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Search results 2501 to 2600 out of 2731 for Akt1

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Strain
MGI:5829199 | B6.Cg-Tg(Ins2-Akt1*)3Mbb
Attribute String: congenic, mutant strain, transgenic
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Allele
Gt(ROSA)26Sor<tm1(AKT1*E17K,EGFP)Maib> | MGI:7509229
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Maike Buchner
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence
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Genotype
Genotype
Symbol: Tg(Myh6-Akt1*T308D*S473D)1Siz/?
Background: Not Specified
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Myh6-Akt1)564Anr/?
Background: involves: C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Myh6-Akt1)20Anr/?
Background: involves: C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Myh6-Akt1)20Anr/?
Background: involves: C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Lck-Akt1*E40K)E-3Pnt/?
Background: involves: C3H/He * C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Lck-Akt1*E40K)E-3Pnt/?
Background: Not Specified
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Ins2-Akt1*)3Mbb/?
Background: involves: C57BL/6 * SJL
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Ins2-Akt1*)3Mbb/?
Background: B6.Cg-Tg(Ins2-Akt1*)3Mbb
Zygosity: ot
Has Mutant Allele: true
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Publication
27340174 | J:233300
First Author: Smithson LJ
Year: 2016
Journal: Genes Dev
Title: Proteomic analysis reveals GIT1 as a novel mTOR complex component critical for mediating astrocyte survival.
Volume: 30
Issue: 12
Pages: 1383-8
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Publication
26919188 | J:253439
First Author: Wittenberg AD
Year: 2016
Journal: PLoS One
Title: Phosphorylated Ribosomal Protein S6 Is Required for Akt-Driven Hyperplasia and Malignant Transformation, but Not for Hypertrophy, Aneuploidy and Hyperfunction of Pancreatic β-Cells.
Volume: 11
Issue: 2
Pages: e0149995
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Publication
18442046 | J:136227
First Author: Elghazi L
Year: 2008
Journal: Genesis
Title: Generation of a reporter mouse line expressing Akt and EGFP upon Cre-mediated recombination.
Volume: 46
Issue: 5
Pages: 256-64
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Protein Coding Gene
MGI:99683 | Ptk6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q64434
Organism: Mus musculus/domesticus
Length: 451  
Fragment?: false
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Publication
16443763 | J:106428
First Author: Fatrai S
Year: 2006
Journal: Diabetes
Title: Akt induces beta-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity.
Volume: 55
Issue: 2
Pages: 318-25
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Allele
Tg(CD2-Akt1*)4-1Psoh | MGI:5300976
Name: transgene insertion 4-1, Pamela Ohashi
Allele Type: Transgenic
Attribute String: Constitutively active, Inserted expressed sequence
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Genotype
Genotype
Symbol: Tg(Lck-Akt1*)M-1Pnt/?
Background: involves: C3H/He * C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tcra/Tcra Tg(Lck-Akt1*E40K)E-3Pnt/?
Background: involves: 129S2/SvPas * C3H/He * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdk6/Cdk6 Tg(Lck-Akt1*E40K)E-3Pnt/?
Background: involves: 129S4/SvJae
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdk6/Cdk6<+> Tg(Lck-Akt1*E40K)E-3Pnt/?
Background: involves: 129S4/SvJae
Zygosity: cx
Has Mutant Allele: true
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Publication
26267528 | J:224917
First Author: Toker A
Year: 2015
Journal: Cancer Cell
Title: PIPPing on AKT1: How Many Phosphatases Does It Take to Turn off PI3K?
Volume: 28
Issue: 2
Pages: 143-5
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Protein Domain
IPR039027 | RAC_alpha
Type: Family
Description: Protein kinase B (PKB), also called Akt or RAC, is a phosphatidylinositol 3'-kinase (PI3K)-dependent Ser/Thr kinase which alters the activity of the targeted protein []. Akt regulates numerous cellular processes, including cell growth, differentiation, proliferation, apoptosis, and glucose metabolism. Among its many roles, Akt appears to be common to signaling pathways that mediate the metabolic effects of insulin in several physiologically important target tissues [, ]. Human Akt has three isoforms derived for distinct genes: Akt1/PKBalpha, Akt2/PKBbeta, and Akt3/PKBgamma.This entry includes the isoforms alpha. Akt1 and Akt2 have distinct functions; they are involved in the control of growth and metabolism, respectively [, ].
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Protein Coding Gene
MGI:88279 | Cbl
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P22682
Organism: Mus musculus/domesticus
Length: 913  
Fragment?: false
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Strain
MGI:5829207 | B6.Cg-Rps6kb2<tm1Gtho> Tg(Ins2-Akt1*)3Mbb
Attribute String: congenic, mutant strain, targeted mutation, transgenic
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Publication
23383068 | J:195787
First Author: O'Donnell RK
Year: 2013
Journal: PLoS One
Title: Overexpression of MyrAkt1 in endothelial cells leads to erythropoietin- and BMP4-independent splenic erythropoiesis in mice.
Volume: 8
Issue: 1
Pages: e55095
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Genotype
Genotype
Symbol: Tg(Myh6-Akt1*T308D*S473D)1Siz/? Tg(Myh6-Pik3ca)1Siz/?
Background: involves: FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rag2/Rag2 Tg(Lck-Akt1*)M-1Pnt/?
Background: involves: 129S/SvEv * C3H/He * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rag1/Rag1 Tg(Lck-Akt1*E40K)E-3Pnt/?
