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Search results 2601 to 2700 out of 3029 for Pdx1

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Type Details Score
Genotype
Genotype
Symbol: Lats1/Lats1 Lats2/Lats2 Tg(Pdx1-cre)89.1Dam/?
Background: involves: 129S6/SvEvTac * C57BL/6Brd * CBA * CD-1
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kdm6b/Kdm6b Neurog3/Neurog3<+> Tg(Pdx1-cre)6Tuv/?
Background: involves: 129S6/SvEvTac * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rr124128/Rr124128 Tg(Pdx1-cre)6Tuv/?
Background: involves: C57BL/6J * C57BL/6N * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Publication
18421434 | J:137920
First Author: Mehrabian M
Year: 2008
Journal: Diabetologia
Title: Identification of ALOX5 as a gene regulating adiposity and pancreatic function.
Volume: 51
Issue: 6
Pages: 978-88
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Publication
26546129 | J:230840
First Author: Jurczyk A
Year: 2016
Journal: FASEB J
Title: Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β.
Volume: 30
Issue: 2
Pages: 983-93
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Publication
28642969 | J:252014
First Author: Ida S
Year: 2017
Journal: Diabetologia
Title: Diverse metabolic effects of O-GlcNAcylation in the pancreas but limited effects in insulin-sensitive organs in mice.
Volume: 60
Issue: 9
Pages: 1761-1769
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Publication
12493745 | J:82924
First Author: Terauchi Y
Year: 2003
Journal: J Biol Chem
Title: Impact of genetic background and ablation of insulin receptor substrate (IRS)-3 on IRS-2 knock-out mice.
Volume: 278
Issue: 16
Pages: 14284-90
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Publication
23531612 | J:198216
First Author: Crivello M
Year: 2013
Journal: Am J Physiol Endocrinol Metab
Title: Postnatal development of the endocrine pancreas in mice lacking functional GABAB receptors.
Volume: 304
Issue: 10
Pages: E1064-76
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Publication
22374815 | J:188469
First Author: Johnson CL
Year: 2012
Journal: J Pathol
Title: Activation of protein kinase Cδ leads to increased pancreatic acinar cell dedifferentiation in the absence of MIST1.
Volume: 228
Issue: 3
Pages: 351-65
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Publication
24989997 | J:218130
First Author: Chen YC
Year: 2014
Journal: Diabetologia
Title: Mig6 haploinsufficiency protects mice against streptozotocin-induced diabetes.
Volume: 57
Issue: 10
Pages: 2066-75
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Publication
23251699 | J:195661
First Author: van der Meulen T
Year: 2012
Journal: PLoS One
Title: Urocortin 3 marks mature human primary and embryonic stem cell-derived pancreatic alpha and beta cells.
Volume: 7
Issue: 12
Pages: e52181
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Publication
28377501 | J:243672
First Author: Mitchell RK
Year: 2017
Journal: J Biol Chem
Title: The transcription factor Pax6 is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca2+ dynamics in adult mice.
Volume: 292
Issue: 21
Pages: 8892-8906
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Publication
22230751 | J:182707
First Author: Miki R
Year: 2012
Journal: Mech Dev
Title: Fate maps of ventral and dorsal pancreatic progenitor cells in early somite stage mouse embryos.
Volume: 128
Issue: 11-12
Pages: 597-609
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Publication
1825611 | -
First Author: Russell GC
Year: 1991
Journal: Biochim Biophys Acta
Title: Sequence similarities within the family of dihydrolipoamide acyltransferases and discovery of a previously unidentified fungal enzyme.
Volume: 1076
Issue: 2
Pages: 225-32
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Publication
20865670 | -
First Author: Kang HS
Year: 2010
Journal: Histol Histopathol
Title: Gli-similar (Glis) Krüppel-like zinc finger proteins: insights into their physiological functions and critical roles in neonatal diabetes and cystic renal disease.
Volume: 25
Issue: 11
Pages: 1481-96
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Publication
21996748 | J:186130
First Author: Whipple CA
Year: 2012
Journal: Oncogene
Title: A KrasG12D-driven genetic mouse model of pancreatic cancer requires glypican-1 for efficient proliferation and angiogenesis.
Volume: 31
Issue: 20
Pages: 2535-44
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Publication
22565310 | J:188293
First Author: Hamidi T
Year: 2012
Journal: J Clin Invest
Title: Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis.
Volume: 122
Issue: 6
Pages: 2092-103
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Publication
24949970 | J:214528
First Author: Soleimanpour SA
Year: 2014
Journal: Cell
Title: The diabetes susceptibility gene Clec16a regulates mitophagy.
Volume: 157
Issue: 7
Pages: 1577-90
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Publication
21051638 | J:218666
First Author: Kraman M
Year: 2010
Journal: Science
Title: Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha.
Volume: 330
Issue: 6005
Pages: 827-30
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Publication
20627934 | J:169626
First Author: Artner I
Year: 2010
Journal: Diabetes
Title: MafA and MafB regulate genes critical to beta-cells in a unique temporal manner.
Volume: 59
Issue: 10
Pages: 2530-9
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Publication
32179091 | J:348824
First Author: Ma Y
Year: 2020
Journal: Gastroenterology
Title: Combination of PD-1 Inhibitor and OX40 Agonist Induces Tumor Rejection and Immune Memory in Mouse Models of Pancreatic Cancer.
Volume: 159
Issue: 1
Pages: 306-319.e12
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Publication
21059956 | J:166586
First Author: Yang Y
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Reversal of preexisting hyperglycemia in diabetic mice by acute deletion of the Men1 gene.
Volume: 107
Issue: 47
Pages: 20358-63
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Publication
29914854 | J:315908
 
