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Search results 2701 to 2800 out of 3295 for Kras

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Type Details Score
Allele
Kras<tm1Cya> | MGI:7657290
Name: Kirsten rat sarcoma viral oncogene homolog; targeted mutation 1, Cyagen Biosciences
Allele Type: Targeted
Attribute String: Conditional ready
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Protein Coding Gene
MGI:1346866 | Map2k1
Type: protein_coding_gene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Braf/Braf<+> Tg(CAG-cre)2Osb/?
Background: involves: C57BL * C57BL/6J * DBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+>
Background: B6.129-Braf
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Raf1/Raf1 H2az2/H2az2<+>
Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J
Zygosity: cn
Has Mutant Allele: true
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DO Term
DOID:0060233 | cardiofaciocutaneous syndrome
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Genotype
Genotype
Symbol: Braf/Braf<+> Tg(CAG-cre)2Osb/?
Background: involves: C57BL * C57BL/6J * DBA * ICR
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Map2k1/Map2k1
Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL/J
Zygosity: hm
Has Mutant Allele: true
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Publication
25329316 | J:217430
First Author: Esteve-Puig R
Year: 2014
Journal: PLoS Genet
Title: A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation.
Volume: 10
Issue: 10
Pages: e1004721
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Publication
18172296 | J:131037
First Author: Gurumurthy S
Year: 2008
Journal: Cancer Res
Title: LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis.
Volume: 68
Issue: 1
Pages: 55-63
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Publication
25588837 | J:223226
First Author: Krawchuk D
Year: 2015
Journal: J Cell Sci
Title: Loss of LKB1 leads to impaired epithelial integrity and cell extrusion in the early mouse embryo.
Volume: 128
Issue: 5
Pages: 1011-22
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Publication
25256100 | J:316262
 
First Author: Pooya S
Year: 2014
Journal: Nat Commun
Title: The tumour suppressor LKB1 regulates myelination through mitochondrial metabolism.
Volume: 5
Pages: 4993
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Publication
18245476 | J:131865
First Author: Contreras CM
Year: 2008
Journal: Cancer Res
Title: Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas.
Volume: 68
Issue: 3
Pages: 759-66
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Publication
18311138 | J:134476
First Author: Katajisto P
Year: 2008
Journal: Nat Genet
Title: LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis.
Volume: 40
Issue: 4
Pages: 455-9
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Publication
19541609 | J:150834
First Author: Shackelford DB
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome.
Volume: 106
Issue: 27
Pages: 11137-42
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Genotype
Genotype
Symbol: Stk11/Stk11<+>
Background: involves: 129S6/SvEvTac * FVB/N
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Stk11/Stk11<+>
Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Stk11/Stk11
Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Stk11/Stk11<+>
Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N * SJL
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Stk11/Stk11
Background: involves: 129S6/SvEvTac
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kras/Kras<+> Stk11/Stk11
Background: involves: 129S4/SvJae * 129S6/SvEvTac
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kras/Kras<+> Stk11/Stk11
Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Stk11/Stk11
Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Publication
31399545 | J:278719
First Author: Hashimoto S
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer.
Volume: 116
Issue: 35
Pages: 17450-17459
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Publication
24019382 | J:204513
First Author: Trejo CL
Year: 2013
Journal: Cancer Res
Title: Mutationally activated PIK3CA(H1047R) cooperates with BRAF(V600E) to promote lung cancer progression.
Volume: 73
Issue: 21
Pages: 6448-61
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Strain
MGI:5770149 | B6N.129S6-Bhlha15<tm2(Kras)Skz>/J
Attribute String: congenic, mutant strain, targeted mutation
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Allele
Kras<em1Jqmn> | MGI:6718983
Name: Kirsten rat sarcoma viral oncogene homolog; endonuclease-mediated mutation 1, Patrick Jacquemin
Allele Type: Endonuclease-mediated
Attribute String: Reporter
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Allele
Kras<em1Smoc> | MGI:7290755
Name: Kirsten rat sarcoma viral oncogene homolog; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Strain
MGI:7657601 | C57BL/6J-Kras<tm1Cya>/Cya
Attribute String: coisogenic, targeted mutation, mutant strain
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Genotype
Genotype
Symbol: Bhlha15/Bhlha15<+>
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Allele
Pten<tm2.1Ppp> | MGI:2679886
Name: phosphatase and tensin homolog; targeted mutation 2.1, Pier Paolo Pandolfi
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Publication
16397237 | J:105076
First Author: Tuveson DA
Year: 2006
Journal: Cancer Res
Title: Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma.