Background: involves: 129S7/SvEvBrd * C3H/He * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rps6kb1/Rps6kb1 Tg(Ins2-Akt1*)3Mbb/?
Background: B6.Cg-Rps6kb1 Tg(Ins2-Akt1*)3Mbb
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rps6kb2/Rps6kb2 Tg(Ins2-Akt1*)3Mbb/?
Background: B6.Cg-Rps6kb2 Tg(Ins2-Akt1*)3Mbb
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(CAG-lacZ,-Akt1*,-EGFP)56Ebm/? Tg(Ins2-cre)23Herr/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(CAG-lacZ,-Akt1*,-EGFP)56Ebm/? Tg(Ela1-cre)16Eps/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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HT Experiment
E-GEOD-11662 | GADD45a in ventilator-induced lung injury: role of Akt signaling
Series Id: GSE11662
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein Domain
IPR045101 | PTP_PTEN
Type: Domain
Description: This entry represents the phosphatase domain found in PTEN, which is a magnesium-dependent bifunctional phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase/dual-specificity protein phosphatase PTEN (; ; ), which possesses the following catalytic activities:Phosphatidylinositol 3,4,5-trisphosphate + H(2)O = phosphatidylinositol 4,5-bisphosphate + phosphate.A phosphoprotein + H(2)O = a protein + phosphate.Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.This protein acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins []. It also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate. The lipid phosphatase activity is critical for its tumour suppressor function []. PTEN antagonizes the PI3K-AKT/PKB signalling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form of PTEN cooperates with AIP1 to suppress AKT1 activation. PTEN dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion form [].
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Protein Domain
IPR017361 | Bifunc_PIno_P3_Pase/Pase_PTEN
Type: Family
Description: This entry represents the magnesium-dependent bifunctional phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase/dual-specificity protein phosphatase PTEN (; ; ), which possesses the following catalytic activities:Phosphatidylinositol 3,4,5-trisphosphate + H(2)O = phosphatidylinositol 4,5-bisphosphate + phosphate.A phosphoprotein + H(2)O = a protein + phosphate.Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.This protein acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins []. It also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate. The lipid phosphatase activity is critical for its tumour suppressor function []. PTEN antagonizes the PI3K-AKT/PKB signalling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form of PTEN cooperates with AIP1 to suppress AKT1 activation. PTEN dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion form [].
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Publication
17324556 | -
First Author: Xiao Y
Year: 2007
Journal: Cell Signal
Title: PTEN catalysis of phospholipid dephosphorylation reaction follows a two-step mechanism in which the conserved aspartate-92 does not function as the general acid--mechanistic analysis of a familial Cowden disease-associated PTEN mutation.
Volume: 19
Issue: 7
Pages: 1434-45
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Publication
18794879 | J:142580
First Author: Yin Y
Year: 2008
Journal: Oncogene
Title: PTEN: a new guardian of the genome.
Volume: 27
Issue: 41
Pages: 5443-53
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Publication
18838554 | -
First Author: Degtyarev M
Year: 2008
Journal: J Cell Biol
Title: Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents.
Volume: 183
Issue: 1
Pages: 101-16
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Publication
17545582 | J:122176
First Author: Phung TL
Year: 2007
Journal: Cancer Res
Title: Endothelial Akt signaling is rate-limiting for rapamycin inhibition of mouse mammary tumor progression.
Volume: 67
Issue: 11
Pages: 5070-5
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Publication
34112805 | J:307913
First Author: Ecker V
Year: 2021
Journal: Nat Commun
Title: Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia.
Volume: 12
Issue: 1
Pages: 3526
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Publication
15126356 | J:89743
First Author: Hutchinson JN
Year: 2004
Journal: Cancer Res
Title: Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion.
Volume: 64
Issue: 9
Pages: 3171-8
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Publication
11752445 | J:73487
First Author: Malstrom S
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Tumor induction by an Lck-MyrAkt transgene is delayed by mechanisms controlling the size of the thymus.
Volume: 98
Issue: 26
Pages: 14967-72
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Publication
11418630 | J:134063
First Author: Parsons MJ
Year: 2001
Journal: J Immunol
Title: Expression of active protein kinase B in T cells perturbs both T and B cell homeostasis and promotes inflammation.
Volume: 167
Issue: 1
Pages: 42-8
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Genotype
Genotype
Symbol: Rps6kb1/Rps6kb1 Rps6kb2/Rps6kb2 Tg(Ins2-Akt1*)3Mbb/?
Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(CAG-lacZ,-Akt1*,-EGFP)56Ebm/? Tg(Pdx1-cre)89.1Dam/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Publication
27050099 | J:231826
First Author: Lee JK
Year: 2016
Journal: Cancer Cell
Title: N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells.
Volume: 29
Issue: 4
Pages: 536-547
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Publication
11387480 | J:71491
First Author: Cho H
Year: 2001
Journal: Science
Title: Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta).
Volume: 292
Issue: 5522
Pages: 1728-31
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Publication
32749453 | J:298712
 