First Author: Burke SJ
Year: 2018
Journal: Mol Metab
Title: Pancreatic deletion of the interleukin-1 receptor disrupts whole body glucose homeostasis and promotes islet β-cell de-differentiation.
Volume: 14
Pages: 95-107
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Publication
35479410 | J:332306
First Author: Nayak D
Year: 2022
Journal: iScience
Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer.
Volume: 25
Issue: 5
Pages: 104193
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Publication
30366930 | J:271300
First Author: Biffi G
Year: 2019
Journal: Cancer Discov
Title: IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma.
Volume: 9
Issue: 2
Pages: 282-301
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Publication
37641131 | J:348898
First Author: Bastos N
Year: 2023
Journal: J Transl Med
Title: SMC3 epigenetic silencing regulates Rab27a expression and drives pancreatic cancer progression.
Volume: 21
Issue: 1
Pages: 578
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Publication
26479921 | J:228885
First Author: Alam MS
Year: 2015
Journal: Nat Med
Title: Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits pancreatic cancer progression.
Volume: 21
Issue: 11
Pages: 1337-43
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Publication
36384095 | J:348556
First Author: Frank KJ
Year: 2022
Journal: Cell Rep Med
Title: Extensive preclinical validation of combined RMC-4550 and LY3214996 supports clinical investigation for KRAS mutant pancreatic cancer.
Volume: 3
Issue: 11
Pages: 100815
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Publication
23873029 | J:212617
First Author: Tan EH
Year: 2014
Journal: Oncogene
Title: Functions of TAp63 and p53 in restraining the development of metastatic cancer.
Volume: 33
Issue: 25
Pages: 3325-33
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Publication
33323382 | J:303990
First Author: Kon N
Year: 2021
Journal: Cancer Res
Title: Robust p53 Stabilization Is Dispensable for Its Activation and Tumor Suppressor Function.
Volume: 81
Issue: 4
Pages: 935-944
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Publication
34188043 | J:307917
First Author: Isermann T
Year: 2021
Journal: Nat Commun
Title: Suppression of HSF1 activity by wildtype p53 creates a driving force for p53 loss-of-heterozygosity.
Volume: 12
Issue: 1
Pages: 4019
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Publication
34388391 | J:316758
First Author: Koikawa K
Year: 2021
Journal: Cell
Title: Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy.
Volume: 184
Issue: 18
Pages: 4753-4771.e27
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Publication
31911451 | J:285832
First Author: Zhang Y
Year: 2020
Journal: Cancer Discov
Title: Regulatory T-cell Depletion Alters the Tumor Microenvironment and Accelerates Pancreatic Carcinogenesis.
Volume: 10
Issue: 3
Pages: 422-439
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Publication
38935717 | J:352250
First Author: Mahadevan KK
Year: 2024
Journal: Science
Title: Type I conventional dendritic cells facilitate immunotherapy in pancreatic cancer.
Volume: 384
Issue: 6703
Pages: eadh4567
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Publication
31183403 | J:288756
First Author: Hari P
Year: 2019
Journal: Sci Adv
Title: The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype.
Volume: 5
Issue: 6
Pages: eaaw0254
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Publication
22738914 | J:191028
First Author: Lampson BL
Year: 2012
Journal: Cancer Res
Title: Targeting eNOS in pancreatic cancer.
Volume: 72
Issue: 17
Pages: 4472-82
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Publication
28808255 | J:250841
First Author: Zaytouni T
Year: 2017
Journal: Nat Commun
Title: Critical role for arginase 2 in obesity-associated pancreatic cancer.
Volume: 8
Issue: 1
Pages: 242
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Publication
18515092 | J:141804
First Author: Fendrich V
Year: 2008
Journal: Gastroenterology
Title: Hedgehog signaling is required for effective regeneration of exocrine pancreas.
Volume: 135
Issue: 2
Pages: 621-31
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Publication
29533787 | J:258620
First Author: Andricovich J
Year: 2018
Journal: Cancer Cell
Title: Loss of KDM6A Activates Super-Enhancers to Induce Gender-Specific Squamous-like Pancreatic Cancer and Confers Sensitivity to BET Inhibitors.
Volume: 33
Issue: 3
Pages: 512-526.e8
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Publication
17114584 | J:116130
First Author: Bardeesy N
Year: 2006
Journal: Genes Dev
Title: Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer.
Volume: 20
Issue: 22
Pages: 3130-46
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Publication
28294115 | J:244261
 
