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Search results 2701 to 2800 out of 3050 for Rag1

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Type Details Score
Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
22044391 | J:178637
First Author: Hassaballa AE
Year: 2011
Journal: Immunology
Title: Accumulation of B1-like B cells in transgenic mice over-expressing catalytically inactive RAG1 in the periphery.
Volume: 134
Issue: 4
Pages: 469-86
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Publication
23716691 | J:197392
First Author: Um JH
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Metabolic sensor AMPK directly phosphorylates RAG1 protein and regulates V(D)J recombination.
Volume: 110
Issue: 24
Pages: 9873-8
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Interaction Experiment
Maitra R (2009)
Description: A WW-like module in the RAG1 N-terminal domain contributes to previously unidentified protein-protein interactions.
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Publication
17028591 | -
First Author: Lu CP
Year: 2006
Journal: Nat Struct Mol Biol
Title: Amino acid residues in Rag1 crucial for DNA hairpin formation.
Volume: 13
Issue: 11
Pages: 1010-5
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Allele
Aifm1<tm1Pngr> | MGI:2159372
Name: apoptosis-inducing factor, mitochondrion-associated 1; targeted mutation 1, Josef M Penninger
Allele Type: Targeted
Attribute String: Null/knockout
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SO Term
SO:0002282 | Transib_TIR_transposon
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Strain
MGI:4352729 | 129P2/OlaHsd-Aifm1<tm1Pngr>
Attribute String: coisogenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Aifm1/?
Background: 129P2/OlaHsd-Aifm1
Zygosity: ot
Has Mutant Allele: true
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Allele
Rag2<tm1Fwa> | MGI:1858556
Name: recombination activating gene 2; targeted mutation 1, Frederick W Alt
Allele Type: Targeted
Attribute String: Null/knockout
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Gene
5897 | RAG2
Type: gene
Organism: human
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Publication
8861909 | -
First Author: Difilippantonio MJ
Year: 1996
Journal: Cell
Title: RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination.
Volume: 87
Issue: 2
Pages: 253-62
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CL Term
CL:0002049 | fraction C precursor B cell
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Publication
28213501 | J:252723
First Author: Fisher MR
Year: 2017
Journal: J Immunol
Title: Immature Lymphocytes Inhibit Rag1 and Rag2 Transcription and V(D)J Recombination in Response to DNA Double-Strand Breaks.
Volume: 198
Issue: 7
Pages: 2943-2956
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Publication
8521468 | -
First Author: McBlane JF
Year: 1995
Journal: Cell
Title: Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps.
Volume: 83
Issue: 3
Pages: 387-95
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Publication
9094713 | -
First Author: Agrawal A
Year: 1997
Journal: Cell
Title: RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination.
Volume: 89
Issue: 1
Pages: 43-53
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Publication
10678172 | -
First Author: Fugmann SD
Year: 2000
Journal: Mol Cell
Title: Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex.
Volume: 5
Issue: 1
Pages: 97-107
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Protein Coding Gene
MGI:104779 | Prkdc
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Rag2<tm1Avla> | MGI:3713766
Name: recombination activating gene 2; targeted mutation 1, Anna Villa
Allele Type: Targeted
Attribute String: Hypomorph
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Allele
Rag1<tm1Jsek> | MGI:3840831
Name: recombination activating 1; targeted mutation 1, JoAnne Sekiguchi
Allele Type: Targeted
Attribute String: Hypomorph
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Genotype
Genotype
Symbol: Rag2/Rag2
Background: involves: 129S/SvEv * MF1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Prkdc/Prkdc
Background: C.BKa-Prkdc
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0090013 | severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive
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DO Term
DOID:0060011 | recombinase activating gene 1 deficiency
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Protein Coding Gene
MGI:97849 | Rag2
Type: protein_coding_gene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Rag2/Rag2
Background: involves: 129/Sv * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rag1/Rag1
Background: involves: 129S6/SvEvTac
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0060010 | Omenn syndrome
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DO Term
DOID:0112253 | combined cellular and humoral immune defects with granulomas
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Gene
64421 | DCLRE1C
Type: gene
Organism: human
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HT Experiment
GSE86780 | Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
11279485 | J:68434
First Author: Joza N
Year: 2001
Journal: Nature
Title: Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death.
