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Search results 2701 to 2800 out of 3068 for Ret

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Type Details Score
Protein Domain
Type: Domain
Description: Ret is a single transmembrane-spanning receptor tyrosine kinase (RTK) that plays critical roles in the development of vertebrates. It contains four consecutive cadherin-like domains (CLD). This entry represents the first CLD at the N-terminal. Several regions within RET-CLD1 have been shown to be important for ligand-coreceptor binding. CLD1 and CLD2 have a distinctive clamshell shape and CLD1 is essential for CLD2 folding. CLD1 contains 2 sites for GDNF receptor alpha 1 binding [].
Protein Domain
Type: Family
Description: Proteins in this entry have an N-terminal FKBP-type peptidyl-prolyl cis-trans isomerase domain followed by a C-terminal tetratricopeptide repeat-containing domain. Included in this entry are: aryl-hydrocarbon-interacting protein-like 1 (AIPL1), which is associated with inherited blindness and interacts with cell cycle regulator protein NUB1 []; and AH receptor-interacting protein (AIP), which interacts with the tyrosine kinase receptor RET [], and mutations in AIP are associated with familial isolated pituitary adenomas [].
Strain
Attribute String: mutant strain, congenic, transgenic, spontaneous mutation
Allele
Name: transgene insertion 1, Frank Costantini
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Strain
Attribute String: mutant strain, congenic, transgenic
Strain
Attribute String: mutant strain, congenic, transgenic
Strain
Attribute String: mutant stock, transgenic
Strain
Attribute String: mutant strain
Strain
Attribute String: mutant stock, targeted mutation
Genotype
Symbol: Kit/Kit Tg(Mt1-RET)304Ina/?
Background: involves: BALB/c * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Kit/Kit<+> Tg(Mt1-RET)304Ina/?
Background: involves: BALB/c * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Publication
First Author: Henry J
Year: 1997
Journal: Biochem Biophys Res Commun
Title: B30.2-like domain proteins: a growing family.
Volume: 235
Issue: 1
Pages: 162-5
Strain
Attribute String: mutant strain, congenic, transgenic, spontaneous mutation
Publication
First Author: Kato M
Year: 2006
Journal: J Invest Dermatol
Title: Novel hairless RET-transgenic mouse line with melanocytic nevi and anagen hair follicles.
Volume: 126
Issue: 11
Pages: 2547-50
Publication
First Author: Fidanza M
Year: 2017
Journal: Eur J Immunol
Title: IFN-γ directly inhibits murine B-cell precursor leukemia-initiating cell proliferation early in life.
Volume: 47
Issue: 5
Pages: 892-899
Publication
First Author: Kumar V
Year: 2017
Journal: Cancer Cell
Title: Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors.
Volume: 32
Issue: 5
Pages: 654-668.e5
Strain
Attribute String: mutant strain, transgenic, congenic
Strain
Attribute String: transgenic, mutant strain
Genotype
Symbol: Ednrb/Ednrb<+> Tg(Mt1-RET)304Ina/?
Background: involves: 129S7/SvEvBrd * BALB/c * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 1321  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 461  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1043  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 695  
Fragment?: false
Publication
First Author: Zurek B
Year: 2012
Journal: PLoS One
Title: TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation.
Volume: 7
Issue: 7
Pages: e41255
Publication
First Author: Zoumpoulidou G
Year: 2012
Journal: J Natl Cancer Inst
Title: Role of the tripartite motif protein 27 in cancer development.
Volume: 104
Issue: 12
Pages: 941-52
Publication  
First Author: Liu Y
Year: 2014
Journal: Brain Res
Title: Deficiency of Trim27 protects dopaminergic neurons from apoptosis in the neurotoxin model of Parkinson's disease.