First Author: Varga J
Year: 2020
Journal: J Exp Med
Title: AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer.
Volume: 217
Issue: 10
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Publication
20876733 | J:164880
First Author: Lee DY
Year: 2010
Journal: Genes Dev
Title: Neurofibromatosis-1 regulates neuroglial progenitor proliferation and glial differentiation in a brain region-specific manner.
Volume: 24
Issue: 20
Pages: 2317-29
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Publication
19155308 | J:144975
First Author: Hu MG
Year: 2009
Journal: Cancer Res
Title: A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesis.
Volume: 69
Issue: 3
Pages: 810-8
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Publication
26673325 | J:269853
First Author: Alejandro EU
Year: 2015
Journal: Cell Rep
Title: Disruption of O-linked N-Acetylglucosamine Signaling Induces ER Stress and β Cell Failure.
Volume: 13
Issue: 11
Pages: 2527-2538
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Genotype
Genotype
Symbol: Tg(CAG-lacZ,-Akt1*,-EGFP)56Ebm/? Tg(Fabp7-cre,-lacZ)3Gtm/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Publication
27053161 | J:236899
 
First Author: Hosokawa H
Year: 2016
Journal: Nat Commun
Title: Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells.
Volume: 7
Pages: 11289
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Publication
20424120 | J:160703
First Author: Dillon RL
Year: 2010
Journal: Cancer Res
Title: Distinct biological roles for the akt family in mammary tumor progression.
Volume: 70
Issue: 11
Pages: 4260-4
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Publication
18691549 | J:139572
First Author: Majumder PK
Year: 2008
Journal: Cancer Cell
Title: A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression.
Volume: 14
Issue: 2
Pages: 146-55
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Publication
26100075 | J:223018
 
First Author: Braccini L
Year: 2015
Journal: Nat Commun
Title: PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling.
Volume: 6
Pages: 7400
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Publication
20510932 | J:167946
First Author: Li Z
Year: 2010
Journal: Cell
Title: Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization.
Volume: 141
Issue: 5
Pages: 859-71
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Publication
16075055 | J:100144
First Author: Shiojima I
Year: 2005
Journal: J Clin Invest
Title: Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure.
Volume: 115
Issue: 8
Pages: 2108-18
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Publication
24291004 | J:206975
First Author: Piovan E
Year: 2013
Journal: Cancer Cell
Title: Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia.
Volume: 24
Issue: 6
Pages: 766-76
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Publication
15156201 | J:90631
First Author: Majumder PK
Year: 2004
Journal: Nat Med
Title: mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways.
Volume: 10
Issue: 6
Pages: 594-601
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Publication
27026523 | J:269687
 
First Author: Miao L
Year: 2016
Journal: Elife
Title: mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system.
Volume: 5
Pages: e14908
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Publication
18983969 | J:149868
First Author: Ema M
Year: 2008
Journal: Cell Stem Cell
Title: Krüppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs.
Volume: 3
Issue: 5
Pages: 555-67
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Publication
29440301 | J:260462
 
First Author: Sharma M
Year: 2018
Journal: Development
Title: Cyclical expression of GDNF is required for spermatogonial stem cell homeostasis.
Volume: 145
Issue: 5
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Publication
23666637 | J:317623
First Author: Hodgkinson CP
Year: 2013
Journal: Stem Cells
Title: Abi3bp is a multifunctional autocrine/paracrine factor that regulates mesenchymal stem cell biology.
Volume: 31
Issue: 8
Pages: 1669-82
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Publication
31080136 | J:352724
First Author: Hashimoto H
Year: 2019
Journal: Cell Stem Cell
Title: Cardiac Reprogramming Factors Synergistically Activate Genome-wide Cardiogenic Stage-Specific Enhancers.
Volume: 25
Issue: 1
Pages: 69-86.e5
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Publication
25673849 | J:219877
First Author: Lv K
Year: 2015
Journal: J Neurosci
Title: Trip6 promotes dendritic morphogenesis through dephosphorylated GRIP1-dependent myosin VI and F-actin organization.
Volume: 35
Issue: 6
Pages: 2559-71
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Publication
27184848 | J:235755
First Author: Vandanmagsar B
Year: 2016
Journal: Cell Rep
Title: Impaired Mitochondrial Fat Oxidation Induces FGF21 in Muscle.
Volume: 15
Issue: 8
Pages: 1686-99
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Publication
27297104 | J:236100
First Author: Okoro EU
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Akt isoform-dependent regulation of ATP-Binding cassette A1 expression by apolipoprotein E.
Volume: 477
Issue: 1
Pages: 123-8
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Publication
28007786 | J:237912
First Author: Kanatsu-Shinohara M
Year: 2016
Journal: Genes Dev
Title: Myc/Mycn-mediated glycolysis enhances mouse spermatogonial stem cell self-renewal.
Volume: 30
Issue: 23
Pages: 2637-2648
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Publication
28667123 | J:244986
First Author: Valentino E
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Mutant p53 potentiates the oncogenic effects of insulin by inhibiting the tumor suppressor DAB2IP.
Volume: 114
Issue: 29
Pages: 7623-7628
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Publication
26859676 | J:259804
First Author: Malanga D
Year: 2016
Journal: PLoS One
Title: AKT1E¹⁷K Is Oncogenic in Mouse Lung and Cooperates with Chemical Carcinogens in Inducing Lung Cancer.
Volume: 11
Issue: 2
Pages: e0147334
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Publication
37653038 | J:343160
First Author: Chen K
Year: 2023
Journal: Exp Mol Med
Title: CircFam190a: a critical positive regulator of osteoclast differentiation via enhancement of the AKT1/HSP90β complex.
Volume: 55
Issue: 9
Pages: 2051-2066
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Publication
32238574 | J:286849
 
First Author: Zhou Y
Year: 2020
Journal: Sci Transl Med
Title: PBX1 expression in uterine natural killer cells drives fetal growth.
Volume: 12
Issue: 537
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Publication
27633013 | J:235647
First Author: Liu X
Year: 2016
Journal: Genes Dev
Title: Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar-ductal metaplasia.
Volume: 30
Issue: 17
Pages: 1943-55
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Publication
29109121 | J:252647
First Author: Tran CW
Year: 2017
Journal: J Immunol
Title: Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation.
Volume: 199
Issue: 12
Pages: 4056-4065
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Publication
18039971 | J:135278
First Author: Rao S
Year: 2007
Journal: Development
Title: Obligatory participation of macrophages in an angiopoietin 2-mediated cell death switch.
Volume: 134
Issue: 24
Pages: 4449-58
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Publication
21765414 | J:176473
First Author: Yang K
Year: 2011
Journal: Nat Immunol
Title: The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function.
Volume: 12
Issue: 9
Pages: 888-97
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Publication
18524868 | J:138636
First Author: Wright GL
Year: 2008
Journal: FASEB J
Title: VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase.
Volume: 22
Issue: 9
Pages: 3264-75
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Publication
20940307 | J:178436
First Author: Xu D
Year: 2010
Journal: J Biol Chem
Title: Regulation of PTEN stability and activity by Plk3.
Volume: 285
Issue: 51
Pages: 39935-42
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Publication
29079702 | J:258311
First Author: Gu J
Year: 2018
Journal: Diabetes
Title: Metallothionein Preserves Akt2 Activity and Cardiac Function via Inhibiting TRB3 in Diabetic Hearts.
Volume: 67
Issue: 3
Pages: 507-517
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Publication
28213469 | J:241530
First Author: Molina SA
Year: 2017
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Insulin signaling via the PI3-kinase/Akt pathway regulates airway glucose uptake and barrier function in a CFTR-dependent manner.
Volume: 312
Issue: 5
Pages: L688-L702
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Publication
19524295 | J:155641
First Author: Esquiliano DR
Year: 2009
Journal: Placenta
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