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Search results 2601 to 2700 out of 2733 for C6

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0.018s

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Hits by Strain

Type Details Score
Protein
Q8K182
Organism: Mus musculus/domesticus
Length: 587  
Fragment?: false
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Protein
A2A997
Organism: Mus musculus/domesticus
Length: 580  
Fragment?: false
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Protein
Q9QXT7
Organism: Mus musculus/domesticus
Length: 769  
Fragment?: false
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Protein
Q8CDC1
Organism: Mus musculus/domesticus
Length: 428  
Fragment?: false
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Protein
Q3TWH9
Organism: Mus musculus/domesticus
Length: 549  
Fragment?: false
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Protein
E9PYD7
Organism: Mus musculus/domesticus
Length: 549  
Fragment?: false
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Protein
A2A998
Organism: Mus musculus/domesticus
Length: 543  
Fragment?: false
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Protein
D3YXF5
Organism: Mus musculus/domesticus
Length: 845  
Fragment?: false
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Protein
A0A0G2JF30
Organism: Mus musculus/domesticus
Length: 422  
Fragment?: false
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Protein
Q8K2Z1
Organism: Mus musculus/domesticus
Length: 400  
Fragment?: false
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Protein
A0A0R4J032
Organism: Mus musculus/domesticus
Length: 561  
Fragment?: false
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Protein
Q91X70
Organism: Mus musculus/domesticus
Length: 769  
Fragment?: false
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Protein Domain
IPR001456 | HC-pro
Type: Family
Description: This enrry represents the potyvirus helper component protease found in genome polyproteins of potyviruses. It is is a cysteine peptidase belonging to the MEROPS peptidase family C6 (clan CA). The helper component-proteinase is required for aphid transmission.A cysteine peptidase is a proteolytic enzyme that hydrolyses a peptide bond using the thiol group of a cysteine residue as a nucleophile. Hydrolysis involves usually a catalytic triad consisting of the thiol group of the cysteine, the imidazolium ring of a histidine, and a third residue, usually asparagine or aspartic acid, to orientate and activate the imidazolium ring. In only one family of cysteine peptidases, is the role of the general base assigned to a residue other than a histidine: in peptidases from family C89 (acid ceramidase) an arginine is the general base. Cysteine peptidases can be grouped into fourteen different clans, with members of each clan possessing a tertiary fold unique to the clan. Four clans of cysteine peptidases share structural similarities with serine and threonine peptidases and asparagine lyases. From sequence similarities, cysteine peptidases can be clustered into over 80 different families []. Clans CF, CM, CN, CO, CP and PD contain only one family.Cysteine peptidases are often active at acidic pH and are therefore confined to acidic environments, such as the animal lysosome or plant vacuole. Cysteine peptidases can be endopeptidases, aminopeptidases, carboxypeptidases, dipeptidyl-peptidases or omega-peptidases. They are inhibited by thiol chelators such as iodoacetate, iodoacetic acid, N-ethylmaleimide or p-chloromercuribenzoate.Clan CA includes proteins with a papain-like fold. There is a catalytic triad which occurs in the order: Cys/His/Asn (or Asp). A fourth residue, usually Gln, is important for stabilising the acyl intermediate that forms during catalysis, and this precedes the active site Cys. The fold consists of two subdomains with the active site between them. One subdomain consists of a bundle of helices, with the catalytic Cys at the end of one of them, and the other subdomain is a β-barrel with the active site His and Asn (or Asp). There are over thirty families in the clan, and tertiary structures have been solved for members of most of these. Peptidases in clan CA are usually sensitive to the small molecule inhibitor E64, which is ineffective against peptidases from other clans of cysteine peptidases [].Clan CD includes proteins with a caspase-like fold. Proteins in the clan have an α/β/α sandwich structure. There is a catalytic dyad which occurs in the order His/Cys. The active site His occurs in a His-Gly motif and the active site Cys occurs in an Ala-Cys motif; both motifs are preceded by a block of hydrophobic residues []. Specificity is predominantly directed towards residues that occupy the S1 binding pocket, so that caspases cleave aspartyl bonds, legumains cleave asparaginyl bonds, and gingipains cleave lysyl or arginyl bonds.Clan CE includes proteins with an adenain-like fold. The fold consists of two subdomains with the active site between them. One domain is a bundle of helices, and the other a β-barrell. The subdomains are in the opposite order to those found in peptidases from clan CA, and this is reflected in the order of active site residues: His/Asn/Gln/Cys. This has prompted speculation that proteins in clans CA and CE are related, and that members of one clan are derived from a circular permutation of the structure of the other.Clan CL includes proteins with a sortase B-like fold. Peptidases in the clan hydrolyse and transfer bacterial cell wall peptides. The fold shows a closed β-barrel decorated with helices with the active site at one end of the barrel []. The active site consists of a His/Cys catalytic dyad.Cysteine peptidases with a chymotrypsin-like fold are included in clan PA, which also includes serine peptidases. Cysteine peptidases that are N-terminal nucleophile hydrolases are included in clan PB. Cysteine peptidases with a tertiary structure similar to that of the serine-type aspartyl dipeptidase are included in clan PC. Cysteine peptidases with an intein-like fold are included in clan PD, which also includes asparagine lyases.