Volume: 66
Issue: 1
Pages: 242-7
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DO Term
DOID:0111530 | linear nevus sebaceous syndrome
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Allele
Kras<tm1(Hras)Rdl> | MGI:3581451
Name: Kirsten rat sarcoma viral oncogene homolog; targeted mutation 1, Roberto Di Lauro
Allele Type: Targeted
Attribute String: Inserted expressed sequence, Null/knockout
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Allele
Eef1a1<tm1(Kras*)Arge> | MGI:3837679
Name: eukaryotic translation elongation factor 1 alpha 1; targeted mutation 1, Argiris Efstratiadis
Allele Type: Targeted
Attribute String: Conditional ready, Constitutively active, Inserted expressed sequence
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Allele
Kras<tm2(Kras)Rdl> | MGI:4830590
Name: Kirsten rat sarcoma viral oncogene homolog; targeted mutation 2, Roberto Di Lauro
Allele Type: Targeted
Attribute String: Inserted expressed sequence, Null/knockout
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Allele
Kras<tm4Bbd> | MGI:5649293
Name: Kirsten rat sarcoma viral oncogene homolog; targeted mutation 4, Mariano Barbacid
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout
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Allele
Actb<tm3(Kras*)Arge> | MGI:7388568
Name: actin, beta; targeted mutation 3, Argiris Efstratiadis
Allele Type: Targeted
Attribute String: Conditional ready, Constitutively active, Inserted expressed sequence
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HT Experiment
E-MTAB-5833 | Atp4b-Cre;Cdh1(fl/fl);Kras(LSL-G12D/+);Trp53(fl/fl);Rosa26(LSL-YFP/LSL-YFP) mouse stomach vs. Atp4b-Cre;Cdh1(fl/+);Kras(LSL-G12D/+);Trp53(fl/fl);Rosa26(LSL-YFP/LSL-YFP) mouse stomach microarray
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Gene
4893 | NRAS
Type: gene
Organism: human
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Publication
34610416 | J:314038
 
First Author: Kanagasabai T
Year: 2021
Journal: Cancer Lett
Title: MicroRNA-21 deficiency suppresses prostate cancer progression through downregulation of the IRS1-SREBP-1 signaling pathway.
Volume: 525
Pages: 46-54
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Publication
23454771 | J:196375
First Author: Knight DA
Year: 2013
Journal: J Clin Invest
Title: Host immunity contributes to the anti-melanoma activity of BRAF inhibitors.
Volume: 123
Issue: 3
Pages: 1371-81
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Publication
28202513 | J:242087
First Author: Steinberg SM
Year: 2017
Journal: Cancer Res
Title: Myeloid Cells That Impair Immunotherapy Are Restored in Melanomas with Acquired Resistance to BRAF Inhibitors.
Volume: 77
Issue: 7
Pages: 1599-1610
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Publication
31433989 | J:285688
First Author: Di Mitri D
Year: 2019
Journal: Cell Rep
Title: Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer.
Volume: 28
Issue: 8
Pages: 2156-2168.e5
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Publication
36599297 | J:332546
First Author: Tsai CH
Year: 2023
Journal: Cell Metab
Title: Immunoediting instructs tumor metabolic reprogramming to support immune evasion.
Volume: 35
Issue: 1
Pages: 118-133.e7
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Publication
26198641 | J:224447
 
First Author: Pencik J
Year: 2015
Journal: Nat Commun
Title: STAT3 regulated ARF expression suppresses prostate cancer metastasis.
Volume: 6
Pages: 7736
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Publication
30664764 | J:282386
First Author: Cheng WC
Year: 2019
Journal: Nat Immunol
Title: Uncoupling protein 2 reprograms the tumor microenvironment to support the anti-tumor immune cycle.
Volume: 20
Issue: 2
Pages: 206-217
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Publication
26317218 | J:243021
First Author: Filtz EA
Year: 2015
Journal: PLoS One
Title: Rb1 and Pten Co-Deletion in Osteoblast Precursor Cells Causes Rapid Lipoma Formation in Mice.
Volume: 10
Issue: 8
Pages: e0136729
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Publication
24493834 | J:208767
First Author: Trent CM
Year: 2014
Journal: J Lipid Res
Title: Lipoprotein lipase activity is required for cardiac lipid droplet production.
Volume: 55
Issue: 4
Pages: 645-58
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Publication
19443706 | J:148919
First Author: Rodriguez OC
Year: 2009
Journal: Am J Pathol
Title: A reduction in Pten tumor suppressor activity promotes ErbB-2-induced mouse prostate adenocarcinoma formation through the activation of signaling cascades downstream of PDK1.
Volume: 174
Issue: 6
Pages: 2051-60
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Publication
17283127 | J:118219
First Author: Yeager N
Year: 2007
Journal: Cancer Res
Title: Pten loss in the mouse thyroid causes goiter and follicular adenomas: insights into thyroid function and Cowden disease pathogenesis.
