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Type Details Score
Publication
First Author: Pozzi A
Year: 1995
Journal: Exp Cell Res
Title: Analysis of multiple gap junction gene products in the rodent and human mammary gland.
Volume: 220
Issue: 1
Pages: 212-9
Publication
First Author: Blanchart A
Year: 2011
Journal: Glia
Title: Peripheral contributions to olfactory bulb cell populations (migrations towards the olfactory bulb).
Volume: 59
Issue: 2
Pages: 278-92
Publication
First Author: Steinecke A
Year: 2012
Journal: J Neurosci
Title: Disrupted-in-Schizophrenia 1 (DISC1) is necessary for the correct migration of cortical interneurons.
Volume: 32
Issue: 2
Pages: 738-45
Publication
First Author: Gortat A
Year: 2012
Journal: J Biol Chem
Title: Single point mutation in Bin/Amphiphysin/Rvs (BAR) sequence of endophilin impairs dimerization, membrane shaping, and Src homology 3 domain-mediated partnership.
Volume: 287
Issue: 6
Pages: 4232-47
Publication
First Author: Lerner A
Year: 1993
Journal: J Immunol
Title: CD3 zeta/eta/theta locus is colinear with and transcribed antisense to the gene encoding the transcription factor Oct-1.
Volume: 151
Issue: 6
Pages: 3152-62
Publication
First Author: Alberola-Die A
Year: 2011
Journal: J Neurochem
Title: Multiple inhibitory actions of lidocaine on Torpedo nicotinic acetylcholine receptors transplanted to Xenopus oocytes.
Volume: 117
Issue: 6
Pages: 1009-19
Publication
First Author: Descargues P
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation.
Volume: 105
Issue: 7
Pages: 2487-92
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
Publication
First Author: Wang J
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Pancreatic beta cells lack a low glucose and O2-inducible mitochondrial protein that augments cell survival.
Volume: 103
Issue: 28
Pages: 10636-41
Publication
First Author: Juriloff DM
Year: 1992
Journal: J Craniofac Genet Dev Biol
Title: Is Far a Hox mutation?
Volume: 12
Issue: 3
Pages: 119-29
Publication
First Author: McJunkin K
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Reversible suppression of an essential gene in adult mice using transgenic RNA interference.
Volume: 108
Issue: 17
Pages: 7113-8
Publication
First Author: Dang MT
Year: 2005
Journal: Exp Neurol
Title: Generation and characterization of Dyt1 DeltaGAG knock-in mouse as a model for early-onset dystonia.
Volume: 196
Issue: 2
Pages: 452-63
Publication
First Author: Simankova A
Year: 2021
Journal: Glia
Title: Ddx20, DEAD box helicase 20, is essential for the differentiation of oligodendrocyte and maintenance of myelin gene expression.
Volume: 69
Issue: 11
Pages: 2559-2574
Publication
First Author: Kumar A
Year: 2014
Journal: Dev Dyn
Title: Loss of function of mouse Pax-Interacting Protein 1-associated glutamate rich protein 1a (Pagr1a) leads to reduced Bmp2 expression and defects in chorion and amnion development.
Volume: 243
Issue: 7
Pages: 937-47
Publication  
First Author: Pyronneau A
Year: 2017
Journal: Sci Signal
Title: Aberrant Rac1-cofilin signaling mediates defects in dendritic spines, synaptic function, and sensory perception in fragile X syndrome.
Volume: 10
Issue: 504
Publication  
First Author: Maeda A
Year: 2015
Journal: Bone
Title: Induction of CXCL2 and CCL2 by pressure force requires IL-1β-MyD88 axis in osteoblasts.
Volume: 74
Pages: 76-82
Publication
First Author: Gupta A
Year: 2019
Journal: Biochem Biophys Res Commun
Title: Connexin43 regulates osteoprotegerin expression via ERK1/2 -dependent recruitment of Sp1.
Volume: 509
Issue: 3
Pages: 728-733
Publication
First Author: Zine A
Year: 2001
Journal: J Neurosci
Title: Hes1 and Hes5 activities are required for the normal development of the hair cells in the mammalian inner ear.
Volume: 21
Issue: 13
Pages: 4712-20
Publication
First Author: Martinez-Ferre A
Year: 2016
Journal: Brain Struct Funct
Title: Fgf15 regulates thalamic development by controlling the expression of proneural genes.