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Publication
24146773 | J:209112
First Author: Shimizu H
Year: 2013
Journal: PLoS One
Title: The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo.
Volume: 8
Issue: 10
Pages: e75754
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Protein
P0DOY1
Organism: Mus musculus/domesticus
Length: 740  
Fragment?: false
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Protein
J3QNW0
Organism: Mus musculus/domesticus
Length: 1501  
Fragment?: false
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Publication
8127644 | -
First Author: Kumar S
Year: 1994
Journal: Nucleic Acids Res
Title: The DNA (cytosine-5) methyltransferases.
Volume: 22
Issue: 1
Pages: 1-10
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Protein
Q9WU60
Organism: Mus musculus/domesticus
Length: 1428  
Fragment?: false
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Protein
B9EIU3
Organism: Mus musculus/domesticus
Length: 1428  
Fragment?: false
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Publication
2890503 | J:8920
First Author: Lonai P
Year: 1987
Journal: DNA
Title: New murine homeoboxes: structure, chromosomal assignment, and differential expression in adult erythropoiesis.
Volume: 6
Issue: 5
Pages: 409-18
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Publication
2463210 | J:32282
First Author: Graham A
Year: 1988
Journal: Genes Dev
Title: Characterization of a murine homeo box gene, Hox-2.6, related to the Drosophila Deformed gene.
Volume: 2
Issue: 11
Pages: 1424-38
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Publication
2566383 | J:9784
First Author: Graham A
Year: 1989
Journal: Cell
Title: The murine and Drosophila homeobox gene complexes have common features of organization and expression.
Volume: 57
Issue: 3
Pages: 367-78
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Publication
2906328 | J:9628
First Author: Do MS
Year: 1988
Journal: Genomics
Title: Gene organization of murine homeobox-containing gene clusters.
Volume: 3
Issue: 3
Pages: 195-200
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Publication
1346798 | J:1905
First Author: Takahashi Y
Year: 1992
Journal: J Exp Med
Title: Mapping of the nu gene using congenic nude strains and in situ hybridization.
Volume: 175
Issue: 3
Pages: 873-6
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Publication
30348760 | J:267460
First Author: Hrycaj SM
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Hox5 genes direct elastin network formation during alveologenesis by regulating myofibroblast adhesion.
Volume: 115
Issue: 45
Pages: E10605-E10614
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Publication
11518511 | J:71389
First Author: Manley NR
Year: 2001
Journal: Dev Biol
Title: Hoxb2 and hoxb4 act together to specify ventral body wall formation.
Volume: 237
Issue: 1
Pages: 130-44
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Publication
9694798 | J:49154
First Author: Partanen J
Year: 1998
Journal: Genes Dev
Title: Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos.
Volume: 12
Issue: 15
Pages: 2332-44
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Publication
22872086 | J:317819
First Author: Minguillon C
Year: 2012
Journal: Development
Title: Hox genes regulate the onset of Tbx5 expression in the forelimb.
Volume: 139
Issue: 17
Pages: 3180-8
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Publication
18562676 | J:139748
First Author: Dinger ME
Year: 2008
Journal: Genome Res
Title: Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation.
Volume: 18
Issue: 9
Pages: 1433-45
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Publication
19091803 | J:145738
First Author: Wang LL
Year: 2009
Journal: Hum Reprod
Title: Ethanol exposure induces differential microRNA and target gene expression and teratogenic effects which can be suppressed by folic acid supplementation.
