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Search results 2401 to 2500 out of 3582 for Tlr4

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Hits by Strain

Type Details Score
Interaction Experiment
Dauphinee SM (2013)
Description: SASH1 Is a Scaffold Molecule in Endothelial TLR4 Signaling.
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Allele
Tlr4<tm1Aki> | MGI:1860885
Name: toll-like receptor 4; targeted mutation 1, Shizuo Akira
Allele Type: Targeted
Attribute String: Null/knockout
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HT Experiment
E-GEOD-29311 | LPS hypersensitivity of gp130 mutant mice is independent of elevated hematopoietic TLR4 signaling
Series Id: GSE29311
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Allele
Tril<tm1.1Kaf> | MGI:6508377
Name: TLR4 interactor with leucine-rich repeats; targeted mutation 1.1, Katherine A Fitzgerald
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
18025177 | J:154820
First Author: Rui Y
Year: 2007
Journal: J Immunol
Title: PECAM-1 ligation negatively regulates TLR4 signaling in macrophages.
Volume: 179
Issue: 11
Pages: 7344-51
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Publication
12055629 | J:92494
First Author: Nagai Y
Year: 2002
Journal: Nat Immunol
Title: Essential role of MD-2 in LPS responsiveness and TLR4 distribution.
Volume: 3
Issue: 7
Pages: 667-72
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Protein Coding Gene
MGP_CAROLIEiJ_G0028398 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0030756 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0030725 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0030652 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0030737 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0030450 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1914123 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0031192 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0029853 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0030424 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0030574 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0030526 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0030659 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0030560 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0031222 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0029566 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0029930 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0022148 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0029400 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:7471219
Assay Type: RT-PCR
Annotation Date: 2023-05-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754423
Stage: TS23
Assay Id: MGI:7471246
Age: embryonic day 15.5
Specimen Label: E15.5 Rp58+/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7471219
Assay Type: RT-PCR
Annotation Date: 2023-05-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754423
Stage: TS23
Assay Id: MGI:7471246
Age: embryonic day 15.5
Specimen Label: E15.5 Rp58-/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7471219
Assay Type: RT-PCR
Annotation Date: 2023-05-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754426
Stage: TS26
Assay Id: MGI:7471246
Age: embryonic day 18.5
Specimen Label: E18.5 Rp58+/+
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:7471219
Assay Type: RT-PCR
Annotation Date: 2023-05-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754426
Stage: TS26
Assay Id: MGI:7471246
Age: embryonic day 18.5
Specimen Label: E18.5 Rp58-/-
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:4428561
Assay Type: RNA in situ
Annotation Date: 2024-04-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7623585
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4428561
Assay Type: RNA in situ
Annotation Date: 2024-04-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7623585
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:4428561
Assay Type: RNA in situ
Annotation Date: 2023-03-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3576022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7444169
Age: embryonic day 14.5
Image: S1A
Note: Expression was detected throughout the valve endothelium and mesenchyme.
Specimen Label: S1A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:4428561
Assay Type: RNA in situ
Annotation Date: 2023-03-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3515422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7444169
Age: embryonic day 14.5
Image: S1A
Note: Expression was detected throughout the valve endothelium and mesenchyme.
Specimen Label: S1A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4428561
Assay Type: RNA in situ
Annotation Date: 2024-04-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7623585
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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Publication
33362762 | J:337279
 
First Author: Kiyan Y
Year: 2020
Journal: Front Immunol
Title: TLR4 Response to LPS Is Reinforced by Urokinase Receptor.
Volume: 11
Pages: 573550
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Publication
29472103 | J:270123
 
