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Search results 2701 to 2785 out of 2785 for Tgfb1

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Hits by Strain

Type Details Score
Genotype
Genotype
Symbol: Tg(Dspp-TGFB1)3Kul/?
Background: FVB/N-Tg(Dspp-TGFB1)3Kul
Zygosity: ot
Has Mutant Allele: true
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Publication
10025398 | -
First Author: Munger JS
Year: 1999
Journal: Cell
Title: The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis.
Volume: 96
Issue: 3
Pages: 319-28
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Protein Domain
IPR015436 | Integrin_bsu-6
Type: Family
Description: Integrins are the major metazoan receptors for cell adhesion to extracellular matrix proteins and, in vertebrates, also play important roles in certain cell-cell adhesions, make transmembrane connections to the cytoskeleton and activate many intracellular signalling pathways [, ]. An integrin receptor is a heterodimer composed of alpha and beta subunits. Each subunit crosses the membrane once, with most of the polypeptide residing in the extracellular space, and has two short cytoplasmic domains. Some members of this family have EGF repeats at the C terminus and also have a vWA domain inserted within the integrin domain at the N terminus.Most integrins recognise relatively short peptide motifs, and in general require an acidic amino acid to be present. Ligand specificity depends upon both the alpha and beta subunits []. There are at least 18 types of alpha and 8 types of beta subunits recognised in humans []. Each alpha subunit tends to associate only with one type of beta subunit, but there are exceptions to this rule []. Each association of alpha and beta subunits has its own binding specificity and signalling properties. Many integrins require activation on the cell surface before they can bind ligands. Integrins frequently intercommunicate, and binding at one integrin receptor activate or inhibit another.Integrin Beta-6 associates with Alpha-V to form the receptor for the TGFB1 latency-associated peptide (LAP) []. Cells expressing this integrin combination induce spatially restricted activation of TGFB1, while mice lacking the integrin display exaggerated inflammation and are protected from pulmonary fibrosis.
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Publication
32905781 | J:350342
First Author: Liu J
Year: 2020
Journal: Cell Rep
Title: YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways.
Volume: 32
Issue: 10
Pages: 108120
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Publication
32393780 | J:292230
First Author: Halder LD
Year: 2020
Journal: Nat Commun
Title: Immune modulation by complement receptor 3-dependent human monocyte TGF-β1-transporting vesicles.
Volume: 11
Issue: 1
Pages: 2331
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Publication
30842416 | J:276456
First Author: Zhao B
Year: 2019
Journal: Nat Commun
Title: Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation.
Volume: 10
Issue: 1
Pages: 1071
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Publication
38134933 | J:351869
First Author: Kirschenbaum D
Year: 2024
Journal: Cell
Title: Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma.
Volume: 187
Issue: 1
Pages: 149-165.e23
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Publication
30753853 | J:274954
 
First Author: Mattos RM
Year: 2019
Journal: Mol Cell Endocrinol
Title: Galectin-3 plays an important role in endometriosis development and is a target to endometriosis treatment.
Volume: 486
Pages: 1-10
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Publication
20511416 | J:163556
First Author: Buday A
Year: 2010
Journal: Am J Physiol Heart Circ Physiol
Title: Elevated systemic TGF-beta impairs aortic vasomotor function through activation of NADPH oxidase-driven superoxide production and leads to hypertension, myocardial remodeling, and increased plaque formation in apoE(-/-) mice.
Volume: 299
Issue: 2
Pages: H386-95
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Publication
24598802 | J:210519
First Author: Casalena G
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: Mpv17 in mitochondria protects podocytes against mitochondrial dysfunction and apoptosis in vivo and in vitro.
Volume: 306
Issue: 11
Pages: F1372-80
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Publication
24086574 | J:207739
First Author: Shi S
Year: 2013
Journal: PLoS One
Title: Smad2-dependent downregulation of miR-30 is required for TGF-β-induced apoptosis in podocytes.
Volume: 8
Issue: 9
Pages: e75572
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Publication
19679673 | J:166322
First Author: Xavier S
Year: 2009
Journal: J Am Soc Nephrol
Title: TbetaRI independently activates Smad- and CD2AP-dependent pathways in podocytes.
Volume: 20
Issue: 10
Pages: 2127-37
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Publication
28176763 | J:244207
 
