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Search results 2701 to 2800 out of 4514 for Cdc42

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Type Details Score
Publication
First Author: Cen H
Year: 1993
Journal: Mol Cell Biol
Title: Regulated and constitutive activity by CDC25Mm (GRF), a Ras-specific exchange factor.
Volume: 13
Issue: 12
Pages: 7718-24
Publication
First Author: Crespo P
Year: 2011
Journal: Bioarchitecture
Title: Ras and Rho GTPases on the move: The RasGRF connection.
Volume: 1
Issue: 4
Pages: 200-204
Publication
First Author: Fernández-Medarde A
Year: 2011
Journal: Biochim Biophys Acta
Title: The RasGrf family of mammalian guanine nucleotide exchange factors.
Volume: 1815
Issue: 2
Pages: 170-88
Publication  
First Author: Faghihi MA
Year: 2010
Journal: PLoS One
Title: RNAi screen indicates widespread biological function for human natural antisense transcripts.
Volume: 5
Issue: 10
Protein Domain
Type: Family
Description: Serine/threonine-protein kinase MRCK (myotonic dystrophy kinase-related CDC42-binding kinase) is an serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in actin-myosin regulation and activities including cell adhesion, motility and invasion [, ]. Three isoforms have been described in mammals: alpha, beta and gamma [, ]. This entry represent the serine/threonine-protein kinase MRCK alpha. It also includes the Drosophila homologue Genghis khan (Gek) [, ].
Protein Domain
Type: Family
Description: Formin-binding protein 1-like (FNBP1L, also known as Toca-1) is part of the Toca-1-N-WASP complex that induces the formation of filopodia and endocytic vesicles []. FNBP1L consists of an F-BAR domain, a Cdc42 binding site and an SH3 domain []. It belongs to the CIP4 (Cdc42 interacting protein-4) subfamily of the F-BAR (F for FCH, Fer-CIP4 homology domain) protein family. The F-BAR proteins have been implicated in cell membrane processes such as membrane invagination, tubulation and endocytosis [].
Protein Domain
Type: Family
Description: Serine/threonine-protein kinase MRCK (myotonic dystrophy kinase-related CDC42-binding kinase) is an serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in actin-myosin regulation and activities including cell adhesion, motility and invasion [, ]. Three isoforms have been described in mammals: alpha, beta and gamma [, ]. This entry represent the serine/threonine-protein kinase MRCK beta. It may have important roles in tumour progression [].
Protein Domain
Type: Family
Description: Cell cycle progression protein 1 (CCPG1), also known as cell cycle progression restoration protein 8 (CPR8) [], is a scaffold protein that interacts with the Rho guanine nucleotide exchange factor Dbs and modulates its exchange specificity. CCPG1 binds to the Dbl homology/pleckstrin homology domain tandem motif of Dbs and inhibits its exchange activity toward RhoA, but not Cdc42 []. CCPG1 may be involved in cell cycle regulation [].
Publication
First Author: Worthylake DK
Year: 2004
Journal: Structure
Title: Crystal structure of the DH/PH fragment of Dbs without bound GTPase.
Volume: 12
Issue: 6
Pages: 1078-86
Publication
First Author: Ieguchi K
Year: 2007
Journal: J Biol Chem
Title: Role of the guanine nucleotide exchange factor Ost in negative regulation of receptor endocytosis by the small GTPase Rac1.
Volume: 282
Issue: 32
Pages: 23296-305
Protein
Organism: Mus musculus/domesticus
Length: 118  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 195  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 155  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 338  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 178  
Fragment?: false
Publication
First Author: Symons M
Year: 1996
Journal: Cell
Title: Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization.
Volume: 84
Issue: 5
Pages: 723-34
Publication
First Author: Thompson G
Year: 1998
Journal: Biochemistry
Title: Delineation of the Cdc42/Rac-binding domain of p21-activated kinase.
Volume: 37
Issue: 21
Pages: 7885-91
Publication
First Author: Lei M
Year: 2000
Journal: Cell
Title: Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch.
Volume: 102
Issue: 3
Pages: 387-97
Publication
First Author: Hoffman GR
Year: 2000
Journal: Cell
Title: Flipping the switch: the structural basis for signaling through the CRIB motif.
Volume: 102
Issue: 4
Pages: 403-6
Publication
First Author: Ng Y
Year: 2004
Journal: J Biol Chem
Title: Expression of the human myotonic dystrophy kinase-related Cdc42-binding kinase gamma is regulated by promoter DNA methylation and Sp1 binding.