First Author: Yi YS
Year: 2018
Journal: EBioMedicine
Title: p204 Is Required for Canonical Lipopolysaccharide-induced TLR4 Signaling in Mice.
Volume: 29
Pages: 78-91
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Publication
30397349 | J:282512
First Author: Perkins DJ
Year: 2018
Journal: Nat Immunol
Title: Autocrine-paracrine prostaglandin E2 signaling restricts TLR4 internalization and TRIF signaling.
Volume: 19
Issue: 12
Pages: 1309-1318
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Publication
23921128 | J:201624
First Author: Chen CL
Year: 2013
Journal: J Clin Invest
Title: Reciprocal regulation by TLR4 and TGF-β in tumor-initiating stem-like cells.
Volume: 123
Issue: 7
Pages: 2832-49
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Publication
16585591 | J:131184
First Author: Qureshi ST
Year: 2006
Journal: J Immunol
Title: Inducible activation of TLR4 confers resistance to hyperoxia-induced pulmonary apoptosis.
Volume: 176
Issue: 8
Pages: 4950-8
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Publication
31537875 | J:284663
First Author: Kiyan Y
Year: 2019
Journal: Sci Rep
Title: Heparanase-2 protects from LPS-mediated endothelial injury by inhibiting TLR4 signalling.
Volume: 9
Issue: 1
Pages: 13591
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Publication
34162749 | J:307729
 
First Author: Yu J
Year: 2021
Journal: Sci Transl Med
Title: Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis.
Volume: 13
Issue: 599
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Pathway
R-MMU-937061 | TRIF (TICAM1)-mediated TLR4 signaling
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Pathway
R-MMU-166166 | MyD88-independent TLR4 cascade
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Publication
33055214 | J:303336
First Author: Swanson L
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin.
Volume: 117
Issue: 43
Pages: 26895-26906
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GO Term
GO:0034142 | toll-like receptor 4 signaling pathway
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GO Term
GO:0035660 | MyD88-dependent toll-like receptor 4 signaling pathway
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GO Term
GO:0035669 | TRAM-dependent toll-like receptor 4 signaling pathway
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Protein
Q8BQ47
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: false
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Publication
19948740 | J:159941
First Author: Wan T
Year: 2010
Journal: J Biol Chem
Title: AIP1 functions as Arf6-GAP to negatively regulate TLR4 signaling.
Volume: 285
Issue: 6
Pages: 3750-7
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Publication
36920907 | J:334735
First Author: Luo S
Year: 2023
Journal: Cell Rep
Title: METTL3-mediated m6A mRNA methylation regulates neutrophil activation through targeting TLR4 signaling.
Volume: 42
Issue: 3
Pages: 112259
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Publication
23390517 | J:199428
First Author: Martirosyan A
Year: 2013
Journal: PLoS One
Title: Lipopolysaccharides with acylation defects potentiate TLR4 signaling and shape T cell responses.
Volume: 8
Issue: 2
Pages: e55117
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Publication
36949755 | J:334295
First Author: Hernandez JC
Year: 2023
Journal: iScience
Title: LIN28 and histone H3K4 methylase induce TLR4 to generate tumor-initiating stem-like cells.
Volume: 26
Issue: 3
Pages: 106254
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Publication
26655905 | J:244736
First Author: Seifert L
Year: 2015
Journal: Cell Rep
Title: Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppressing TLR4 Signaling Pathways.
Volume: 13
Issue: 9
Pages: 1909-1921
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Publication
30552619 | J:295613
First Author: Wei ZM
Year: 2019
Journal: Immunol Res
Title: FcRγ deficiency improves survival in experimental sepsis by down-regulating TLR4 signaling pathway.
Volume: 67
Issue: 1
Pages: 77-83
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Publication
24911202 | J:213486
First Author: Wan Y
Year: 2014
Journal: FEBS Lett
Title: Separation of zinc-dependent and zinc-independent events during early LPS-stimulated TLR4 signaling in macrophage cells.
Volume: 588
Issue: 17
Pages: 2928-35
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Publication
22984080 | J:190650
First Author: Lee SR
Year: 2012
Journal: J Immunol
Title: Receptor cross-talk spatially restricts p-ERK during TLR4 stimulation of autoreactive B cells.
Volume: 189
Issue: 8
Pages: 3859-68
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Publication
20686699 | J:163068
First Author: Bhattacharjee RN
Year: 2010
Journal: PLoS One
Title: Telomere-mediated chromosomal instability triggers TLR4 induced inflammation and death in mice.
Volume: 5
Issue: 7
Pages: e11873
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Publication
29447283 | J:257402
First Author: Cosin-Roger J
Year: 2018
Journal: PLoS One
Title: Gp96 deficiency affects TLR4 functionality and impairs ERK and p38 phosphorylation.
Volume: 13
Issue: 2
Pages: e0193003
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Publication
28471051 | J:243292
First Author: Döring C
Year: 2017
Journal: Glia
Title: A presumed antagonistic LPS identifies distinct functional organization of TLR4 in mouse microglia.
Volume: 65
Issue: 7
Pages: 1176-1185
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Publication
34025672 | J:308460
 
