| Type |
Details |
Score |
| GXD Expression |
| Probe: |
MGI:1631136 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1690623 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827750 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_007060_16 |
|
| Specimen Label: |
euxassay_007060_16 |
| Detected: |
true |
| Specimen Num: |
16 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1631136 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1690623 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827750 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_007060_17 |
|
| Specimen Label: |
euxassay_007060_17 |
| Detected: |
true |
| Specimen Num: |
17 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1631136 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1690623 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827750 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_007060_18 |
|
| Specimen Label: |
euxassay_007060_18 |
| Detected: |
true |
| Specimen Num: |
18 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1631136 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1690623 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827750 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_007060_19 |
|
| Specimen Label: |
euxassay_007060_19 |
| Detected: |
true |
| Specimen Num: |
19 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757723 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_02 |
|
| Specimen Label: |
euxassay_002055_02 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757723 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_03 |
|
| Specimen Label: |
euxassay_002055_03 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757723 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_04 |
|
| Specimen Label: |
euxassay_002055_04 |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757723 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_05 |
|
| Specimen Label: |
euxassay_002055_05 |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757723 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_06 |
|
| Specimen Label: |
euxassay_002055_06 |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757723 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_07 |
|
| Specimen Label: |
euxassay_002055_07 |
| Detected: |
true |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757723 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_08 |
|
| Specimen Label: |
euxassay_002055_08 |
| Detected: |
true |
| Specimen Num: |
8 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757723 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_09 |
|
| Specimen Label: |
euxassay_002055_09 |
| Detected: |
true |
| Specimen Num: |
9 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757723 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_10 |
|
| Specimen Label: |
euxassay_002055_10 |
| Detected: |
true |
| Specimen Num: |
10 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757723 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_11 |
|
| Specimen Label: |
euxassay_002055_11 |
| Detected: |
true |
| Specimen Num: |
11 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757723 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_12 |
|
| Specimen Label: |
euxassay_002055_12 |
| Detected: |
true |
| Specimen Num: |
12 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757723 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_13 |
|
| Specimen Label: |
euxassay_002055_13 |
| Detected: |
true |
| Specimen Num: |
13 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1631136 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1755823 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827750 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_007060_05 |
|
| Specimen Label: |
euxassay_007060_05 |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1631136 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1755823 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827750 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_007060_06 |
|
| Specimen Label: |
euxassay_007060_06 |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1631136 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1755823 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827750 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_007060_07 |
|
| Specimen Label: |
euxassay_007060_07 |
| Detected: |
true |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1631136 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1755823 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827750 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_007060_08 |
|
| Specimen Label: |
euxassay_007060_08 |
| Detected: |
true |
| Specimen Num: |
8 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1631136 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1755823 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827750 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_007060_09 |
|
| Specimen Label: |
euxassay_007060_09 |
| Detected: |
true |
| Specimen Num: |
9 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1631136 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1755823 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827750 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_007060_10 |
|
| Specimen Label: |
euxassay_007060_10 |
| Detected: |
true |
| Specimen Num: |
10 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1631136 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1755823 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827750 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_007060_11 |
|
| Specimen Label: |
euxassay_007060_11 |
| Detected: |
true |
| Specimen Num: |
11 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1631136 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1755823 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827750 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_007060_12 |
