptoxanthin and hesperidin on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced pulmonary tumorigenesis in mice. |
| Volume: |
174 |
| Issue: |
2 |
| Pages: |
141-50 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ramakrishna G |
| Year: |
2002 |
| Journal: |
Toxicol Appl Pharmacol |
| Title: |
Decrease in K-ras p21 and increase in Raf1 and activated Erk 1 and 2 in murine lung tumors initiated by N-nitrosodimethylamine and promoted by 2,3,7,8-tetrachlorodibenzo-p-dioxin. |
| Volume: |
179 |
| Issue: |
1 |
| Pages: |
21-34 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chuang SE |
| Year: |
2000 |
| Journal: |
Carcinogenesis |
| Title: |
Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis. |
| Volume: |
21 |
| Issue: |
2 |
| Pages: |
331-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yamaguchi M |
| Year: |
1990 |
| Journal: |
Mol Cell Biol |
| Title: |
Drosophila proliferating cell nuclear antigen (cyclin) gene: structure, expression during development, and specific binding of homeodomain proteins to its 5'-flanking region. |
| Volume: |
10 |
| Issue: |
3 |
| Pages: |
872-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hamilton JA |
| Year: |
1992 |
| Journal: |
J Immunol |
| Title: |
Inhibition of S-phase progression in macrophages is linked to G1/S-phase suppression of DNA synthesis genes. |
| Volume: |
148 |
| Issue: |
12 |
| Pages: |
4028-35 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yamaguchi M |
| Year: |
1994 |
| Journal: |
Eur J Biochem |
| Title: |
Differential effect of p53 on the promoters of mouse DNA polymerase beta gene and proliferating-cell-nuclear-antigen gene. |
| Volume: |
221 |
| Issue: |
1 |
| Pages: |
227-37 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jónsson ZO |
| Year: |
1998 |
| Journal: |
EMBO J |
| Title: |
Regulation of DNA replication and repair proteins through interaction with the front side of proliferating cell nuclear antigen. |
| Volume: |
17 |
| Issue: |
8 |
| Pages: |
2412-25 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rennecke J |
| Year: |
1999 |
| Journal: |
Int J Cancer |
| Title: |
Protein-kinase-Cmu expression correlates with enhanced keratinocyte proliferation in normal and neoplastic mouse epidermis and in cell culture. |
| Volume: |
80 |
| Issue: |
1 |
| Pages: |
98-103 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cassell HS |
| Year: |
1998 |
| Journal: |
Int J Exp Pathol |
| Title: |
The association between murine cytomegalovirus induced hepatitis and the accumulation of oval cells. |
| Volume: |
79 |
| Issue: |
6 |
| Pages: |
433-41 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ma G |
| Year: |
1999 |
| Journal: |
Lasers Surg Med |
| Title: |
Promotional effects of CO(2) laser and scalpel incision on 4-NQO-induced premalignant lesions of mouse tongue. |
| Volume: |
25 |
| Issue: |
3 |
| Pages: |
207-12 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xue Y |
| Year: |
2002 |
| Journal: |
Biochemistry |
| Title: |
A minimal exonuclease domain of WRN forms a hexamer on DNA and possesses both 3'- 5' exonuclease and 5'-protruding strand endonuclease activities. |
| Volume: |
41 |
| Issue: |
9 |
| Pages: |
2901-12 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chang DY |
| Year: |
2002 |
| Journal: |
J Biol Chem |
| Title: |
Functional interaction of MutY homolog with proliferating cell nuclear antigen in fission yeast, Schizosaccharomyces pombe. |
| Volume: |
277 |
| Issue: |
14 |
| Pages: |
11853-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pajari AM |
| Year: |
2003 |
| Journal: |
Int J Cancer |
| Title: |
Promotion of intestinal tumor formation by inulin is associated with an accumulation of cytosolic beta-catenin in Min mice. |
| Volume: |
106 |
| Issue: |
5 |
| Pages: |
653-60 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim DH |
| Year: |
2003 |
| Journal: |
Aliment Pharmacol Ther |
| Title: |
Long-term evaluation of mice model infected with Helicobacter pylori: focus on gastric pathology including gastric cancer. |
| Volume: |
18 Suppl 1 |
|
| Pages: |
14-23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shankar K |
| Year: |
2003 |
| Journal: |
FASEB J |
| Title: |
Activation of PPAR-alpha in streptozotocin-induced diabetes is essential for resistance against acetaminophen toxicity. |
| Volume: |
17 |
| Issue: |
12 |
| Pages: |
1748-50 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Valacchi G |
| Year: |
2004 |
| Journal: |
Free Radic Biol Med |
| Title: |
In vivo ozone exposure induces antioxidant/stress-related responses in murine lung and skin. |
| Volume: |
36 |
| Issue: |
5 |
| Pages: |
673-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mutoh H |
| Year: |
2004 |
| Journal: |
Gut |
| Title: |
Cdx1 induced intestinal metaplasia in the transgenic mouse stomach: comparative study with Cdx2 transgenic mice. |
| Volume: |
53 |
| Issue: |
10 |
| Pages: |
1416-23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yu H |
| Year: |
2004 |
| Journal: |
World J Gastroenterol |
| Title: |
Effect of hepatoma H22 on lymphatic endothelium in vitro. |
| Volume: |
10 |
| Issue: |
23 |
| Pages: |
3428-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dai C |
| Year: |
2005 |
| Journal: |
Neoplasia |
| Title: |
The characteristics of astrocytomas and oligodendrogliomas are caused by two distinct and interchangeable signaling formats. |
| Volume: |
7 |
| Issue: |
4 |
| Pages: |
397-406 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sun BC |
| Year: |
2005 |
| Journal: |
World J Gastroenterol |
| Title: |
Sulindac induces apoptosis and protects against colon carcinoma in mice. |
| Volume: |
11 |
| Issue: |
18 |
| Pages: |
2822-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Akasaka Y |
| Year: |
2005 |
| Journal: |
Histopathology |
| Title: |
Expression of a candidate marker for progenitor cells, Musashi-1, in the proliferative regions of human antrum and its decreased expression in intestinal metaplasia. |
| Volume: |
47 |
| Issue: |
4 |
| Pages: |
348-56 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Moto M |
| Year: |
2006 |
| Journal: |
Arch Toxicol |
| Title: |
Absence of liver tumor-initiating activity of kojic acid in mice. |
| Volume: |
80 |
| Issue: |
5 |
| Pages: |
299-304 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wu H |
| Year: |
2006 |
| Journal: |
J Vet Med Sci |
| Title: |
Immunohistochemical analysis for Mdm2 and p53 proteins in methylcholanthrene-induced mouse rhabdomyosarcomas. |
| Volume: |
68 |
| Issue: |
5 |
| Pages: |
427-31 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Raina K |
| Year: |
2007 |
| Journal: |
Cancer Res |
| Title: |
Oral grape seed extract inhibits prostate tumor growth and progression in TRAMP mice. |
| Volume: |
67 |
| Issue: |
12 |
| Pages: |
5976-82 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Inoue M |
| Year: |
2006 |
| Journal: |
Int J Exp Pathol |
| Title: |
Immunohistochemical detection of myogenin and p21 in methylcholanthrene-induced mouse rhabdomyosarcomas. |
| Volume: |
87 |
| Issue: |
6 |
| Pages: |
445-50 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lucas da Silva LB |
| Year: |
2008 |
| Journal: |
J Exp Ther Oncol |
| Title: |
FTY720 treatment in experimentally urethane-induced lung tumors. |
| Volume: |
7 |
| Issue: |
1 |
| Pages: |
9-15 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mayoral R |
| Year: |
2008 |
| Journal: |
Biochem J |
| Title: |
Constitutive expression of cyclo-oxygenase 2 transgene in hepatocytes protects against liver injury. |
| Volume: |
416 |
| Issue: |
3 |
| Pages: |
337-46 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kamel S |
| Year: |
2009 |
| Journal: |
Bone |
| Title: |
Morpholino-mediated knockdown in primary chondrocytes implicates Hoxc8 in regulation of cell cycle progression. |
| Volume: |
44 |
| Issue: |
4 |
| Pages: |
708-16 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shansab M |
| Year: |
2011 |
| Journal: |
Mol Immunol |
| Title: |
p21 is dispensable for AID-mediated class switch recombination and mutagenesis of immunoglobulin genes during somatic hypermutation. |
| Volume: |
48 |
| Issue: |
6-7 |
| Pages: |
973-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Siqueira MF |
| Year: |
2011 |
| Journal: |
Bone |
| Title: |
FOXO1 modulates osteoblast differentiation. |
| Volume: |
48 |
| Issue: |
5 |
| Pages: |
1043-51 |
|
•
•
•
•
•
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| Publication |
| First Author: |
McCulloch SD |
| Year: |
2009 |
| Journal: |
Nucleic Acids Res |
| Title: |
The efficiency and fidelity of 8-oxo-guanine bypass by DNA polymerases delta and eta. |
| Volume: |
37 |
| Issue: |
9 |
| Pages: |
2830-40 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mortusewicz O |
| Year: |
2011 |
| Journal: |
Nucleic Acids Res |
| Title: |
PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms. |
| Volume: |
39 |
| Issue: |
12 |
| Pages: |
5045-56 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Uddin AN |
| Year: |
2012 |
| Journal: |
Toxicol Appl Pharmacol |
| Title: |
A novel mechanism of filaggrin induction and sunburn prevention by β-damascenone in Skh-1 mice. |
| Volume: |
265 |
| Issue: |
3 |
| Pages: |
335-41 |
|
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•
•
•
•
|
| Publication |
| First Author: |
Chaudhary SC |
| Year: |
2013 |
| Journal: |
Toxicol Appl Pharmacol |
| Title: |
Nitric oxide-releasing sulindac is a novel skin cancer chemopreventive agent for UVB-induced photocarcinogenesis. |
| Volume: |
268 |
| Issue: |
3 |
| Pages: |
249-55 |
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•
•
•
•
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| Publication |
| First Author: |
Lv L |
| Year: |
2013 |
| Journal: |
Nucleic Acids Res |
| Title: |
Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation. |
| Volume: |
41 |
| Issue: |
22 |
| Pages: |
10312-22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tomioka Y |
| Year: |
2014 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
A soluble form of Siglec-9 provides an antitumor benefit against mammary tumor cells expressing MUC1 in transgenic mice. |
| Volume: |
450 |
| Issue: |
1 |
| Pages: |
532-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tomita K |
| Year: |
2014 |
| Journal: |
Am J Physiol Gastrointest Liver Physiol |
| Title: |
Epiregulin promotes the emergence and proliferation of adult liver progenitor cells. |
| Volume: |
307 |
| Issue: |
1 |
| Pages: |
G50-7 |
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•
•
•
•
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| Publication |
| First Author: |
Hułas-Stasiak M |
| Year: |
2017 |
| Journal: |
PLoS One |
| Title: |
The effects of dexamethasone administered during pregnancy on the postpartum spiny mouse ovary. |
| Volume: |
12 |
| Issue: |
8 |
| Pages: |
e0183528 |
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•
•
•
•
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| Publication |
| First Author: |
Patidar PL |
| Year: |
2016 |
| Journal: |
Nucleic Acids Res |
| Title: |
The Kub5-Hera/RPRD1B interactome: a novel role in preserving genetic stability by regulating DNA mismatch repair. |
| Volume: |
44 |
| Issue: |
4 |
| Pages: |
1718-31 |
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•
•
•
•
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| Publication |
| First Author: |
Papageorgiou DN |
| Year: |
2016 |
| Journal: |
Biochim Biophys Acta |
| Title: |
Distinct and overlapping DNMT1 interactions with multiple transcription factors in erythroid cells: Evidence for co-repressor functions. |
| Volume: |
1859 |
| Issue: |
12 |
| Pages: |
1515-1526 |
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•
•
•
•
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| Publication |
| First Author: |
Xie G |
| Year: |
2019 |
| Journal: |
Am J Pathol |
| Title: |
Hepatocyte Peroxisome Proliferator-Activated Receptor α Enhances Liver Regeneration after Partial Hepatectomy in Mice. |
| Volume: |
189 |
| Issue: |
2 |
| Pages: |
272-282 |
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•
•
•
•
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| Publication |
| First Author: |
Cao Y |
| Year: |
2019 |
| Journal: |
Sci Rep |
| Title: |
Plasma High Mobility Group Box 1 (HMGB1), Osteopontin (OPN), and Hyaluronic Acid (HA) as Admissible Biomarkers for Endometriosis. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
9272 |
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•
•
•
•
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| Publication |
| First Author: |
Kim KH |
| Year: |
2019 |
| Journal: |
Sci Rep |
| Title: |
Sexually dimorphic leanness and hypermobility in p16Ink4a/CDKN2A-deficient mice coincides with phenotypic changes in the cerebellum. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
11167 |
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•
•
•
•
|
| Publication |
| First Author: |
Yang Z |
| Year: |
2019 |
| Journal: |
J Cell Mol Med |
| Title: |
Dynein axonemal intermediate chain 2 plays a role in gametogenesis by activation of Stat3. |
| Volume: |
23 |
| Issue: |
1 |
| Pages: |
417-425 |
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•
•
•
•
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| Publication |
| First Author: |
Zhao C |
| Year: |
2020 |
| Journal: |
Pathol Res Pract |
| Title: |
Knockout of TLR4 promotes fracture healing by activating Wnt/β-catenin signaling pathway. |
| Volume: |
216 |
| Issue: |
2 |
| Pages: |
152766 |
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•
•
•
•
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| Publication |
| First Author: |
Arnason T |
| Year: |
2013 |
| Journal: |
Cancer Biol Ther |
| Title: |
Cables1 is a tumor suppressor gene that regulates intestinal tumor progression in Apc(Min) mice. |
| Volume: |
14 |
| Issue: |
7 |
| Pages: |
672-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee SJ |
| Year: |
2016 |
| Journal: |
Pharmacol Res |
| Title: |
Osteopontin plays a key role in vascular smooth muscle cell proliferation via EGFR-mediated activation of AP-1 and C/EBPβ pathways. |
| Volume: |
108 |
|
| Pages: |
1-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu G |
| Year: |
2020 |
| Journal: |
Ren Fail |
| Title: |
miR-25-3p promotes proliferation and inhibits autophagy of renal cells in polycystic kidney mice by regulating ATG14-Beclin 1. |
| Volume: |
42 |
| Issue: |
1 |
| Pages: |
333-342 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tan G |
| Year: |
2020 |
| Journal: |
J Hematol Oncol |
| Title: |
HMGB1 released from GSDME-mediated pyroptotic epithelial cells participates in the tumorigenesis of colitis-associated colorectal cancer through the ERK1/2 pathway. |
| Volume: |
13 |
| Issue: |
1 |
| Pages: |
149 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wei P |
| Year: |
2024 |
| Journal: |
Biochim Biophys Acta Mol Basis Dis |
| Title: |
Urotensin II receptor deficiency ameliorates ligation-induced carotid intimal hyperplasia partially through the RhoA-YAP1 pathway. |
| Volume: |
1870 |
| Issue: |
5 |
| Pages: |
167170 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
196
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
163
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
168
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Longhese MP |
| Year: |
1997 |
| Journal: |
EMBO J |
| Title: |
The novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast. |
| Volume: |
16 |
| Issue: |
17 |
| Pages: |
5216-26 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Eichinger CS |
| Year: |
2011 |
| Journal: |
Trends Biochem Sci |
| Title: |
9-1-1: PCNA's specialized cousin. |
| Volume: |
36 |
| Issue: |
11 |
| Pages: |
563-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marinsek N |
| Year: |
2006 |
| Journal: |
EMBO Rep |
| Title: |
GINS, a central nexus in the archaeal DNA replication fork. |
| Volume: |
7 |
| Issue: |
5 |
| Pages: |
539-45 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sims AE |
| Year: |
2007 |
| Journal: |
Nat Struct Mol Biol |
| Title: |
FANCI is a second monoubiquitinated member of the Fanconi anemia pathway. |
| Volume: |
14 |
| Issue: |
6 |
| Pages: |
564-7 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
216
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
144
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
92
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
DNA replication in eukaryotes results from a highly coordinated interaction between proteins, often as part of protein complexes, and the DNA template. One of the key early steps leading to DNA replication is formation of the pre-replication complex, or pre-RC. The pre-RC is formed by the sequential binding of the origin recognition complex (ORC), Cdc6 and Cdt1 proteins, and the MCM complex. Activation of the pre-RC into the initiation complex (IC) is achieved via the action of S-phase kinases, eventually leading to the loading of the replication machinery.Recently, a novel replication complex, GINS (for Go, Ichi, Nii, and San; five, one, two, and three in Japanese), has been identified [, ]. The precise function of GINS is not known. However, genetic and two-hybrid interactions indicate that it mediates the loading of the enzymatic replication machinery at a step after the action of the S-phase kinases []. Furthermore, GINS may be a part of the replication machinery itself, since it is found associated with replicating DNA [, ]. Electron microscopy of GINS shows that it forms a ring-like structure [], reminiscent of the structure of PCNA [], the DNA polymerase delta replication clamp. This observation, coupled with the observed interactions for GINS, indicates that the complex may represent the replication clamp for DNA polymerase epsilon [].The GINS complex is essential for initiation of DNA replication in Xenopus egg extracts []. This 100kDa stable complex includes Sld5, Psf1, Psf2, and Psf3. Homologues of these components are found also in other eukaryotes []. The archaeal GINS complex contains two subunits (SSO0772/gins23 and SO1049/gins15 in Sulfolobus) that are poorly conserved homologues of the eukaryotic GINS subunits []. Only Gins23 is included in this entry.The eukaryotic GINS subunits are homologous. The four subunits of the complex consist of two domains each, termed the α-helical (A) and β-strand (B) domains. The A and B domains of Sld5/Psf1 are permuted with respect to Psf1/Psf3 []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Homologous_superfamily |