Volume: 410
Issue: 6828
Pages: 549-54
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Allele
Prkdc<scid> | MGI:1857113
 
Name: protein kinase, DNA activated, catalytic polypeptide; severe combined immunodeficiency
Allele Type: Spontaneous
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HT Experiment
GSE49233 | A Unifying Model for Molecular Determinants of the Pre-selection Vb Repertoire [RNA-Seq]
Series Id: E-GEOD-49233
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Allele
Rag1<tm1Jmj> | MGI:5604716
Name: recombination activating 1; targeted mutation 1, Jessica Jones
Allele Type: Targeted
Attribute String: Not Specified
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Allele
Rag1<em2Dgs> | MGI:7262704
Name: recombination activating 1; endonuclease-mediated mutation 2, David G Schatz
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Allele
Rag1<tm1(GFP)Imku> | MGI:2388344
Name: recombination activating 1; targeted mutation 1, Nobuo Sakaguchi
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Strain
MGI:5604758 | STOCK Rag1<tm1Jmj>/Mmnc
Attribute String: mutant stock, targeted mutation
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Allele
Rag1<em1Dgs> | MGI:7262701
Name: recombination activating 1; endonuclease-mediated mutation 1, David G Schatz
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Protein Domain
IPR019485 | RAG1_Znf
Type: Domain
Description: The development of B and T cells depends on the rearrangement of variable (V),diversity (D), and joining(J) gene segments to produce mature Ig and T cellreceptor coding regions. This rearrangement process, known as V(D)Jrecombination is initiated by the complex, multi-domain proteins RAG1 andRAG2. The RAG proteins catalyze DNA cleavage in the first phase of thereaction using a recombination signal sequence (RSS) that flanks V, D and Jsegments [, , ].RAG1 contains a zinc-binding dimerization domain immediately N-terminal to thecatalytic core region, which in turn contains a putative DNA-binding domain at its N terminus. The dimerization domain consists of azinc C3HC4 RING finger and a C2H2 zinc RAG1-type finger.The C2H2 RAG1-type zinc finger contains the hallmarks of a classical zincfinger structure with a two stranded β-sheet and an α-helix [].
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Allele
Rag1<tm1Mom> | MGI:1857241
Name: recombination activating 1; targeted mutation 1, Peter Mombaerts
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Rag1<tm1Fwa> | MGI:2681693
 
Name: recombination activating 1; targeted mutation 1, Frederick W Alt
Allele Type: Targeted
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Allele
Rag1<m3Btlr> | MGI:6286258
Name: recombination activating 1; mutation 3, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Allele
Rag1<m4Btlr> | MGI:6283875
Name: recombination activating 1; mutation 4, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Allele
Rag1<em2Lutzy> | MGI:6861839
Name: recombination activating 1; endonuclease-mediated mutation 2, Cathy Lutz
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready
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Allele
Rag1<em2Cya> | MGI:7657314
Name: recombination activating 1; endonuclease-mediated mutation 2, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Rag1/Rag1
Background: involves: C57BL/6 * CBA
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rag1/Rag1<+>
Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Zygosity: ht
Has Mutant Allele: true
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Publication
7796294 | J:27341
First Author: Chang Y
Year: 1995
Journal: Immunity
Title: Development of B cells in scid mice with immunoglobulin transgenes: implications for the control of V(D)J recombination.
Volume: 2
Issue: 6
Pages: 607-16
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Publication
9846485 | J:153796
First Author: McMahan CJ
Year: 1998
Journal: Immunity
Title: RAG reexpression and DNA recombination at T cell receptor loci in peripheral CD4+ T cells.
Volume: 9
Issue: 5
Pages: 637-47
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Publication
17980153 | J:128511
First Author: Son YM
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Modulation of RAG/DNA complex by HSP70 in V(D)J recombination.
Volume: 365
Issue: 1
Pages: 113-7
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Publication
23076336 | J:243389
First Author: Reed NP
Year: 2013
Journal: Genes Immun
Title: Reciprocal regulation of Rag expression in thymocytes by the zinc-finger proteins, Zfp608 and Zfp609.
Volume: 14
Issue: 1
Pages: 7-12
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Publication
9645367 | J:48190
First Author: Crompton T
Year: 1998
Journal: Eur J Immunol
Title: Distinct roles of the interleukin-7 receptor alpha chain in fetal and adult thymocyte development revealed by analysis of interleukin-7 receptor alpha-deficient mice.
Volume: 28
Issue: 6
Pages: 1859-66
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Publication
28628091 | J:258991
First Author: Dolezal E
Year: 2017
Journal: Nat Immunol
Title: The BTG2-PRMT1 module limits pre-B cell expansion by regulating the CDK4-Cyclin-D3 complex.
Volume: 18
Issue: 8
Pages: 911-920
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Publication
18978794 | J:143228
First Author: Dengler HS
Year: 2008
Journal: Nat Immunol
Title: Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation.
Volume: 9
Issue: 12
Pages: 1388-98
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Publication
36316474 | J:333184
First Author: Lee RD
Year: 2022
Journal: Nat Immunol
Title: Nuclear corepressors NCOR1/NCOR2 regulate B cell development, maintain genomic integrity and prevent transformation.
Volume: 23
Issue: 12
Pages: 1763-1776
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Publication
17057722 | J:116103
First Author: Zhang F
Year: 2006
Journal: Nat Immunol
Title: Control of thymocyte development and recombination-activating gene expression by the zinc finger protein Zfp608.
Volume: 7
Issue: 12
Pages: 1309-16
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Publication
34033676 | J:329657
 
First Author: Chen CC
Year: 2021
Journal: J Exp Med
Title: Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activity is required for V(D)J recombination.