Volume: 24
Issue: 3
Pages: 562-79
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Publication
2482246 | J:10240
First Author: Nadeau JH
Year: 1989
Journal: Genomics
Title: A family of type I keratin genes and the homeobox-2 gene complex are closely linked to the rex locus on mouse chromosome 11.
Volume: 5
Issue: 3
Pages: 454-62
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Publication
1685115 | J:32030
First Author: Graham A
Year: 1991
Journal: Development
Title: The murine Hox-2 genes display dynamic dorsoventral patterns of expression during central nervous system development.
Volume: 112
Issue: 1
Pages: 255-64
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Publication
1688181 | J:33651
 
First Author: Hunt P
Year: 1991
Journal: Dev Suppl
Title: The branchial Hox code and its implications for gene regulation, patterning of the nervous system and head evolution.
Volume: Suppl 2
Pages: 63-77
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Publication
11869294 | J:79649
First Author: Kawazoe Y
Year: 2002
Journal: Dev Growth Differ
Title: Region-specific gastrointestinal Hox code during murine embryonal gut development.
Volume: 44
Issue: 1
Pages: 77-84
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Protein
P13864
Organism: Mus musculus/domesticus
Length: 1620  
Fragment?: false
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Protein
O88508
Organism: Mus musculus/domesticus
Length: 908  
Fragment?: false
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Protein
O88509
Organism: Mus musculus/domesticus
Length: 859  
Fragment?: false
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Protein
Q3KR45
Organism: Mus musculus/domesticus
Length: 860  
Fragment?: false
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Protein
Q541E5
Organism: Mus musculus/domesticus
Length: 796  
Fragment?: false
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Protein
Q3UHZ3
Organism: Mus musculus/domesticus
Length: 1619  
Fragment?: false
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Protein
Q7TSJ0
Organism: Mus musculus/domesticus
Length: 1627  
Fragment?: false
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Publication
1989904 | J:15697
First Author: Mitchell PJ
Year: 1991
Journal: Genes Dev
Title: Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis.
Volume: 5
Issue: 1
Pages: 105-19
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Publication
1972280 | J:10556
First Author: Rubock MJ
Year: 1990
Journal: Proc Natl Acad Sci U S A
Title: A yeast artificial chromosome containing the mouse homeobox cluster Hox-2.
Volume: 87
Issue: 12
Pages: 4751-5
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Publication
10885747 | J:62577
First Author: Medina-Martínez O
Year: 2000
Journal: Dev Biol
Title: A large targeted deletion of Hoxb1-Hoxb9 produces a series of single-segment anterior homeotic transformations.
Volume: 222
Issue: 1
Pages: 71-83
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Publication
24141719 | J:229073
First Author: Kam MK
Year: 2014
Journal: Cell Death Differ
Title: Perturbation of Hoxb5 signaling in vagal and trunk neural crest cells causes apoptosis and neurocristopathies in mice.
Volume: 21
Issue: 2
Pages: 278-89
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Publication
37390208 | J:337924
First Author: Wu SR
Year: 2023
Journal: Sci Adv
Title: Atoh1 drives the heterogeneity of the pontine nuclei neurons and promotes their differentiation.
Volume: 9
Issue: 26
Pages: eadg1671
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Publication
8555112 | J:29061
First Author: Luo J
Year: 1995
Journal: Mech Dev
Title: Mice lacking all isoforms of retinoic acid receptor beta develop normally and are susceptible to the teratogenic effects of retinoic acid.
Volume: 53
Issue: 1
Pages: 61-71
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Publication
17572674 | J:123007
First Author: Wu S
Year: 2007
Journal: Nat Genet
Title: Toward simpler and faster genome-wide mutagenesis in mice.
Volume: 39
Issue: 7
Pages: 922-30
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Publication
10579975 | J:60124
First Author: Pitera JE
Year: 1999
Journal: Gastroenterology
Title: Coordinated expression of 3' hox genes during murine embryonal gut development: an enteric Hox code.
Volume: 117
Issue: 6
Pages: 1339-51
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Publication
2571936 | J:32270
First Author: Wilkinson DG
Year: 1989
Journal: Nature
Title: Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain.