First Author: Gundry C
Year: 2017
Journal: Nat Commun
Title: Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion.
Volume: 8
Pages: 14646
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Publication
22113502 | J:198619
First Author: Qiu W
Year: 2011
Journal: Oncotarget
Title: Disruption of p16 and activation of Kras in pancreas increase ductal adenocarcinoma formation and metastasis in vivo.
Volume: 2
Issue: 11
Pages: 862-73
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Publication
16585505 | J:108298
First Author: Bardeesy N
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse.
Volume: 103
Issue: 15
Pages: 5947-52
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Publication
20807812 | J:164210
First Author: Hill R
Year: 2010
Journal: Cancer Res
Title: PTEN loss accelerates KrasG12D-induced pancreatic cancer development.
Volume: 70
Issue: 18
Pages: 7114-24
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Publication
22611036 | J:187012
First Author: Singh M
Year: 2012
Journal: J Pathol
Title: Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumour models.
Volume: 227
Issue: 4
Pages: 417-30
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Publication
21056012 | J:166678
First Author: Skoulidis F
Year: 2010
Journal: Cancer Cell
Title: Germline Brca2 heterozygosity promotes Kras(G12D) -driven carcinogenesis in a murine model of familial pancreatic cancer.
Volume: 18
Issue: 5
Pages: 499-509
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Publication
25878147 | J:220300
First Author: Massó-Vallés D
Year: 2015
Journal: Cancer Res
Title: Ibrutinib exerts potent antifibrotic and antitumor activities in mouse models of pancreatic adenocarcinoma.
Volume: 75
Issue: 8
Pages: 1675-81
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Publication
35188462 | J:343962
   