Volume: 1588
Pages: 17-24
Protein Domain
Type: Domain
Description: This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C terminus of TRIM27, also known as RING finger protein 76 (RNF76) or RET finger protein (RFP). TRIM proteins are defined by the presence of the tripartite motif RING/B-box/coiled-coil region and are also known as RBCC proteins []. TRIM27 exhibits either nuclear or cytosolic localization depending on the cell type. TRIM27 negatively regulates nucleotide-binding oligomerizationdomain containing 2 (NOD2)-mediated signaling by proteasomal degradation of NOD2, suggesting that TRIM27 could be a new target for therapeutic intervention in NOD2-associated diseases such as Crohn's []. High expression of TRIM27 is observed in several human cancers, including breast and endometrial cancer, where elevated TRIM27 expression predicts poor prognosis []. Also, TRIM27 forms an oncogenic fusion protein with Ret proto-oncogene. It is involved in different stages of spermatogenesis and its significant expression in male germ cells and seminomas, suggests that TRIM27 may be associated with the regulation of testicular germ cell proliferation and histological-type of germ cell tumors [, ]. TRIM27 could also be a predictive marker for chemoresistance in ovarian cancer patients []. In the neurotoxin model of Parkinson's disease (PD), deficiency of TRIM27 decreases apoptosis and protects dopaminergic neurons, making TRIM27 an effective potential target during the treatment of PD [].
Publication
First Author: Hanks SK
Year: 1988
Journal: Science
Title: The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.
Volume: 241
Issue: 4861
Pages: 42-52
Publication
First Author: Manning G
Year: 2002
Journal: Trends Biochem Sci
Title: Evolution of protein kinase signaling from yeast to man.
Volume: 27
Issue: 10
Pages: 514-20
Publication
First Author: Manning G
Year: 2002
Journal: Science
Title: The protein kinase complement of the human genome.
Volume: 298
Issue: 5600
Pages: 1912-34
Publication
First Author: Stout TJ
Year: 2004
Journal: Curr Pharm Des
Title: High-throughput structural biology in drug discovery: protein kinases.
Volume: 10
Issue: 10
Pages: 1069-82
Publication
First Author: Li B
Year: 2004
Journal: Comb Chem High Throughput Screen
Title: Creating chemical diversity to target protein kinases.
Volume: 7
Issue: 5
Pages: 453-72
Publication
First Author: Cairns LA
Year: 1997
Journal: Oncogene
Title: Immortalization of neuro-endocrine cells from adrenal tumors arising in SV40 T-transgenic mice.
Volume: 14
Issue: 25
Pages: 3093-8
Publication
First Author: Baloh RH
Year: 1998
Journal: Neuron
Title: Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex.
Volume: 21
Issue: 6
Pages: 1291-302
Publication
First Author: Mason I I
Year: 1996
Journal: Mol Cell Neurosci
Title: The GDNF Receptor: Recent Progress and Unanswered Questions
Volume: 8
Issue: 2/3
Pages: 112-9
Publication
First Author: Saarma M
Year: 2000
Journal: Eur J Biochem
Title: GDNF - a stranger in the TGF-beta superfamily?
Volume: 267
Issue: 24
Pages: 6968-71
Publication
First Author: Pichel JG
Year: 1996
Journal: Nature
Title: Defects in enteric innervation and kidney development in mice lacking GDNF.
Volume: 382
Issue: 6586
Pages: 73-6
Publication
First Author: Ramer MS
Year: 2000
Journal: Nature
Title: Functional regeneration of sensory axons into the adult spinal cord.
Volume: 403
Issue: 6767
Pages: 312-6
Publication
First Author: Meng X
Year: 2000
Journal: Science
Title: Regulation of cell fate decision of undifferentiated spermatogonia by GDNF.
Volume: 287
Issue: 5457
Pages: 1489-93
Protein Domain
Type: Family
Description: The GDNF family members (consists of GDNF, neurturin, artemin and persephin) are structurally similar to transforming growth factor-beta. Unlike other members of the TGF-beta superfamily, which signal through the receptor serine-threonine kinases, GDNF family ligands activate intracellular signalling cascades via the receptor tyrosine kinase Ret. GDNF family ligands binds to GDNF family receptor alpha (GFRalpha) and then the GDNF family ligand-GFRalpha complex binds to and stimulates autophosphorylation of Ret. For instance, GDNF binds to GFRalpha1, Neurturin binds to GFRalpha2, artemin to GFRalpha3 and persephin activates Ret by binding to GFRalpha4. The GDNF family members support the survival of dopamine neurons and motoneurons, and some of them also regulate the development of enteric, sympathetic and parasympathetic neurons []. GDNF also functions in the regeneration of sensory axons after spinal cord injury [], regulation of spermatogonia renewal and differentiation during male spermatogenesis []. It is also involved in kidney development [].
Protein Domain
Type: Family
Description: Glial cell line-derived neurotrophic factor (GDNF) and its related factorsneurturin (NTN), artemin (ART) and persephin (PSP), are members of the GDNFfamily of neurotrophic factors. They form a sub-group in the transforming growth factor-beta (TGF-beta) superfamily. These factors are involved inthe promotion of neurone survival, exerting their effects through specific receptors.The GDNF family receptors (GFRs) are glycosyl-phosphatidylinositol-linked,cell surface receptors []. Four receptor subtypes, termed GFRalpha-1 to 4, are currently recognised. Homologues for the GFRalpha-1 receptor subtype have been cloned from mammalian and avian tissue. The receptor is activated by GDNF [], although there is evidence it can also bind neurturin, the principal ligand for GFRalpha-2 [].Activation of GFRalpha-1 triggers its interaction with the membrane-bound receptor kinase Ret. This induces Ret homo-dimerisation, triggering a cascade of intracellular signalling events such as the activation of the Ras-mitogen-activated protein kinase (MAPK), phosphoinositol-3-kinase (PI3K), Jun N-terminal kinase (JNK) and phospholipase C gamma (PLC gamma) dependent pathways [].
Protein Domain
Type: Family
Description: Glial cell line-derived neurotrophic factor (GDNF) and its related factorsneurturin (NTN), artemin (ART) and persephin (PSP), are members of the GDNFfamily of neurotrophic factors. They form a sub-group in the transforming growth factor-beta (TGF-beta) superfamily. These factors are involved inthe promotion of neurone survival, exerting their effects through specific receptors.The GDNF family receptors (GFRs) are glycosyl-phosphatidylinositol-linked,cell surface receptors []. Four receptor subtypes, termed GFRalpha-1 to 4, are currently recognised. Homologues for the GFRalpha-2 receptor subtype have been cloned from mammalian and avian tissue. The receptor is preferentially activated by neurturin, although there is evidence that GFRalpha-2 can also bindGDNF if pre-coupled to its effector molecule [].Activation of GFRalpha-2 triggers its interaction with the membrane-bound receptor kinase Ret. This induces Ret homo-dimerisation, triggering a cascade of intracellular signalling events such as the activation of the Ras-mitogen-activated protein kinase (MAPK), phosphoinositol-3-kinase (PI3K), Jun N-terminal kinase (JNK) and phospholipase C gamma (PLC gamma) dependent pathways [].
Protein Domain
Type: Family
Description: Glial cell line-derived neurotrophic factor (GDNF) and its related factorsneurturin (NTN), artemin (ART) and persephin (PSP), are members of the GDNFfamily of neurotrophic factors. They form a sub-group in the transforming growth factor-beta (TGF-beta) superfamily. These factors are involved inthe promotion of neurone survival, exerting their effects through specific receptors.The GDNF family receptors (GFRs) are glycosyl-phosphatidylinositol-linked,cell surface receptors []. Four receptor subtypes, termed GFRalpha-1 to 4, are currently recognised. GFRalpha-3 has been cloned from mammalian tissue []. It represents the least conserved member of the GFR family in terms of amino acid sequence, and is activated by artemin [].Activation of GFR family members triggers their interaction with the membrane-bound receptor kinase Ret. This induces Ret homo-dimerisation, triggering a cascade of intracellular signalling events such as the activation of the Ras-mitogen-activated protein kinase (MAPK), phosphoinositol-3-kinase (PI3K), Jun N-terminal kinase (JNK) and phospholipase C gamma (PLC gamma) dependent pathways [].
Publication
First Author: Terme M
Year: 2011
Journal: Cancer Res
Title: IL-18 induces PD-1-dependent immunosuppression in cancer.
Volume: 71
Issue: 16
Pages: 5393-9
Publication
First Author: Jayaraman P
Year: 2012
Journal: J Immunol
Title: Tumor-expressed inducible nitric oxide synthase controls induction of functional myeloid-derived suppressor cells through modulation of vascular endothelial growth factor release.
Volume: 188
Issue: 11
Pages: 5365-76
Publication
First Author: Hong M
Year: 2011
Journal: Cancer Res
Title: Chemotherapy induces intratumoral expression of chemokines in cutaneous melanoma, favoring T-cell infiltration and tumor control.
Volume: 71
Issue: 22
Pages: 6997-7009
Publication
First Author: Eyles J
Year: 2010
Journal: J Clin Invest
Title: Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma.
Volume: 120
Issue: 6
Pages: 2030-9
Publication
First Author: Kwak T
Year: 2020
Journal: Cell Rep
Title: Distinct Populations of Immune-Suppressive Macrophages Differentiate from Monocytic Myeloid-Derived Suppressor Cells in Cancer.
Volume: 33
Issue: 13
Pages: 108571
Genotype
Symbol: Immp2l/? Tg(Mt1-RET)304Ina/?
Background: involves: BALB/c * C57BL/6 * CBA/Ca
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Kitl/Kitl Tg(Mt1-RET)304Ina/?
Background: involves: BALB/c * C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 672  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 351  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 508  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 806  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 424  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1064  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1302  
Fragment?: false
Publication
First Author: Nomoto S
Year: 1998
Journal: Biochem Biophys Res Commun
Title: Molecular cloning and expression analysis of GFR alpha-3, a novel cDNA related to GDNFR alpha and NTNR alpha.
Volume: 244
Issue: 3
Pages: 849-53
Publication
First Author: Milbrandt J
Year: 1998
Journal: Neuron
Title: Persephin, a novel neurotrophic factor related to GDNF and neurturin.
Volume: 20
Issue: 2
Pages: 245-53
Publication
First Author: Harada H
Year: 1999
Journal: Mol Cell Biol
Title: HERF1, a novel hematopoiesis-specific RING finger protein, is required for terminal differentiation of erythroid cells.
Volume: 19
Issue: 5
Pages: 3808-15
Publication
First Author: Yin Z
Year: 2021
Journal: Nat Commun
Title: Structural basis for a complex I mutation that blocks pathological ROS production.
Volume: 12
Issue: 1
Pages: 707
Publication
First Author: Enomoto H
Year: 1998
Journal: Neuron
Title: GFR alpha1-deficient mice have deficits in the enteric nervous system and kidneys.
Volume: 21
Issue: 2
Pages: 317-24
Publication
First Author: Rossi J
Year: 1999
Journal: Neuron
Title: Retarded growth and deficits in the enteric and parasympathetic nervous system in mice lacking GFR alpha2, a functional neurturin receptor.
Volume: 22
Issue: 2
Pages: 243-52
Publication
First Author: Huett A
Year: 2009
Journal: Exp Cell Res
Title: The cytoskeletal scaffold Shank3 is recruited to pathogen-induced actin rearrangements.
Volume: 315
Issue: 12
Pages: 2001-11
Publication
First Author: Yu M
Year: 2019
Journal: Biochem Biophys Res Commun
Title: Intrauterine low-protein diet disturbs metanephric gene expression and induces urinary tract developmental abnormalities in mice.
Volume: 513
Issue: 3
Pages: 732-739
Publication
First Author: Macià A
Year: 2012
Journal: Oncogene
Title: Sprouty1 is a candidate tumor-suppressor gene in medullary thyroid carcinoma.
Volume: 31
Issue: 35
Pages: 3961-72
Publication
First Author: Decressac M
Year: 2012
Journal: Sci Transl Med
Title: α-Synuclein-induced down-regulation of Nurr1 disrupts GDNF signaling in nigral dopamine neurons.
Volume: 4
Issue: 163
Pages: 163ra156
Publication
First Author: Zeng Z
Year: 2021
Journal: Nat Commun
Title: Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors.
Volume: 12
Issue: 1
Pages: 3641
Publication
First Author: Leone V
Year: 2015
Journal: Oncotarget
Title: Ccdc6 knock-in mice develop thyroid hyperplasia associated to an enhanced CREB1 activity.
Volume: 6
Issue: 17
Pages: 15628-38
Publication
First Author: Rimm DL
Year: 1994
Journal: Biochem Biophys Res Commun
Title: Molecular cloning of human E-cadherin suggests a novel subdivision of the cadherin superfamily.
Volume: 200
Issue: 3
Pages: 1754-61
Publication
First Author: Treanor JJ
Year: 1996
Journal: Nature
Title: Characterization of a multicomponent receptor for GDNF.
Volume: 382
Issue: 6586
Pages: 80-3
Publication
First Author: Hasegawa N
Year: 1996
Journal: Biochem Biophys Res Commun
Title: A RING finger motif regulates transforming activity of the rfp/ret fusion gene.
Volume: 225
Issue: 2
Pages: 627-31
Publication
First Author: Heuckeroth RO
Year: 1997
Journal: Genomics
Title: Neurturin, a novel neurotrophic factor, is localized to mouse chromosome 17 and human chromosome 19p13.3.
Volume: 44
Issue: 1
Pages: 137-40
Publication
First Author: Puliti A
Year: 1997
Journal: Cytogenet Cell Genet
Title: Assignment of mouse Gfra1, the homologue of a new human HSCR candidate gene, to the telomeric region of mouse chromosome 19.
Volume: 78
Issue: 3-4
Pages: 291-4
Publication
First Author: Yoong LF
Year: 2009
Journal: Mol Cell Neurosci
Title: GDNF-induced cell signaling and neurite outgrowths are differentially mediated by GFRalpha1 isoforms.
Volume: 41
Issue: 4
Pages: 464-73
Publication
First Author: Santoro M
Year: 1996
Journal: Oncogene
Title: Development of thyroid papillary carcinomas secondary to tissue-specific expression of the RET/PTC1 oncogene in transgenic mice.
Volume: 12
Issue: 8
Pages: 1821-6
Publication
First Author: Li L
Year: 2019
Journal: Nat Metab
Title: Muscle stem cell renewal suppressed by Gas1 can be reversed by GDNF in mice.
Volume: 1
Issue: 10
Pages: 985-995
Publication  
First Author: Lasser S
Year: 2024
Journal: Int J Mol Sci
Title: Generation of Myeloid-Derived Suppressor Cells Mediated by MicroRNA-125a-5p in Melanoma.
Volume: 25
Issue: 12
Publication
First Author: Airaksinen MS
Year: 1999
Journal: Mol Cell Neurosci
Title: GDNF family neurotrophic factor signaling: four masters, one servant?
Volume: 13
Issue: 5
Pages: 313-25
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Creedon DJ
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons.
Volume: 94
Issue: 13
Pages: 7018-23
Publication
First Author: Thompson J
Year: 1998
Journal: Mol Cell Neurosci
Title: GFRalpha-4, a new GDNF family receptor.
Volume: 11
Issue: 3
Pages: 117-26
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 351  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 722  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 593  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 86  
Fragment?: false