Volume: 341
Issue: 6241
Pages: 405-9
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Publication
1363087 | J:3101
First Author: Conlon RA
Year: 1992
Journal: Development
Title: Exogenous retinoic acid rapidly induces anterior ectopic expression of murine Hox-2 genes in vivo.
Volume: 116
Issue: 2
Pages: 357-68
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Publication
1348361 | J:46
First Author: Nazarali A
Year: 1992
Journal: Proc Natl Acad Sci U S A
Title: Hox-1.11 and Hox-4.9 homeobox genes.
Volume: 89
Issue: 7
Pages: 2883-7
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Publication
10208743 | J:54641
First Author: Minoo P
Year: 1999
Journal: Dev Biol
Title: Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(-/-) mouse embryos.
Volume: 209
Issue: 1
Pages: 60-71
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Publication
24525295 | J:208763
First Author: Ahn Y
Year: 2014
Journal: Dev Biol
Title: Long-range regulation by shared retinoic acid response elements modulates dynamic expression of posterior Hoxb genes in CNS development.
Volume: 388
Issue: 1
Pages: 134-44
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Publication
23585229 | J:202792
First Author: Boucherat O
Year: 2013
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Partial functional redundancy between Hoxa5 and Hoxb5 paralog genes during lung morphogenesis.
Volume: 304
Issue: 12
Pages: L817-30
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Publication
36577717 | J:335070
First Author: Li MH
Year: 2023
Journal: Dev Dyn
Title: Characterization of a novel Hoxa5eGFP mouse line.
Volume: 252
Issue: 4
Pages: 536-546
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Publication
19922872 | J:155755
First Author: Voss AK
Year: 2009
Journal: Dev Cell
Title: Moz and retinoic acid coordinately regulate H3K9 acetylation, Hox gene expression, and segment identity.
Volume: 17
Issue: 5
Pages: 674-86
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Publication
8105001 | J:14757
First Author: Detmer K
Year: 1993
Journal: J Invest Dermatol
Title: Expression of class I homeobox genes in fetal and adult murine skin.
Volume: 101
Issue: 4
Pages: 517-22
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Publication
9415485 | J:44152
First Author: Mollard R
Year: 1997
Journal: Int J Dev Biol
Title: Homeobox genes from clusters A and B demonstrate characteristics of temporal colinearity and differential restrictions in spatial expression domains in the branching mouse lung.
Volume: 41
Issue: 5
Pages: 655-66
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Publication
10328847 | J:55054
First Author: Ford HL
Year: 1998
Journal: Cell Biol Int
Title: Homeobox genes: a link between development, cell cycle, and cancer?
Volume: 22
Issue: 6
Pages: 397-400
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Publication
27650319 | J:241156
First Author: Lizen B
Year: 2017
Journal: J Comp Neurol
Title: HOXA5 localization in postnatal and adult mouse brain is suggestive of regulatory roles in postmitotic neurons.
Volume: 525
Issue: 5
Pages: 1155-1175
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Protein
Q6A051
Organism: Mus musculus/domesticus
Length: 1378  
Fragment?: false
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Protein
P60882
Organism: Mus musculus/domesticus
Length: 2789  
Fragment?: false
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Publication
- | J:46439
     
First Author: Freeman TC
Year: 1998
Journal: MGI Direct Data Submission
Title: Expression Mapping of Mouse Genes
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Publication
12693553 | J:83413
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 1
Pages: 35-48
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Publication
23307742 | J:193244
First Author: Di Meglio T
Year: 2013
Journal: Science
Title: Ezh2 orchestrates topographic migration and connectivity of mouse precerebellar neurons.
Volume: 339
Issue: 6116
Pages: 204-7
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Publication
9334279 | J:44237
First Author: Goh KL
Year: 1997
Journal: Development
Title: Mesodermal defects and cranial neural crest apoptosis in alpha5 integrin-null embryos.
Volume: 124
Issue: 21
Pages: 4309-19
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Publication
18547144 | J:139385
First Author: Geisen MJ
Year: 2008
Journal: PLoS Biol
Title: Hox paralog group 2 genes control the migration of mouse pontine neurons through slit-robo signaling.
Volume: 6
Issue: 6
Pages: e142
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Publication
9639506 | J:48502
First Author: Yagi H
Year: 1998
Journal: Blood
Title: Growth disturbance in fetal liver hematopoiesis of Mll-mutant mice.