Volume: 279
Issue: 33
Pages: 34156-64
Publication
First Author: Tan I
Year: 2008
Journal: Cell
Title: A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow.
Volume: 135
Issue: 1
Pages: 123-36
Publication
First Author: Tan I
Year: 2011
Journal: FEBS Lett
Title: Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase.
Volume: 585
Issue: 9
Pages: 1260-8
Publication
First Author: Unbekandt M
Year: 2014
Journal: J Mol Med (Berl)
Title: The actin-myosin regulatory MRCK kinases: regulation, biological functions and associations with human cancer.
Volume: 92
Issue: 3
Pages: 217-25
Publication
First Author: Bu W
Year: 2009
Journal: J Biol Chem
Title: The Toca-1-N-WASP complex links filopodial formation to endocytosis.
Volume: 284
Issue: 17
Pages: 11622-36
Publication
First Author: Liu Z
Year: 2009
Journal: J Biol Chem
Title: The rho-specific guanine nucleotide exchange factor Dbs regulates breast cancer cell migration.
Volume: 284
Issue: 23
Pages: 15771-80
Publication
First Author: Kostenko EV
Year: 2005
Journal: J Biol Chem
Title: The Sec14 homology domain regulates the cellular distribution and transforming activity of the Rho-specific guanine nucleotide exchange factor Dbs.
Volume: 280
Issue: 4
Pages: 2807-17
Publication
First Author: Klinger MB
Year: 2004
Journal: Eur J Immunol
Title: The RhoA- and CDC42-specific exchange factor Dbs promotes expansion of immature thymocytes and deletion of double-positive and single-positive thymocytes.
Volume: 34
Issue: 3
Pages: 806-816
Publication
First Author: Salazar MA
Year: 2003
Journal: J Biol Chem
Title: Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton.
Volume: 278
Issue: 49
Pages: 49031-43
Publication
First Author: Kim AS
Year: 2000
Journal: Nature
Title: Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein.
Volume: 404
Issue: 6774
Pages: 151-8
Publication
First Author: Hori K
Year: 2014
Journal: Cell Rep
Title: Cytoskeletal regulation by AUTS2 in neuronal migration and neuritogenesis.
Volume: 9
Issue: 6
Pages: 2166-79
Publication
First Author: Ursino GM
Year: 2020
Journal: EMBO Rep
Title: ABCA12 regulates insulin secretion from β-cells.
Volume: 21
Issue: 3
Pages: e48692
Publication
First Author: Alberts AS
Year: 1998
Journal: EMBO J
Title: Activation of RhoA and SAPK/JNK signalling pathways by the RhoA-specific exchange factor mNET1.
Volume: 17
Issue: 14
Pages: 4075-85
Publication
First Author: Xu K
Year: 2011
Journal: Dev Cell
Title: Blood vessel tubulogenesis requires Rasip1 regulation of GTPase signaling.
Volume: 20
Issue: 4
Pages: 526-39
Publication
First Author: Park SH
Year: 1995
Journal: Oncogene
Title: A putative effector of Ral has homology to Rho/Rac GTPase activating proteins.
Volume: 11
Issue: 11
Pages: 2349-55
Publication
First Author: Kholmanskikh SS
Year: 2003
Journal: J Neurosci
Title: Disregulated RhoGTPases and actin cytoskeleton contribute to the migration defect in Lis1-deficient neurons.
Volume: 23
Issue: 25
Pages: 8673-81
Publication
First Author: He X
Year: 2013
Journal: Structure
Title: Structural basis for autoinhibition of the guanine nucleotide exchange factor FARP2.
Volume: 21
Issue: 3
Pages: 355-64
Publication
First Author: Qu J
Year: 2003
Journal: Mol Cell Biol
Title: PAK4 kinase is essential for embryonic viability and for proper neuronal development.
Volume: 23
Issue: 20
Pages: 7122-33
Publication  
First Author: Majmundar AJ
Year: 2021
Journal: Sci Adv
Title: Recessive NOS1AP variants impair actin remodeling and cause glomerulopathy in humans and mice.
Volume: 7
Issue: 1
Publication
First Author: Snyder JT
Year: 2002
Journal: Nat Struct Biol
Title: Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.
Volume: 9
Issue: 6
Pages: 468-75
Publication
First Author: Raghunathan A
Year: 2001
Journal: Exp Cell Res
Title: Functional analysis of B144/LST1: a gene in the tumor necrosis factor cluster that induces formation of long filopodia in eukaryotic cells.
Volume: 268
Issue: 2
Pages: 230-44
Publication
First Author: Cory GO
Year: 2002
Journal: J Biol Chem
Title: Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein.
Volume: 277
Issue: 47
Pages: 45115-21
Publication
First Author: Tapon N
Year: 1998
Journal: EMBO J
Title: A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways.
Volume: 17
Issue: 5
Pages: 1395-404
Publication
First Author: Nasu-Nishimura Y
Year: 2006
Journal: Genes Cells
Title: Role of the Rho GTPase-activating protein RICS in neurite outgrowth.
Volume: 11
Issue: 6
Pages: 607-14
Publication
First Author: Tao W
Year: 2001
Journal: Genes Dev
Title: Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1.
Volume: 15
Issue: 14
Pages: 1796-807
Publication
First Author: Matsuo N
Year: 2003
Journal: Mol Cell Neurosci
Title: Roles of STEF/Tiam1, guanine nucleotide exchange factors for Rac1, in regulation of growth cone morphology.
Volume: 24
Issue: 1
Pages: 69-81
Publication
First Author: Kim SM
Year: 2011
Journal: Exp Cell Res
Title: Control of growth cone motility and neurite outgrowth by SPIN90.
Volume: 317
Issue: 16
Pages: 2276-87
Publication
First Author: Brantley-Sieders DM
Year: 2009
Journal: Mol Cancer Res
Title: Host deficiency in Vav2/3 guanine nucleotide exchange factors impairs tumor growth, survival, and angiogenesis in vivo.
Volume: 7
Issue: 5
Pages: 615-23
Publication
First Author: Wei C
Year: 2008
Journal: Nat Med
Title: Modification of kidney barrier function by the urokinase receptor.
Volume: 14
Issue: 1
Pages: 55-63
Publication
First Author: Cheng CM
Year: 2003
Journal: J Neurosci Res
Title: Insulin-like growth factor 1 is essential for normal dendritic growth.
Volume: 73
Issue: 1
Pages: 1-9
Publication
First Author: Schreck C
Year: 2017
Journal: J Exp Med
Title: Niche WNT5A regulates the actin cytoskeleton during regeneration of hematopoietic stem cells.
Volume: 214
Issue: 1
Pages: 165-181
Publication  
First Author: Miyamura N
Year: 2017
Journal: Nat Commun
Title: YAP determines the cell fate of injured mouse hepatocytes in vivo.
Volume: 8
Pages: 16017
Publication
First Author: Bijata M
Year: 2017
Journal: Cell Rep
Title: Synaptic Remodeling Depends on Signaling between Serotonin Receptors and the Extracellular Matrix.
Volume: 19
Issue: 9
Pages: 1767-1782
Publication
First Author: Tu Z
Year: 2022
Journal: Cell Rep
Title: Autism-associated chromatin remodeler CHD8 regulates erythroblast cytokinesis and fine-tunes the balance of Rho GTPase signaling.
Volume: 40
Issue: 2
Pages: 111072
Publication
First Author: Kunimura K
Year: 2019
Journal: Cell Rep
Title: S100A4 Protein Is Essential for the Development of Mature Microfold Cells in Peyer's Patches.
Volume: 29
Issue: 9
Pages: 2823-2834.e7
Publication
First Author: Ye S
Year: 2016
Journal: Int J Biol Sci
Title: LIS1 Regulates Osteoclastogenesis through Modulation of M-SCF and RANKL Signaling Pathways and CDC42.
Volume: 12
Issue: 12
Pages: 1488-1499
Publication
First Author: Hara-Chikuma M
Year: 2012
Journal: J Exp Med
Title: Chemokine-dependent T cell migration requires aquaporin-3-mediated hydrogen peroxide uptake.
Volume: 209
Issue: 10
Pages: 1743-52
Publication
First Author: Rehn M
Year: 2022
Journal: Cell Rep
Title: PTBP1 promotes hematopoietic stem cell maintenance and red blood cell development by ensuring sufficient availability of ribosomal constituents.
Volume: 39
Issue: 6
Pages: 110793
Publication
First Author: Nayak RC
Year: 2019
Journal: Nat Commun
Title: The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors.
Volume: 10
Issue: 1
Pages: 46
Publication
First Author: Grande-García A
Year: 2007
Journal: J Cell Biol
Title: Caveolin-1 regulates cell polarization and directional migration through Src kinase and Rho GTPases.
Volume: 177
Issue: 4
Pages: 683-94
Publication
First Author: Lee HS
Year: 2015
Journal: Mol Cell Biol
Title: Protein tyrosine phosphatase-PEST and β8 integrin regulate spatiotemporal patterns of RhoGDI1 activation in migrating cells.