Volume: 67
Issue: 3
Pages: 959-66
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Publication
14691534 | J:86212
First Author: Trotman LC
Year: 2003
Journal: PLoS Biol
Title: Pten dose dictates cancer progression in the prostate.
Volume: 1
Issue: 3
Pages: E59
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Publication
29202476 | J:258373
First Author: Ollila S
Year: 2018
Journal: J Clin Invest
Title: Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway.
Volume: 128
Issue: 1
Pages: 402-414
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Strain
MGI:4868759 | 129S1.Cg-Cdkn1b<tm1Ako> Tg(TPO-cre)1Shk Pten<tm2.1Ppp>
Attribute String: congenic, targeted mutation, transgenic
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Publication
20676139 | J:165293
First Author: Antico-Arciuch VG
Year: 2010
Journal: Oncogene
Title: Cross-talk between PI3K and estrogen in the mouse thyroid predisposes to the development of follicular carcinomas with a higher incidence in females.
Volume: 29
Issue: 42
Pages: 5678-86
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Publication
24910389 | J:316436
First Author: Xie Y
Year: 2014
Journal: Mol Oncol
Title: Slug regulates E-cadherin repression via p19Arf in prostate tumorigenesis.
Volume: 8
Issue: 7
Pages: 1355-64
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Publication
27356744 | J:264783
First Author: Xie Y
Year: 2016
Journal: Oncotarget
Title: MMP7 interacts with ARF in nucleus to potentiate tumor microenvironments for prostate cancer progression in vivo.
Volume: 7
Issue: 30
Pages: 47609-47619
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Publication
19690330 | J:260259
First Author: Chen Z
Year: 2009
Journal: Sci Signal
Title: Differential p53-independent outcomes of p19(Arf) loss in oncogenesis.
Volume: 2
Issue: 84
Pages: ra44
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Publication
29185453 | J:255776
First Author: Xie Y
Year: 2017
Journal: Sci Rep
Title: Dysregulation of YAP by ARF Stimulated with Tea-derived Carbon Nanodots.
Volume: 7
Issue: 1
Pages: 16577
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Publication
20237562 | J:158121
First Author: Lin HK
Year: 2010
Journal: Nature
Title: Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence.
Volume: 464
Issue: 7287
Pages: 374-9
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Publication
25995385 | J:225608
First Author: Dorr C
Year: 2015
Journal: Mol Cancer Res
Title: Transposon Mutagenesis Screen Identifies Potential Lung Cancer Drivers and CUL3 as a Tumor Suppressor.
Volume: 13
Issue: 8
Pages: 1238-47
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Publication
20197621 | J:158734
First Author: Alimonti A
Year: 2010
Journal: J Clin Invest
Title: A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis.
Volume: 120
Issue: 3
Pages: 681-93
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Strain
MGI:5897836 | 129.Cg-Tg(TPO-cre)1Shk Trp53<tm1Brn> Pten<tm2.1Ppp>
Attribute String: congenic, mutant strain, targeted mutation, transgenic
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Publication
29784854 | J:264280
First Author: Saito R
Year: 2018
Journal: Cancer Res
Title: Molecular Subtype-Specific Immunocompetent Models of High-Grade Urothelial Carcinoma Reveal Differential Neoantigen Expression and Response to Immunotherapy.
Volume: 78
Issue: 14
Pages: 3954-3968
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Publication
31092557 | J:317985
First Author: Nowak DG
Year: 2019
Journal: J Cell Biol
Title: The PHLPP2 phosphatase is a druggable driver of prostate cancer progression.
Volume: 218
Issue: 6
Pages: 1943-1957
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Publication
27728797 | J:236719
First Author: Murray NR
Year: 2016
Journal: Cancer Cell
Title: SOX2 Determines Lineage Restriction: Modeling Lung Squamous Cell Carcinoma in the Mouse.
Volume: 30
Issue: 4
Pages: 505-507
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Publication
29904909 | J:288801
First Author: Sementino E
Year: 2018
Journal: J Cell Physiol
Title: Inactivation of Tp53 and Pten drives rapid development of pleural and peritoneal malignant mesotheliomas.
Volume: 233
Issue: 11
Pages: 8952-8961
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Publication
22190384 | J:211100
First Author: Antico Arciuch VG
Year: 2011
Journal: Oncotarget
Title: Thyrocyte-specific inactivation of p53 and Pten results in anaplastic thyroid carcinomas faithfully recapitulating human tumors.
Volume: 2
Issue: 12
Pages: 1109-26
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Publication
24444712 | J:211600
First Author: Cho H
Year: 2014
Journal: Cancer Discov
Title: RapidCaP, a novel GEM model for metastatic prostate cancer analysis and therapy, reveals myc as a driver of Pten-mutant metastasis.
