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Type Details Score
Protein Domain
Type: Family
Description: This entry represents lactate utilization protein A, which is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source.
Protein Domain
Type: Family
Description: Members of this family closely resemble quinoproteins and quinohemoproteins such as PQQ-dependent methanol, glucose, and shikimate dehydrogenases, but restricted to species of Acidobacteria unable to synthesize PQQ. Seven members occur in Candidatus Solibacter usitatus Ellin6076, eleven in Acidobacteriaceae bacterium KBS 96, etc. Members have N-terminal signal sequences. They lack the pair of adjacent Cys residues, involved in electron transfer, typical for family , and they lack CxxCH motifs for cytochrome c-like heme-binding. What cofactor these paralogous families of enzymes might use is unclear.
Protein Domain
Type: Family
Description: This family of proteins is regulated by the ferric uptake regulator protein Fur []. This family does not regulate the lutABC operon encoding iron sulfur-containing enzymes necessary for growth on lactate [].
Protein Domain
Type: Family
Description: EVA1A, also known as TMEM166, regulates cell autophagy and apoptosis [, ].
Protein Domain
Type: Family
Description: This entry represents glyoxysomal malate synthases and one of two bacterial forms, designated malate synthase A.Malate synthase and isocitrate lyase are the two characteristic enzymes of the glyoxylate cycle. The glyoxylate cycle allows certain organisms, like plants and fungi, to derive their carbon requirements from two-carbon compounds, by bypassing the two carboxylation steps of the citric acid cycle []. Isocitrate lyase, first catalyzes the aldol cleavage of isocitrate to succinate (an intermediate of the tricarboxylic acid cycle) and glyoxylate. Then malate synthase catalyzes the condensation of acetyl CoA with glyoxylate to yield malate (another intermediate of the tricarboxylic acid cycle) [].
Publication
First Author: Orts-Del'immagine A
Year: 2012
Journal: J Physiol
Title: Properties of subependymal cerebrospinal fluid contacting neurones in the dorsal vagal complex of the mouse brainstem.
Volume: 590
Issue: 16
Pages: 3719-41
Publication
First Author: Karki A
Year: 2015
Journal: PLoS One
Title: Silencing Mist1 Gene Expression Is Essential for Recovery from Acute Pancreatitis.
Volume: 10
Issue: 12
Pages: e0145724
Publication
First Author: Lustgarten Guahmich N
Year: 2020
Journal: Angiogenesis
Title: Endothelial deletion of ADAM10, a key regulator of Notch signaling, causes impaired decidualization and reduced fertility in female mice.
Volume: 23
Issue: 3
Pages: 443-458
Publication
First Author: Zaidan N
Year: 2022
Journal: Stem Cell Reports
Title: Endothelial-specific Gata3 expression is required for hematopoietic stem cell generation.
Volume: 17
Issue: 8
Pages: 1788-1798
Protein
Organism: Mus musculus/domesticus
Length: 165  
Fragment?: true
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Saito A
Year: 2011
Journal: J Biol Chem
Title: Endoplasmic reticulum stress response mediated by the PERK-eIF2(alpha)-ATF4 pathway is involved in osteoblast differentiation induced by BMP2.
Volume: 286
Issue: 6
Pages: 4809-18
Publication
First Author: Boyer A
Year: 2016
Journal: Biol Reprod
Title: mTOR Regulates Gap Junction Alpha-1 Protein Trafficking in Sertoli Cells and Is Required for the Maintenance of Spermatogenesis in Mice.
Volume: 95
Issue: 1
Pages: 13
Publication
First Author: Majumder S
Year: 2016
Journal: Cell Rep
Title: G-Protein-Coupled Receptor-2-Interacting Protein-1 Controls Stalk Cell Fate by Inhibiting Delta-like 4-Notch1 Signaling.
Volume: 17
Issue: 10
Pages: 2532-2541
Publication
First Author: Janovick JA
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy.
Volume: 110
Issue: 52
Pages: 21030-5
Publication
First Author: Sabò A
Year: 2014
Journal: Nature
Title: Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis.
Volume: 511
Issue: 7510
Pages: 488-492
Publication
First Author: Sun L
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: A mitotic recombination system for mouse chromosome 17.
Volume: 105
Issue: 11
Pages: 4237-41
Publication
First Author: Smith CJ
Year: 1999
Journal: Trends Cell Biol
Title: Clathrin: anatomy of a coat protein.
Volume: 9
Issue: 9
Pages: 335-8
Publication
First Author: Harney AS
Year: 2015
Journal: Cancer Discov
Title: Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA.
Volume: 5
Issue: 9
Pages: 932-43
Publication
First Author: Tsaousi A
Year: 2016
Journal: PLoS One
Title: Plaque Size Is Decreased but M1 Macrophage Polarization and Rupture Related Metalloproteinase Expression Are Maintained after Deleting T-Bet in ApoE Null Mice.
Volume: 11
Issue: 2
Pages: e0148873
Publication  
First Author: Perhal A
Year: 2019
Journal: Front Med (Lausanne)
Title: Increased Reactive Oxygen Species Generation Contributes to the Atherogenic Activity of the B2 Bradykinin Receptor.
Volume: 6
Pages: 32
Publication
First Author: Maklad A
Year: 2009
Journal: J Invest Dermatol
Title: The EGFR is required for proper innervation to the skin.
Volume: 129
Issue: 3
Pages: 690-8
Publication
First Author: Assali A
Year: 2017
Journal: Sci Rep
Title: RIM1/2 in retinal ganglion cells are required for the refinement of ipsilateral axons and eye-specific segregation.
Volume: 7
Issue: 1
Pages: 3236
Publication
First Author: Itoh A
Year: 2009
Journal: Biochem Biophys Res Commun
Title: Impaired regenerative response of primary sensory neurons in ZPK/DLK gene-trap mice.
Volume: 383
Issue: 2
Pages: 258-62
Publication    
First Author: Buznikov A
Year: 2001
Journal: GenBank Submission
Title: Mus musculus tetraspanin mRNA, complete cds
Pages: AF242591
Publication
First Author: Jang SW
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone.
Volume: 107
Issue: 6
Pages: 2687-92
Publication
First Author: Kovacevic I
Year: 2015
Journal: Circ Res
Title: The F-BAR Protein NOSTRIN Dictates the Localization of the Muscarinic M3 Receptor and Regulates Cardiovascular Function.
Volume: 117
Issue: 5
Pages: 460-9
Publication  
First Author: Yermalovich AV
Year: 2024
Journal: Dev Biol
Title: An essential role for Cmtr2 in mammalian embryonic development.
Volume: 516
Pages: 47-58
Publication
First Author: Kusnadi A
Year: 2019
Journal: Immunity
Title: The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair.
Volume: 51
Issue: 2
Pages: 241-257.e9
Publication
First Author: Shimojo H
Year: 2008
Journal: J Mol Biol
Title: Novel structural and functional mode of a knot essential for RNA binding activity of the Esa1 presumed chromodomain.
Volume: 378
Issue: 5
Pages: 987-1001
Publication
First Author: Mildner A
Year: 2013
Journal: Blood
Title: Mononuclear phagocyte miRNome analysis identifies miR-142 as critical regulator of murine dendritic cell homeostasis.
Volume: 121
Issue: 6
Pages: 1016-27
Publication
First Author: Kuhn A
Year: 2007
Journal: Hum Mol Genet
Title: Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage.
Volume: 16
Issue: 15
Pages: 1845-61
Publication
First Author: Chen X
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Endogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogene.
Volume: 106
Issue: 19
Pages: 7979-84
Publication
First Author: Stoica A
Year: 2017
Journal: Glia
Title: The α2β2 isoform combination dominates the astrocytic Na+ /K+ -ATPase activity and is rendered nonfunctional by the α2.G301R familial hemiplegic migraine type 2-associated mutation.
Volume: 65
Issue: 11
Pages: 1777-1793
Protein
Organism: Mus musculus/domesticus
Length: 74  
Fragment?: false
Publication
First Author: Cai H
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling.
Volume: 113
Issue: 51
Pages: 14751-14756
Publication
First Author: Dorn A
Year: 2012
Journal: Cell Immunol
Title: Rap1a deficiency modifies cytokine responses and MAPK-signaling in vitro and impairs the in vivo inflammatory response.
Volume: 276
Issue: 1-2
Pages: 187-95
Publication
First Author: Ueno A
Year: 2007
Journal: Diabetes
Title: Transient upregulation of indoleamine 2,3-dioxygenase in dendritic cells by human chorionic gonadotropin downregulates autoimmune diabetes.
Volume: 56
Issue: 6
Pages: 1686-93
Publication
First Author: Cortini A
Year: 2017
Journal: Ann Rheum Dis
Title: B cell OX40L supports T follicular helper cell development and contributes to SLE pathogenesis.
Volume: 76
Issue: 12
Pages: 2095-2103
Publication
First Author: Prasad KV
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein.
Volume: 94
Issue: 12
Pages: 6346-51
Publication
First Author: McDermott A
Year: 2005
Journal: Development
Title: Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation.
Volume: 132
Issue: 2
Pages: 345-57
Publication
First Author: Chen TH
Year: 1996
Journal: Mol Biol Cell
Title: Structure of pp32, an acidic nuclear protein which inhibits oncogene-induced formation of transformed foci.
Volume: 7
Issue: 12
Pages: 2045-56
Publication
First Author: Oh E
Year: 2012
Journal: J Biol Chem
Title: Munc18-1 regulates first-phase insulin release by promoting granule docking to multiple syntaxin isoforms.
Volume: 287
Issue: 31
Pages: 25821-33
Publication
First Author: Rudolf A
Year: 2016
Journal: Cell Rep
Title: β-Catenin Activation in Muscle Progenitor Cells Regulates Tissue Repair.
Volume: 15
Issue: 6
Pages: 1277-90
Publication
First Author: Ma C
Year: 2016
Journal: Nature
Title: NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis.
Volume: 531
Issue: 7593
Pages: 253-7
Publication
First Author: Serezani CH
Year: 2012
Journal: J Immunol
Title: Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF/PU.1 axis.
Volume: 189
Issue: 2
Pages: 906-15
Publication
First Author: Khmaladze Ia
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Mannan induces ROS-regulated, IL-17A-dependent psoriasis arthritis-like disease in mice.
Volume: 111
Issue: 35
Pages: E3669-78
Publication
First Author: Jeong A
Year: 2021
Journal: Acta Neuropathol Commun
Title: Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice.
Volume: 9
Issue: 1
Pages: 129
Publication
First Author: Frame JM
Year: 2016
Journal: Stem Cells
Title: Definitive Hematopoiesis in the Yolk Sac Emerges from Wnt-Responsive Hemogenic Endothelium Independently of Circulation and Arterial Identity.
Volume: 34
Issue: 2
Pages: 431-44
Publication  
First Author: Bhate A
Year: 2015
Journal: Nat Commun
Title: ESRP2 controls an adult splicing programme in hepatocytes to support postnatal liver maturation.
Volume: 6
Pages: 8768
Publication
First Author: Lawrie A
Year: 2011
Journal: Am J Pathol
Title: Paigen diet-fed apolipoprotein E knockout mice develop severe pulmonary hypertension in an interleukin-1-dependent manner.
Volume: 179
Issue: 4
Pages: 1693-705
Publication
First Author: Murao A
Year: 2020
Journal: FASEB J
Title: Extracellular CIRP and TREM-1 axis promotes ICAM-1-Rho-mediated NETosis in sepsis.
Volume: 34
Issue: 7
Pages: 9771-9786
Publication
First Author: Guignandon A
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Cyclic strain promotes shuttling of PYK2/Hic-5 complex from focal contacts in osteoblast-like cells.
Volume: 343
Issue: 2
Pages: 407-14
Publication
First Author: Bielak-Zmijewska A
Year: 2008
Journal: Dev Biol
Title: Cdc42 protein acts upstream of IQGAP1 and regulates cytokinesis in mouse oocytes and embryos.
Volume: 322
Issue: 1
Pages: 21-32
Publication
First Author: Putoux A
Year: 2019
Journal: Hum Mol Genet
Title: Altered GLI3 and FGF8 signaling underlies acrocallosal syndrome phenotypes in Kif7 depleted mice.
Volume: 28
Issue: 6
Pages: 877-887
Publication
First Author: Blaisdell A
Year: 2015
Journal: Cancer Cell
Title: Neutrophils Oppose Uterine Epithelial Carcinogenesis via Debridement of Hypoxic Tumor Cells.
Volume: 28
Issue: 6
Pages: 785-799
Publication  
First Author: Tarangelo A
Year: 2015
Journal: Nat Commun
Title: Recruitment of Pontin/Reptin by E2f1 amplifies E2f transcriptional response during cancer progression.
Volume: 6
Pages: 10028
Publication
First Author: Choi YH
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases.