First Author: Hinge A
Year: 2017
Journal: Nat Commun
Title: p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation.
Volume: 8
Pages: 14382
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Publication
14973059 | J:88454
First Author: Deane NG
Year: 2004
Journal: Cancer Res
Title: Enhanced tumor formation in cyclin D1 x transforming growth factor beta1 double transgenic mice with characterization by magnetic resonance imaging.
Volume: 64
Issue: 4
Pages: 1315-22
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Publication
8955056 | J:127685
First Author: Raber J
Year: 1996
Journal: Virology
Title: Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase.
Volume: 226
Issue: 2
Pages: 362-73
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Publication
22301622 | J:183419
First Author: Lan R
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: PTEN loss defines a TGF-β-induced tubule phenotype of failed differentiation and JNK signaling during renal fibrosis.
Volume: 302
Issue: 9
Pages: F1210-23
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Publication
9335500 | J:102272
First Author: Wyss-Coray T
Year: 1997
Journal: Nature
Title: Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease.
Volume: 389
Issue: 6651
Pages: 603-6
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Publication
15333328 | J:104587
First Author: Vicencio AG
Year: 2004
Journal: Am J Respir Cell Mol Biol
Title: Conditional overexpression of bioactive transforming growth factor-beta1 in neonatal mouse lung: a new model for bronchopulmonary dysplasia?
Volume: 31
Issue: 6
Pages: 650-6
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Publication
18403781 | J:152130
First Author: Pulichino AM
Year: 2008
Journal: Am J Respir Cell Mol Biol
Title: Identification of transforming growth factor beta1-driven genetic programs of acute lung fibrosis.
Volume: 39
Issue: 3
Pages: 324-36
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Genotype
Genotype
Symbol: Tg(Gfap-TGFB1)64Lms/? Tg(PDGFB-APPInd)H6Lms/?
Background: involves: BALB/c * SJL
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Pax8-rtTA2S*M2)1Koes/? Tg(tetO-TGFB1*C223S*C225S)1Glk/?
Background: involves: C57BL/6 * DBA
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(KRT5-rtTA)1Glk/? Tg(tetO-TGFB1*C223S*C225S)1Glk/?
Background: involves: FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Scgb1a1-rtTA,-tTS,tetO-TGFB1*)1Eli/?
Background: involves: C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Publication
25007801 | J:232468
First Author: Hoeksema MA
Year: 2014
Journal: EMBO Mol Med
Title: Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions.
Volume: 6
Issue: 9
Pages: 1124-32
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Publication
36911699 | J:335142
 
First Author: Pearson JA
Year: 2023
Journal: Front Immunol
Title: NLRP6 deficiency expands a novel CD103(+) B cell population that confers immune tolerance in NOD mice.
Volume: 14
Pages: 1147925
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Publication
37098757 | J:359642
First Author: Sharma A
Year: 2023
Journal: J Cell Physiol
Title: CD14 is not required for carbon tetrachloride-induced hepatic inflammation and fibrosis with or without lipopolysaccharide challenge.
Volume: 238
Issue: 7
Pages: 1530-1541
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Publication
35725453 | J:334835
First Author: Qin W
Year: 2022
Journal: Respir Res
Title: Myeloid DNA methyltransferase3b deficiency aggravates pulmonary fibrosis by enhancing profibrotic macrophage activation.
Volume: 23
Issue: 1
Pages: 162
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Publication
22785323 | J:317571
First Author: Tsuchiya Y
Year: 2012
Journal: J Reprod Dev
Title: Runx3 expression and its roles in mouse endometrial cells.
Volume: 58
Issue: 5
Pages: 592-8
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Publication
29563234 | J:311060
First Author: Heo JY
Year: 2018
Journal: J Endocrinol
Title: Clusterin deficiency induces lipid accumulation and tissue damage in kidney.
Volume: 237
Issue: 2
Pages: 175-191
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Publication
22279205 | J:180505
First Author: Arnold TD
Year: 2012
Journal: J Neurosci
Title: Defective retinal vascular endothelial cell development as a consequence of impaired integrin αVβ8-mediated activation of transforming growth factor-β.
Volume: 32
Issue: 4
Pages: 1197-206
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Publication
23776564 | J:204231
First Author: Lu P
Year: 2013
Journal: PLoS One
Title: High beta-palmitate fat controls the intestinal inflammatory response and limits intestinal damage in mucin Muc2 deficient mice.
Volume: 8
Issue: 6
Pages: e65878
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Publication
34272410 | J:346540
First Author: Lippai R
Year: 2021
Journal: Sci Rep
Title: Immunomodulatory role of Parkinson's disease 7 in inflammatory bowel disease.
Volume: 11
Issue: 1
Pages: 14582
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Publication
31331942 | J:284135
 
First Author: Li C
Year: 2019
Journal: Development
Title: Secondary crest myofibroblast PDGFRα controls the elastogenesis pathway via a secondary tier of signaling networks during alveologenesis.
Volume: 146
Issue: 15
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Publication
18288100 | J:152878
First Author: Philippe A
Year: 2008
Journal: Kidney Int
Title: A missense mutation in podocin leads to early and severe renal disease in mice.
Volume: 73
Issue: 9
Pages: 1038-47
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Publication
34093596 | J:314528
 
First Author: Yin L
Year: 2021
Journal: Front Immunol
Title: PARK7 Protects Against Chronic Kidney Injury and Renal Fibrosis by Inducing SOD2 to Reduce Oxidative Stress.
Volume: 12
Pages: 690697
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Publication
27334059 | J:301994
First Author: Zempo H
Year: 2016
Journal: Hypertens Res
Title: Influence of periostin-positive cell-specific Klf5 deletion on aortic thickening in DOCA-salt hypertensive mice.
Volume: 39
Issue: 11
Pages: 764-768
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Publication
33495844 | J:309508
 
First Author: Tokinoya K
Year: 2021
Journal: Mol Med Rep
Title: Effects of renalase deficiency on liver fibrosis markers in a nonalcoholic steatohepatitis mouse model.
Volume: 23
Issue: 3
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Publication
22095742 | J:186286
First Author: Li L
Year: 2012
Journal: J Cell Biochem
Title: MiR-17-92 cluster regulates cell proliferation and collagen synthesis by targeting TGFB pathway in mouse palatal mesenchymal cells.
Volume: 113
Issue: 4
Pages: 1235-44
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Publication
25326798 | J:228929
First Author: Zhao M
Year: 2014
Journal: Nat Med
Title: Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells.
Volume: 20
Issue: 11
Pages: 1321-6
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Publication
29596569 | J:265532
First Author: Sharkey DJ
Year: 2018
Journal: Biol Reprod
Title: Interferon-gamma inhibits seminal plasma induction of colony-stimulating factor 2 in mouse and human reproductive tract epithelial cells.
Volume: 99
Issue: 3
Pages: 514-526
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Publication
30427927 | J:267332
First Author: Worton LE
Year: 2018
Journal: PLoS One
Title: Botulinum toxin A-induced muscle paralysis stimulates Hdac4 and differential miRNA expression.
Volume: 13
Issue: 11
Pages: e0207354
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Publication
38001687 | J:343062
 
First Author: Alavi M
Year: 2023
Journal: Cancers (Basel)
Title: Krüppel-like Factor 5 Plays an Important Role in the Pathogenesis of Chronic Pancreatitis.
Volume: 15
Issue: 22
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Publication
19490417 | J:356542
First Author: Milks MW
Year: 2009
Journal: Liver Int
Title: The role of Ifng in alterations in liver gene expression in a mouse model of fulminant autoimmune hepatitis.
Volume: 29
Issue: 9
Pages: 1307-15
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Publication
37263346 | J:339672
First Author: Chen Y
Year: 2023
Journal: Am J Pathol
Title: Transcription Factor Forkhead Box O1 Mediates Transforming Growth Factor-β1-Induced Apoptosis in Hepatocytes.
Volume: 193
Issue: 9
Pages: 1143-1155
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Publication
24714204 | J:214780
First Author: Forkel S
Year: 2014
Journal: J Invest Dermatol
Title: Inositoylated platelet-activating factor (Ino-C2-PAF) modulates dynamic lymphocyte-endothelial cell interactions and alleviates psoriasis-like skin inflammation in two complementary mouse models.
Volume: 134
Issue: 10
Pages: 2510-2520
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Publication
15289506 | J:92469
First Author: Lee CG
Year: 2004
Journal: J Exp Med
Title: Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis.
Volume: 200
Issue: 3
Pages: 377-89
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Publication
28467929 | J:253285
First Author: Calvier L
Year: 2017
Journal: Cell Metab
Title: PPARγ Links BMP2 and TGFβ1 Pathways in Vascular Smooth Muscle Cells, Regulating Cell Proliferation and Glucose Metabolism.
Volume: 25
Issue: 5
Pages: 1118-1134.e7
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Publication
32127548 | J:294598
First Author: Cardot-Ruffino V
Year: 2020
Journal: Sci Rep
Title: Generation of a conditional Flpo/FRT mouse model expressing constitutively active TGFβ in fibroblasts.
Volume: 10
Issue: 1
Pages: 3880
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Publication
16319316 | J:202878
First Author: Tong XK
Year: 2005
Journal: J Neurosci
Title: Vascular remodeling versus amyloid beta-induced oxidative stress in the cerebrovascular dysfunctions associated with Alzheimer's disease.
Volume: 25
Issue: 48
Pages: 11165-74
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Publication
23954171 | J:211979
First Author: Papadopoulos P
Year: 2014
Journal: Neurobiol Aging
Title: Selective benefits of simvastatin in bitransgenic APPSwe,Ind/TGF-β1 mice.
Volume: 35
Issue: 1
Pages: 203-12
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Publication
23874687 | J:204403
First Author: Papadopoulos P
Year: 2013
Journal: PLoS One
Title: Pioglitazone improves reversal learning and exerts mixed cerebrovascular effects in a mouse model of Alzheimer's disease with combined amyloid-β and cerebrovascular pathology.
Volume: 8
Issue: 7
Pages: e68612
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Publication
23889563 | J:321454
First Author: Zhang L
Year: 2013
Journal: Br J Pharmacol
Title: Endothelial TRPV4 channels mediate dilation of cerebral arteries: impairment and recovery in cerebrovascular pathologies related to Alzheimer's disease.
Volume: 170
Issue: 3
Pages: 661-70
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Publication
17079673 | J:114703
First Author: Buckwalter MS
Year: 2006
Journal: J Neurosci
Title: Increased T cell recruitment to the CNS after amyloid beta 1-42 immunization in Alzheimer's mice overproducing transforming growth factor-beta 1.
Volume: 26
Issue: 44
Pages: 11437-41
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Publication
21483750 | J:172234
First Author: Swindell WR
Year: 2011
Journal: PLoS One
Title: Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis.
Volume: 6
Issue: 4
Pages: e18266
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Publication
30232270 | J:285269
 
First Author: Lee CM
Year: 2018
Journal: JCI Insight
Title: Laminin α1 is a genetic modifier of TGF-β1-stimulated pulmonary fibrosis.
Volume: 3
Issue: 18
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Genotype
Genotype
Symbol: Tg(KRT5-tTA)1216Glk/? Tg(tetO-TGFB1*C223S*C225S)1Glk/?
Background: involves: FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Egr1/Egr1 Tg(Scgb1a1-rtTA,-tTS,tetO-TGFB1*)1Eli/?
Background: involves: 129 * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Gfap-TGFB1)64Lms/? Zbtb20/?
Background: involves: BALB/c * C57BL/6 * DBA/2 * SJL
Zygosity: cx
Has Mutant Allele: true
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Publication
32065054 | J:297706
First Author: Nosalski R
Year: 2020
Journal: Circ Res
Title: T-Cell-Derived miRNA-214 Mediates Perivascular Fibrosis in Hypertension.
Volume: 126
Issue: 8
Pages: 988-1003
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Publication
24871103 | J:217343
First Author: Lancha A
Year: 2014
Journal: PLoS One
Title: Osteopontin deletion prevents the development of obesity and hepatic steatosis via impaired adipose tissue matrix remodeling and reduced inflammation and fibrosis in adipose tissue and liver in mice.
Volume: 9
Issue: 5
Pages: e98398
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Publication
15509792 | J:94225
First Author: Gao F
Year: 2004
Journal: Mol Cell Biol
Title: The Wt1+/R394W mouse displays glomerulosclerosis and early-onset renal failure characteristic of human Denys-Drash syndrome.
Volume: 24
Issue: 22
Pages: 9899-910
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Publication
17415547 | J:141728
First Author: Lassila M
Year: 2007
Journal: Diabetologia
Title: Plasminogen activator inhibitor-1 production is pathogenetic in experimental murine diabetic renal disease.
Volume: 50
Issue: 6
Pages: 1315-26
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Publication
30586711 | J:287803
First Author: Xie Y
Year: 2019
Journal: Circulation
Title: LMO7 Is a Negative Feedback Regulator of Transforming Growth Factor β Signaling and Fibrosis.
Volume: 139
Issue: 5
Pages: 679-693
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Publication
34078403 | J:310411
First Author: Ónody A
Year: 2021
Journal: J Transl Med
Title: Interleukin-24 regulates mucosal remodeling in inflammatory bowel diseases.
Volume: 19
Issue: 1
Pages: 237
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Publication
19164180 | J:149631
First Author: Adriaenssens T
Year: 2009
Journal: Biol Reprod
Title: Differences in collagen expression in cumulus cells after exposure to highly purified menotropin or recombinant follicle-stimulating hormone in a mouse follicle culture model.
Volume: 80
Issue: 5
Pages: 1015-25
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Publication
28542608 | J:245454
First Author: Nakamura K
Year: 2017
Journal: PLoS One
Title: Increase in complement iC3b is associated with anti-inflammatory cytokine expression during late pregnancy in mice.
Volume: 12
Issue: 5
Pages: e0178442
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Publication
32574573 | J:293858
 