Volume: 221
Issue: 6
Pages: 3095-109
Publication
First Author: Munitz A
Year: 2008
Journal: J Allergy Clin Immunol
Title: Resistin-like molecule alpha enhances myeloid cell activation and promotes colitis.
Volume: 122
Issue: 6
Pages: 1200-1207.e1
Publication
First Author: Akeson AL
Year: 2003
Journal: Dev Biol
Title: Temporal and spatial regulation of VEGF-A controls vascular patterning in the embryonic lung.
Volume: 264
Issue: 2
Pages: 443-55
Publication
First Author: Franco A
Year: 2000
Journal: Nat Immunol
Title: Epitope affinity for MHC class I determines helper requirement for CTL priming.
Volume: 1
Issue: 2
Pages: 145-50
Publication
First Author: Forster A
Year: 2005
Journal: Nat Methods
Title: The invertor knock-in conditional chromosomal translocation mimic.
Volume: 2
Issue: 1
Pages: 27-30
Publication
First Author: Shimizu A
Year: 2015
Journal: Biochem Biophys Res Commun
Title: G7731A mutation in mouse mitochondrial tRNALys regulates late-onset disorders in transmitochondrial mice.
Volume: 459
Issue: 1
Pages: 66-70
Publication
First Author: Arakawa A
Year: 2010
Journal: Structure
Title: The C-terminal BAG domain of BAG5 induces conformational changes of the Hsp70 nucleotide-binding domain for ADP-ATP exchange.
Volume: 18
Issue: 3
Pages: 309-19
Publication
First Author: Werner A
Year: 2015
Journal: Nature
Title: Cell-fate determination by ubiquitin-dependent regulation of translation.
Volume: 525
Issue: 7570
Pages: 523-7
Publication
First Author: Díaz-Magaña A
Year: 2009
Journal: J Bacteriol
Title: Short-chain chromate ion transporter proteins from Bacillus subtilis confer chromate resistance in Escherichia coli.
Volume: 191
Issue: 17
Pages: 5441-5
Publication  
First Author: Korpetinou A
Year: 2014
Journal: Front Oncol
Title: Serglycin: at the crossroad of inflammation and malignancy.
Volume: 3
Pages: 327
Publication
First Author: Madania A
Year: 1999
Journal: Mol Biol Cell
Title: The Saccharomyces cerevisiae homologue of human Wiskott-Aldrich syndrome protein Las17p interacts with the Arp2/3 complex.
Volume: 10
Issue: 10
Pages: 3521-38
Publication
First Author: Fokine A
Year: 2013
Journal: J Mol Biol
Title: The molecular architecture of the bacteriophage T4 neck.
Volume: 425
Issue: 10
Pages: 1731-44
Publication
First Author: Vitaliano-Prunier A
Year: 2008
Journal: Nat Cell Biol
Title: Ubiquitylation of the COMPASS component Swd2 links H2B ubiquitylation to H3K4 trimethylation.
Volume: 10
Issue: 11
Pages: 1365-71
Publication
First Author: Iuso A
Year: 2014
Journal: PLoS One
Title: Impairment of Drosophila orthologs of the human orphan protein C19orf12 induces bang sensitivity and neurodegeneration.
Volume: 9
Issue: 2
Pages: e89439
Publication
First Author: Mai-Prochnow A
Year: 2008
Journal: J Bacteriol
Title: Hydrogen peroxide linked to lysine oxidase activity facilitates biofilm differentiation and dispersal in several gram-negative bacteria.
Volume: 190
Issue: 15
Pages: 5493-501
Publication
First Author: Murthi A
Year: 2010
Journal: Mol Biol Cell
Title: Regulation of tRNA bidirectional nuclear-cytoplasmic trafficking in Saccharomyces cerevisiae.
Volume: 21
Issue: 4
Pages: 639-49
Publication
First Author: Vermeulen A
Year: 2005
Journal: RNA
Title: The contributions of dsRNA structure to Dicer specificity and efficiency.
Volume: 11
Issue: 5
Pages: 674-82
Publication
First Author: Rosengren A
Year: 2014
Journal: Appl Microbiol Biotechnol
Title: An Aspergillus nidulans β-mannanase with high transglycosylation capacity revealed through comparative studies within glycosidase family 5.