Volume: 108
Issue: 26
Pages: 10679-84
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: White SA
Year: 2020
Journal: Sci Rep
Title: Bax and Bak jointly control survival and dampen the early unfolded protein response in pancreatic β-cells under glucolipotoxic stress.
Volume: 10
Issue: 1
Pages: 10986
Publication
First Author: Goggolidou P
Year: 2014
Journal: Hum Mol Genet
Title: Atmin mediates kidney morphogenesis by modulating Wnt signaling.
Volume: 23
Issue: 20
Pages: 5303-16
HT Experiment
Series Id: GSE58712
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment  
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Lelli A
Year: 2016
Journal: J Cell Biol
Title: Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth.
Volume: 212
Issue: 2
Pages: 231-44
Publication
First Author: López-Parra M
Year: 2008
Journal: J Lipid Res
Title: Regulatory effects of arachidonate 5-lipoxygenase on hepatic microsomal TG transfer protein activity and VLDL-triglyceride and apoB secretion in obese mice.
Volume: 49
Issue: 12
Pages: 2513-23
Publication
First Author: van Oosten M
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Differential role of transcription-coupled repair in UVB-induced G2 arrest and apoptosis in mouse epidermis.
Volume: 97
Issue: 21
Pages: 11268-73
Publication
First Author: Koenen TB
Year: 2011
Journal: Diabetes
Title: Hyperglycemia activates caspase-1 and TXNIP-mediated IL-1beta transcription in human adipose tissue.
Volume: 60
Issue: 2
Pages: 517-24
Publication
First Author: Méjat A
Year: 2005
Journal: Nat Neurosci
Title: Histone deacetylase 9 couples neuronal activity to muscle chromatin acetylation and gene expression.
Volume: 8
Issue: 3
Pages: 313-21
Publication
First Author: Link A
Year: 2007
Journal: Nat Immunol
Title: Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells.
Volume: 8
Issue: 11
Pages: 1255-65
Publication
First Author: Schreiber A
Year: 2010
Journal: Kidney Int
Title: Phosphoinositol 3-kinase-gamma mediates antineutrophil cytoplasmic autoantibody-induced glomerulonephritis.
Volume: 77
Issue: 2
Pages: 118-28
Publication
First Author: Spudich A
Year: 2005
Journal: Neurobiol Dis
Title: Aggravation of ischemic brain injury by prion protein deficiency: role of ERK-1/-2 and STAT-1.
Volume: 20
Issue: 2
Pages: 442-9
Publication
First Author: Boire A
Year: 2017
Journal: Cell
Title: Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis.
Volume: 168
Issue: 6
Pages: 1101-1113.e13
Publication
First Author: Croquelois A
Year: 2005
Journal: Hepatology
Title: Inducible inactivation of Notch1 causes nodular regenerative hyperplasia in mice.
Volume: 41
Issue: 3
Pages: 487-96
Publication
First Author: Gonzalez A
Year: 1997
Journal: Immunity
Title: Genetic control of diabetes progression.
Volume: 7
Issue: 6
Pages: 873-83
Publication
First Author: Plagge A
Year: 2004
Journal: Nat Genet
Title: The imprinted signaling protein XL alpha s is required for postnatal adaptation to feeding.
Volume: 36
Issue: 8
Pages: 818-26
Publication
First Author: Krzyzosiak A
Year: 2018
Journal: Cell
Title: Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B.
Volume: 174
Issue: 5
Pages: 1216-1228.e19
Publication  
First Author: Delekate A
Year: 2014
Journal: Nat Commun
Title: Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer's disease mouse model.
Volume: 5
Pages: 5422
Publication
First Author: Fukamizu A
Year: 1994
Journal: Kidney Int
Title: Cortical expression of the human angiotensinogen gene in the kidney of transgenic mice.
Volume: 46
Issue: 6
Pages: 1533-5
Publication
First Author: Fukamizu A
Year: 1989
Journal: Biochem Biophys Res Commun
Title: Tissue-specific expression of the human renin gene in transgenic mice.
Volume: 165
Issue: 2
Pages: 826-32
Publication
First Author: Perez-Lopez A
Year: 2019
Journal: J Immunol
Title: CRTAM Shapes the Gut Microbiota and Enhances the Severity of Infection.
Volume: 203
Issue: 2
Pages: 532-543
Publication
First Author: Rönnbäck A
Year: 2012
Journal: Neurobiol Aging
Title: Amyloid neuropathology in the single Arctic APP transgenic model affects interconnected brain regions.
Volume: 33
Issue: 4
Pages: 831.e11-9
Publication
First Author: Nair A
Year: 2023
Journal: Cell
Title: An approximate line attractor in the hypothalamus encodes an aggressive state.
Volume: 186
Issue: 1
Pages: 178-193.e15
Publication
First Author: Nakamura K
Year: 2007
Journal: Microbiol Immunol
Title: Dectin-1 is not required for the host defense to Cryptococcus neoformans.
Volume: 51
Issue: 11
Pages: 1115-9
Publication
First Author: Baud A
Year: 2021
Journal: Genome Biol
Title: Dissecting indirect genetic effects from peers in laboratory mice.
Volume: 22
Issue: 1
Pages: 216
Publication    
First Author: Kappas A
Year: 1995
Title: The Porphyrias
Volume: II
Pages: 2103-59
Publication
First Author: Jamieson RV
Year: 1998
Journal: Dev Biol
Title: Sertoli cell differentiation and Y-chromosome activity: a developmental study of X-linked transgene activity in sex-reversed X/XSxra mouse embryos.
Volume: 199
Issue: 2
Pages: 235-44
Publication
First Author: Flores-Toro JA
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas.
Volume: 117
Issue: 2
Pages: 1129-1138
Publication
First Author: Cariappa A
Year: 2005
Journal: J Immunol
Title: The CD9 tetraspanin is not required for the development of peripheral B cells or for humoral immunity.
Volume: 175
Issue: 5
Pages: 2925-30
Publication  
First Author: Lu A
Year: 2013
Journal: Neuroscience
Title: Matrix metalloproteinase-2 deletions protect against hemorrhagic transformation after 1 h of cerebral ischemia and 23 h of reperfusion.
Volume: 253
Pages: 361-7
Publication
First Author: Toma A
Year: 2015
Journal: PLoS One
Title: Structural basis for ubiquitin recognition by ubiquitin-binding zinc finger of FAAP20.
Volume: 10
Issue: 3
Pages: e0120887
Publication
First Author: Ashtekar A
Year: 2018
Journal: J Clin Endocrinol Metab
Title: Alterations in Sod2-Induced Oxidative Stress Affect Endocrine Cancer Progression.
Volume: 103
Issue: 11
Pages: 4135-4145
Publication  
First Author: Takahashi A
Year: 2019
Journal: Int J Mol Sci
Title: The CCR4-NOT Deadenylase Complex Maintains Adipocyte Identity.
Volume: 20
Issue: 21
Publication
First Author: Mukaj A
Year: 2020
Journal: Mol Biol Evol
Title: Prdm9 Intersubspecific Interactions in Hybrid Male Sterility of House Mouse.
Volume: 37
Issue: 12
Pages: 3423-3438
Publication
First Author: Wegener A
Year: 2017
Journal: J Neurochem
Title: Sp2 is the only glutamine-rich specificity protein with minor impact on development and differentiation in myelinating glia.
Volume: 140
Issue: 2
Pages: 245-256
Publication
First Author: Ehrenstein MR
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Targeted gene disruption reveals a role for natural secretory IgM in the maturation of the primary immune response.
Volume: 95
Issue: 17
Pages: 10089-93
Publication    
First Author: Riahi Y
Year: 2018
Journal: Elife
Title: Inhibition of mTORC1 by ER stress impairs neonatal β-cell expansion and predisposes to diabetes in the Akita mouse.
Volume: 7
Publication  
First Author: Aranburu A
Year: 2023
Journal: Front Immunol
Title: Clonal relationships of memory B cell subsets in autoimmune mice.
Volume: 14
Pages: 1129234
Publication  
First Author: Mondal A
Year: 2016
Journal: EBioMedicine
Title: IDO1 is an Integral Mediator of Inflammatory Neovascularization.
Volume: 14
Pages: 74-82
Publication
First Author: Bafica A
Year: 2005
Journal: J Exp Med
Title: TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis.
Volume: 202
Issue: 12
Pages: 1715-24
Publication
First Author: Utreja A
Year: 2016
Journal: Osteoarthritis Cartilage
Title: Cell and matrix response of temporomandibular cartilage to mechanical loading.
Volume: 24
Issue: 2
Pages: 335-44