First Author: Marcheva B
Year: 2022
Journal: Elife
Title: P2Y1 purinergic receptor identified as a diabetes target in a small-molecule screen to reverse circadian β-cell failure.
Volume: 11
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Publication
21481787 | J:170982
First Author: Fukuda A
Year: 2011
Journal: Cancer Cell
Title: Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression.
Volume: 19
Issue: 4
Pages: 441-55
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Publication
29490942 | J:262303
First Author: Sangrador I
Year: 2018
Journal: Cancer Res
Title: Zeb1 in Stromal Myofibroblasts Promotes Kras-Driven Development of Pancreatic Cancer.
Volume: 78
Issue: 10
Pages: 2624-2637
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Publication
18725219 | J:142261
First Author: Heiser PW
Year: 2008
Journal: Gastroenterology
Title: Stabilization of beta-catenin induces pancreas tumor formation.
Volume: 135
Issue: 4
Pages: 1288-300
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Publication
25259922 | J:214947
First Author: Sherman MH
Year: 2014
Journal: Cell
Title: Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy.
Volume: 159
Issue: 1
Pages: 80-93
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Publication
19208348 | J:148722
First Author: Golson ML
Year: 2009
Journal: Gastroenterology
Title: Ductal malformation and pancreatitis in mice caused by conditional Jag1 deletion.
Volume: 136
Issue: 5
Pages: 1761-71.e1
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Publication
32591410 | J:296309
First Author: Yamauchi Y
Year: 2020
Journal: Cancer Res
Title: Rb and p53 Execute Distinct Roles in the Development of Pancreatic Neuroendocrine Tumors.
Volume: 80
Issue: 17
Pages: 3620-3630
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Publication
19022256 | J:146087
First Author: Bonal C
Year: 2009
Journal: Gastroenterology
Title: Pancreatic inactivation of c-Myc decreases acinar mass and transdifferentiates acinar cells into adipocytes in mice.
Volume: 136
Issue: 1
Pages: 309-319.e9
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Publication
21474066 | J:310528
First Author: Kennedy AL
Year: 2011
Journal: Mol Cell
Title: Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis.
Volume: 42
Issue: 1
Pages: 36-49
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Publication
31578522 | J:283349
First Author: Aykut B
Year: 2019
Journal: Nature
Title: The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL.
Volume: 574
Issue: 7777
Pages: 264-267
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Publication
24747746 | J:213238
First Author: Wang L
Year: 2014
Journal: Nat Med
Title: Pten deletion in RIP-Cre neurons protects against type 2 diabetes by activating the anti-inflammatory reflex.
Volume: 20
Issue: 5
Pages: 484-92
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Publication
26452271 | J:243686
First Author: Weyandt JD
Year: 2015
Journal: PLoS One
Title: Wild-Type Hras Suppresses the Earliest Stages of Tumorigenesis in a Genetically Engineered Mouse Model of Pancreatic Cancer.
Volume: 10
Issue: 10
Pages: e0140253
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Publication
12814555 | J:128154
First Author: Lammert E
Year: 2003
Journal: Curr Biol
Title: Role of VEGF-A in vascularization of pancreatic islets.
Volume: 13
Issue: 12
Pages: 1070-4
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Publication
31270275 | J:277117
 
First Author: Panni RZ
Year: 2019
Journal: Sci Transl Med
Title: Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies.
Volume: 11
Issue: 499
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Publication
26279302 | J:309335
First Author: Zhang S
Year: 2016
Journal: Oncogene
Title: Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer.
Volume: 35
Issue: 19
Pages: 2485-95
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Publication
26151762 | J:225995
   
First Author: Krah NM
Year: 2015
Journal: Elife
Title: The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma.
Volume: 4
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Publication
24305049 | J:207920
First Author: Rosenfeldt MT
Year: 2013
Journal: Nature
Title: p53 status determines the role of autophagy in pancreatic tumour development.
Volume: 504
Issue: 7479
Pages: 296-300
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Publication
39037766 | J:353863
First Author: Bermejo-Rodriguez C
Year: 2024
Journal: Cancer Res
Title: Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis.
Volume: 84
Issue: 18
Pages: 2968-2984
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Publication
31534224 | J:280631
First Author: Morris JP 4th
Year: 2019
Journal: Nature
Title: α-Ketoglutarate links p53 to cell fate during tumour suppression.
Volume: 573
Issue: 7775
Pages: 595-599
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Publication
21266354 | J:169401
First Author: Timpson P
Year: 2011
Journal: Cancer Res
Title: Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53.
Volume: 71
Issue: 3
Pages: 747-57
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Publication
22945649 | J:199980
First Author: Norris AM
Year: 2013
Journal: Oncogene
Title: AGR2 is a SMAD4-suppressible gene that modulates MUC1 levels and promotes the initiation and progression of pancreatic intraepithelial neoplasia.
Volume: 32
Issue: 33
Pages: 3867-76
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Publication
33127675 | J:313903
 