Volume: 35
Issue: 8
Pages: 1401-13
Publication  
First Author: Tetreault MP
Year: 2016
Journal: Sci Rep
Title: KLF4 transcriptionally activates non-canonical WNT5A to control epithelial stratification.
Volume: 6
Pages: 26130
Publication
First Author: Haubert D
Year: 2007
Journal: EMBO J
Title: PtdIns(4,5)P-restricted plasma membrane localization of FAN is involved in TNF-induced actin reorganization.
Volume: 26
Issue: 14
Pages: 3308-21
Publication  
First Author: Du X
Year: 2020
Journal: J Exp Med
Title: Mevalonate metabolism-dependent protein geranylgeranylation regulates thymocyte egress.
Volume: 217
Issue: 2
Publication  
First Author: Phee H
Year: 2014
Journal: Elife
Title: Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation.
Volume: 3
Pages: e02270
Publication
First Author: Hirsch E
Year: 2002
Journal: Mol Cell Biol
Title: Defective dendrite elongation but normal fertility in mice lacking the Rho-like GTPase activator Dbl.
Volume: 22
Issue: 9
Pages: 3140-8
Publication  
First Author: Bernadzki KM
Year: 2020
Journal: Front Mol Neurosci
Title: Arhgef5 Binds α-Dystrobrevin 1 and Regulates Neuromuscular Junction Integrity.
Volume: 13
Pages: 104
Publication
First Author: Martinez-Lopez N
Year: 2023
Journal: Nat Cell Biol
Title: mTORC2-NDRG1-CDC42 axis couples fasting to mitochondrial fission.
Volume: 25
Issue: 7
Pages: 989-1003
Publication
First Author: Tu X
Year: 2020
Journal: Sci Rep
Title: Rac1 is a downstream effector of PKCα in structural synaptic plasticity.
Volume: 10
Issue: 1
Pages: 1777
Publication  
First Author: Abraham S
Year: 2015
Journal: Nat Commun
Title: A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis.
Volume: 6
Pages: 7286
Publication
First Author: Zhang Q
Year: 2014
Journal: J Exp Med
Title: DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity.
Volume: 211
Issue: 13
Pages: 2549-66
Publication  
First Author: Jung H
Year: 2016
Journal: Nat Commun
Title: Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity.
Volume: 7
Pages: 13674
Publication
First Author: Wang L
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Cdc42GAP regulates c-Jun N-terminal kinase (JNK)-mediated apoptosis and cell number during mammalian perinatal growth.
Volume: 102
Issue: 38
Pages: 13484-9
Publication
First Author: Sawada Y
Year: 2015
Journal: J Exp Med
Title: Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses.
Volume: 212
Issue: 11
Pages: 1921-30
Publication
First Author: Braun LJ
Year: 2020
Journal: Blood
Title: Platelets docking to VWF prevent leaks during leukocyte extravasation by stimulating Tie-2.
Volume: 136
Issue: 5
Pages: 627-639
Publication
First Author: Fang J
Year: 2017
Journal: Nat Immunol
Title: Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.
Volume: 18
Issue: 2
Pages: 236-245
Publication
First Author: Kim MH
Year: 2009
Journal: J Neurosci
Title: Enhanced NMDA receptor-mediated synaptic transmission, enhanced long-term potentiation, and impaired learning and memory in mice lacking IRSp53.
Volume: 29
Issue: 5
Pages: 1586-95
Publication  
First Author: Chou AM
Year: 2017
Journal: Sci Rep
Title: Redundant functions of I-BAR family members, IRSp53 and IRTKS, are essential for embryonic development.
Volume: 7
Pages: 40485
Publication
First Author: Martins R
Year: 2016
Journal: Nat Immunol
Title: Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions.
Volume: 17
Issue: 12
Pages: 1361-1372
Publication
First Author: Schlienger S
Year: 2023
Journal: Sci Adv
Title: Genetics of mirror movements identifies a multifunctional complex required for Netrin-1 guidance and lateralization of motor control.
Volume: 9
Issue: 19
Pages: eadd5501
Publication
First Author: Zhong JL
Year: 2003
Journal: Dev Dyn
Title: Pak1 and its T212 phosphorylated form accumulate in neurones and epithelial cells of the developing rodent.
Volume: 228
Issue: 1
Pages: 121-7
Publication
First Author: Jiménez C
Year: 2000
Journal: J Cell Biol
Title: Role of the PI3K regulatory subunit in the control of actin organization and cell migration.
