| Type |
Details |
Score |
| Protein Domain |
| Type: |
Family |
| Description: |
This entry represents lactate utilization protein A, which is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Members of this family closely resemble quinoproteins and quinohemoproteins such as PQQ-dependent methanol, glucose, and shikimate dehydrogenases, but restricted to species of Acidobacteria unable to synthesize PQQ. Seven members occur in Candidatus Solibacter usitatus Ellin6076, eleven in Acidobacteriaceae bacterium KBS 96, etc. Members have N-terminal signal sequences. They lack the pair of adjacent Cys residues, involved in electron transfer, typical for family , and they lack CxxCH motifs for cytochrome c-like heme-binding. What cofactor these paralogous families of enzymes might use is unclear. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This family of proteins is regulated by the ferric uptake regulator protein Fur []. This family does not regulate the lutABC operon encoding iron sulfur-containing enzymes necessary for growth on lactate []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
EVA1A, also known as TMEM166, regulates cell autophagy and apoptosis [, ]. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry represents glyoxysomal malate synthases and one of two bacterial forms, designated malate synthase A.Malate synthase and isocitrate lyase are the two characteristic enzymes of the glyoxylate cycle. The glyoxylate cycle allows certain organisms, like plants and fungi, to derive their carbon requirements from two-carbon compounds, by bypassing the two carboxylation steps of the citric acid cycle []. Isocitrate lyase, first catalyzes the aldol cleavage of isocitrate to succinate (an intermediate of the tricarboxylic acid cycle) and glyoxylate. Then malate synthase catalyzes the condensation of acetyl CoA with glyoxylate to yield malate (another intermediate of the tricarboxylic acid cycle) []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Orts-Del'immagine A |
| Year: |
2012 |
| Journal: |
J Physiol |
| Title: |
Properties of subependymal cerebrospinal fluid contacting neurones in the dorsal vagal complex of the mouse brainstem. |
| Volume: |
590 |
| Issue: |
16 |
| Pages: |
3719-41 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Karki A |
| Year: |
2015 |
| Journal: |
PLoS One |
| Title: |
Silencing Mist1 Gene Expression Is Essential for Recovery from Acute Pancreatitis. |
| Volume: |
10 |
| Issue: |
12 |
| Pages: |
e0145724 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lustgarten Guahmich N |
| Year: |
2020 |
| Journal: |
Angiogenesis |
| Title: |
Endothelial deletion of ADAM10, a key regulator of Notch signaling, causes impaired decidualization and reduced fertility in female mice. |
| Volume: |
23 |
| Issue: |
3 |
| Pages: |
443-458 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zaidan N |
| Year: |
2022 |
| Journal: |
Stem Cell Reports |
| Title: |
Endothelial-specific Gata3 expression is required for hematopoietic stem cell generation. |
| Volume: |
17 |
| Issue: |
8 |
| Pages: |
1788-1798 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
165
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Saito A |
| Year: |
2011 |
| Journal: |
J Biol Chem |
| Title: |
Endoplasmic reticulum stress response mediated by the PERK-eIF2(alpha)-ATF4 pathway is involved in osteoblast differentiation induced by BMP2. |
| Volume: |
286 |
| Issue: |
6 |
| Pages: |
4809-18 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Boyer A |
| Year: |
2016 |
| Journal: |
Biol Reprod |
| Title: |
mTOR Regulates Gap Junction Alpha-1 Protein Trafficking in Sertoli Cells and Is Required for the Maintenance of Spermatogenesis in Mice. |
| Volume: |
95 |
| Issue: |
1 |
| Pages: |
13 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Majumder S |
| Year: |
2016 |
| Journal: |
Cell Rep |
| Title: |
G-Protein-Coupled Receptor-2-Interacting Protein-1 Controls Stalk Cell Fate by Inhibiting Delta-like 4-Notch1 Signaling. |
| Volume: |
17 |
| Issue: |
10 |
| Pages: |
2532-2541 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Janovick JA |
| Year: |
2013 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy. |
| Volume: |
110 |
| Issue: |
52 |
| Pages: |
21030-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sabò A |
| Year: |
2014 |
| Journal: |
Nature |
| Title: |
Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis. |
| Volume: |
511 |
| Issue: |
7510 |
| Pages: |
488-492 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sun L |
| Year: |
2008 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
A mitotic recombination system for mouse chromosome 17. |
| Volume: |
105 |
| Issue: |
11 |
| Pages: |
4237-41 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Smith CJ |
| Year: |
1999 |
| Journal: |
Trends Cell Biol |
| Title: |
Clathrin: anatomy of a coat protein. |
| Volume: |
9 |
| Issue: |
9 |
| Pages: |
335-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Harney AS |
| Year: |
2015 |
| Journal: |
Cancer Discov |
| Title: |
Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA. |
| Volume: |
5 |
| Issue: |
9 |
| Pages: |
932-43 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tsaousi A |
| Year: |
2016 |
| Journal: |
PLoS One |
| Title: |
Plaque Size Is Decreased but M1 Macrophage Polarization and Rupture Related Metalloproteinase Expression Are Maintained after Deleting T-Bet in ApoE Null Mice. |
| Volume: |
11 |
| Issue: |
2 |
| Pages: |
e0148873 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Perhal A |
| Year: |
2019 |
| Journal: |
Front Med (Lausanne) |
| Title: |
Increased Reactive Oxygen Species Generation Contributes to the Atherogenic Activity of the B2 Bradykinin Receptor. |
| Volume: |
6 |
|
| Pages: |
32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Maklad A |
| Year: |
2009 |
| Journal: |
J Invest Dermatol |
| Title: |
The EGFR is required for proper innervation to the skin. |
| Volume: |
129 |
| Issue: |
3 |
| Pages: |
690-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Assali A |
| Year: |
2017 |
| Journal: |
Sci Rep |
| Title: |
RIM1/2 in retinal ganglion cells are required for the refinement of ipsilateral axons and eye-specific segregation. |
| Volume: |
7 |
| Issue: |
1 |
| Pages: |
3236 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Itoh A |
| Year: |
2009 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Impaired regenerative response of primary sensory neurons in ZPK/DLK gene-trap mice. |
| Volume: |
383 |
| Issue: |
2 |
| Pages: |
258-62 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Buznikov A |
| Year: |
2001 |
| Journal: |
GenBank Submission |
| Title: |
Mus musculus tetraspanin mRNA, complete cds |
|
|
| Pages: |
AF242591 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jang SW |
| Year: |
2010 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. |
| Volume: |
107 |
| Issue: |
6 |
| Pages: |
2687-92 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kovacevic I |
| Year: |
2015 |
| Journal: |
Circ Res |
| Title: |
The F-BAR Protein NOSTRIN Dictates the Localization of the Muscarinic M3 Receptor and Regulates Cardiovascular Function. |
| Volume: |
117 |
| Issue: |
5 |
| Pages: |
460-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yermalovich AV |
| Year: |
2024 |
| Journal: |
Dev Biol |
| Title: |
An essential role for Cmtr2 in mammalian embryonic development. |
| Volume: |
516 |
|
| Pages: |
47-58 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kusnadi A |
| Year: |
2019 |
| Journal: |
Immunity |
| Title: |
The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair. |
| Volume: |
51 |
| Issue: |
2 |
| Pages: |
241-257.e9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shimojo H |
| Year: |
2008 |
| Journal: |
J Mol Biol |
| Title: |
Novel structural and functional mode of a knot essential for RNA binding activity of the Esa1 presumed chromodomain. |
| Volume: |
378 |
| Issue: |
5 |
| Pages: |
987-1001 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mildner A |
| Year: |
2013 |
| Journal: |
Blood |
| Title: |
Mononuclear phagocyte miRNome analysis identifies miR-142 as critical regulator of murine dendritic cell homeostasis. |
| Volume: |
121 |
| Issue: |
6 |
| Pages: |
1016-27 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kuhn A |
| Year: |
2007 |
| Journal: |
Hum Mol Genet |
| Title: |
Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage. |
| Volume: |
16 |
| Issue: |
15 |
| Pages: |
1845-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen X |
| Year: |
2009 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Endogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogene. |
| Volume: |
106 |
| Issue: |
19 |
| Pages: |
7979-84 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stoica A |
| Year: |
2017 |
| Journal: |
Glia |
| Title: |
The α2β2 isoform combination dominates the astrocytic Na+ /K+ -ATPase activity and is rendered nonfunctional by the α2.G301R familial hemiplegic migraine type 2-associated mutation. |
| Volume: |
65 |
| Issue: |
11 |
| Pages: |
1777-1793 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
74
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cai H |
| Year: |
2016 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling. |
| Volume: |
113 |
| Issue: |
51 |
| Pages: |
14751-14756 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dorn A |
| Year: |
2012 |
| Journal: |
Cell Immunol |
| Title: |
Rap1a deficiency modifies cytokine responses and MAPK-signaling in vitro and impairs the in vivo inflammatory response. |
| Volume: |
276 |
| Issue: |
1-2 |
| Pages: |
187-95 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ueno A |
| Year: |
2007 |
| Journal: |
Diabetes |
| Title: |
Transient upregulation of indoleamine 2,3-dioxygenase in dendritic cells by human chorionic gonadotropin downregulates autoimmune diabetes. |
| Volume: |
56 |
| Issue: |
6 |
| Pages: |
1686-93 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cortini A |
| Year: |
2017 |
| Journal: |
Ann Rheum Dis |
| Title: |
B cell OX40L supports T follicular helper cell development and contributes to SLE pathogenesis. |
| Volume: |
76 |
| Issue: |
12 |
| Pages: |
2095-2103 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Prasad KV |
| Year: |
1997 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein. |
| Volume: |
94 |
| Issue: |
12 |
| Pages: |
6346-51 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
McDermott A |
| Year: |
2005 |
| Journal: |
Development |
| Title: |
Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation. |
| Volume: |
132 |
| Issue: |
2 |
| Pages: |
345-57 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen TH |
| Year: |
1996 |
| Journal: |
Mol Biol Cell |
| Title: |
Structure of pp32, an acidic nuclear protein which inhibits oncogene-induced formation of transformed foci. |
| Volume: |
7 |
| Issue: |
12 |
| Pages: |
2045-56 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Oh E |
| Year: |
2012 |
| Journal: |
J Biol Chem |
| Title: |
Munc18-1 regulates first-phase insulin release by promoting granule docking to multiple syntaxin isoforms. |
| Volume: |
287 |
| Issue: |
31 |
| Pages: |
25821-33 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rudolf A |
| Year: |
2016 |
| Journal: |
Cell Rep |
| Title: |
β-Catenin Activation in Muscle Progenitor Cells Regulates Tissue Repair. |
| Volume: |
15 |
| Issue: |
6 |
| Pages: |
1277-90 |
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•
•
•
•
|
| Publication |
| First Author: |
Ma C |
| Year: |
2016 |
| Journal: |
Nature |
| Title: |
NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis. |
| Volume: |
531 |
| Issue: |
7593 |
| Pages: |
253-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Serezani CH |
| Year: |
2012 |
| Journal: |
J Immunol |
| Title: |
Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF/PU.1 axis. |
| Volume: |
189 |
| Issue: |
2 |
| Pages: |
906-15 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Khmaladze Ia |
| Year: |
2014 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Mannan induces ROS-regulated, IL-17A-dependent psoriasis arthritis-like disease in mice. |
| Volume: |
111 |
| Issue: |
35 |
| Pages: |
E3669-78 |
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•
•
•
•
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| Publication |
| First Author: |
Jeong A |
| Year: |
2021 |
| Journal: |
Acta Neuropathol Commun |
| Title: |
Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
129 |
|
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•
•
•
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| Publication |
| First Author: |
Frame JM |
| Year: |
2016 |
| Journal: |
Stem Cells |
| Title: |
Definitive Hematopoiesis in the Yolk Sac Emerges from Wnt-Responsive Hemogenic Endothelium Independently of Circulation and Arterial Identity. |
| Volume: |
34 |
| Issue: |
2 |
| Pages: |
431-44 |
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•
•
•
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| Publication |
| First Author: |
Bhate A |
| Year: |
2015 |
| Journal: |
Nat Commun |
| Title: |
ESRP2 controls an adult splicing programme in hepatocytes to support postnatal liver maturation. |
| Volume: |
6 |
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| Pages: |
8768 |
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•
•
•
•
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| Publication |
| First Author: |
Lawrie A |
| Year: |
2011 |
| Journal: |
Am J Pathol |
| Title: |
Paigen diet-fed apolipoprotein E knockout mice develop severe pulmonary hypertension in an interleukin-1-dependent manner. |
| Volume: |
179 |
| Issue: |
4 |
| Pages: |
1693-705 |
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•
•
•
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| Publication |
| First Author: |
Murao A |
| Year: |
2020 |
| Journal: |
FASEB J |
| Title: |
Extracellular CIRP and TREM-1 axis promotes ICAM-1-Rho-mediated NETosis in sepsis. |
| Volume: |
34 |
| Issue: |
7 |
| Pages: |
9771-9786 |
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•
•
•
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| Publication |
| First Author: |
Guignandon A |
| Year: |
2006 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Cyclic strain promotes shuttling of PYK2/Hic-5 complex from focal contacts in osteoblast-like cells. |
| Volume: |
343 |
| Issue: |
2 |
| Pages: |
407-14 |
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•
•
•
•
|
| Publication |
| First Author: |
Bielak-Zmijewska A |
| Year: |
2008 |
| Journal: |
Dev Biol |
| Title: |
Cdc42 protein acts upstream of IQGAP1 and regulates cytokinesis in mouse oocytes and embryos. |
| Volume: |
322 |
| Issue: |
1 |
| Pages: |
21-32 |
|
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•
•
•
•
|
| Publication |
| First Author: |
Putoux A |
| Year: |
2019 |
| Journal: |
Hum Mol Genet |
| Title: |
Altered GLI3 and FGF8 signaling underlies acrocallosal syndrome phenotypes in Kif7 depleted mice. |
| Volume: |
28 |
| Issue: |
6 |
| Pages: |
877-887 |
|
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•
•
•
•
|
| Publication |
| First Author: |
Blaisdell A |
| Year: |
2015 |
| Journal: |
Cancer Cell |
| Title: |
Neutrophils Oppose Uterine Epithelial Carcinogenesis via Debridement of Hypoxic Tumor Cells. |
| Volume: |
28 |
| Issue: |
6 |
| Pages: |
785-799 |
|
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•
•
•
•
|
| Publication |
| First Author: |
Tarangelo A |
| Year: |
2015 |
| Journal: |
Nat Commun |
| Title: |
Recruitment of Pontin/Reptin by E2f1 amplifies E2f transcriptional response during cancer progression. |
| Volume: |
6 |
|
| Pages: |
10028 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Choi YH |
| Year: |
2011 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases. |
| Volume: |
108 |
| Issue: |
26 |
| Pages: |
10679-84 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
White SA |
| Year: |
2020 |
| Journal: |
Sci Rep |
| Title: |
Bax and Bak jointly control survival and dampen the early unfolded protein response in pancreatic β-cells under glucolipotoxic stress. |
| Volume: |
10 |
| Issue: |
1 |
| Pages: |
10986 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Goggolidou P |
| Year: |
2014 |
| Journal: |
Hum Mol Genet |
| Title: |
Atmin mediates kidney morphogenesis by modulating Wnt signaling. |
| Volume: |
23 |
| Issue: |
20 |
| Pages: |
5303-16 |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE58712 |
| Experiment Type: |
transcription profiling by array |
| Study Type: |
WT vs. Mutant |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
transcription profiling by array |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lelli A |
| Year: |
2016 |
| Journal: |
J Cell Biol |
| Title: |
Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth. |
| Volume: |
212 |
| Issue: |
2 |
| Pages: |
231-44 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
López-Parra M |
| Year: |
2008 |
| Journal: |
J Lipid Res |
| Title: |
Regulatory effects of arachidonate 5-lipoxygenase on hepatic microsomal TG transfer protein activity and VLDL-triglyceride and apoB secretion in obese mice. |
| Volume: |
49 |
| Issue: |
12 |
| Pages: |
2513-23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
van Oosten M |
| Year: |
2000 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Differential role of transcription-coupled repair in UVB-induced G2 arrest and apoptosis in mouse epidermis. |
| Volume: |
97 |
| Issue: |
21 |
| Pages: |
11268-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Koenen TB |
| Year: |
2011 |
| Journal: |
Diabetes |
| Title: |
Hyperglycemia activates caspase-1 and TXNIP-mediated IL-1beta transcription in human adipose tissue. |
| Volume: |
60 |
| Issue: |
2 |
| Pages: |
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