Volume: 4
Issue: 3
Pages: 318-33
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Publication
27683179 | J:350188
First Author: Zhang KJ
Year: 2017
Journal: Clin Cancer Res
Title: A Potent In Vivo Antitumor Efficacy of Novel Recombinant Type I Interferon.
Volume: 23
Issue: 8
Pages: 2038-2049
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Publication
19016531 | J:141373
First Author: Henley T
Year: 2008
Journal: Eur J Immunol
Title: B-cell responses to B-cell activation factor of the TNF family (BAFF) are impaired in the absence of PI3K delta.
Volume: 38
Issue: 12
Pages: 3543-8
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Publication
39303726 | J:357411
First Author: Calì B
Year: 2024
Journal: Cancer Cell
Title: Coagulation factor X promotes resistance to androgen-deprivation therapy in prostate cancer.
Volume: 42
Issue: 10
Pages: 1676-1692.e11
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Publication
32788364 | J:295972
First Author: Li Q
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis.
Volume: 117
Issue: 34
Pages: 20538-20548
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Publication
15958561 | J:99385
First Author: Xiao A
Year: 2005
Journal: Cancer Res
Title: Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation.
Volume: 65
Issue: 12
Pages: 5172-80
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Publication
25056937 | J:317519
First Author: Nazarian A
Year: 2014
Journal: Mol Cell Proteomics
Title: Inhibition of circulating dipeptidyl peptidase 4 activity in patients with metastatic prostate cancer.
Volume: 13
Issue: 11
Pages: 3082-96
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Publication
22700876 | J:189280
First Author: Keng VW
Year: 2012
Journal: Cancer Res
Title: PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors.
Volume: 72
Issue: 13
Pages: 3405-13
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Publication
30478082 | J:274104
First Author: Li XX
Year: 2019
Journal: G3 (Bethesda)
Title: Conditional Inactivation of Nf1 and Pten in Schwann Cells Results in Abnormal Neuromuscular Junction Maturation.
Volume: 9
Issue: 1
Pages: 297-303
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Publication
29872062 | J:262552
First Author: Cabral-Costa JV
Year: 2018
Journal: Sci Rep
Title: Intermittent fasting uncovers and rescues cognitive phenotypes in PTEN neuronal haploinsufficient mice.
Volume: 8
Issue: 1
Pages: 8595
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Publication
33214645 | J:300231
First Author: de Mello NP
Year: 2020
Journal: Sci Rep
Title: Inverse sex-based expression profiles of PTEN and Klotho in mice.
Volume: 10
Issue: 1
Pages: 20189
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Publication
29453322 | J:260731
First Author: Ding M
Year: 2018
Journal: Mol Cancer Res
Title: The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote Hypoxia Tolerance in PTEN-driven Prostate Cancer.
Volume: 16
Issue: 4
Pages: 682-695
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Publication
23817021 | J:200002
First Author: Chen Y
Year: 2013
Journal: Nat Med
Title: ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss.
Volume: 19
Issue: 8
Pages: 1023-9
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Publication
28292441 | J:239660
First Author: Blattner M
Year: 2017
Journal: Cancer Cell
Title: SPOP Mutation Drives Prostate Tumorigenesis In Vivo through Coordinate Regulation of PI3K/mTOR and AR Signaling.
Volume: 31
Issue: 3
Pages: 436-451
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Publication
27869166 | J:241247
First Author: Lu W
Year: 2017
Journal: Oncogene
Title: SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer.
Volume: 36
Issue: 10
Pages: 1364-1373
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Publication
32323921 | J:294705
First Author: Oberhuber M
Year: 2020
Journal: Mol Syst Biol
Title: STAT3-dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer.
Volume: 16
Issue: 4
Pages: e9247
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Publication
34547241 | J:315701
First Author: Igelmann S
Year: 2021
Journal: Mol Cell
Title: A hydride transfer complex reprograms NAD metabolism and bypasses senescence.
Volume: 81
Issue: 18
Pages: 3848-3865.e19
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Publication
37055829 | J:334748
First Author: Alvarez-Arzola R
Year: 2023
Journal: Cell Commun Signal
Title: VSSP-activated macrophages mediate senescence and tumor inhibition in a preclinical model of advanced prostate cancer.
Volume: 21
Issue: 1
Pages: 76
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Publication
23428429 | J:198151
First Author: Nguyen AH
Year: 2013
Journal: Hum Mol Genet
Title: Gata3 antagonizes cancer progression in Pten-deficient prostates.
Volume: 22
Issue: 12
Pages: 2400-10
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Publication
31452834 | J:315777
First Author: Mohammad AH
Year: 2019
Journal: Oncotarget
Title: V-ATPase-associated prorenin receptor is upregulated in prostate cancer after PTEN loss.
Volume: 10
Issue: 48
Pages: 4923-4936
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Publication
23727861 | J:203214
First Author: Wang G
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