First Author: Rossi Sebastiano M
Year: 2020
Journal: Sci Adv
Title: ACSL3-PAI-1 signaling axis mediates tumor-stroma cross-talk promoting pancreatic cancer progression.
Volume: 6
Issue: 44
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Publication
24642931 | J:257234
 
First Author: Cruz-Monserrate Z
Year: 2014
Journal: Sci Rep
Title: Targeting pancreatic ductal adenocarcinoma acidic microenvironment.
Volume: 4
Pages: 4410
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Publication
37169967 | J:335562
     
First Author: Ely ZA
Year: 2023
Journal: Nat Biotechnol
Title: A prime editor mouse to model a broad spectrum of somatic mutations in vivo.
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Publication
31940491 | J:287255
First Author: Blagih J
Year: 2020
Journal: Cell Rep
Title: Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses.
Volume: 30
Issue: 2
Pages: 481-496.e6
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Publication
26438692 | J:226536
First Author: Gopinathan A
Year: 2015
Journal: Dis Model Mech
Title: GEMMs as preclinical models for testing pancreatic cancer therapies.
Volume: 8
Issue: 10
Pages: 1185-200
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Publication
24362629 | J:208277
First Author: Mohseni M
Year: 2014
Journal: Nat Cell Biol
Title: A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway.
Volume: 16
Issue: 1
Pages: 108-17
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Publication
24898060 | J:214456
First Author: Alderton GK
Year: 2014
Journal: Nat Rev Cancer
Title: Microenvironment: An exercise in restraint.
Volume: 14
Issue: 7
Pages: 449
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Publication
24784840 | J:212549
First Author: Park JW
Year: 2014
Journal: Mol Cancer Res
Title: Cooperativity of E-cadherin and Smad4 loss to promote diffuse-type gastric adenocarcinoma and metastasis.
Volume: 12
Issue: 8
Pages: 1088-99
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Publication
27506299 | J:310029
First Author: Grünwald B
Year: 2016
Journal: Gastroenterology
Title: Pancreatic Premalignant Lesions Secrete Tissue Inhibitor of Metalloproteinases-1, Which Activates Hepatic Stellate Cells Via CD63 Signaling to Create a Premetastatic Niche in the Liver.
Volume: 151
Issue: 5
Pages: 1011-1024.e7
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Publication
26929329 | J:230996
First Author: Saloman JL
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer.
Volume: 113
Issue: 11
Pages: 3078-83
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Publication
32648540 | J:293907
   
First Author: Lau AN
Year: 2020
Journal: Elife
Title: Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma.
Volume: 9
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Publication
29596465 | J:261064
First Author: Germino EA
Year: 2018
Journal: PLoS One
Title: Homozygous KSR1 deletion attenuates morbidity but does not prevent tumor development in a mouse model of RAS-driven pancreatic cancer.
Volume: 13
Issue: 3
Pages: e0194998
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Publication
24856585 | J:213505
First Author: Rhim AD
Year: 2014
Journal: Cancer Cell
Title: Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma.
Volume: 25
Issue: 6
Pages: 735-47
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Publication
22698406 | J:189283
First Author: Bayne LJ
Year: 2012
Journal: Cancer Cell
Title: Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer.
Volume: 21
Issue: 6
Pages: 822-35
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Publication
22265420 | J:181291
First Author: Rhim AD
Year: 2012
Journal: Cell
Title: EMT and dissemination precede pancreatic tumor formation.
Volume: 148
Issue: 1-2
Pages: 349-61
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Publication
23284900 | J:195622
First Author: Avila JL
Year: 2012
Journal: PLoS One
Title: Notch1 is not required for acinar-to-ductal metaplasia in a model of Kras-induced pancreatic ductal adenocarcinoma.
Volume: 7
Issue: 12
Pages: e52133
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Publication
22439937 | J:189345
First Author: Provenzano PP
Year: 2012
Journal: Cancer Cell
Title: Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma.
Volume: 21
Issue: 3
Pages: 418-29
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Publication
23384121 | J:196611
First Author: van Asselt SJ
Year: 2013
Journal: Cilia
Title: Pancreatic cyst development: insights from von Hippel-Lindau disease.
Volume: 2
Issue: 1
Pages: 3
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Publication
23977255 | J:206428
First Author: Puri S
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