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Search results 2501 to 2600 out of 2670 for Myod1

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Type Details Score
Protein Domain
IPR011598 | bHLH_dom
Type: Domain
Description: A number of eukaryotic proteins, which probably are sequence specific DNA-binding proteins that act as transcription factors, share a conserved domain of 40 to 50 amino acid residues. It has been proposed []that this domain is formed of two amphipathic helices joined by a variable length linker region that could form a loop. This 'helix-loop-helix' (HLH) domain mediates protein dimerization and has been found in the proteins listed below []. Most of these proteins have an extra basic region of about 15 amino acid residues that is adjacent to the HLH domain and specifically binds to DNA. They are referred as basic helix-loop-helix proteins (bHLH), and are classified in two groups: class A (ubiquitous) and class B (tissue-specific). Members of the bHLH family bind variations on the core sequence 'CANNTG', also referred to asthe E-box motif. The homo- or heterodimerization mediated by the HLH domain is independent of, but necessary for DNA binding, as two basic regions are required for DNA binding activity. The HLH proteins lacking the basic domain (Emc, Id) function as negative regulators, since they form heterodimers, but fail to bind DNA. The hairy-related proteins (hairy, E(spl), deadpan) also repress transcription although they can bind DNA. The proteins of this subfamily act together with co-repressor proteins, like groucho, through their -terminal motif WRPW.Proteins containing a HLH domain include:The myc family of cellular oncogenes [], which is currently known to contain four members: c-myc, N-myc, L-myc, and B-myc. The myc genes are thought to play a role in cellular differentiation and proliferation.Proteins involved in myogenesis (the induction of muscle cells). In mammals MyoD1 (Myf-3), myogenin (Myf-4), Myf-5, and Myf-6 (Mrf4 or herculin), in birds CMD1 (QMF-1), in Xenopus MyoD and MF25, in Caenorhabditis elegans CeMyoD, and in Drosophila nautilus (nau).Vertebrate proteins that bind specific DNA sequences ('E boxes') in various immunoglobulin chains enhancers: E2A or ITF-1 (E12/pan-2 and E47/pan-1), ITF-2 (tcf4), TFE3, and TFEB.Vertebrate neurogenic differentiation factor 1 that acts as differentiation factor during neurogenesis.Vertebrate MAX protein, a transcription regulator that forms a sequence- specific DNA-binding protein complex with myc or mad.Vertebrate Max Interacting Protein 1 (MXI1 protein) which acts as a transcriptional repressor and may antagonize myc transcriptional activity by competing for max.Proteins of the bHLH/PAS superfamily which are transcriptional activators. In mammals, AH receptor nuclear translocator (ARNT), single-minded homologues (SIM1 and SIM2), hypoxia-inducible factor 1 alpha (HIF1A), AH receptor (AHR), neuronal pas domain proteins (NPAS1 and NPAS2), endothelial pas domain protein 1 (EPAS1), mouse ARNT2, and human BMAL1. In Drosophila, single-minded (SIM), AH receptor nuclear translocator (ARNT), trachealess protein (TRH), and similar protein (SIMA).Mammalian transcription factors HES, which repress transcription by acting on two types of DNA sequences, the E box and the N box.Mammalian MAD protein (max dimerizer) which acts as transcriptional repressor and may antagonize myc transcriptional activity by competing for max.Mammalian Upstream Stimulatory Factor 1 and 2 (USF1 and USF2), which bind to a symmetrical DNA sequence that is found in a variety of viral and cellular promoters.Human lyl-1 protein; which is involved, by chromosomal translocation, in T- cell leukemia.Human transcription factor AP-4.Mouse helix-loop-helix proteins MATH-1 and MATH-2 which activate E box- dependent transcription in collaboration with E47.Mammalian stem cell protein (SCL) (also known as tal1), a protein which may play an important role in hemopoietic differentiation. SCL is involved, by chromosomal translocation, in stem-cell leukemia.Mammalian proteins Id1 to Id4 []. Id (inhibitor of DNA binding) proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting binding to DNA.Drosophila extra-macrochaetae (emc) protein, which participates in sensory organ patterning by antagonizing the neurogenic activity of the achaete- scute complex. Emc is the homologue of mammalian Id proteins.Human Sterol Regulatory Element Binding Protein 1 (SREBP-1), a transcriptional activator that binds to the sterol regulatory element 1 (SRE-1) found in the flanking region of the LDLR gene and in other genes.Drosophila achaete-scute (AS-C) complex proteins T3 (l'sc), T4 (scute), T5 (achaete) and T8 (asense). The AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.Mammalian homologues of achaete-scute proteins, the MASH-1 and MASH-2 proteins.Drosophila atonal protein (ato) which is involved in neurogenesis.