First Author: Pastille E
Year: 2021
Journal: Front Immunol
Title: Inhibition of TLR4 Signaling Impedes Tumor Growth in Colitis-Associated Colon Cancer.
Volume: 12
Pages: 669747
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Publication
34185707 | J:313011
 
First Author: Otsuki S
Year: 2021
Journal: JCI Insight
Title: Monocyte-released HERV-K dUTPase engages TLR4 and MCAM causing endothelial mesenchymal transition.
Volume: 6
Issue: 15
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Publication
38799439 | J:352314
 
First Author: Alugupalli KR
Year: 2024
Journal: Front Immunol
Title: A TLR4 ligand-based adjuvant for promoting the immunogenicity of typhoid subunit vaccines.
Volume: 15
Pages: 1383476
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Publication
23536892 | J:200174
First Author: Sender V
Year: 2013
Journal: PLoS One
Title: Surfactant protein-A modulates LPS-induced TLR4 localization and signaling via β-arrestin 2.
Volume: 8
Issue: 3
Pages: e59896
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HT Experiment
GSE225140 | METTL3 mediated m6A mRNA methylation regulates neutrophil activation through targeting TLR4 signaling (Ribosome-Seq)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE225141 | METTL3 mediated m6A mRNA methylation regulates neutrophil activation through targeting TLR4 signaling (RNA-Seq)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
27053419 | J:269181
 
First Author: Wezel A
Year: 2016
Journal: Sci Rep
Title: Deficiency of the TLR4 analogue RP105 aggravates vein graft disease by inducing a pro-inflammatory response.
Volume: 6
Pages: 24248
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Publication
28045026 | J:243825
 
First Author: Wang Y
Year: 2017
Journal: Nat Commun
Title: Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2.
Volume: 8
Pages: 13997
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Genotype
Genotype
Symbol: Tril/Tril
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Publication
27022195 | J:340703
First Author: Tatematsu M
Year: 2016
Journal: J Immunol
Title: Raftlin Controls Lipopolysaccharide-Induced TLR4 Internalization and TICAM-1 Signaling in a Cell Type-Specific Manner.
Volume: 196
Issue: 9
Pages: 3865-76
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Publication
23318418 | J:204878
First Author: Li Y
Year: 2014
Journal: Oncogene
Title: Constitutive TLR4 signalling in intestinal epithelium reduces tumor load by increasing apoptosis in APC(Min/+) mice.
Volume: 33
Issue: 3
Pages: 369-77
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Publication
18256364 | J:149925
First Author: Banas MC
Year: 2008
Journal: J Am Soc Nephrol
Title: TLR4 links podocytes with the innate immune system to mediate glomerular injury.
Volume: 19
Issue: 4
Pages: 704-13
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Publication
30123107 | J:312247
 
First Author: Krasovska V
Year: 2018
Journal: Front Mol Neurosci
Title: Regulation of IL-6 Secretion by Astrocytes via TLR4 in the Fragile X Mouse Model.
Volume: 11
Pages: 272
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Publication
24659688 | J:209988
First Author: Cui W
Year: 2014
Journal: J Immunol
Title: TLR4 ligands lipopolysaccharide and monophosphoryl lipid a differentially regulate effector and memory CD8+ T Cell differentiation.
Volume: 192
Issue: 9
Pages: 4221-32
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Publication
22357629 | J:183109
First Author: Wimmer N
Year: 2012
Journal: J Immunol
Title: Lymphotoxin β receptor activation on macrophages induces cross-tolerance to TLR4 and TLR9 ligands.
Volume: 188
Issue: 7
Pages: 3426-33
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Publication
20511556 | J:161435
First Author: Kong X
Year: 2010
Journal: J Immunol
Title: NADPH oxidase-dependent reactive oxygen species mediate amplified TLR4 signaling and sepsis-induced mortality in Nrf2-deficient mice.
Volume: 185
Issue: 1
Pages: 569-77
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Publication
19781786 | J:155232
First Author: Muto J
Year: 2009
Journal: Mol Immunol
Title: Engagement of CD44 by hyaluronan suppresses TLR4 signaling and the septic response to LPS.
Volume: 47
Issue: 2-3
Pages: 449-56
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Publication
23345333 | J:193486
First Author: Piao W
Year: 2013
Journal: J Immunol
Title: Inhibition of TLR4 signaling by TRAM-derived decoy peptides in vitro and in vivo.
Volume: 190
Issue: 5
Pages: 2263-72
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Publication
35463988 | J:325592
 
First Author: Mota RF
Year: 2022
Journal: Biomed Res Int
Title: RANKL Impairs the TLR4 Pathway by Increasing TRAF6 and RANK Interaction in Macrophages.
Volume: 2022
Pages: 7740079
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Publication
23457630 | J:197179
First Author: Gandhapudi SK
Year: 2013
Journal: PLoS One
Title: TRIF is required for TLR4 mediated adjuvant effects on T cell clonal expansion.
Volume: 8
Issue: 2
Pages: e56855
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Publication
19574428 | J:150799
First Author: Iwata Y
Year: 2009
Journal: Am J Pathol
Title: CD19, a response regulator of B lymphocytes, regulates wound healing through hyaluronan-induced TLR4 signaling.
Volume: 175
Issue: 2
Pages: 649-60
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Publication
33510368 | J:354836
First Author: Liu L
Year: 2021
Journal: Sci Rep
Title: Surfactant protein A reduces TLR4 and inflammatory cytokine mRNA levels in neonatal mouse ileum.
Volume: 11
Issue: 1
Pages: 2593
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Publication
23716300 | J:201345
First Author: Orr MT
Year: 2013
Journal: Eur J Immunol
Title: MyD88 and TRIF synergistic interaction is required for TH1-cell polarization with a synthetic TLR4 agonist adjuvant.
Volume: 43
Issue: 9
Pages: 2398-408
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Publication
28860634 | J:256461
First Author: Bezhaeva T
Year: 2017
Journal: Sci Rep
Title: Deficiency of TLR4 homologue RP105 aggravates outward remodeling in a murine model of arteriovenous fistula failure.
Volume: 7
Issue: 1
Pages: 10269
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Publication
24945347 | J:216834
First Author: Bastiaansen AJ
Year: 2014
Journal: PLoS One
Title: TLR4 accessory molecule RP105 (CD180) regulates monocyte-driven arteriogenesis in a murine hind limb ischemia model.
Volume: 9
Issue: 6
Pages: e99882
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Publication
33816466 | J:314062
 