Volume: 151
Issue: 2
Pages: 249-62
Publication
First Author: Park E
Year: 2003
Journal: J Biol Chem
Title: The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42.
Volume: 278
Issue: 21
Pages: 19220-9
Publication
First Author: Yoshizawa M
Year: 2003
Journal: Gene Expr Patterns
Title: Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain.
Volume: 3
Issue: 3
Pages: 375-81
Publication
First Author: Seth A
Year: 2006
Journal: J Cell Biol
Title: Autoinhibition regulates cellular localization and actin assembly activity of the diaphanous-related formins FRLalpha and mDia1.
Volume: 174
Issue: 5
Pages: 701-13
Publication
First Author: Liu Z
Year: 2006
Journal: J Biol Chem
Title: Transformation by the Rho-specific guanine nucleotide exchange factor Dbs requires ROCK I-mediated phosphorylation of myosin light chain.
Volume: 281
Issue: 23
Pages: 16043-51
Publication
First Author: Feng Q
Year: 2006
Journal: Nat Cell Biol
Title: Cool-1 functions as an essential regulatory node for EGF receptor- and Src-mediated cell growth.
Volume: 8
Issue: 9
Pages: 945-56
Publication
First Author: Eun SY
Year: 2006
Journal: J Immunol
Title: Cutting edge: rho activation and actin polarization are dependent on plexin-A1 in dendritic cells.
Volume: 177
Issue: 7
Pages: 4271-5
Publication
First Author: Kang JS
Year: 2008
Journal: J Cell Biol
Title: A Cdo-Bnip-2-Cdc42 signaling pathway regulates p38alpha/beta MAPK activity and myogenic differentiation.
Volume: 182
Issue: 3
Pages: 497-507
Publication
First Author: Wang JB
Year: 2009
Journal: J Cell Sci
Title: IQGAP1 regulates cell proliferation through a novel CDC42-mTOR pathway.
Volume: 122
Issue: Pt 12
Pages: 2024-33
Publication
First Author: Koch S
Year: 2009
Journal: Mol Biol Cell
Title: Dkk-1 inhibits intestinal epithelial cell migration by attenuating directional polarization of leading edge cells.
Volume: 20
Issue: 22
Pages: 4816-25
Publication
First Author: Jossin Y
Year: 2011
Journal: Nat Neurosci
Title: Reelin, Rap1 and N-cadherin orient the migration of multipolar neurons in the developing neocortex.
Volume: 14
Issue: 6
Pages: 697-703
Publication
First Author: Ichida M
Year: 2011
Journal: FEBS Lett
Title: Changes in cell migration of mesenchymal cells during osteogenic differentiation.
Volume: 585
Issue: 24
Pages: 4018-24
Publication
First Author: Keestra AM
Year: 2013
Journal: Nature
Title: Manipulation of small Rho GTPases is a pathogen-induced process detected by NOD1.
Volume: 496
Issue: 7444
Pages: 233-7
Publication
First Author: Hanin G
Year: 2014
Journal: Hum Mol Genet
Title: Competing targets of microRNA-608 affect anxiety and hypertension.
Volume: 23
Issue: 17
Pages: 4569-80
Publication
First Author: Xiang X
Year: 2016
Journal: FEBS Lett
Title: Arhgef1 negatively regulates neurite outgrowth through activation of RhoA signaling pathways.
Volume: 590
Issue: 17
Pages: 2940-55
Publication  
First Author: Kage F
Year: 2017
Journal: Nat Commun
Title: FMNL formins boost lamellipodial force generation.
Volume: 8
Pages: 14832
Publication
First Author: Penkert RR
Year: 2004
Journal: Nat Struct Mol Biol
Title: Internal recognition through PDZ domain plasticity in the Par-6-Pals1 complex.
Volume: 11
Issue: 11
Pages: 1122-7
Publication  
First Author: Deb Roy A
Year: 2017
Journal: Nat Commun
Title: Optogenetic activation of Plexin-B1 reveals contact repulsion between osteoclasts and osteoblasts.
Volume: 8
Pages: 15831
Publication
First Author: Diring J
Year: 2019
Journal: Nat Cell Biol
Title: RPEL-family rhoGAPs link Rac/Cdc42 GTP loading to G-actin availability.
Volume: 21
Issue: 7
Pages: 845-855
Publication
First Author: Vohnoutka RB
Year: 2019
Journal: Mol Biol Cell
Title: The focal adhesion scaffold protein Hic-5 regulates vimentin organization in fibroblasts.
Volume: 30
Issue: 25
Pages: 3037-3056