First Author: Daseke MJ 2nd
Year: 2020
Journal: J Mol Cell Cardiol
Title: Exogenous IL-4 shuts off pro-inflammation in neutrophils while stimulating anti-inflammation in macrophages to induce neutrophil phagocytosis following myocardial infarction.
Volume: 145
Pages: 112-121
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Publication
30127380 | J:341805
First Author: Chen WY
Year: 2019
Journal: Cell Mol Immunol
Title: Human dendritic cell-specific ICAM-3-grabbing non-integrin downstream signaling alleviates renal fibrosis via Raf-1 activation in systemic candidiasis.
Volume: 16
Issue: 3
Pages: 288-301
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Publication
17209037 | J:120886
First Author: Kang HR
Year: 2007
Journal: J Biol Chem
Title: Transforming growth factor (TGF)-beta1 stimulates pulmonary fibrosis and inflammation via a Bax-dependent, bid-activated pathway that involves matrix metalloproteinase-12.
Volume: 282
Issue: 10
Pages: 7723-32
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Publication
25892237 | J:228377
First Author: Endo F
Year: 2015
Journal: Cell Rep
Title: Astrocyte-derived TGF-β1 accelerates disease progression in ALS mice by interfering with the neuroprotective functions of microglia and T cells.
Volume: 11
Issue: 4
Pages: 592-604
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Publication
33162981 | J:308215
 
First Author: Wiemann S
Year: 2020
Journal: Front Immunol
Title: Loss of the Extracellular Matrix Molecule Tenascin-C Leads to Absence of Reactive Gliosis and Promotes Anti-inflammatory Cytokine Expression in an Autoimmune Glaucoma Mouse Model.
Volume: 11
Pages: 566279
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Publication
36317529 | J:338120
First Author: Zheng M
Year: 2022
Journal: Circulation
Title: Hippo-Yap Signaling Maintains Sinoatrial Node Homeostasis.
Volume: 146
Issue: 22
Pages: 1694-1711
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Publication
18724376 | J:140925
First Author: Traykova-Brauch M
Year: 2008
Journal: Nat Med
Title: An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice.
Volume: 14
Issue: 9
Pages: 979-84
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Publication
32338642 | J:341149
First Author: Li R
Year: 2020
Journal: J Clin Invest
Title: Myofibroblast contraction is essential for generating and regenerating the gas-exchange surface.
Volume: 130
Issue: 6
Pages: 2859-2871
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Publication
32805279 | J:305340
First Author: Willers M
Year: 2020
Journal: Gastroenterology
Title: S100A8 and S100A9 Are Important for Postnatal Development of Gut Microbiota and Immune System in Mice and Infants.
Volume: 159
Issue: 6
Pages: 2130-2145.e5
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Protein
Q9D2L4
Organism: Mus musculus/domesticus
Length: 290  
Fragment?: false
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Publication
17429444 | J:121548
First Author: Gudjonsson JE
Year: 2007
Journal: J Invest Dermatol
Title: Mouse models of psoriasis.
Volume: 127
Issue: 6
Pages: 1292-308
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Protein
Q9Z0T9
Organism: Mus musculus/domesticus
Length: 787  
Fragment?: false
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Protein
B1AYG7
Organism: Mus musculus/domesticus
Length: 755  
Fragment?: true
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Protein
B1AYG6
Organism: Mus musculus/domesticus
Length: 764  
Fragment?: false
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Publication
14689578 | -
First Author: Demetriou MC
Year: 2004
Journal: J Cell Biochem
Title: Integrin clipping: a novel adhesion switch?
Volume: 91
Issue: 1
Pages: 26-35
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Publication
2467745 | -
First Author: Cheresh DA
Year: 1989
Journal: Cell
Title: A novel vitronectin receptor integrin (alpha v beta x) is responsible for distinct adhesive properties of carcinoma cells.
Volume: 57
Issue: 1
Pages: 59-69
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Publication
12234368 | -
 
First Author: Arnaout MA
Year: 2002
Journal: Immunol Rev
Title: Integrin structure: new twists and turns in dynamic cell adhesion.
Volume: 186
Pages: 125-40
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Publication
12297042 | -
First Author: Hynes RO
Year: 2002
Journal: Cell
Title: Integrins: bidirectional, allosteric signaling machines.
Volume: 110
Issue: 6
Pages: 673-87
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Publication
12361595 | -
First Author: Bökel C
Year: 2002
Journal: Dev Cell
Title: Integrins in development: moving on, responding to, and sticking to the extracellular matrix.
Volume: 3
Issue: 3
Pages: 311-21
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