|
| Specimen Label: |
euxassay_007060_12 |
| Detected: |
true |
| Specimen Num: |
12 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1631136 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1755823 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827750 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_007060_13 |
|
| Specimen Label: |
euxassay_007060_13 |
| Detected: |
true |
| Specimen Num: |
13 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1631136 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1755823 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827750 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_007060_14 |
|
| Specimen Label: |
euxassay_007060_14 |
| Detected: |
true |
| Specimen Num: |
14 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1631136 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1755823 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827750 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_007060_15 |
|
| Specimen Label: |
euxassay_007060_15 |
| Detected: |
true |
| Specimen Num: |
15 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1631136 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1755823 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827750 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_007060_16 |
|
| Specimen Label: |
euxassay_007060_16 |
| Detected: |
true |
| Specimen Num: |
16 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1631136 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1755823 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827750 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_007060_17 |
|
| Specimen Label: |
euxassay_007060_17 |
| Detected: |
true |
| Specimen Num: |
17 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1784723 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_13 |
|
| Specimen Label: |
euxassay_002055_13 |
| Detected: |
true |
| Specimen Num: |
13 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1784723 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_14 |
|
| Specimen Label: |
euxassay_002055_14 |
| Detected: |
true |
| Specimen Num: |
14 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1784723 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_16 |
|
| Specimen Label: |
euxassay_002055_16 |
| Detected: |
true |
| Specimen Num: |
16 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Strong |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1789623 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_12 |
|
| Specimen Label: |
euxassay_002055_12 |
| Detected: |
true |
| Specimen Num: |
12 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Strong |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1789623 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_13 |
|
| Specimen Label: |
euxassay_002055_13 |
| Detected: |
true |
| Specimen Num: |
13 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689423 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_01 |
|
| Specimen Label: |
euxassay_002055_01 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689423 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_02 |
|
| Specimen Label: |
euxassay_002055_02 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689423 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_03 |
|
| Specimen Label: |
euxassay_002055_03 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689423 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_04 |
|
| Specimen Label: |
euxassay_002055_04 |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689423 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_05 |
|
| Specimen Label: |
euxassay_002055_05 |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689423 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_06 |
|
| Specimen Label: |
euxassay_002055_06 |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689423 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_07 |
|
| Specimen Label: |
euxassay_002055_07 |
| Detected: |
true |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689423 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_08 |
|
| Specimen Label: |
euxassay_002055_08 |
| Detected: |
true |
| Specimen Num: |
8 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689423 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_09 |
|
| Specimen Label: |
euxassay_002055_09 |
| Detected: |
true |
| Specimen Num: |
9 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689423 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_10 |
|
| Specimen Label: |
euxassay_002055_10 |
| Detected: |
true |
| Specimen Num: |
10 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689423 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_11 |
|
| Specimen Label: |
euxassay_002055_11 |
| Detected: |
true |
| Specimen Num: |
11 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689423 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_12 |
|
| Specimen Label: |
euxassay_002055_12 |
| Detected: |
true |
| Specimen Num: |
12 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689423 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_13 |
|
| Specimen Label: |
euxassay_002055_13 |
| Detected: |
true |
| Specimen Num: |
13 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689423 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_14 |
|
| Specimen Label: |
euxassay_002055_14 |
| Detected: |
true |
| Specimen Num: |
14 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689423 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_15 |
|
| Specimen Label: |
euxassay_002055_15 |
| Detected: |
true |
| Specimen Num: |
15 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689423 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_16 |
|
| Specimen Label: |
euxassay_002055_16 |
| Detected: |
true |
| Specimen Num: |
16 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689423 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_17 |
|
| Specimen Label: |
euxassay_002055_17 |
| Detected: |
true |
| Specimen Num: |
17 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689423 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_18 |
|
| Specimen Label: |
euxassay_002055_18 |
| Detected: |
true |
| Specimen Num: |
18 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689423 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_19 |
|
| Specimen Label: |
euxassay_002055_19 |
| Detected: |
true |
| Specimen Num: |
19 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689423 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_20 |
|
| Specimen Label: |
euxassay_002055_20 |
| Detected: |
true |
| Specimen Num: |
20 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689423 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_21 |
|
| Specimen Label: |
euxassay_002055_21 |
| Detected: |
true |
| Specimen Num: |
21 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689423 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_22 |
|
| Specimen Label: |
euxassay_002055_22 |
| Detected: |
true |
| Specimen Num: |
22 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1684977 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689423 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827736 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002055_23 |
|
| Specimen Label: |
euxassay_002055_23 |
| Detected: |
true |
| Specimen Num: |
23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shao H |
| Year: |
1999 |
| Journal: |
GenBank Submission |
| Title: |
Mus musculus GTP-binding protein ROC2 (Roc2) mRNA, complete cds |
|
|
| Pages: |
AF084463 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This entry represents the CRIB domain. Many putative downstream effectors of the small GTPases Cdc42 and Rac contain a GTPase binding domain (GBD), also called p21 binding domain (PBD), which has been shown to specifically bind the GTP bound form of Cdc42 or Rac, with a preference for Cdc42 [, ]. The most conserved region of GBD/PBD domains is the N-terminal Cdc42/Rac interactive binding motif (CRIB), which consists of about 16 amino acids with the consensus sequence I-S-x-P-x(2,4)-F-x-H-x(2)-H-V-G [].Although the CRIB motif is necessary for the binding to Cdc42 and Rac, it is not sufficient to give high-affinity binding [, ]. A less well conserved inhibitory switch (IS) domain responsible for maintaining the proteins in a basal (autoinhibited) state is located C-terminaly of the CRIB-motif [, , ].GBD domains can adopt related but distinct folds depending on context. Although GBD domains are largely unstructured in the free state, the IS domain forms an N-terminal β-hairpin that immediately follows the conserved CRIB motif and a central bundle of three α-helices in the autoinhibited state. The interaction between GBD domains and their respective G proteins leads to the formation of a high-affinity complex in which unstructured regions of both the effector and the G protein become rigid. CRIB motifs from various GBD domains interact with Cdc42 in a similar manner, forming an intermolecular β-sheet with strand β-2 of Cdc42. Outside the CRIB motif, the C-terminal of the various GBD domains are very divergent and show variation in their mode of binding to Cdc42, perhaps determining the specificity of the interaction. Binding of Cdc42 or Rac to the GBD domain causes a dramatic conformational change, refolding part of the IS domain and unfolding the rest [, , , , ].Some proteins known to contain a CRIB domain are listed below:Mammalian activated Cdc42-associated kinases (ACKs), nonreceptor tyrosine kinases implicated in integrin-coupled pathways.Mammalian p21-activated kinases (PAK1 to PAK4), serine/threonine kinases that modulate cytoskeletal assembly and activate MAP-kinase pathways.Mammalian Actin nucleation-promoting factor WAS (also known as Wiskott-Aldrich Symdrom Proteins, WASPs), non-kinase proteins involved in the organisation of the actin cytoskeleton.Yeast STE20 and CLA4, the homologues of mammalian PAKs. STE20 is involved in the mating/pheromone MAP kinase cascade. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Homologous_superfamily |
| Description: |
This entry represents the CRIB domain superfamily. Many putative downstream effectors of the small GTPases Cdc42 and Rac contain a GTPase binding domain (GBD), also called p21 binding domain (PBD), which has been shown to specifically bind the GTP bound form of Cdc42 or Rac, with a preference for Cdc42 [, ]. The most conserved region of GBD/PBD domains is the N-terminal Cdc42/Rac interactive binding motif (CRIB), which consists of about 16 amino acids with the consensus sequence I-S-x-P-x(2,4)-F-x-H-x(2)-H-V-G [].Although the CRIB motif is necessary for the binding to Cdc42 and Rac, it is not sufficient to give high-affinity binding [, ]. A less well conserved inhibitory switch (IS) domain responsible for maintaining the proteins in a basal (autoinhibited) state is located C-terminaly of the CRIB-motif [, , ].GBD domains can adopt related but distinct folds depending on context. Although GBD domains are largely unstructured in the free state, the IS domain forms an N-terminal beta; hairpin that immediately follows the conserved CRIB motif and a central bundle of three alpha; helices in the autoinhibited state. The interaction between GBD domains and their respective G proteins leads to the formation of a high-affinity complex in which unstructured regions of both the effector and the G protein become rigid. CRIB motifs from various GBD domains interact with Cdc42 in a similar manner, forming an intermolecular beta;-sheet with strand beta;-2 of Cdc42. Outside the CRIB motif, the C-termini of the various GBD domains are very divergent and show variation in their mode of binding to Cdc42, perhaps determining the specificity of the interaction. Binding of Cdc42 or Rac to the GBD domain causes a dramatic conformational change, refolding part of the IS domain and unfolding the rest [, , , , ].Some proteins known to contain a CRIB domain are listed below:Mammalian activated Cdc42-associated kinases (ACKs), nonreceptor tyrosine kinases implicated in integrin-coupled pathways.Mammalian p21-activated kinases (PAK1 to PAK4), serine/threonine kinases that modulate cytoskeletal assembly and activate MAP-kinase pathways.Mammalian Actin nucleation-promoting factor WAS proteins (WASPs), non-kinase proteins involved in the organisation of the actin cytoskeleton.Yeast STE20 and CLA4, the homologues of mammalian PAKs. STE20 is involved in the mating/pheromone MAP kinase cascade. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Baruzzi A |
| Year: |
2010 |
| Journal: |
FEBS Lett |
| Title: |
c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration. |
| Volume: |
584 |
| Issue: |
1 |
| Pages: |
15-21 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang J |
| Year: |
2005 |
| Journal: |
Nat Immunol |
| Title: |
An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis. |
| Volume: |
6 |
| Issue: |
9 |
| Pages: |
911-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Klein S |
| Year: |
2005 |
| Journal: |
FEBS Lett |
| Title: |
AlFx affects the formation of focal complexes by stabilizing the Arf-GAP ASAP1 in a complex with Arf1. |
| Volume: |
579 |
| Issue: |
25 |
| Pages: |
5741-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hart MC |
| Year: |
2000 |
| Journal: |
BMC Genomics |
| Title: |
Mapping of the mouse actin capping protein beta subunit gene. |
| Volume: |
1 |
|
| Pages: |
1 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
232
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fulcoli FG |
| Year: |
2016 |
| Journal: |
Nat Commun |
| Title: |
Rebalancing gene haploinsufficiency in vivo by targeting chromatin. |
| Volume: |
7 |
|
| Pages: |
11688 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hasenpusch-Theil K |
| Year: |
2020 |
| Journal: |
Elife |
| Title: |
A transient role of the ciliary gene Inpp5e in controlling direct versus indirect neurogenesis in cortical development. |
| Volume: |
9 |
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Boon AC |
| Year: |
2009 |
| Journal: |
J Virol |
| Title: |
Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice. |
| Volume: |
83 |
| Issue: |
20 |
| Pages: |
10417-26 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
178
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tsuji T |
| Year: |
2011 |
| Journal: |
Cell Mol Neurobiol |
| Title: |
Ect2, an ortholog of Drosophila's pebble, negatively regulates neurite outgrowth in neuroblastoma × glioma hybrid NG108-15 cells. |
| Volume: |
31 |
| Issue: |
5 |
| Pages: |
663-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bouvard D |
| Year: |
2007 |
| Journal: |
Development |
| Title: |
Defective osteoblast function in ICAP-1-deficient mice. |
| Volume: |
134 |
| Issue: |
14 |
| Pages: |
2615-25 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
84
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chang DD |
| Year: |
1997 |
| Journal: |
J Cell Biol |
| Title: |
ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin. |
| Volume: |
138 |
| Issue: |
5 |
| Pages: |
1149-57 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Degani S |
| Year: |
2002 |
| Journal: |
J Cell Biol |
| Title: |
The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading. |
| Volume: |
156 |
| Issue: |
2 |
| Pages: |
377-87 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yüce O |
| Year: |
2005 |
| Journal: |
J Cell Biol |
| Title: |
An ECT2-centralspindlin complex regulates the localization and function of RhoA. |
| Volume: |
170 |
| Issue: |
4 |
| Pages: |
571-82 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Saito S |
| Year: |
2004 |
| Journal: |
J Biol Chem |
| Title: |
Deregulation and mislocalization of the cytokinesis regulator ECT2 activate the Rho signaling pathways leading to malignant transformation. |
| Volume: |
279 |
| Issue: |
8 |
| Pages: |
7169-79 |
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| Publication |
| First Author: |
Solski PA |
| Year: |
2004 |
| Journal: |
J Biol Chem |
| Title: |
Requirement for C-terminal sequences in regulation of Ect2 guanine nucleotide exchange specificity and transformation. |
| Volume: |
279 |
| Issue: |
24 |
| Pages: |
25226-33 |
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| Publication |
| First Author: |
Tatsumoto T |
| Year: |
1999 |
| Journal: |
J Cell Biol |
| Title: |
Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis. |
| Volume: |
147 |
| Issue: |
5 |
| Pages: |
921-8 |
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| Publication |
| First Author: |
Wennerberg K |
| Year: |
2002 |
| Journal: |
J Biol Chem |
| Title: |
RhoG signals in parallel with Rac1 and Cdc42. |
| Volume: |
277 |
| Issue: |
49 |
| Pages: |
47810-7 |
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| Publication |
| First Author: |
Fields AP |
| Year: |
2010 |
| Journal: |
Adv Enzyme Regul |
| Title: |
The guanine nucleotide exchange factor (GEF) Ect2 is an oncogene in human cancer. |
| Volume: |
50 |
| Issue: |
1 |
| Pages: |
190-200 |
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| Publication |
| First Author: |
Salhia B |
| Year: |
2008 |
| Journal: |
Am J Pathol |
| Title: |
The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma. |
| Volume: |
173 |
| Issue: |
6 |
| Pages: |
1828-38 |
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| Publication |
| First Author: |
Hirata D |
| Year: |
2009 |
| Journal: |
Clin Cancer Res |
| Title: |
Involvement of epithelial cell transforming sequence-2 oncoantigen in lung and esophageal cancer progression. |
| Volume: |
15 |
| Issue: |
1 |
| Pages: |
256-66 |
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| Publication |
| First Author: |
Zhang ML |
| Year: |
2008 |
| Journal: |
Hepatobiliary Pancreat Dis Int |
| Title: |
Correlation between ECT2 gene expression and methylation change of ECT2 promoter region in pancreatic cancer. |
| Volume: |
7 |
| Issue: |
5 |
| Pages: |
533-8 |
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| Publication |
| First Author: |
Innocenti M |
| Year: |
1999 |
| Journal: |
FEBS Lett |
| Title: |
CDC25(Mm)/Ras-GRF1 regulates both Ras and Rac signaling pathways. |
| Volume: |
460 |
| Issue: |
2 |
| Pages: |
357-62 |
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| Protein Domain |
| Type: |
Family |
| Description: |
Epithelial Cell Transforming Sequence 2 (Ect2) is a guanine nucleotide exchange factor (GEF) that catalyses the exchange of GDP for GTP. Like other GEFs, Ect2 serves as molecular switches in diverse signaling pathways, including cell polarity, mitotic spindle assembly, cytokinesis, etc [, , ]. Ect2 interacts with several members of the Rho GTPase family including, RhoA, RhoB, RhoC, RhoG, Rac1 and Cdc42 [, , , , ]. Ect2 regulates the formation of the actomyosin contractile ring at mitotic exit through activation of RhoA and functions in metaphase for the process of spindle assembly through activation of Cdc42 []. Ect2 is regulated through a number of mechanisms including phosphorylation, intracellular localization and intra- and inter-molecular interactions []. Ect2 is established as a human oncogene []. It is highly expressed in a variety of human tumors including brain lung, bladder, esophageal, pancreatic and ovarian tumors [, , , , ]. Ect2 is also suggested to play a role in neuronal differentiation and brain development []. |
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| Protein Domain |
| Type: |
Family |
| Description: |
ICAP-1 is a serine/threonine-rich protein that binds to the cytoplasmic domains of beta-1 integrins in a highly specific manner, binding to a NPXY sequence motif on the beta-1 integrin. The cytoplasmic domains of integrins are essential for cell adhesion, and the fact that phosphorylation of ICAP-1 by interaction with the cell-matrix implies an important role of ICAP-1 during integrin-dependent cell adhesion []. Over expression of ICAP-1 strongly reduces the integrin-mediated cell spreading on extracellular matrix and inhibits both Cdc42 and Rac1. In addition, ICAP-1 induces release of Cdc42 from cellular membranes and prevents the dissociation of GDP from this GTPase []. An additional function of ICAP-1 is to promote differentiation of osteoprogenitors by supporting their condensation through modulating the integrin high affinity state []. |
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| Protein Domain |
| Type: |
Family |
| Description: |
RasGRF1 belong to the RasGRF family. It regulates both Ras and Rac signalling pathways []. It has been implicated in memory formation, postnatal growth, glucose homeostasis and photoreception [].RasGRF is a Ras family guanine nucleotide exchange factor sharing homology with Saccharomyces cerevisiae Cdc25 that stimulates nucleotide exchange on S. cerevisiae RAS []. RasGRF N-terminal region contains a Dbl homology (DH) domain which is generally present in GEFs for the Rho family of small G proteins, whereas the C-terminal Cdc25-related domain is linked to Ras GTPase signalling []. The presence of regulatory domains for Rho and Ras GTPases implicates the role of RasGRF in the control of the both pathways []. Two RasGRF, RasGRF1 and 2, have been identified in mammals []. Their function can be inhibited by its interaction with Cdc42 in its inactive GDP bound form. Reciprocally, the effects of Cdc42 on cytoskeletal dynamics can be inhibited by RasGRF1/2 []. |
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| Protein Domain |
| Type: |
Domain |
| Description: |
This entry represents the PH domain of guanine nucleotide exchange factor DBS. The DBS PH domain participates in binding to both the Cdc42 and RhoA GTPases []. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner [].DBS, also called MCF2L or OST, functions as a Rho GTPase guanine nucleotide exchange factor (RhoGEF), facilitating the exchange of GDP and GTP. It was originally isolated from a cDNA screen for sequences that cause malignant growth. It plays roles in regulating clathrin-mediated endocytosis and cell migration through its activation of Rac1 and Cdc42 [, ]. Depending on cell type, DBS can also activate RhoA and RhoG [, ]. DBS contains a Sec14-like domain [], spectrin-like repeats, a RhoGEF or Dbl homology (DH) domain, a Pleckstrin homology (PH) domain [], and an SH3 domain. |
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| Publication |
| First Author: |
Fam NP |
| Year: |
1997 |
| Journal: |
Mol Cell Biol |
| Title: |
Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras. |
| Volume: |
17 |
| Issue: |
3 |
| Pages: |
1396-406 |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
753
 |
| Fragment?: |
false |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
105
 |
| Fragment?: |
true |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
778
 |
| Fragment?: |
false |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
93
 |
| Fragment?: |
false |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
153
 |
| Fragment?: |
false |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
196
 |
| Fragment?: |
true |
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| Publication |
| First Author: |
Gontang AC |
| Year: |
2011 |
| Journal: |
Development |
| Title: |
The cytoskeletal regulator Genghis khan is required for columnar target specificity in the Drosophila visual system. |
| Volume: |
138 |
| Issue: |
22 |
| Pages: |
4899-909 |
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