Type |
Details |
Score |
Publication |
First Author: |
Shim DW |
Year: |
2024 |
Journal: |
Exp Mol Med |
Title: |
Deficiency of circadian clock gene Bmal1 exacerbates noncanonical inflammasome-mediated pyroptosis and lethality via Rev-erbα-C/EBPβ-SAA1 axis. |
Volume: |
56 |
Issue: |
2 |
Pages: |
370-382 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang LS |
Year: |
2020 |
Journal: |
Immunity |
Title: |
mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury. |
Volume: |
52 |
Issue: |
3 |
Pages: |
475-486.e5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Weiss ES |
Year: |
2018 |
Journal: |
Blood |
Title: |
Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndrome. |
Volume: |
131 |
Issue: |
13 |
Pages: |
1442-1455 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guo DH |
Year: |
2020 |
Journal: |
J Clin Invest |
Title: |
Visceral adipose NLRP3 impairs cognition in obesity via IL-1R1 on CX3CR1+ cells. |
Volume: |
130 |
Issue: |
4 |
Pages: |
1961-1976 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen KW |
Year: |
2021 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signaling. |
Volume: |
118 |
Issue: |
28 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Vesela B |
Year: |
2015 |
Journal: |
J Mol Histol |
Title: |
Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue. |
Volume: |
46 |
Issue: |
4-5 |
Pages: |
443-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wright SS |
Year: |
2025 |
Journal: |
Cell |
Title: |
Transplantation of gasdermin pores by extracellular vesicles propagates pyroptosis to bystander cells. |
Volume: |
188 |
Issue: |
2 |
Pages: |
280-291.e17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang P |
Year: |
2021 |
Journal: |
Sci Adv |
Title: |
NLRC4 inflammasome-dependent cell death occurs by a complementary series of three death pathways and determines lethality in mice. |
Volume: |
7 |
Issue: |
43 |
Pages: |
eabi9471 |
|
•
•
•
•
•
|
Publication |
First Author: |
Buck M |
Year: |
2001 |
Journal: |
Mol Cell |
Title: |
C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival. |
Volume: |
8 |
Issue: |
4 |
Pages: |
807-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wilson HL |
Year: |
2004 |
Journal: |
J Immunol |
Title: |
Secretion of intracellular IL-1 receptor antagonist (type 1) is dependent on P2X7 receptor activation. |
Volume: |
173 |
Issue: |
2 |
Pages: |
1202-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu L |
Year: |
2017 |
Journal: |
J Crohns Colitis |
Title: |
The Pathogenic Role of NLRP3 Inflammasome Activation in Inflammatory Bowel Diseases of Both Mice and Humans. |
Volume: |
11 |
Issue: |
6 |
Pages: |
737-750 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lawson PR |
Year: |
2000 |
Journal: |
Int Immunol |
Title: |
A novel PCR-based technique using expressed sequence tags and gene homology for murine genetic mapping: localization of the complement genes. |
Volume: |
12 |
Issue: |
3 |
Pages: |
231-40 |
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•
•
•
•
•
|
Publication |
First Author: |
Vercammen D |
Year: |
1998 |
Journal: |
J Exp Med |
Title: |
Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor. |
Volume: |
187 |
Issue: |
9 |
Pages: |
1477-85 |
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•
•
•
•
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Publication |
First Author: |
Robb L |
Year: |
1999 |
Journal: |
Genomics |
Title: |
Assignment of the human helix-loop-helix transcription factor gene musculin/activated B-cell factor-1 (MSC) to chromosome 8q21 and its mouse homologue (Msc) to the proximal region of chromosome 1. |
Volume: |
57 |
Issue: |
2 |
Pages: |
318-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Araki T |
Year: |
1999 |
Journal: |
Exp Cell Res |
Title: |
Caspase activity is required for nephrogenesis in the developing mouse metanephros. |
Volume: |
248 |
Issue: |
2 |
Pages: |
423-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Haass C |
Year: |
1999 |
Journal: |
Nature |
Title: |
Apoptosis. Dead end for neurodegeneration? |
Volume: |
399 |
Issue: |
6733 |
Pages: |
204-5, 207 |
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•
•
•
•
•
|
Publication |
First Author: |
Griffith JW |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
Pure Hemozoin is inflammatory in vivo and activates the NALP3 inflammasome via release of uric acid. |
Volume: |
183 |
Issue: |
8 |
Pages: |
5208-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohno T |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages. |
Volume: |
183 |
Issue: |
12 |
Pages: |
7890-7 |
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•
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•
•
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Publication |
First Author: |
Cunningham CC |
Year: |
2012 |
Journal: |
Clin Immunol |
Title: |
Osteoarthritis-associated basic calcium phosphate crystals induce pro-inflammatory cytokines and damage-associated molecules via activation of Syk and PI3 kinase. |
Volume: |
144 |
Issue: |
3 |
Pages: |
228-36 |
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•
•
•
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Publication |
First Author: |
Erener S |
Year: |
2012 |
Journal: |
Mol Cell |
Title: |
Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-κB target genes. |
Volume: |
46 |
Issue: |
2 |
Pages: |
200-11 |
|
•
•
•
•
•
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Publication |
First Author: |
Man SM |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1β production. |
Volume: |
191 |
Issue: |
10 |
Pages: |
5239-46 |
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•
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•
•
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Publication |
First Author: |
Karmakar M |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP. |
Volume: |
7 |
|
Pages: |
10555 |
|
•
•
•
•
•
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Publication |
First Author: |
Reinke S |
Year: |
2020 |
Journal: |
Cell Rep |
Title: |
Non-canonical Caspase-1 Signaling Drives RIP2-Dependent and TNF-α-Mediated Inflammation In Vivo. |
Volume: |
30 |
Issue: |
8 |
Pages: |
2501-2511.e5 |
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•
•
•
•
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Publication |
First Author: |
Yang J |
Year: |
2016 |
Journal: |
Cell Death Dis |
Title: |
Hemorrhagic shock primes for lung vascular endothelial cell pyroptosis: role in pulmonary inflammation following LPS. |
Volume: |
7 |
Issue: |
9 |
Pages: |
e2363 |
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•
•
•
•
•
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Publication |
First Author: |
Jang KK |
Year: |
2023 |
Journal: |
Cell Host Microbe |
Title: |
Antimicrobial overproduction sustains intestinal inflammation by inhibiting Enterococcus colonization. |
Volume: |
31 |
Issue: |
9 |
Pages: |
1450-1468.e8 |
|
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•
•
•
•
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Publication |
First Author: |
Hara H |
Year: |
2018 |
Journal: |
Cell |
Title: |
The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection. |
Volume: |
175 |
Issue: |
6 |
Pages: |
1651-1664.e14 |
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•
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•
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Publication |
First Author: |
Masters SL |
Year: |
2012 |
Journal: |
Immunity |
Title: |
NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells. |
Volume: |
37 |
Issue: |
6 |
Pages: |
1009-23 |
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Publication |
First Author: |
Donado CA |
Year: |
2020 |
Journal: |
Cell Rep |
Title: |
A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling. |
Volume: |
31 |
Issue: |
1 |
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107466 |
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Publication |
First Author: |
Yao Y |
Year: |
2017 |
Journal: |
Nat Commun |
Title: |
Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin. |
Volume: |
8 |
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Pages: |
15402 |
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Publication |
First Author: |
Wang W |
Year: |
2022 |
Journal: |
Cell Rep |
Title: |
Mobilizing phospholipids on tumor plasma membrane implicates phosphatidylserine externalization blockade for cancer immunotherapy. |
Volume: |
41 |
Issue: |
5 |
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111582 |
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Publication |
First Author: |
Dostert C |
Year: |
2009 |
Journal: |
PLoS One |
Title: |
Malarial hemozoin is a Nalp3 inflammasome activating danger signal. |
Volume: |
4 |
Issue: |
8 |
Pages: |
e6510 |
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Publication |
First Author: |
Nozaki K |
Year: |
2022 |
Journal: |
Nature |
Title: |
Caspase-7 activates ASM to repair gasdermin and perforin pores. |
Volume: |
606 |
Issue: |
7916 |
Pages: |
960-967 |
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Publication |
First Author: |
Gasse P |
Year: |
2009 |
Journal: |
Am J Respir Crit Care Med |
Title: |
Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis. |
Volume: |
179 |
Issue: |
10 |
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903-13 |
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Publication |
First Author: |
Gomes MT |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
Critical role of ASC inflammasomes and bacterial type IV secretion system in caspase-1 activation and host innate resistance to Brucella abortus infection. |
Volume: |
190 |
Issue: |
7 |
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3629-38 |
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Publication |
First Author: |
Duffy EB |
Year: |
2016 |
Journal: |
J Leukoc Biol |
Title: |
FcγR mediates TLR2- and Syk-dependent NLRP3 inflammasome activation by inactivated Francisella tularensis LVS immune complexes. |
Volume: |
100 |
Issue: |
6 |
Pages: |
1335-1347 |
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Publication |
First Author: |
Deng M |
Year: |
2015 |
Journal: |
Sci Signal |
Title: |
Shedding of the tumor necrosis factor (TNF) receptor from the surface of hepatocytes during sepsis limits inflammation through cGMP signaling. |
Volume: |
8 |
Issue: |
361 |
Pages: |
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First Author: |
Hildebrand JM |
Year: |
2020 |
Journal: |
Nat Commun |
Title: |
A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction. |
Volume: |
11 |
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First Author: |
Pinto AK |
Year: |
2014 |
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PLoS Pathog |
Title: |
Deficient IFN signaling by myeloid cells leads to MAVS-dependent virus-induced sepsis. |
Volume: |
10 |
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4 |
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e1004086 |
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Year: |
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Cell Rep |
Title: |
Cyclopentenone Prostaglandins and Structurally Related Oxidized Lipid Species Instigate and Share Distinct Pro- and Anti-inflammatory Pathways. |
Volume: |
30 |
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4399-4417.e7 |
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First Author: |
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Year: |
2020 |
Journal: |
Nature |
Title: |
Galactosaminogalactan activates the inflammasome to provide host protection. |
Volume: |
588 |
Issue: |
7839 |
Pages: |
688-692 |
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First Author: |
de Vasconcelos NM |
Year: |
2020 |
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Cell Rep |
Title: |
An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages. |
Volume: |
32 |
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First Author: |
Dutra FF |
Year: |
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Journal: |
Proc Natl Acad Sci U S A |
Title: |
Hemolysis-induced lethality involves inflammasome activation by heme. |
Volume: |
111 |
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First Author: |
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Nature |
Title: |
Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. |
Volume: |
546 |
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First Author: |
Zheng M |
Year: |
2020 |
Journal: |
Cell |
Title: |
Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense. |
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181 |
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First Author: |
Dupaul-Chicoine J |
Year: |
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Journal: |
Immunity |
Title: |
The Nlrp3 Inflammasome Suppresses Colorectal Cancer Metastatic Growth in the Liver by Promoting Natural Killer Cell Tumoricidal Activity. |
Volume: |
43 |
Issue: |
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A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread. |
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TLR9-independent CD8(+) T cell responses in hepatic AAV gene transfer through IL-1R1-MyD88 signaling. |
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Insights into the Role of Innate Immunity in Cervicovaginal Papillomavirus Infection from Studies Using Gene-Deficient Mice. |
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Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium. |
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Cell Rep |
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Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium. |
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Nat Microbiol |
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2020 |
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J Immunol |
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RIPK3 Promotes Mefv Expression and Pyrin Inflammasome Activation via Modulation of mTOR Signaling. |
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10 |
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Cell |
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Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
686
 |
Fragment?: |
false |
|
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
686
 |
Fragment?: |
false |
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Publication |
First Author: |
Pierini R |
Year: |
2012 |
Journal: |
Cell Death Differ |
Title: |
AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages. |
Volume: |
19 |
Issue: |
10 |
Pages: |
1709-21 |
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Publication |
First Author: |
Sheedy FJ |
Year: |
2013 |
Journal: |
Nat Immunol |
Title: |
CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation. |
Volume: |
14 |
Issue: |
8 |
Pages: |
812-20 |
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Publication |
First Author: |
Jones JW |
Year: |
2010 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis. |
Volume: |
107 |
Issue: |
21 |
Pages: |
9771-6 |
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Publication |
First Author: |
Nett MA |
Year: |
1992 |
Journal: |
J Immunol |
Title: |
Molecular cloning of the murine IL-1 beta converting enzyme cDNA. |
Volume: |
149 |
Issue: |
10 |
Pages: |
3254-9 |
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Publication |
First Author: |
Van de Craen M |
Year: |
1997 |
Journal: |
FEBS Lett |
Title: |
Characterization of seven murine caspase family members. |
Volume: |
403 |
Issue: |
1 |
Pages: |
61-9 |
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Publication |
First Author: |
Tamura M |
Year: |
2007 |
Journal: |
Genomics |
Title: |
Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner. |
Volume: |
89 |
Issue: |
5 |
Pages: |
618-29 |
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Publication |
First Author: |
Orning P |
Year: |
2018 |
Journal: |
Science |
Title: |
Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death. |
Volume: |
362 |
Issue: |
6418 |
Pages: |
1064-1069 |
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Publication |
First Author: |
Zhao Y |
Year: |
2011 |
Journal: |
Nature |
Title: |
The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus. |
Volume: |
477 |
Issue: |
7366 |
Pages: |
596-600 |
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Publication |
First Author: |
Boyden ED |
Year: |
2006 |
Journal: |
Nat Genet |
Title: |
Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. |
Volume: |
38 |
Issue: |
2 |
Pages: |
240-4 |
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Publication |
First Author: |
Lara-Tejero M |
Year: |
2006 |
Journal: |
J Exp Med |
Title: |
Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis. |
Volume: |
203 |
Issue: |
6 |
Pages: |
1407-12 |
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Publication |
First Author: |
Levy M |
Year: |
2015 |
Journal: |
Cell |
Title: |
Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling. |
Volume: |
163 |
Issue: |
6 |
Pages: |
1428-43 |
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Publication |
First Author: |
Samir P |
Year: |
2019 |
Journal: |
Nature |
Title: |
DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome. |
Volume: |
573 |
Issue: |
7775 |
Pages: |
590-594 |
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Publication |
First Author: |
Mariathasan S |
Year: |
2006 |
Journal: |
Nature |
Title: |
Cryopyrin activates the inflammasome in response to toxins and ATP. |
Volume: |
440 |
Issue: |
7081 |
Pages: |
228-32 |
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Publication |
First Author: |
Tortola L |
Year: |
2012 |
Journal: |
J Clin Invest |
Title: |
Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalk. |
Volume: |
122 |
Issue: |
11 |
Pages: |
3965-76 |
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Publication |
First Author: |
Lu B |
Year: |
2012 |
Journal: |
Nature |
Title: |
Novel role of PKR in inflammasome activation and HMGB1 release. |
Volume: |
488 |
Issue: |
7413 |
Pages: |
670-4 |
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Publication |
First Author: |
Sakamaki K |
Year: |
1998 |
Journal: |
Eur J Biochem |
Title: |
Molecular cloning and characterization of mouse caspase-8. |
Volume: |
253 |
Issue: |
2 |
Pages: |
399-405 |
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Publication |
First Author: |
Van de Craen M |
Year: |
1998 |
Journal: |
J Mol Biol |
Title: |
Molecular cloning and identification of murine caspase-8. |
Volume: |
284 |
Issue: |
4 |
Pages: |
1017-26 |
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Publication |
First Author: |
Fritsch M |
Year: |
2019 |
Journal: |
Nature |
Title: |
Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis. |
Volume: |
575 |
Issue: |
7784 |
Pages: |
683-687 |
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Publication |
First Author: |
Gladiator A |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
Cutting edge: IL-17-secreting innate lymphoid cells are essential for host defense against fungal infection. |
Volume: |
190 |
Issue: |
2 |
Pages: |
521-5 |
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Publication |
First Author: |
Jhingran A |
Year: |
2015 |
Journal: |
PLoS Pathog |
Title: |
Compartment-specific and sequential role of MyD88 and CARD9 in chemokine induction and innate defense during respiratory fungal infection. |
Volume: |
11 |
Issue: |
1 |
Pages: |
e1004589 |
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Publication |
First Author: |
Ydens E |
Year: |
2015 |
Journal: |
J Neuroinflammation |
Title: |
Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes. |
Volume: |
12 |
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Pages: |
143 |
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Publication |
First Author: |
Bruchard M |
Year: |
2015 |
Journal: |
Nat Immunol |
Title: |
The receptor NLRP3 is a transcriptional regulator of TH2 differentiation. |
Volume: |
16 |
Issue: |
8 |
Pages: |
859-70 |
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Publication |
First Author: |
Guarda G |
Year: |
2009 |
Journal: |
Nature |
Title: |
T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes. |
Volume: |
460 |
Issue: |
7252 |
Pages: |
269-73 |
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Publication |
First Author: |
Burns K |
Year: |
2000 |
Journal: |
Nat Cell Biol |
Title: |
Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. |
Volume: |
2 |
Issue: |
6 |
Pages: |
346-51 |
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Publication |
First Author: |
Banoth B |
Year: |
2020 |
Journal: |
J Biol Chem |
Title: |
ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis). |
Volume: |
295 |
Issue: |
52 |
Pages: |
18276-18283 |
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Publication |
First Author: |
Devos M |
Year: |
2020 |
Journal: |
J Exp Med |
Title: |
Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation. |
Volume: |
217 |
Issue: |
7 |
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Publication |
First Author: |
Stienstra R |
Year: |
2010 |
Journal: |
Cell Metab |
Title: |
The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity. |
Volume: |
12 |
Issue: |
6 |
Pages: |
593-605 |
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Publication |
First Author: |
Biffi G |
Year: |
2019 |
Journal: |
Cancer Discov |
Title: |
IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma. |
Volume: |
9 |
Issue: |
2 |
Pages: |
282-301 |
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Publication |
First Author: |
Nagareddy PR |
Year: |
2014 |
Journal: |
Cell Metab |
Title: |
Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity. |
Volume: |
19 |
Issue: |
5 |
Pages: |
821-35 |
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Publication |
First Author: |
Sun S |
Year: |
2012 |
Journal: |
Diabetes |
Title: |
The ATP-P2X7 signaling axis is dispensable for obesity-associated inflammasome activation in adipose tissue. |
Volume: |
61 |
Issue: |
6 |
Pages: |
1471-8 |
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