| Description: |
DNA replication in eukaryotes results from a highly coordinated interaction between proteins, often as part of protein complexes, and the DNA template. One of the key early steps leading to DNA replication is formation of the pre-replication complex, or pre-RC. The pre-RC is formed by the sequential binding of the origin recognition complex (ORC), Cdc6 and Cdt1 proteins, and the MCM complex. Activation of the pre-RC into the initiation complex (IC) is achieved via the action of S-phase kinases, eventually leading to the loading of the replication machinery.Recently, a novel replication complex, GINS (for Go, Ichi, Nii, and San; five, one, two, and three in Japanese), has been identified [, ]. The precise function of GINS is not known. However, genetic and two-hybrid interactions indicate that it mediates the loading of the enzymatic replication machinery at a step after the action of the S-phase kinases []. Furthermore, GINS may be a part of the replication machinery itself, since it is found associated with replicating DNA [, ]. Electron microscopy of GINS shows that it forms a ring-like structure [], reminiscent of the structure of PCNA [], the DNA polymerase delta replication clamp. This observation, coupled with the observed interactions for GINS, indicates that the complex may represent the replication clamp for DNA polymerase epsilon [].The GINS complex is essential for initiation of DNA replication in Xenopus egg extracts []. This 100kDa stable complex includes Sld5, Psf1, Psf2, and Psf3. Homologues of these components are found also in other eukaryotes []. The archaeal GINS complex contains two subunits (SSO0772/gins23 and SO1049/gins15 in Sulfolobus) that are poorly conserved homologues of the eukaryotic GINS subunits []. Only Gins23 is included in this entry.The eukaryotic GINS subunits are homologous. The four subunits of the complex consist of two domains each, termed the α-helical (A) and β-strand (B) domains. The A and B domains of Sld5/Psf1 are permuted with respect to Psf1/Psf3 []. |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
185
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yin G |
| Year: |
2014 |
| Journal: |
PLoS One |
| Title: |
Impaired angiogenesis during fracture healing in GPCR kinase 2 interacting protein-1 (GIT1) knock out mice. |
| Volume: |
9 |
| Issue: |
2 |
| Pages: |
e89127 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang F |
| Year: |
2020 |
| Journal: |
Biomed Res Int |
| Title: |
Bafilomycin A1 Accelerates Chronic Refractory Wound Healing in db/db Mice. |
| Volume: |
2020 |
|
| Pages: |
6265701 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Migheli A |
| Year: |
1997 |
| Journal: |
Am J Pathol |
| Title: |
Diverse cell death pathways result from a single missense mutation in weaver mouse. |
| Volume: |
151 |
| Issue: |
6 |
| Pages: |
1629-38 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lundgren K |
| Year: |
1997 |
| Journal: |
Genes Dev |
| Title: |
Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53. |
| Volume: |
11 |
| Issue: |
6 |
| Pages: |
714-25 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marek I |
| Year: |
2017 |
| Journal: |
Biol Sex Differ |
| Title: |
Sex differences in the development of vascular and renal lesions in mice with a simultaneous deficiency of Apoe and the integrin chain Itga8. |
| Volume: |
8 |
|
| Pages: |
19 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Qi H |
| Year: |
2023 |
| Journal: |
Mol Med |
| Title: |
Knockdown of DEC2 expression inhibits the proliferation of mesangial cells through suppressed glycolysis and p38 MAPK/Erk pathway in lupus nephritis. |
| Volume: |
29 |
| Issue: |
1 |
| Pages: |
99 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fang Z |
| Year: |
2004 |
| Journal: |
Fertil Steril |
| Title: |
Intact progesterone receptors are essential to counteract the proliferative effect of estradiol in a genetically engineered mouse model of endometriosis. |
| Volume: |
82 |
| Issue: |
3 |
| Pages: |
673-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Irwin RW |
| Year: |
2015 |
| Journal: |
PLoS One |
| Title: |
Allopregnanolone preclinical acute pharmacokinetic and pharmacodynamic studies to predict tolerability and efficacy for Alzheimer's disease. |
| Volume: |
10 |
| Issue: |
6 |
| Pages: |
e0128313 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Kang BY |
| Year: |
2016 |
| Journal: |
Am J Respir Cell Mol Biol |
| Title: |
Peroxisome Proliferator-Activated Receptor γ and microRNA 98 in Hypoxia-Induced Endothelin-1 Signaling. |
| Volume: |
54 |
| Issue: |
1 |
| Pages: |
136-46 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Britt KL |
| Year: |
2004 |
| Journal: |
Biol Reprod |
| Title: |
Estrogen actions on follicle formation and early follicle development. |
| Volume: |
71 |
| Issue: |
5 |
| Pages: |
1712-23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li J |
| Year: |
2005 |
| Journal: |
Cell Cycle |
| Title: |
Loss of caveolin-1 causes the hyper-proliferation of intestinal crypt stem cells, with increased sensitivity to whole body gamma-radiation. |
| Volume: |
4 |
| Issue: |
12 |
| Pages: |
1817-25 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jeppsson S |
| Year: |
2017 |
| Journal: |
Am J Physiol Gastrointest Liver Physiol |
| Title: |
Neuropeptide Y (NPY) promotes inflammation-induced tumorigenesis by enhancing epithelial cell proliferation. |
| Volume: |
312 |
| Issue: |
2 |
| Pages: |
G103-G111 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Calingasan NY |
| Year: |
2008 |
| Journal: |
Neuroscience |
| Title: |
Influence of mitochondrial enzyme deficiency on adult neurogenesis in mouse models of neurodegenerative diseases. |
| Volume: |
153 |
| Issue: |
4 |
| Pages: |
986-96 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mack JT |
| Year: |
2011 |
| Journal: |
Cancer Lett |
| Title: |
ABCA2 transporter deficiency reduces incidence of TRAMP prostate tumor metastasis and cellular chemotactic migration. |
| Volume: |
300 |
| Issue: |
2 |
| Pages: |
154-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Qiu ZF |
| Year: |
2003 |
| Journal: |
J Invest Surg |
| Title: |
Piroxicam-induced regression of intestinal adenomatous polyps in APC(delta474) mice. |
| Volume: |
16 |
| Issue: |
2 |
| Pages: |
71-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Matsumoto T |
| Year: |
2000 |
| Journal: |
Liver |
| Title: |
Androgen dependency of hepatocarcinogenesis in TGFalpha transgenic mice. |
| Volume: |
20 |
| Issue: |
3 |
| Pages: |
228-33 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kalailingam P |
| Year: |
2023 |
| Journal: |
Cancers (Basel) |
| Title: |
Conditional Knockout of N-WASP Enhanced the Formation of Keratinizing Squamous Cell Carcinoma Induced by KRas(G12D). |
| Volume: |
15 |
| Issue: |
18 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mori I |
| Year: |
2001 |
| Journal: |
J Vet Med Sci |
| Title: |
Aberrant expression of cyclin D1 in pulmonary proliferative lesions induced by high doses of urethane in transgenic mice carrying the human prototype c-H-ras gene. |
| Volume: |
63 |
| Issue: |
3 |
| Pages: |
261-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lu X |
| Year: |
2016 |
| Journal: |
Matrix Biol |
| Title: |
The ameloblastin extracellular matrix molecule enhances bone fracture resistance and promotes rapid bone fracture healing. |
| Volume: |
52-54 |
|
| Pages: |
113-126 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wu Y |
| Year: |
2023 |
| Journal: |
Front Immunol |
| Title: |
HBSP improves kidney ischemia-reperfusion injury and promotes repair in properdin deficient mice via enhancing phagocytosis of tubular epithelial cells. |
| Volume: |
14 |
|
| Pages: |
1183768 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang Y |
| Year: |
2022 |
| Journal: |
Cells |
| Title: |
TRPM2 Promotes Atherosclerotic Progression in a Mouse Model of Atherosclerosis. |
| Volume: |
11 |
| Issue: |
9 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Choi H |
| Year: |
2023 |
| Journal: |
Free Radic Biol Med |
| Title: |
Extracellular SOD modulates canonical TNFα signaling and α5β1 integrin transactivation in vascular smooth muscle cells. |
| Volume: |
209 |
| Issue: |
Pt 1 |
| Pages: |
152-164 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Takahashi Y |
| Year: |
2019 |
| Journal: |
Front Cell Neurosci |
| Title: |
Expression of Oncofetal Antigen 5T4 in Murine Taste Papillae. |
| Volume: |
13 |
|
| Pages: |
343 |
|
•
•
•
•
•
|