Volume: 92
Issue: 1
Pages: 108-17
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Publication
12753872 | J:83831
First Author: Masinde GL
Year: 2003
Journal: Bone
Title: Quantitative trait loci for periosteal circumference (PC): identification of single loci and epistatic effects in F2 MRL/SJL mice.
Volume: 32
Issue: 5
Pages: 554-60
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Publication
30931988 | J:278544
First Author: Abdelhamed ZA
Year: 2019
Journal: Sci Rep
Title: The ciliary Frizzled-like receptor Tmem67 regulates canonical Wnt/β-catenin signalling in the developing cerebellum via Hoxb5.
Volume: 9
Issue: 1
Pages: 5446
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Publication
18554416 | J:139177
First Author: Hoffman BG
Year: 2008
Journal: Genome Biol
Title: Identification of transcripts with enriched expression in the developing and adult pancreas.
Volume: 9
Issue: 6
Pages: R99
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Publication
10512203 | J:93290
First Author: Araki K
Year: 1999
Journal: Cell Mol Biol (Noisy-le-grand)
Title: Exchangeable gene trap using the Cre/mutated lox system.
Volume: 45
Issue: 5
Pages: 737-50
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Publication
15840001 | J:110088
First Author: Taniwaki T
Year: 2005
Journal: Dev Growth Differ
Title: Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.
Volume: 47
Issue: 3
Pages: 163-72
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Publication
30470704 | J:293331
 
First Author: Martinez-Chavez E
Year: 2018
Journal: Development
Title: The zinc-finger transcription factor GLI3 is a regulator of precerebellar neuronal migration.
Volume: 145
Issue: 24
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Publication
38636517 | J:347974
     
First Author: Zhou B
Year: 2024
Journal: Dev Cell
Title: Identification of signaling pathways that specify a subset of migrating enteric neural crest cells at the wavefront in mouse embryos.
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Publication
10642791 | J:59069
First Author: Klingensmith J
Year: 1999
Journal: Dev Biol
Title: Neural induction and patterning in the mouse in the absence of the node and its derivatives.
Volume: 216
Issue: 2
Pages: 535-49
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Publication
24218595 | J:203059
First Author: Xu B
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Hox5 interacts with Plzf to restrict Shh expression in the developing forelimb.
Volume: 110
Issue: 48
Pages: 19438-43
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Publication
30169530 | J:265501
First Author: Kim H
Year: 2018
Journal: PLoS One
Title: Ablation of Ezh2 in neural crest cells leads to aberrant enteric nervous system development in mice.
Volume: 13
Issue: 8
Pages: e0203391
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Publication
39289460 | J:354191
First Author: Kc R
Year: 2024
Journal: Commun Biol
Title: Multimodal Hox5 activity generates motor neuron diversity.
Volume: 7
Issue: 1
Pages: 1166
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Publication
26235626 | J:232894
First Author: Hrycaj SM
Year: 2015
Journal: Cell Rep
Title: Hox5 Genes Regulate the Wnt2/2b-Bmp4-Signaling Axis during Lung Development.
Volume: 12
Issue: 6
Pages: 903-12
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Publication
32553152 | J:306314
First Author: Maheshwari U
Year: 2020
Journal: Cell Rep
Title: Postmitotic Hoxa5 Expression Specifies Pontine Neuron Positional Identity and Input Connectivity of Cortical Afferent Subsets.
Volume: 31
Issue: 11
Pages: 107767
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Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
16632597 | J:109593
First Author: Heanue TA
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Expression profiling the developing mammalian enteric nervous system identifies marker and candidate Hirschsprung disease genes.
Volume: 103
Issue: 18
Pages: 6919-24
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Publication
26329601 | J:239777
First Author: Boucherat O
Year: 2015
Journal: Development
Title: Epithelial inactivation of Yy1 abrogates lung branching morphogenesis.
Volume: 142
Issue: 17
Pages: 2981-95
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Publication
20211142 | J:160776
First Author: Ravasi T
Year: 2010
Journal: Cell
Title: An atlas of combinatorial transcriptional regulation in mouse and man.
Volume: 140
Issue: 5
Pages: 744-52
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Publication
15618518 | J:91257
First Author: Gray PA
Year: 2004
Journal: Science
Title: Mouse brain organization revealed through direct genome-scale TF expression analysis.
Volume: 306
Issue: 5705
Pages: 2255-7
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
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