First Author: Dong W
Year: 2021
Journal: Front Cell Dev Biol
Title: BRG1 Links TLR4 Trans-Activation to LPS-Induced SREBP1a Expression and Liver Injury.
Volume: 9
Pages: 617073
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Publication
33830504 | J:317470
First Author: Rosa JM
Year: 2021
Journal: Br J Pharmacol
Title: TLR4 pathway impairs synaptic number and cerebrovascular functions through astrocyte activation following traumatic brain injury.
Volume: 178
Issue: 17
Pages: 3395-3413
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Publication
16785552 | J:134439
First Author: Huang X
Year: 2006
Journal: J Immunol
Title: SIGIRR promotes resistance against Pseudomonas aeruginosa keratitis by down-regulating type-1 immunity and IL-1R1 and TLR4 signaling.
Volume: 177
Issue: 1
Pages: 548-56
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Publication
25203747 | J:221519
First Author: Oblak A
Year: 2014
Journal: PLoS One
Title: Species-specific activation of TLR4 by hypoacylated endotoxins governed by residues 82 and 122 of MD-2.
Volume: 9
Issue: 9
Pages: e107520
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Publication
26364141 | J:233731
First Author: Wei M
Year: 2015
Journal: Mol Immunol
Title: Effects of ROS-relative NF-κB signaling on high glucose-induced TLR4 and MCP-1 expression in podocyte injury.
Volume: 68
Issue: 2 Pt A
Pages: 261-71
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Publication
29222167 | J:256894
First Author: Jakka P
Year: 2018
Journal: J Immunol
Title: Cytoplasmic Linker Protein CLIP170 Negatively Regulates TLR4 Signaling by Targeting the TLR Adaptor Protein TIRAP.
Volume: 200
Issue: 2
Pages: 704-714
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Publication
34784389 | J:315185
First Author: Nogueira DS
Year: 2021
Journal: PLoS Pathog
Title: Eosinophils mediate SIgA production triggered by TLR2 and TLR4 to control Ascaris suum infection in mice.
Volume: 17
Issue: 11
Pages: e1010067
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Publication
27156126 | J:318397
 
First Author: Xue L
Year: 2016
Journal: Int Immunopharmacol
Title: The effects of D3R on TLR4 signaling involved in the regulation of METH-mediated mast cells activation.
Volume: 36
Pages: 187-198
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Publication
37984750 | J:343743
 
First Author: Liu H
Year: 2024
Journal: Free Radic Biol Med
Title: Protectin D1 inhibits TLR4 signaling pathway to alleviate non-alcoholic steatohepatitis via upregulating IRAK-M.
Volume: 210
Pages: 42-53
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Publication
21670738 | J:356482
First Author: Greenhill CJ
Year: 2012
Journal: Immunol Cell Biol
Title: LPS hypersensitivity of gp130 mutant mice is independent of elevated haemopoietic TLR4 signaling.
Volume: 90
Issue: 5
Pages: 559-63
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Publication
31597445 | J:316281
First Author: Singh RK
Year: 2020
Journal: Arterioscler Thromb Vasc Biol
Title: TLR4 (Toll-Like Receptor 4)-Dependent Signaling Drives Extracellular Catabolism of LDL (Low-Density Lipoprotein) Aggregates.
Volume: 40
Issue: 1
Pages: 86-102
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First Author: Wang FX
Year: 2018
Journal: Brain Behav Immun
Title: TRIF contributes to epileptogenesis in temporal lobe epilepsy during TLR4 activation.
Volume: 67
Pages: 65-76
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Publication
30883606 | J:273550
First Author: Skjesol A
Year: 2019
Journal: PLoS Pathog
Title: The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2.
Volume: 15
Issue: 3
Pages: e1007684
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Publication
31412243 | J:300930
First Author: Huggins MA
Year: 2019
Journal: Cell Rep
Title: Microbial Exposure Enhances Immunity to Pathogens Recognized by TLR2 but Increases Susceptibility to Cytokine Storm through TLR4 Sensitization.
Volume: 28
Issue: 7
Pages: 1729-1743.e5
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17395780 | J:145405
First Author: Wang Y
Year: 2007
Journal: Blood
Title: Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4.
Volume: 110
Issue: 3
Pages: 962-71
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20385881 | J:161005
First Author: Keck S
Year: 2010
Journal: J Immunol
Title: Activation of murine macrophages via TLR2 and TLR4 is negatively regulated by a Lyn/PI3K module and promoted by SHIP1.
Volume: 184
Issue: 10
Pages: 5809-18
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