Volume: 218
Issue: 8
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Publication
12871643 | J:84563
First Author: Hsu LY
Year: 2003
Journal: Immunity
Title: A conserved transcriptional enhancer regulates RAG gene expression in developing B cells.
Volume: 19
Issue: 1
Pages: 105-17
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Publication
38787962 | J:351330
First Author: Chen R
Year: 2024
Journal: Sci Immunol
Title: NUDCD3 deficiency disrupts V(D)J recombination to cause SCID and Omenn syndrome.
Volume: 9
Issue: 95
Pages: eade5705
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Publication
23438597 | J:203755
First Author: Lee BS
Year: 2013
Journal: Mol Cell Biol
Title: The BCL11A transcription factor directly activates RAG gene expression and V(D)J recombination.
Volume: 33
Issue: 9
Pages: 1768-81
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Publication
12433370 | J:171970
First Author: Liang HE
Year: 2002
Journal: Immunity
Title: The "dispensable" portion of RAG2 is necessary for efficient V-to-DJ rearrangement during B and T cell development.
Volume: 17
Issue: 5
Pages: 639-51
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Publication
11466623 | J:70546
First Author: Drynan LF
Year: 2001
Journal: Oncogene
Title: T cell tumorigenesis in Lmo2 transgenic mice is independent of V-D-J recombinase activity.
Volume: 20
Issue: 32
Pages: 4412-5
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Publication
8662087 | J:34489
First Author: Hansen JD
Year: 1996
Journal: Immunogenetics
Title: The recombination activating gene 2 (RAG2) of the rainbow trout Oncorhynchus mykiss.
Volume: 44
Issue: 3
Pages: 203-11
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Publication
9022004 | J:38447
First Author: Crompton T
Year: 1997
Journal: Eur J Immunol
Title: A transgenic T cell receptor restores thymocyte differentiation in interleukin-7 receptor alpha chain-deficient mice.
Volume: 27
Issue: 1
Pages: 100-4
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Publication
31350389 | J:279313
First Author: Ji Z
Year: 2019
Journal: Nat Commun
Title: The histone methyltransferase Setd2 is indispensable for V(D)J recombination.
Volume: 10
Issue: 1
Pages: 3353
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Publication
30596405 | J:295115
First Author: Zriwil A
Year: 2018
Journal: Br J Haematol
Title: Direct role of FLT3 in regulation of early lymphoid progenitors.
Volume: 183
Issue: 4
Pages: 588-600
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Strain
MGI:2161492 | C.129S7(B6)-Rag1<tm1Mom>/J
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:5661050 | A.129S7(B6)-Rag1<tm1Mom>/TungJ
Attribute String: targeted mutation, mutant strain, congenic
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Strain
MGI:2164681 | CLil.129S7(B6)-Rag1<tm1Mom>
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:6197465 | FVB.129S7(B6)-Rag1<tm1Mom>/LcsnJ
Attribute String: targeted mutation, mutant strain, congenic
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Strain
MGI:2163461 | B6.129S7-Rag1<tm1Mom>/J
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:5504651 | BXSB.129S7(B6)-Rag1<tm1Mom>/DcrJ
Attribute String: congenic, mutant strain, targeted mutation, spontaneous mutation
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Strain
MGI:2164720 | NOD.129S7(B6)-Rag1<tm1Mom>
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:7764755 | C.129S7(B6)-Rag1<tm1Mom>/Tvg
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:3582299 | B6.129S7-Rag1<tm1Mom>
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:3623777 | NOD.129P2-Rag1<tm1Mom>
Attribute String: targeted mutation, mutant strain, congenic
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Strain
MGI:2162419 | B6;129S7-Rag1<tm1Mom>/J
Attribute String: targeted mutation, mutant stock
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Strain
MGI:2165365 | NOD.129S7(B6)-Rag1<tm1Mom>/J
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:6200624 | B6.129S7-Rag1<tm1Mom>/JAusb
Attribute String: targeted mutation, mutant strain, congenic
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Allele
Tg(Rag2-EGFP)1Mnz | MGI:3784416
Name: transgene insertion 1, Michel C Nussenzweig
Allele Type: Transgenic
Attribute String: Reporter
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Strain
MGI:3810421 | FVB-Tg(Rag2-EGFP)1Mnz/J
Attribute String: coisogenic, transgenic
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Publication
17908937 | J:126924
First Author: McCaughtry TM
Year: 2007
Journal: J Exp Med
Title: Thymic emigration revisited.
Volume: 204
Issue: 11
Pages: 2513-20
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Publication
23918956 | J:202497
First Author: Guy-Grand D
Year: 2013
Journal: J Exp Med
Title: Origin, trafficking, and intraepithelial fate of gut-tropic T cells.
Volume: 210
Issue: 9
Pages: 1839-54
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Strain
MGI:6286259 | C57BL/6J-Rag1<m3Btlr>
Attribute String: mutant strain, coisogenic, chemically induced mutation
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Strain
MGI:6283876 | C57BL/6J-Rag1<m4Btlr>
Attribute String: mutant strain, coisogenic, chemically induced mutation
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom