| Type |
Details |
Score |
| Protein Domain |
| Type: |
Domain |
| Description: |
Ret is a single transmembrane-spanning receptor tyrosine kinase (RTK) that plays critical roles in the development of vertebrates. It contains four consecutive cadherin-like domains (CLD). This entry represents the first CLD at the N-terminal. Several regions within RET-CLD1 have been shown to be important for ligand-coreceptor binding. CLD1 and CLD2 have a distinctive clamshell shape and CLD1 is essential for CLD2 folding. CLD1 contains 2 sites for GDNF receptor alpha 1 binding []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Proteins in this entry have an N-terminal FKBP-type peptidyl-prolyl cis-trans isomerase domain followed by a C-terminal tetratricopeptide repeat-containing domain. Included in this entry are: aryl-hydrocarbon-interacting protein-like 1 (AIPL1), which is associated with inherited blindness and interacts with cell cycle regulator protein NUB1 []; and AH receptor-interacting protein (AIP), which interacts with the tyrosine kinase receptor RET [], and mutations in AIP are associated with familial isolated pituitary adenomas []. |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, congenic, transgenic, spontaneous mutation |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 1, Frank Costantini |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, congenic, transgenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, congenic, transgenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, targeted mutation |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Kit/Kit Tg(Mt1-RET)304Ina/? |
| Background: |
involves: BALB/c * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Kit/Kit<+> Tg(Mt1-RET)304Ina/? |
| Background: |
involves: BALB/c * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Henry J |
| Year: |
1997 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
B30.2-like domain proteins: a growing family. |
| Volume: |
235 |
| Issue: |
1 |
| Pages: |
162-5 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, congenic, transgenic, spontaneous mutation |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kato M |
| Year: |
2006 |
| Journal: |
J Invest Dermatol |
| Title: |
Novel hairless RET-transgenic mouse line with melanocytic nevi and anagen hair follicles. |
| Volume: |
126 |
| Issue: |
11 |
| Pages: |
2547-50 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fidanza M |
| Year: |
2017 |
| Journal: |
Eur J Immunol |
| Title: |
IFN-γ directly inhibits murine B-cell precursor leukemia-initiating cell proliferation early in life. |
| Volume: |
47 |
| Issue: |
5 |
| Pages: |
892-899 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kumar V |
| Year: |
2017 |
| Journal: |
Cancer Cell |
| Title: |
Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors. |
| Volume: |
32 |
| Issue: |
5 |
| Pages: |
654-668.e5 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, transgenic, congenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
transgenic, mutant strain |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Ednrb/Ednrb<+> Tg(Mt1-RET)304Ina/? |
| Background: |
involves: 129S7/SvEvBrd * BALB/c * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1321
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
461
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1043
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
695
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zurek B |
| Year: |
2012 |
| Journal: |
PLoS One |
| Title: |
TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation. |
| Volume: |
7 |
| Issue: |
7 |
| Pages: |
e41255 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zoumpoulidou G |
| Year: |
2012 |
| Journal: |
J Natl Cancer Inst |
| Title: |
Role of the tripartite motif protein 27 in cancer development. |
| Volume: |
104 |
| Issue: |
12 |
| Pages: |
941-52 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu Y |
| Year: |
2014 |
| Journal: |
Brain Res |
| Title: |
Deficiency of Trim27 protects dopaminergic neurons from apoptosis in the neurotoxin model of Parkinson's disease. |
| Volume: |
1588 |
|
| Pages: |
17-24 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C terminus of TRIM27, also known as RING finger protein 76 (RNF76) or RET finger protein (RFP). TRIM proteins are defined by the presence of the tripartite motif RING/B-box/coiled-coil region and are also known as RBCC proteins []. TRIM27 exhibits either nuclear or cytosolic localization depending on the cell type. TRIM27 negatively regulates nucleotide-binding oligomerizationdomain containing 2 (NOD2)-mediated signaling by proteasomal degradation of NOD2, suggesting that TRIM27 could be a new target for therapeutic intervention in NOD2-associated diseases such as Crohn's []. High expression of TRIM27 is observed in several human cancers, including breast and endometrial cancer, where elevated TRIM27 expression predicts poor prognosis []. Also, TRIM27 forms an oncogenic fusion protein with Ret proto-oncogene. It is involved in different stages of spermatogenesis and its significant expression in male germ cells and seminomas, suggests that TRIM27 may be associated with the regulation of testicular germ cell proliferation and histological-type of germ cell tumors [, ]. TRIM27 could also be a predictive marker for chemoresistance in ovarian cancer patients []. In the neurotoxin model of Parkinson's disease (PD), deficiency of TRIM27 decreases apoptosis and protects dopaminergic neurons, making TRIM27 an effective potential target during the treatment of PD []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hanks SK |
| Year: |
1988 |
| Journal: |
Science |
| Title: |
The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. |
| Volume: |
241 |
| Issue: |
4861 |
| Pages: |
42-52 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Manning G |
| Year: |
2002 |
| Journal: |
Trends Biochem Sci |
| Title: |
Evolution of protein kinase signaling from yeast to man. |
| Volume: |
27 |
| Issue: |
10 |
| Pages: |
514-20 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Manning G |
| Year: |
2002 |
| Journal: |
Science |
| Title: |
The protein kinase complement of the human genome. |
| Volume: |
298 |
| Issue: |
5600 |
| Pages: |
1912-34 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stout TJ |
| Year: |
2004 |
| Journal: |
Curr Pharm Des |
| Title: |
High-throughput structural biology in drug discovery: protein kinases. |
| Volume: |
10 |
| Issue: |
10 |
| Pages: |
1069-82 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li B |
| Year: |
2004 |
| Journal: |
Comb Chem High Throughput Screen |
| Title: |
Creating chemical diversity to target protein kinases. |
| Volume: |
7 |
| Issue: |
5 |
| Pages: |
453-72 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cairns LA |
| Year: |
1997 |
| Journal: |
Oncogene |
| Title: |
Immortalization of neuro-endocrine cells from adrenal tumors arising in SV40 T-transgenic mice. |
| Volume: |
14 |
| Issue: |
25 |
| Pages: |
3093-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Baloh RH |
| Year: |
1998 |
| Journal: |
Neuron |
| Title: |
Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex. |
| Volume: |
21 |
| Issue: |
6 |
| Pages: |
1291-302 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mason I I |
| Year: |
1996 |
| Journal: |
Mol Cell Neurosci |
| Title: |
The GDNF Receptor: Recent Progress and Unanswered Questions |
| Volume: |
8 |
| Issue: |
2/3 |
| Pages: |
112-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Saarma M |
| Year: |
2000 |
| Journal: |
Eur J Biochem |
| Title: |
GDNF - a stranger in the TGF-beta superfamily? |
| Volume: |
267 |
| Issue: |
24 |
| Pages: |
6968-71 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pichel JG |
| Year: |
1996 |
| Journal: |
Nature |
| Title: |
Defects in enteric innervation and kidney development in mice lacking GDNF. |
| Volume: |
382 |
| Issue: |
6586 |
| Pages: |
73-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ramer MS |
| Year: |
2000 |
| Journal: |
Nature |
| Title: |
Functional regeneration of sensory axons into the adult spinal cord. |
| Volume: |
403 |
| Issue: |
6767 |
| Pages: |
312-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Meng X |
| Year: |
2000 |
| Journal: |
Science |
| Title: |
Regulation of cell fate decision of undifferentiated spermatogonia by GDNF. |
| Volume: |
287 |
| Issue: |
5457 |
| Pages: |
1489-93 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
The GDNF family members (consists of GDNF, neurturin, artemin and persephin) are structurally similar to transforming growth factor-beta. Unlike other members of the TGF-beta superfamily, which signal through the receptor serine-threonine kinases, GDNF family ligands activate intracellular signalling cascades via the receptor tyrosine kinase Ret. GDNF family ligands binds to GDNF family receptor alpha (GFRalpha) and then the GDNF family ligand-GFRalpha complex binds to and stimulates autophosphorylation of Ret. For instance, GDNF binds to GFRalpha1, Neurturin binds to GFRalpha2, artemin to GFRalpha3 and persephin activates Ret by binding to GFRalpha4. The GDNF family members support the survival of dopamine neurons and motoneurons, and some of them also regulate the development of enteric, sympathetic and parasympathetic neurons []. GDNF also functions in the regeneration of sensory axons after spinal cord injury [], regulation of spermatogonia renewal and differentiation during male spermatogenesis []. It is also involved in kidney development []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Glial cell line-derived neurotrophic factor (GDNF) and its related factorsneurturin (NTN), artemin (ART) and persephin (PSP), are members of the GDNFfamily of neurotrophic factors. They form a sub-group in the transforming growth factor-beta (TGF-beta) superfamily. These factors are involved inthe promotion of neurone survival, exerting their effects through specific receptors.The GDNF family receptors (GFRs) are glycosyl-phosphatidylinositol-linked,cell surface receptors []. Four receptor subtypes, termed GFRalpha-1 to 4, are currently recognised. Homologues for the GFRalpha-1 receptor subtype have been cloned from mammalian and avian tissue. The receptor is activated by GDNF [], although there is evidence it can also bind neurturin, the principal ligand for GFRalpha-2 [].Activation of GFRalpha-1 triggers its interaction with the membrane-bound receptor kinase Ret. This induces Ret homo-dimerisation, triggering a cascade of intracellular signalling events such as the activation of the Ras-mitogen-activated protein kinase (MAPK), phosphoinositol-3-kinase (PI3K), Jun N-terminal kinase (JNK) and phospholipase C gamma (PLC gamma) dependent pathways []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Glial cell line-derived neurotrophic factor (GDNF) and its related factorsneurturin (NTN), artemin (ART) and persephin (PSP), are members of the GDNFfamily of neurotrophic factors. They form a sub-group in the transforming growth factor-beta (TGF-beta) superfamily. These factors are involved inthe promotion of neurone survival, exerting their effects through specific receptors.The GDNF family receptors (GFRs) are glycosyl-phosphatidylinositol-linked,cell surface receptors []. Four receptor subtypes, termed GFRalpha-1 to 4, are currently recognised. Homologues for the GFRalpha-2 receptor subtype have been cloned from mammalian and avian tissue. The receptor is preferentially activated by neurturin, although there is evidence that GFRalpha-2 can also bindGDNF if pre-coupled to its effector molecule [].Activation of GFRalpha-2 triggers its interaction with the membrane-bound receptor kinase Ret. This induces Ret homo-dimerisation, triggering a cascade of intracellular signalling events such as the activation of the Ras-mitogen-activated protein kinase (MAPK), phosphoinositol-3-kinase (PI3K), Jun N-terminal kinase (JNK) and phospholipase C gamma (PLC gamma) dependent pathways []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Glial cell line-derived neurotrophic factor (GDNF) and its related factorsneurturin (NTN), artemin (ART) and persephin (PSP), are members of the GDNFfamily of neurotrophic factors. They form a sub-group in the transforming growth factor-beta (TGF-beta) superfamily. These factors are involved inthe promotion of neurone survival, exerting their effects through specific receptors.The GDNF family receptors (GFRs) are glycosyl-phosphatidylinositol-linked,cell surface receptors []. Four receptor subtypes, termed GFRalpha-1 to 4, are currently recognised. GFRalpha-3 has been cloned from mammalian tissue []. It represents the least conserved member of the GFR family in terms of amino acid sequence, and is activated by artemin [].Activation of GFR family members triggers their interaction with the membrane-bound receptor kinase Ret. This induces Ret homo-dimerisation, triggering a cascade of intracellular signalling events such as the activation of the Ras-mitogen-activated protein kinase (MAPK), phosphoinositol-3-kinase (PI3K), Jun N-terminal kinase (JNK) and phospholipase C gamma (PLC gamma) dependent pathways []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Terme M |
| Year: |
2011 |
| Journal: |
Cancer Res |
| Title: |
IL-18 induces PD-1-dependent immunosuppression in cancer. |
| Volume: |
71 |
| Issue: |
16 |
| Pages: |
5393-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jayaraman P |
| Year: |
2012 |
| Journal: |
J Immunol |
| Title: |
Tumor-expressed inducible nitric oxide synthase controls induction of functional myeloid-derived suppressor cells through modulation of vascular endothelial growth factor release. |
| Volume: |
188 |
| Issue: |
11 |
| Pages: |
5365-76 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hong M |
| Year: |
2011 |
| Journal: |
Cancer Res |
| Title: |
Chemotherapy induces intratumoral expression of chemokines in cutaneous melanoma, favoring T-cell infiltration and tumor control. |
| Volume: |
71 |
| Issue: |
22 |
| Pages: |
6997-7009 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Eyles J |
| Year: |
2010 |
| Journal: |
J Clin Invest |
| Title: |
Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma. |
| Volume: |
120 |
| Issue: |
6 |
| Pages: |
2030-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kwak T |
| Year: |
2020 |
| Journal: |
Cell Rep |
| Title: |
Distinct Populations of Immune-Suppressive Macrophages Differentiate from Monocytic Myeloid-Derived Suppressor Cells in Cancer. |
| Volume: |
33 |
| Issue: |
13 |
| Pages: |
108571 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Immp2l/? Tg(Mt1-RET)304Ina/? |
| Background: |
involves: BALB/c * C57BL/6 * CBA/Ca |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Kitl/Kitl Tg(Mt1-RET)304Ina/? |
| Background: |
involves: BALB/c * C57BL/6 * DBA/2 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
672
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
351
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
508
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
806
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
424
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1064
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1302
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nomoto S |
| Year: |
1998 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Molecular cloning and expression analysis of GFR alpha-3, a novel cDNA related to GDNFR alpha and NTNR alpha. |
| Volume: |
244 |
| Issue: |
3 |
| Pages: |
849-53 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Milbrandt J |
| Year: |
1998 |
| Journal: |
Neuron |
| Title: |
Persephin, a novel neurotrophic factor related to GDNF and neurturin. |
| Volume: |
20 |
| Issue: |
2 |
| Pages: |
245-53 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Harada H |
| Year: |
1999 |
| Journal: |
Mol Cell Biol |
| Title: |
HERF1, a novel hematopoiesis-specific RING finger protein, is required for terminal differentiation of erythroid cells. |
| Volume: |
19 |
| Issue: |
5 |
| Pages: |
3808-15 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yin Z |
| Year: |
2021 |
| Journal: |
Nat Commun |
| Title: |
Structural basis for a complex I mutation that blocks pathological ROS production. |
| Volume: |
12 |
| Issue: |
1 |
| Pages: |
707 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Enomoto H |
| Year: |
1998 |
| Journal: |
Neuron |
| Title: |
GFR alpha1-deficient mice have deficits in the enteric nervous system and kidneys. |
| Volume: |
21 |
| Issue: |
2 |
| Pages: |
317-24 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rossi J |
| Year: |
1999 |
| Journal: |
Neuron |
| Title: |
Retarded growth and deficits in the enteric and parasympathetic nervous system in mice lacking GFR alpha2, a functional neurturin receptor. |
| Volume: |
22 |
| Issue: |
2 |
| Pages: |
243-52 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Huett A |
| Year: |
2009 |
| Journal: |
Exp Cell Res |
| Title: |
The cytoskeletal scaffold Shank3 is recruited to pathogen-induced actin rearrangements. |
| Volume: |
315 |
| Issue: |
12 |
| Pages: |
2001-11 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yu M |
| Year: |
2019 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Intrauterine low-protein diet disturbs metanephric gene expression and induces urinary tract developmental abnormalities in mice. |
| Volume: |
513 |
| Issue: |
3 |
| Pages: |
732-739 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Macià A |
| Year: |
2012 |
| Journal: |
Oncogene |
| Title: |
Sprouty1 is a candidate tumor-suppressor gene in medullary thyroid carcinoma. |
| Volume: |
31 |
| Issue: |
35 |
| Pages: |
3961-72 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Decressac M |
| Year: |
2012 |
| Journal: |
Sci Transl Med |
| Title: |
α-Synuclein-induced down-regulation of Nurr1 disrupts GDNF signaling in nigral dopamine neurons. |
| Volume: |
4 |
| Issue: |
163 |
| Pages: |
163ra156 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zeng Z |
| Year: |
2021 |
| Journal: |
Nat Commun |
| Title: |
Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors. |
| Volume: |
12 |
| Issue: |
1 |
| Pages: |
3641 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Leone V |
| Year: |
2015 |
| Journal: |
Oncotarget |
| Title: |
Ccdc6 knock-in mice develop thyroid hyperplasia associated to an enhanced CREB1 activity. |
| Volume: |
6 |
| Issue: |
17 |
| Pages: |
15628-38 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rimm DL |
| Year: |
1994 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Molecular cloning of human E-cadherin suggests a novel subdivision of the cadherin superfamily. |
| Volume: |
200 |
| Issue: |
3 |
| Pages: |
1754-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Treanor JJ |
| Year: |
1996 |
| Journal: |
Nature |
| Title: |
Characterization of a multicomponent receptor for GDNF. |
| Volume: |
382 |
| Issue: |
6586 |
| Pages: |
80-3 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hasegawa N |
| Year: |
1996 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
A RING finger motif regulates transforming activity of the rfp/ret fusion gene. |
| Volume: |
225 |
| Issue: |
2 |
| Pages: |
627-31 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Heuckeroth RO |
| Year: |
1997 |
| Journal: |
Genomics |
| Title: |
Neurturin, a novel neurotrophic factor, is localized to mouse chromosome 17 and human chromosome 19p13.3. |
| Volume: |
44 |
| Issue: |
1 |
| Pages: |
137-40 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Puliti A |
| Year: |
1997 |
| Journal: |
Cytogenet Cell Genet |
| Title: |
Assignment of mouse Gfra1, the homologue of a new human HSCR candidate gene, to the telomeric region of mouse chromosome 19. |
| Volume: |
78 |
| Issue: |
3-4 |
| Pages: |
291-4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yoong LF |
| Year: |
2009 |
| Journal: |
Mol Cell Neurosci |
| Title: |
GDNF-induced cell signaling and neurite outgrowths are differentially mediated by GFRalpha1 isoforms. |
| Volume: |
41 |
| Issue: |
4 |
| Pages: |
464-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Santoro M |
| Year: |
1996 |
| Journal: |
Oncogene |
| Title: |
Development of thyroid papillary carcinomas secondary to tissue-specific expression of the RET/PTC1 oncogene in transgenic mice. |
| Volume: |
12 |
| Issue: |
8 |
| Pages: |
1821-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li L |
| Year: |
2019 |
| Journal: |
Nat Metab |
| Title: |
Muscle stem cell renewal suppressed by Gas1 can be reversed by GDNF in mice. |
| Volume: |
1 |
| Issue: |
10 |
| Pages: |
985-995 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lasser S |
| Year: |
2024 |
| Journal: |
Int J Mol Sci |
| Title: |
Generation of Myeloid-Derived Suppressor Cells Mediated by MicroRNA-125a-5p in Melanoma. |
| Volume: |
25 |
| Issue: |
12 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Airaksinen MS |
| Year: |
1999 |
| Journal: |
Mol Cell Neurosci |
| Title: |
GDNF family neurotrophic factor signaling: four masters, one servant? |
| Volume: |
13 |
| Issue: |
5 |
| Pages: |
313-25 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Creedon DJ |
| Year: |
1997 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons. |
| Volume: |
94 |
| Issue: |
13 |
| Pages: |
7018-23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Thompson J |
| Year: |
1998 |
| Journal: |
Mol Cell Neurosci |
| Title: |
GFRalpha-4, a new GDNF family receptor. |
| Volume: |
11 |
| Issue: |
3 |
| Pages: |
117-26 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
351
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
722
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
593
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
86
 |
| Fragment?: |
false |
|
•
•
•
•
•
|