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Protein
O35185
Organism: Mus musculus/domesticus
Length: 411  
Fragment?: false
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Protein
Q99PV5
Organism: Mus musculus/domesticus
Length: 410  
Fragment?: false
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Q61657
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: false
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Q9JHE6
Organism: Mus musculus/domesticus
Length: 224  
Fragment?: false
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Q9DBX7
Organism: Mus musculus/domesticus
Length: 326  
Fragment?: false
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P28574
Organism: Mus musculus/domesticus
Length: 160  
Fragment?: false
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Q9QUS4
Organism: Mus musculus/domesticus
Length: 339  
Fragment?: false
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O54792
Organism: Mus musculus/domesticus
Length: 157  
Fragment?: false
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Q7TS99
Organism: Mus musculus/domesticus
Length: 240  
Fragment?: false
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Q9Z2E5
Organism: Mus musculus/domesticus
Length: 149  
Fragment?: false
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Q9WV93
Organism: Mus musculus/domesticus
Length: 299  
Fragment?: false
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P10166
Organism: Mus musculus/domesticus
Length: 368  
Fragment?: false
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Q9Z304
Organism: Mus musculus/domesticus
Length: 431  
Fragment?: false
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P10085
Organism: Mus musculus/domesticus
Length: 318  
Fragment?: false
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P70120
Organism: Mus musculus/domesticus
Length: 167  
Fragment?: false
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P15375
Organism: Mus musculus/domesticus
Length: 242  
Fragment?: false
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P24699
Organism: Mus musculus/domesticus
Length: 255  
Fragment?: false
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P03966
Organism: Mus musculus/domesticus
Length: 462  
Fragment?: false
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Q9JKN5
Organism: Mus musculus/domesticus
Length: 260  
Fragment?: false
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Q64221
Organism: Mus musculus/domesticus
Length: 135  
Fragment?: false
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Q02576
Organism: Mus musculus/domesticus
Length: 133  
Fragment?: false
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P48985
Organism: Mus musculus/domesticus
Length: 351  
Fragment?: false
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Q8BKT2
Organism: Mus musculus/domesticus
Length: 225  
Fragment?: false
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P27792
Organism: Mus musculus/domesticus
Length: 278  
Fragment?: false
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P35428
Organism: Mus musculus/domesticus
Length: 282  
Fragment?: false
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Q99NA2
Organism: Mus musculus/domesticus
Length: 322  
Fragment?: false
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Q9EQW6
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: false
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P22091
Organism: Mus musculus/domesticus
Length: 329  
Fragment?: false
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Q62282
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: false
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Q8BGD7
Organism: Mus musculus/domesticus
Length: 802  
Fragment?: false
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Q3U1N2
Organism: Mus musculus/domesticus
Length: 1130  
Fragment?: false
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Q08874
Organism: Mus musculus/domesticus
Length: 526  
Fragment?: false
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Q64092
Organism: Mus musculus/domesticus
Length: 572  
Fragment?: false
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Q9WTW4
Organism: Mus musculus/domesticus
Length: 317  
Fragment?: false
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Q9R210
Organism: Mus musculus/domesticus
Length: 475  
Fragment?: false
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P12979
Organism: Mus musculus/domesticus
Length: 224  
Fragment?: false
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Q62414
Organism: Mus musculus/domesticus
Length: 383  
Fragment?: false
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P48986
Organism: Mus musculus/domesticus
Length: 337  
Fragment?: false
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Q0VGJ1
Organism: Mus musculus/domesticus
Length: 339  
Fragment?: false
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Q3UKG7
Organism: Mus musculus/domesticus
Length: 534  
Fragment?: false
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Q8BRJ9
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: false
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Q9QUM5
Organism: Mus musculus/domesticus
Length: 299  
Fragment?: false
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Q0VEJ7
Organism: Mus musculus/domesticus
Length: 242  
Fragment?: false
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Q542S0
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: false
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I6L9I6
Organism: Mus musculus/domesticus
Length: 348  
Fragment?: false
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A0A571BE88
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: false
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Q8C5F1
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: false
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Q810L7
Organism: Mus musculus/domesticus
Length: 454  
Fragment?: false
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F6W7D6
Organism: Mus musculus/domesticus
Length: 334  
Fragment?: true
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Q3TZH7
Organism: Mus musculus/domesticus