Volume: 98
Issue: 24
Pages: 10091-104
Publication
First Author: Yang C
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: A mouse model for nonsense mutation bypass therapy shows a dramatic multiday response to geneticin.
Volume: 104
Issue: 39
Pages: 15394-9
Publication
First Author: Xue D
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen.
Volume: 100
Issue: 13
Pages: 7503-8
Publication  
First Author: Gericke A
Year: 2013
Journal: Exp Eye Res
Title: Contribution of nitric oxide synthase isoforms to cholinergic vasodilation in murine retinal arterioles.
Volume: 109
Pages: 60-6
Publication
First Author: Rosner A
Year: 2002
Journal: Am J Pathol
Title: Pathway pathology: histological differences between ErbB/Ras and Wnt pathway transgenic mammary tumors.
Volume: 161
Issue: 3
Pages: 1087-97
Publication
First Author: Yanagiya A
Year: 2012
Journal: Mol Cell
Title: Translational homeostasis via the mRNA cap-binding protein, eIF4E.
Volume: 46
Issue: 6
Pages: 847-58
Publication
First Author: Prosser HM
Year: 2011
Journal: Nat Biotechnol
Title: A resource of vectors and ES cells for targeted deletion of microRNAs in mice.
Volume: 29
Issue: 9
Pages: 840-5
Publication
First Author: Behrens A
Year: 2002
Journal: EMBO J
Title: Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver.
Volume: 21
Issue: 7
Pages: 1782-90
Publication  
First Author: Kumar A
Year: 2016
Journal: Front Cell Neurosci
Title: Neuronal Actin Dynamics, Spine Density and Neuronal Dendritic Complexity Are Regulated by CAP2.
Volume: 10
Pages: 180
Publication
First Author: Gates FT 3rd
Year: 1981
Journal: Proc Natl Acad Sci U S A
Title: Complete amino acid sequence of murine beta 2-microglobulin: structural evidence for strain-related polymorphism.
Volume: 78
Issue: 1
Pages: 554-8
Publication
First Author: Zanin-Zhorov A
Year: 2007
Journal: J Immunol
Title: Cutting edge: T cells respond to lipopolysaccharide innately via TLR4 signaling.
Volume: 179
Issue: 1
Pages: 41-4
Publication
First Author: Santoro A
Year: 2017
Journal: Cell Metab
Title: DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons.
Volume: 25
Issue: 3
Pages: 647-660
Publication
First Author: Minkina A
Year: 2014
Journal: Dev Cell
Title: DMRT1 protects male gonadal cells from retinoid-dependent sexual transdifferentiation.
Volume: 29
Issue: 5
Pages: 511-520
Publication
First Author: Bailey-Downs LC
Year: 2012
Journal: J Gerontol A Biol Sci Med Sci
Title: Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging.
Volume: 67
Issue: 4
Pages: 313-29
Publication
First Author: Lunardi A
Year: 2014
Journal: Oncotarget
Title: Role of aberrant PI3K pathway activation in gallbladder tumorigenesis.
Volume: 5
Issue: 4
Pages: 894-900
Publication
First Author: Kurz A
Year: 2010
Journal: Neuroscience
Title: Alpha-synuclein deficiency affects brain Foxp1 expression and ultrasonic vocalization.
Volume: 166
Issue: 3
Pages: 785-95
Publication
First Author: Gingery A
Year: 2020
Journal: J Cell Physiol
Title: Sclerostin antibody treatment rescues the osteopenic bone phenotype of TGFβ inducible early gene-1 knockout female mice.
Volume: 235
Issue: 7-8
Pages: 5679-5688
Publication  
First Author: Gordon A
Year: 2016
Journal: Mol Cell Neurosci
Title: Expression of Cntnap2 (Caspr2) in multiple levels of sensory systems.
Volume: 70
Pages: 42-53
Publication
First Author: Sau A
Year: 2016
Journal: Cell Stem Cell
Title: Persistent Activation of NF-κB in BRCA1-Deficient Mammary Progenitors Drives Aberrant Proliferation and Accumulation of DNA Damage.
Volume: 19
Issue: 1
Pages: 52-65
Publication
First Author: Warnatsch A
Year: 2017
Journal: Immunity
Title: Reactive Oxygen Species Localization Programs Inflammation to Clear Microbes of Different Size.
Volume: 46
Issue: 3
Pages: 421-432
Publication
First Author: Pichlmair A
Year: 2006
Journal: Science
Title: RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates.
Volume: 314
Issue: 5801
Pages: 997-1001
Publication
First Author: Androuin A
Year: 2019
Journal: Sci Rep
Title: Activity-induced MEMRI cannot detect functional brain anomalies in the APPxPS1-Ki mouse model of Alzheimer's disease.
Volume: 9
Issue: 1
Pages: 1140
Publication
First Author: Suzuki A
Year: 2024
Journal: Sci Rep
Title: MAX controls meiotic entry in sexually undifferentiated germ cells.
Volume: 14
Issue: 1
Pages: 5236
Publication
First Author: Simon A
Year: 2000
Journal: Brain Res Dev Brain Res
Title: Paradoxical increase of tyrosine hydroxylase-immunoreactive retinopetal fibers in the weaver mouse.
Volume: 121
Issue: 1
Pages: 113-7
Publication
First Author: Gallerand A
Year: 2021
Journal: Nat Commun
Title: Brown adipose tissue monocytes support tissue expansion.
Volume: 12
Issue: 1
Pages: 5255
Publication
First Author: Hikiji H
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: A distinctive role of the leukotriene B4 receptor BLT1 in osteoclastic activity during bone loss.
Volume: 106
Issue: 50
Pages: 21294-9
Publication
First Author: Kadl A
Year: 2011
Journal: Free Radic Biol Med
Title: Oxidized phospholipid-induced inflammation is mediated by Toll-like receptor 2.
Volume: 51
Issue: 10
Pages: 1903-9
Publication
First Author: Sumoza-Toledo A
Year: 2011
Journal: FASEB J
Title: Dendritic cell maturation and chemotaxis is regulated by TRPM2-mediated lysosomal Ca2+ release.
Volume: 25
Issue: 10
Pages: 3529-42
Publication
First Author: Beverdam A
Year: 2002
Journal: Genesis
Title: Jaw transformation with gain of symmetry after Dlx5/Dlx6 inactivation: mirror of the past?
Volume: 34
Issue: 4
Pages: 221-7
Publication  
First Author: Song CH
Year: 2013
Journal: Neurobiol Dis
Title: Subtle microstructural changes of the striatum in a DYT1 knock-in mouse model of dystonia.
Volume: 54
Pages: 362-71
Publication
First Author: Huber A
Year: 2024
Journal: Cell Rep
Title: Mutant TP53 switches therapeutic vulnerability during gastric cancer progression within interleukin-6 family cytokines.
Volume: 43
Issue: 8
Pages: 114616
Publication  
First Author: Istiaq A
Year: 2022
Journal: Front Cell Dev Biol
Title: Tsukushi proteoglycan maintains RNA splicing and developmental signaling network in GFAP-expressing subventricular zone neural stem/progenitor cells.
Volume: 10
Pages: 994588
Publication
First Author: Ullrich A
Year: 1983
Journal: Nature
Title: Human beta-nerve growth factor gene sequence highly homologous to that of mouse.
Volume: 303
Issue: 5920
Pages: 821-5
Publication
First Author: Orimo A
Year: 1995
Journal: J Biol Chem
Title: Molecular cloning, structure, and expression of mouse estrogen-responsive finger protein Efp. Co-localization with estrogen receptor mRNA in target organs.
Volume: 270
Issue: 41
Pages: 24406-13
Publication
First Author: Zafar A
Year: 2021
Journal: FASEB J
Title: BHLHE40 promotes macrophage pro-inflammatory gene expression and functions.
Volume: 35
Issue: 10
Pages: e21940
Publication
First Author: Begitt A
Year: 2011
Journal: Blood
Title: SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFNγ.
Volume: 118
Issue: 4
Pages: 1002-7
Publication
First Author: Yu A
Year: 2003
Journal: J Biol Chem
Title: Stimulation of phosphatidylserine biosynthesis and facilitation of UV-induced apoptosis in Chinese hamster ovary cells overexpressing phospholipid scramblase 1.
Volume: 278
Issue: 11
Pages: 9706-14
Publication
First Author: Saito A
Year: 2005
Journal: J Cereb Blood Flow Metab
Title: Modulation of p53 degradation via MDM2-mediated ubiquitylation and the ubiquitin-proteasome system during reperfusion after stroke: role of oxidative stress.
Volume: 25
Issue: 2
Pages: 267-80
Publication  
First Author: Conz A
Year: 2021
Journal: Eur J Histochem
Title: Super-resolution study of PIAS SUMO E3-ligases in hippocampal and cortical neurons.
Volume: 65
Issue: s1
Publication
First Author: Roque A
Year: 2005
Journal: J Biol Chem
Title: DNA-induced secondary structure of the carboxyl-terminal domain of histone H1.
Volume: 280
Issue: 37
Pages: 32141-7
Publication
First Author: Zúñiga A
Year: 1999
Journal: J Biol Chem
Title: Interaction of mitogen-activated protein kinases with the kinase interaction motif of the tyrosine phosphatase PTP-SL provides substrate specificity and retains ERK2 in the cytoplasm.
Volume: 274
Issue: 31
Pages: 21900-7
Publication
First Author: Robertson A
Year: 2002
Journal: Gene
Title: Effects of mouse strain, position of integration and tetracycline analogue on the tetracycline conditional system in transgenic mice.
Volume: 282
Issue: 1-2
Pages: 65-74
Publication
First Author: Myer A
Year: 1997
Journal: Dev Biol
Title: Wild-type myoblasts rescue the ability of myogenin-null myoblasts to fuse in vivo.
Volume: 185
Issue: 2
Pages: 127-38
Publication
First Author: Hayashi A
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein 1 in mouse embryo fibroblasts.
Volume: 310
Issue: 3
Pages: 824-9
Publication
First Author: Errico A
Year: 2004
Journal: Hum Mol Genet
Title: Spastin interacts with the centrosomal protein NA14, and is enriched in the spindle pole, the midbody and the distal axon.
Volume: 13
Issue: 18
Pages: 2121-32
Publication
First Author: Craxton A
Year: 1999
Journal: J Biol Chem
Title: Syk and Bruton's tyrosine kinase are required for B cell antigen receptor-mediated activation of the kinase Akt.
Volume: 274
Issue: 43
Pages: 30644-50
Publication
First Author: Bosak A
Year: 2008
Journal: Arch Biochem Biophys
Title: Amino acid residues involved in stereoselective inhibition of cholinesterases with bambuterol.
Volume: 471
Issue: 1
Pages: 72-6
Publication
First Author: Alpár A
Year: 2008
Journal: Eur J Neurosci
Title: Enhanced Ras activity preserves dendritic size and extension as well as synaptic contacts of neurons after functional deprivation in synRas mice.
Volume: 27
Issue: 12
Pages: 3083-94
Publication
First Author: Andres-Hernando A
Year: 2008
Journal: J Biol Chem
Title: Nucleoporin 88 (Nup88) is regulated by hypertonic stress in kidney cells to retain the transcription factor tonicity enhancer-binding protein (TonEBP) in the nucleus.
Volume: 283
Issue: 36
Pages: 25082-90
Publication
First Author: Schmid A
Year: 2010
Journal: J Neurosci
Title: Grueneberg ganglion neurons are finely tuned cold sensors.
Volume: 30
Issue: 22
Pages: 7563-8
Publication
First Author: Sima A
Year: 2009
Journal: Biochim Biophys Acta
Title: Kinetic characterization of recombinant mouse retinal dehydrogenase types 3 and 4 for retinal substrates.
Volume: 1790
Issue: 12
Pages: 1660-4
Publication
First Author: Abellan A
Year: 2010
Journal: Cereb Cortex
Title: Differential expression of LIM-homeodomain factors in Cajal-Retzius cells of primates, rodents, and birds.
Volume: 20
Issue: 8
Pages: 1788-98
Publication
First Author: Priya A
Year: 2014
Journal: Biochim Biophys Acta
Title: Nuclear respiratory factor 2 regulates the transcription of AMPA receptor subunit GluA2 (Gria2).
Volume: 1843
Issue: 12
Pages: 3018-28
Publication
First Author: Ma A
Year: 2017
Journal: J Lipid Res
Title: AMPK activation enhances the anti-atherogenic effects of high density lipoproteins in apoE-/- mice.
Volume: 58
Issue: 8
Pages: 1536-1547
Publication  
First Author: Saha A
Year: 2018
Journal: Gene Expr Patterns
Title: Class I histone deacetylases in retinal progenitors and differentiating ganglion cells.
Volume: 30
Pages: 37-48
Publication
First Author: Das A
Year: 2019
Journal: Am J Physiol Cell Physiol
Title: Novel interaction of antioxidant-1 with TRAF4: role in inflammatory responses in endothelial cells.
Volume: 317
Issue: 6
Pages: C1161-C1171
Publication
First Author: Lade A
Year: 2012
Journal: J Biol Chem
Title: Calpain induces N-terminal truncation of β-catenin in normal murine liver development: diagnostic implications in hepatoblastomas.
Volume: 287
Issue: 27
Pages: 22789-98
Publication
First Author: Holz A
Year: 1997
Journal: J Neurochem
Title: Chromosomal localization of the myelin-associated oligodendrocytic basic protein and expression in the genetically linked neurological mouse mutants ducky and tippy.
Volume: 69
Issue: 5
Pages: 1801-9
Protein Domain
Type: Family
Description: Rfa3 (also known as RPA14) is a component of the replication protein A (RPA) complex, which binds to and removes secondary structure from ssDNA. The RPA complex is involved in DNA replication, repair, and recombination [].
Protein Domain
Type: Family
Description: Rfa1 (also known as RPA70) is a component of the replication protein A (RPA) complex, which binds to and removes secondary structure from ssDNA. The RPA complex is involved in DNA replication, repair, and recombination [].
Protein Domain
Type: Family
Description: Rfa2 (also known as RPA32) is a component of the replication protein A (RPA) complex, which binds to and removes secondary structure from ssDNA. The RPA complex is involved in DNA replication, repair, and recombination [].
Protein Domain
Type: Domain
Description: This entry represents a domain found in lipopolysaccharide assembly protein A (LapA). LabA and LapB function together in the assembly of lipopolysaccharide (LPS) []. This domain is also found in some uncharacterised proteins, such as Rv3760 from Mycobacterium tuberculosis.
Protein Domain
Type: Family
Description: Heme A synthase catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group [].This entry represents the type 2 subfamily, found in some bacteria and eukaryota.
Protein Domain
Type: Family
Description: Rab proteins constitute a family of small GTPases that serve a regulatory role in vesicular membrane traffic [, ]; C-terminal geranylgeranylation is crucial for their membrane association and function. This post-translational modification is catalysed by Rab geranylgeranyl transferase (Rab-GGTase), a multi-subunit enzyme that contains a catalytic heterodimer and an accessory component, termed Rab escort protein (REP)-1 [, ]. REP-1 presents newly-synthesised Rab proteins to the catalytic component, and forms a stable complex with the prenylated proteins following the transfer reaction.cDNA cloning of component A of rat Rab geranylgeranyl transferase (REP) confirms its resemblance to Rab3A guanine nucleotide dissociation inhibitor (GDI) and its identity with the human choroideremia gene product []. A genetic defect in REP underlies human choroideremia. Choroideraemia (or tapetochoroidal dystrophy) is a common form of X-linked blindness characterised by progressive dystrophy of the choroid, retinal pigment epithelium and retina [, , ].
Protein Domain
Type: Family
Description: Fasciclin-like arabinogalactan proteins (FLAs) proteins from Arabidopsis, a subclass of arabinogalactan proteins (AGPs), can be classified in four groups (A-D) based on pair-wise sequence similarity, domain structure, and phylogenetic analysis []. Group A FLAs are characterised by a single fasciclin domain that is flanked by AGP regions and a C-terminal GPI-anchor signal; group B contain two fasciclin domains flanking an AGP region and lack a C-terminal GPI anchor signal sequence; group C have a variable domain structure with one or two fasciclin domains, one or two AGP regions, and a C-terminal GPI anchor signal; FLAs 4 and 19 to 21 formed group D as they have low similarity to each other or to any of the other FLAs [].This family represents Group A Fasciclin-like arabinogalactan proteins (FLAs) from plants, which includes FLAs 6, 7, 9,11,12 and 13 from Arabidopsis []. They are probably cell surface adhesion proteins.