Length: 329  
Fragment?: false
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Q32MU7
Organism: Mus musculus/domesticus
Length: 419  
Fragment?: false
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L0CUZ4
Organism: Mus musculus/domesticus
Length: 464  
Fragment?: false
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A0A1W2P770
Organism: Mus musculus/domesticus
Length: 50  
Fragment?: true
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Q3U0U9
Organism: Mus musculus/domesticus
Length: 167  
Fragment?: false
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Q9JK33
Organism: Mus musculus/domesticus
Length: 329  
Fragment?: false
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A0A1W2P6K7
Organism: Mus musculus/domesticus
Length: 54  
Fragment?: true
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Q3UN97
Organism: Mus musculus/domesticus
Length: 337  
Fragment?: false
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A2AEW1
Organism: Mus musculus/domesticus
Length: 572  
Fragment?: false
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A0A0B4J1L1
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: false
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D3Z4F6
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: true
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Q3UIE0
Organism: Mus musculus/domesticus
Length: 368  
Fragment?: false
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A0A0N4SV79
Organism: Mus musculus/domesticus
Length: 357  
Fragment?: false
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Q3TY96
Organism: Mus musculus/domesticus
Length: 194  
Fragment?: true
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Q3U1L5
Organism: Mus musculus/domesticus
Length: 539  
Fragment?: true
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Q6L8F5
Organism: Mus musculus/domesticus
Length: 410  
Fragment?: false
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D3Z6Q7
Organism: Mus musculus/domesticus
Length: 267  
Fragment?: false
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A0A5H1ZRM6
Organism: Mus musculus/domesticus
Length: 520  
Fragment?: false
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A1L327
Organism: Mus musculus/domesticus
Length: 802  
Fragment?: false
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Q5M8T7
Organism: Mus musculus/domesticus
Length: 337  
Fragment?: false
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Q3V1C5
Organism: Mus musculus/domesticus
Length: 282  
Fragment?: false
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Q9JHC5
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: false
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Q9D0R0
Organism: Mus musculus/domesticus
Length: 299  
Fragment?: false
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Q8VHZ2
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: true
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Q3TYB2
Organism: Mus musculus/domesticus
Length: 383  
Fragment?: false
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A2AEW0
Organism: Mus musculus/domesticus
Length: 537  
Fragment?: false
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Q3UN59
Organism: Mus musculus/domesticus
Length: 260  
Fragment?: false
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Q2TB09
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: false
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Q923F4
Organism: Mus musculus/domesticus
Length: 462  
Fragment?: false
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Q6P203
Organism: Mus musculus/domesticus
Length: 534  
Fragment?: false
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Q3UZZ2
Organism: Mus musculus/domesticus
Length: 282  
Fragment?: false
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Q3U327
Organism: Mus musculus/domesticus
Length: 475  
Fragment?: false
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A2RSK4
Organism: Mus musculus/domesticus
Length: 255  
Fragment?: false
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Protein
E9PZ28
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
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Q8CGH4
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: true
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A0A1W2P7Y8
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: false
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Q8C6Y4
Organism: Mus musculus/domesticus
Length: 361  
Fragment?: true
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Q499J8
Organism: Mus musculus/domesticus
Length: 167  
Fragment?: false
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Q542A5
Organism: Mus musculus/domesticus
Length: 411  
Fragment?: false
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Q3UII1
Organism: Mus musculus/domesticus
Length: 462  
Fragment?: false
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P30561
Organism: Mus musculus/domesticus
Length: 848  
Fragment?: false
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Q8R4S5
Organism: Mus musculus/domesticus
Length: 883  
Fragment?: false
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Q61324
Organism: Mus musculus/domesticus
Length: 712  
Fragment?: false
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Q2VPD4
Organism: Mus musculus/domesticus
Length: 579  
Fragment?: false
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Protein
Q3U1U7
Organism: Mus musculus/domesticus
Length: 701  
Fragment?: false
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Protein
Q8R4S6
Organism: Mus musculus/domesticus
Length: 848  
Fragment?: false
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Q9QZQ0
Organism: Mus musculus/domesticus
Length: 925  
Fragment?: false
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Q0VBL6
Organism: Mus musculus/domesticus
Length: 662  
Fragment?: false
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Protein
P01108
Organism: Mus musculus/domesticus
Length: 439  
Fragment?: false
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A0A5K7RLP0
Organism: Mus musculus/domesticus
Length: 589  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom