|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 2801 to 2900 out of 4514 for Cdc42

<< First    < Previous  |  Next >    Last >>
0.03s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
32483624 | J:304367
First Author: Althoff MJ
Year: 2020
Journal: Blood
Title: Yap1-Scribble polarization is required for hematopoietic stem cell division and fate.
Volume: 136
Issue: 16
Pages: 1824-1836
•
•
•
•
•
Publication
37085479 | J:345319
First Author: Herrejon Chavez F
Year: 2023
Journal: Nat Commun
Title: RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells.
Volume: 14
Issue: 1
Pages: 2290
•
•
•
•
•
Publication
37552602 | J:339924
First Author: He Y
Year: 2023
Journal: Cell Rep
Title: CdGAP is a talin-binding protein and a target of TGF-β signaling that promotes HER2-positive breast cancer growth and metastasis.
Volume: 42
Issue: 8
Pages: 112936
•
•
•
•
•
Publication
20361982 | -
First Author: Shepherd TR
Year: 2010
Journal: J Mol Biol
Title: The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion.
Volume: 398
Issue: 5
Pages: 730-46
•
•
•
•
•
Publication
26887924 | J:234739
 
First Author: Marei H
Year: 2016
Journal: Nat Commun
Title: Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration.
Volume: 7
Pages: 10664
•
•
•
•
•
Publication
24308970 | -
First Author: Boissier P
Year: 2014
Journal: Cell Signal
Title: The guanine nucleotide exchange factor Tiam1: a Janus-faced molecule in cellular signaling.
Volume: 26
Issue: 3
Pages: 483-91
•
•
•
•
•
Publication
16472649 | -
 
First Author: Baird D
Year: 2006
Journal: Methods Enzymol
Title: Biochemical characterization of the Cool (Cloned-out-of-Library)/Pix (Pak-interactive exchange factor) proteins.
Volume: 406
Pages: 58-69
•
•
•
•
•
Publication
12874278 | J:85837
First Author: Kanamori M
Year: 2003
Journal: J Biol Chem
Title: The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells.
Volume: 278
Issue: 40
Pages: 38758-64
•
•
•
•
•
Protein
Q9D279
Organism: Mus musculus/domesticus
Length: 648  
Fragment?: false
•
•
•
•
•
Publication
19893486 | J:156410
First Author: Terawaki S
Year: 2010
Journal: EMBO J
Title: The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module.
Volume: 29
Issue: 1
Pages: 236-50
•
•
•
•
•
Publication
16855024 | -
First Author: Alewine C
Year: 2006
Journal: Mol Biol Cell
Title: TIP-1 has PDZ scaffold antagonist activity.
Volume: 17
Issue: 10
Pages: 4200-11
•
•
•
•
•
Protein
F6Q7M1
Organism: Mus musculus/domesticus
Length: 144  
Fragment?: true
•
•
•
•
•
Protein
F6WBA1
Organism: Mus musculus/domesticus
Length: 106  
Fragment?: true
•
•
•
•
•
Protein
Q1WWN0
Organism: Mus musculus/domesticus
Length: 300  
Fragment?: true
•
•
•
•
•
Protein
A0A087WQC3
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
•
•
•
•
•
Protein
A0A087WQV6
Organism: Mus musculus/domesticus
Length: 77  
Fragment?: true
•
•
•
•
•
Protein
Q3TPC4
Organism: Mus musculus/domesticus
Length: 321  
Fragment?: true
•
•
•
•
•
Protein
Q3TGN4
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: true
•
•
•
•
•
Protein
F6W0C2
Organism: Mus musculus/domesticus
Length: 185  
Fragment?: true
•
•
•
•
•
Protein
Q9CVC4
Organism: Mus musculus/domesticus
Length: 124  
Fragment?: true
•
•
•
•
•
Protein
A0A087WR51
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: true
•
•
•
•
•
Protein
F7D661
Organism: Mus musculus/domesticus
Length: 115  
Fragment?: true
•
•
•
•
•
Protein
Q3TAR2
Organism: Mus musculus/domesticus
Length: 321  
Fragment?: true
•
•
•
•
•
Protein
A0A087WQ89
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: false
•
•
•
•
•
Publication
9383053 | -
First Author: Edwards MC
Year: 1997
Journal: Genetics
Title: Human CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells.
Volume: 147
Issue: 3
Pages: 1063-76
•
•
•
•
•
Publication
10940294 | J:85778
First Author: Reynaud C
Year: 2000
Journal: J Biol Chem
Title: The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element.
Volume: 275
Issue: 43
Pages: 33962-8
•
•
•
•
•
Publication
21139582 | -
First Author: Oliver AW
Year: 2011
Journal: Br J Cancer
Title: The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42.
Volume: 104
Issue: 2
Pages: 324-31
•
•
•
•
•
Publication
11163757 | -
First Author: Olalla L
Year: 2001
Journal: FEBS Lett
Title: The C-terminus of human glutaminase L mediates association with PDZ domain-containing proteins.
Volume: 488
Issue: 3
Pages: 116-22
•
•
•
•
•
Publication
17855605 | -
First Author: Cui H
Year: 2007
Journal: J Neurosci
Title: PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors.
Volume: 27
Issue: 37
Pages: 9901-15
•
•
•
•
•
Publication
22564736 | -
First Author: Han M
Year: 2012
Journal: Biochem Biophys Res Commun
Title: The PDZ protein TIP-1 facilitates cell migration and pulmonary metastasis of human invasive breast cancer cells in athymic mice.
Volume: 422
Issue: 1
Pages: 139-45
•
•
•
•
•
Publication
23574715 | -
First Author: Maier B
Year: 2013
Journal: Cell Cycle
Title: The novel actin/focal adhesion-associated protein MISP is involved in mitotic spindle positioning in human cells.
Volume: 12
Issue: 9
Pages: 1457-71
•
•
•
•
•
Publication
18280496 | -
First Author: Kim J
Year: 2008
Journal: J Mol Biol
Title: Recognition of non-canonical peptides by the yeast Fus1p SH3 domain: elucidation of a common mechanism for diverse SH3 domain specificities.
Volume: 377
Issue: 3
Pages: 889-901
•
•
•
•
•
Publication
19812245 | -
First Author: Barfield RM
Year: 2009
Journal: Mol Biol Cell
Title: The exomer coat complex transports Fus1p to the plasma membrane via a novel plasma membrane sorting signal in yeast.
Volume: 20
Issue: 23
Pages: 4985-96
•
•
•
•
•
Publication
15020407 | -
First Author: Nelson B
Year: 2004
Journal: Genetics
Title: Fus1p interacts with components of the Hog1p mitogen-activated protein kinase and Cdc42p morphogenesis signaling pathways to control cell fusion during yeast mating.
Volume: 166
Issue: 1
Pages: 67-77
•
•
•
•
•
Publication
21626670 | -
First Author: Lesca G
Year: 2011
Journal: Am J Med Genet A
Title: De novo Xq11.11 microdeletion including ARHGEF9 in a boy with mental retardation, epilepsy, macrosomia, and dysmorphic features.
Volume: 155A
Issue: 7
Pages: 1706-11
•
•
•
•
•
Publication
21731583 | -
   
First Author: Marco EJ
Year: 2009
Journal: BMJ Case Rep
Title: ARHGEF9 disruption in a female patient is associated with X linked mental retardation and sensory hyperarousal.
Volume: 2009
•
•
•
•
•
Publication
18615734 | -
First Author: Kalscheuer VM
Year: 2009
Journal: Hum Mutat
Title: A balanced chromosomal translocation disrupting ARHGEF9 is associated with epilepsy, anxiety, aggression, and mental retardation.
Volume: 30
Issue: 1
Pages: 61-8
•
•
•
•
•
Publication
17105769 | -
First Author: Nodé-Langlois R
Year: 2006
Journal: J Cell Sci
Title: Sequential implication of the mental retardation proteins ARHGEF6 and PAK3 in spine morphogenesis.
Volume: 119
Issue: Pt 23
Pages: 4986-93
•
•
•
•
•
Publication
11017088 | -
First Author: Kutsche K
Year: 2000
Journal: Nat Genet
Title: Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation.
Volume: 26
Issue: 2
Pages: 247-50
•
•
•
•
•
Publication
21989057 | J:179026
First Author: Ramakers GJ
Year: 2012
Journal: Hum Mol Genet
Title: Dysregulation of Rho GTPases in the αPix/Arhgef6 mouse model of X-linked intellectual disability is paralleled by impaired structural and synaptic plasticity and cognitive deficits.
Volume: 21
Issue: 2
Pages: 268-86
•
•
•
•
•
Publication
16740596 | -
First Author: Kuwano R
Year: 2006
Journal: Hum Mol Genet
Title: Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease.
Volume: 15
Issue: 13
Pages: 2170-82
•
•
•
•
•
Protein Domain
IPR030061 | GRAF
Type: Family
Description: Rho GTPase-activating protein 26 (ARHGAP26), also known as GTPase regulator associated with focal adhesion kinase (GRAF), is a GTPase-activating protein for the small GTPases of the Rho family RhoA and CDC42 [, ]. GRAF influences cytoskeletal changes mediated by Rho proteins []. It is recognised as a tumor suppressor []. GRAF contains an N-terminal BAR domain, followed by a Pleckstrin homology (PH) domain, a Rho GAP domain, and a C-terminal SH3 domain. The SH3 domain of GRAF binds PKNbeta, a target of the small GTPase Rho [].
•
•
•
•
•
Protein Domain
IPR017268 | Tax1-binding_p3
Type: Family
Description: This entry represents Tax1-binding protein 3, also known as TIP-1, which is a PDZ domain-containing protein that functions in a wide variety of biological events through selective interaction with different proteins. It interacts with the RhoA effector protein rhotekin []. It also associates with glutaminase L [], potassium channel Kir2.3 []and NMDA receptors []. In humans, Tax1-binding protein 3 has been shown to be involved in the activation of Cdc42 by the viral protein HPV16 E6 []. TIP-1 can have both an oncogenic function or act as a tumor suppressor, probably by modulating the transcriptional activity of beta-catenin [, ].
•
•
•
•
•
Protein Domain
IPR040655 | TIAM1_CC-Ex
Type: Domain
Description: Tiam1 is a guanine exchange factor (GEF) for CDC42 and the Rho-family GTPase Rac1, which plays an important role in cell-matrix adhesion and in cell migration [, ]. Tiam1 is involved in multiple steps of tumorigenesis [].This entry represents the CC and Ex subdomain found in the PH-CC-Ex globular domain of the Tiam1 and Tiam2 proteins (T-lymphoma invasion and metastasis). The CC subdomain forms an antiparallel coiled coil with two long α-helices, together with the C-terminal Ex subdomain they form a small globular domain comprising three α-helices. The CC subdomain of the Tiam2 PHCCEx domain follows the C-terminal alpha1 helix of the PH subdomain through a four-residue linker [].
•
•
•
•
•
Protein Domain
IPR035481 | GRAF_SH3
Type: Domain
Description: This entry represents the SH3 domain of GRAF.Rho GTPase-activating protein 26 (ARHGAP26), also known as GTPase regulator associated with focal adhesion kinase (GRAF), is a GTPase-activating protein for the small GTPases of the Rho family RhoA and CDC42 [, ]. GRAF influences cytoskeletal changes mediated by Rho proteins []. It is recognised as a tumor suppressor []. GRAF contains an N-terminal BAR domain, followed by a Pleckstrin homology (PH) domain, a Rho GAP domain, and a C-terminal SH3 domain. The SH3 domain of GRAF binds PKNbeta, a target of the small GTPase Rho [].
•
•
•
•
•
Protein Domain
IPR035485 | GRAF2_SH3
Type: Domain
Description: GRAF2, also called Rho GTPase activating protein 10 (ARHGAP10) or PS-GAP, is a GAP with activity towards Cdc42 and RhoA []. It regulates caspase-activated p21-activated protein kinase-2 (PAK-2p34). GRAF2 interacts with PAK-2p34, leading to its stabilization and decrease of cell death []. It is highly expressed in skeletal muscle, and is involved in alpha-catenin recruitment at cell-cell junctions []. GRAF2 contains an N-terminal BAR domain, followed by a Pleckstrin homology (PH) domain, a Rho GAP domain, and a C-terminal SH3 domain. The SH3 domain of GRAF binds PKNbeta, a target of the small GTPase Rho []. This entry represents the SH3 domain of GRAF2.
•
•
•
•
•
Protein Domain
IPR035493 | FNBP1L_SH3
Type: Domain
Description: This entry represents the SH3 domain of FNBP1L.Formin-binding protein 1-like (FNBP1L, also known as Toca-1) is part of the Toca-1-N-WASP complex that induces the formation of filopodia and endocytic vesicles []. FNBP1L consists of an F-BAR domain, a Cdc42 binding site and an SH3 domain []. It belongs to the CIP4 (Cdc42 interacting protein-4) subfamily of the F-BAR (F for FCH, Fer-CIP4 homology domain) protein family. The F-BAR proteins have been implicated in cell membrane processes such as membrane invagination, tubulation and endocytosis [].
•
•
•
•
•
Protein Domain
IPR035521 | Fus1_SH3
Type: Domain
Description: Fus1 is required at the cell surface for cell fusion during the mating response in yeast. It requires Bch1 and Bud7, which are Chs5-Arf1 binding proteins, for localization to the plasma membrane []. It acts as a scaffold protein to assemble a cell surface complex which is involved in septum degradation and inhibition of the NOG pathway to promote cell fusion []. The SH3 domain of Fus1 interacts with Bin1, a formin that controls the assembly of actin cables in response to Cdc42 signalling. It has been shown to bind the motif, R(S/T)(S/T)SL, instead of PxxP motifs [].
•
•
•
•
•
Protein Domain
IPR035532 | DBS_SH3
Type: Domain
Description: This entry represents the SH3 domain of DBS.DBS, also called MCF2L or OST, functions as a Rho GTPase guanine nucleotide exchange factor (RhoGEF), facilitating the exchange of GDP and GTP. It was originally isolated from a cDNA screen for sequences that cause malignant growth. It plays roles in regulating clathrin-mediated endocytosis and cell migration through its activation of Rac1 and Cdc42 [, ]. Depending on cell type, DBS can also activate RhoA and RhoG [, ]. DBS contains a Sec14-like domain [], spectrin-like repeats, a RhoGEF or Dbl homology (DH) domain, a Pleckstrin homology (PH) domain [], and an SH3 domain.
•
•
•
•
•
Protein Domain
IPR035728 | ARHGEF9_SH3
Type: Domain
Description: ARHGEF9 (Rho guanine nucleotide exchange factor 9, also called PEM2 or collybistin) selectively activates Cdc42 by exchanging bound GDP for free GTP []. It is highly expressed in the brain and it interacts with gephyrin, a postsynaptic protein associated with GABA and glycine receptors. Mutations in the ARHGEF9 gene cause X-linked mental retardation with associated features like seizures, hyper-anxiety, aggressive behavior, and sensory hyperarousal [, , ]. ARHGEF9 contains a SH3 domain followed by RhoGEF (also called Dbl-homologous or DH) and Pleckstrin Homology (PH) domains [].This entry represents the SH3 domain of ARHGEF9.
•
•
•
•
•
Protein Domain
IPR035788 | AlphaPIX_SH3
Type: Domain
Description: Alpha-PIX, also called Rho guanine nucleotide exchange factor 6 (ARHGEF6) or Cool (Cloned out of Library)-2, activates small GTPases by exchanging bound GDP for free GTP []. It acts as a GEF for both Cdc42 and Rac1, and is localized in dendritic spines where it regulates spine morphogenesis []. It controls dendritic length and spine density in the hippocampus. Mutations in the ARHGEF6 gene cause X-linked intellectual disability in humans [, ]. PIX proteins contain an N-terminal SH3 domain followed by RhoGEF (also called Dbl-homologous or DH) and Pleckstrin Homology (PH) domains, and a C-terminal leucine-zipper domain for dimerization. This entry represents the SH3 domain of alpha-PIX.
•
•
•
•
•
Protein Domain
IPR035817 | DNMBP_SH3_N1
Type: Domain
Description: Dynamin-binding protein (DNMBP,also known as Tuba) is a scaffold protein that links dynamin with actin-regulating proteins. It binds a variety of actin regulatory proteins, including N-WASP, CR16, WAVE1, WIRE, PIR121, NAP1, and Ena/VASP proteins, via a C-terminal SH3 domain []. It plays a critical role in ciliogenesis and nephrogenesis, most likely via Cdc42 activation [].The four N-terminal SH3 domains of DNMBP binds the GTPase dynamin, which plays an important role in the fission of endocytic vesicles []. This entry represents the first N-terminal SH3 domain.
•
•
•
•
•
Protein Domain
IPR035818 | DNMBP_SH3_N2
Type: Domain
Description: Dynamin-binding protein (DNMBP, also known as Tuba) is a scaffold protein that links dynamin with actin-regulating proteins. It binds a variety of actin regulatory proteins, including N-WASP, CR16, WAVE1, WIRE, PIR121, NAP1, and Ena/VASP proteins, via a C-terminal SH3 domain []. It plays a critical role in ciliogenesis and nephrogenesis, most likely via Cdc42 activation [].The four N-terminal SH3 domains of DNMBP binds the GTPase dynamin, which plays an important role in the fission of endocytic vesicles []. This entry represents the second N-terminal SH3 domain.
•
•
•
•
•
Protein Domain
IPR035819 | DNMBP_SH3_N3
Type: Domain
Description: Dynamin-binding protein (DNMBP, also known as Tuba) is a scaffold protein that links dynamin with actin-regulating proteins. It binds a variety of actin regulatory proteins, including N-WASP, CR16, WAVE1, WIRE, PIR121, NAP1, and Ena/VASP proteins, via a C-terminal SH3 domain []. It plays a critical role in ciliogenesis and nephrogenesis, most likely via Cdc42 activation [].The four N-terminal SH3 domains of DNMBP binds the GTPase dynamin, which plays an important role in the fission of endocytic vesicles []. This entry represents the third N-terminal SH3 domain.
•
•
•
•
•
Protein Domain
IPR035820 | DNMBP_SH3_C1
Type: Domain
Description: Dynamin-binding protein (DNMBP, also known as Tuba) is a scaffold protein that links dynamin with actin-regulating proteins. It binds a variety of actin regulatory proteins, including N-WASP, CR16, WAVE1, WIRE, PIR121, NAP1, and Ena/VASP proteins, via a C-terminal SH3 domain []. It plays a critical role in ciliogenesis and nephrogenesis, most likely via Cdc42 activation [].The C-terminal SH3 domains of DNMBP bind to N-WASP and Ena/VASP proteins, which are key regulatory proteins of the actin cytoskeleton []. This entry represents the first C-terminal SH3 domain.
•
•
•
•
•
Protein Domain
IPR035494 | FNBP1L_F-BAR
Type: Domain
Description: This entry represents the F-BAR domain of FNBP1L.Formin-binding protein 1-like (FNBP1L, also known as Toca-1) is part of the Toca-1-N-WASP complex that induces the formation of filopodia and endocytic vesicles []. FNBP1L consists of an F-BAR domain, a Cdc42 binding site and an SH3 domain []. It belongs to the CIP4 (Cdc42 interacting protein-4) subfamily of the F-BAR (F for FCH, Fer-CIP4 homology domain) protein family. The F-BAR proteins have been implicated in cell membrane processes such as membrane invagination, tubulation and endocytosis [].
•
•
•
•
•
Protein Domain
IPR035486 | GRAF2
Type: Family
Description: GRAF2, also called Rho GTPase activating protein 10 (ARHGAP10) or PS-GAP, is a GAP with activity towards Cdc42 and RhoA []. It regulates caspase-activated p21-activated protein kinase-2 (PAK-2p34). GRAF2 interacts with PAK-2p34, leading to its stabilization and decrease of cell death []. It is highly expressed in skeletal muscle, and is involved in alpha-catenin recruitment at cell-cell junctions []. GRAF2 contains an N-terminal BAR domain, followed by a Pleckstrin homology (PH) domain, a Rho GAP domain, and a C-terminal SH3 domain. The SH3 domain of GRAF binds PKNbeta, a target of the small GTPase Rho [].
•
•
•
•
•
Publication
17904117 | J:127524
First Author: Davie JK
Year: 2007
Journal: Dev Biol
Title: Target gene selectivity of the myogenic basic helix-loop-helix transcription factor myogenin in embryonic muscle.
Volume: 311
Issue: 2
Pages: 650-64
•
•
•
•
•
Publication
35942939 | J:327434
   
First Author: Ramirez M
Year: 2022
Journal: Elife
Title: Temporal analysis of enhancers during mouse cerebellar development reveals dynamic and novel regulatory functions.
Volume: 11
•
•
•
•
•
Protein Coding Gene
MGI:88057 | Apoe
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:1339975 | Pak1
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Publication
9707409 | -
First Author: Fan WT
Year: 1998
Journal: Curr Biol
Title: The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways.
Volume: 8
Issue: 16
Pages: 935-8
•
•
•
•
•
Publication
23940355 | J:354404
First Author: Schwechter B
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: RasGRF2 Rac-GEF activity couples NMDA receptor calcium flux to enhanced synaptic transmission.
Volume: 110
Issue: 35
Pages: 14462-7
•
•
•
•
•
Publication
17923690 | J:128985
First Author: Ruiz S
Year: 2007
Journal: Mol Cell Biol
Title: RasGRF2, a guanosine nucleotide exchange factor for Ras GTPases, participates in T-cell signaling responses.
Volume: 27
Issue: 23
Pages: 8127-42
•
•
•
•
•
Publication
24737505 | -
First Author: Easton AC
Year: 2014
Journal: Psychopharmacology (Berl)
Title: Rasgrf2 controls noradrenergic involvement in the acute and subchronic effects of alcohol in the brain.
Volume: 231
Issue: 21
Pages: 4199-209
•
•
•
•
•
Publication
32780989 | -
First Author: Zhu J
Year: 2020
Journal: Mol Cell
Title: GIT/PIX Condensates Are Modular and Ideal for Distinct Compartmentalized Cell Signaling.
Volume: 79
Issue: 5
Pages: 782-796.e6
•
•
•
•
•
Publication
16184169 | -
First Author: Sousa S
Year: 2005
Journal: Nat Cell Biol
Title: ARHGAP10 is necessary for alpha-catenin recruitment at adherens junctions and for Listeria invasion.
Volume: 7
Issue: 10
Pages: 954-60
•
•
•
•
•
Publication
12960420 | -
First Author: Kozminski KG
Year: 2003
Journal: Mol Biol Cell
Title: Interaction between a Ras and a Rho GTPase couples selection of a growth site to the development of cell polarity in yeast.
Volume: 14
Issue: 12
Pages: 4958-70
•
•
•
•
•
Publication
15282338 | -
First Author: Bauer Y
Year: 2004
Journal: Mol Biol Cell
Title: A Ras-like GTPase is involved in hyphal growth guidance in the filamentous fungus Ashbya gossypii.
Volume: 15
Issue: 10
Pages: 4622-32
•
•
•
•
•
Publication
9114012 | -
First Author: Park HO
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Two active states of the Ras-related Bud1/Rsr1 protein bind to different effectors to determine yeast cell polarity.
Volume: 94
Issue: 9
Pages: 4463-8
•
•
•
•
•
Publication
10461188 | -
First Author: Bagrodia S
Year: 1999
Journal: Trends Cell Biol
Title: Pak to the future.
Volume: 9
Issue: 9
Pages: 350-5
•
•
•
•
•
Publication
12935897 | -
First Author: Flanders JA
Year: 2003
Journal: FEBS Lett
Title: The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins.
Volume: 550
Issue: 1-3
Pages: 119-23
•
•
•
•
•
Publication
11741931 | -
First Author: Feng Q
Year: 2002
Journal: J Biol Chem
Title: Regulation of the Cool/Pix proteins: key binding partners of the Cdc42/Rac targets, the p21-activated kinases.
Volume: 277
Issue: 7
Pages: 5644-50
•
•
•
•
•
Publication
19969308 | -
First Author: Eriguchi M
Year: 2010
Journal: J Neurol Sci
Title: alpha Pix enhances mutant huntingtin aggregation.
Volume: 290
Issue: 1-2
Pages: 80-5
•
•
•
•
•
Protein Domain
IPR041841 | Rsr1
Type: Family
Description: Rsr1 is a member of the Rap subfamily of the Ras family that is found in fungi. In budding yeasts, Rsr1 is involved in selecting a site for bud growth on the cell cortex, which directs the establishment of cell polarization. The Rho family GTPase cdc42 and its GEF, cdc24, then establish an axis of polarized growth by organizing the actin cytoskeleton and secretory apparatus at the bud site. It is believed that cdc42 interacts directly with Rsr1 in vivo [, ]. In filamentous fungi, polar growth occurs at the tips of hypha and at novel growth sites along the extending hypha. In Ashbya gossypii, Rsr1 is a key regulator of hyphal growth, localizing at the tip region and regulating in apical polarization of the actin cytoskeleton [].Most Ras proteins contain a lipid modification site at the C terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Ras proteins [].
•
•
•
•
•
Protein Domain
IPR046376 | PH_Cool_Pix
Type: Domain
Description: There are two forms of Pix proteins: alpha Pix (also called Rho guanine nucleotide exchange factor (GEF) 6, 90Cool-2 or ARHGEF6) and beta Pix (GEF7, p85Cool-1 or ARHGEF7), which activate small GTPases by exchanging bound GDP for free GTP. betaPix contains an N-terminal SH3 domain, a RhoGEF/DH domain, a PH domain, a GIT1 binding domain (GBD), and a C-terminal coiled-coil (CC) domain []. It acts as a GEF for both Cdc42 and Rac1 [], and plays important roles in regulating neuroendocrine exocytosis, focal adhesion maturation, cell migration, synaptic vesicle localization, and insulin secretion [, , , ]. alphaPix differs in that it contains a calponin homology (CH) domain, which interacts with beta-parvin, N-terminal to the SH3 domain. alphaPix is an exchange factor for Rac1 and Cdc42 and mediates Pak activation on cell adhesion to fibronectin. Mutations in alphaPix can cause X-linked mental retardation. alphaPix also interacts with Huntington's disease protein (htt), and enhances the aggregation of mutant htt (muthtt) by facilitating SDS-soluble muthtt-muthtt interactions. The DH-PH domain of a Pix was required for its binding to htt. In the majority of Rho GEF proteins, the DH-PH domain is responsible for the exchange activity [, , , , ].This entry represents the PH domain of ARHGEF6 and ARHGEF7.
•
•
•
•
•
Protein Domain
IPR030744 | RasGRF2
Type: Family
Description: RasGRF2 belongs to the RasGRF family. It is a dual Ras/Rac guanine nucleotide exchange factor (GEF) that has been shown to be necessary for long-term potentiation in situ [, ]. It is also involved in T-cell signalling responses through Ras GTPases []. RasGRF2 has been linked to alcoholism [].RasGRF is a Ras family guanine nucleotide exchange factor sharing homology with Saccharomyces cerevisiae Cdc25 that stimulates nucleotide exchange on S. cerevisiae RAS []. RasGRF N-terminal region contains a Dbl homology (DH) domain which is generally present in GEFs for the Rho family of small G proteins, whereas the C-terminal Cdc25-related domain is linked to Ras GTPase signalling []. The presence of regulatory domains for Rho and Ras GTPases implicates the role of RasGRF in the control of the both pathways []. Two RasGRF, RasGRF1 and 2, have been identified in mammals []. Their function can be inhibited by its interaction with Cdc42 in its inactive GDP bound form. Reciprocally, the effects of Cdc42 on cytoskeletal dynamics can be inhibited by RasGRF1/2 [].
•
•
•
•
•
Publication
10922467 | -
First Author: Pucharcos C
Year: 2000
Journal: FEBS Lett
Title: Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis.
Volume: 478
Issue: 1-2
Pages: 43-51
•
•
•
•
•
Publication
11432776 | -
First Author: Shibata H
Year: 2001
Journal: J Biochem
Title: PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein, Graf2, which are GTPase activating proteins for Rho family.
Volume: 130
Issue: 1
Pages: 23-31
•
•
•
•
•
Publication
21145950 | -
First Author: Tsyba L
Year: 2011
Journal: Gene
Title: Intersectin multidomain adaptor proteins: regulation of functional diversity.
Volume: 473
Issue: 2
Pages: 67-75
•
•
•
•
•
Protein
Q3ULB5
Organism: Mus musculus/domesticus
Length: 682  
Fragment?: false
•
•
•
•
•
Protein
B2RWY1
Organism: Mus musculus/domesticus
Length: 682  
Fragment?: false
•
•
•
•
•
Protein
Q8C015
Organism: Mus musculus/domesticus
Length: 719  
Fragment?: false
•
•
•
•
•
Protein
Q8BTW9
Organism: Mus musculus/domesticus
Length: 593  
Fragment?: false
•
•
•
•
•
Protein
G5E884
Organism: Mus musculus/domesticus
Length: 544  
Fragment?: false
•
•
•
•
•
Protein
Q8BVB0
Organism: Mus musculus/domesticus
Length: 719  
Fragment?: false
•
•
•
•
•
Protein
A3KGC5
Organism: Mus musculus/domesticus
Length: 366  
Fragment?: true
•
•
•
•
•
Protein
Q3UGK7
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: true
•
•
•
•
•
Publication
10982819 | -
First Author: Longenecker KL
Year: 2000
Journal: J Biol Chem
Title: Structure of the BH domain from graf and its implications for Rho GTPase recognition.
Volume: 275
Issue: 49
Pages: 38605-10
•
•
•
•
•
Publication
9858476 | -
 
First Author: Taylor JM
Year: 1999
Journal: J Cell Sci
Title: Cytoskeletal changes induced by GRAF, the GTPase regulator associated with focal adhesion kinase, are mediated by Rho.
Volume: 112 ( Pt 2)
Pages: 231-42
•
•
•
•
•
Publication
20704716 | -
 
First Author: Qian Z
Year: 2010
Journal: J Exp Clin Cancer Res
Title: GTPase regulator associated with the focal adhesion kinase (GRAF) transcript was down-regulated in patients with myeloid malignancies.
Volume: 29
Pages: 111
•
•
•
•
•
Publication
21088884 | -
First Author: Momboisse F
Year: 2010
Journal: Cell Mol Neurobiol
Title: The Rho guanine nucleotide exchange factors Intersectin 1L and β-Pix control calcium-regulated exocytosis in neuroendocrine PC12 cells.
Volume: 30
Issue: 8
Pages: 1327-33
•
•
•
•
•
Publication
21472000 | -
First Author: Legg K
Year: 2011
Journal: Nat Rev Mol Cell Biol
Title: Cell migration: keeping young and mobile with β-PIX.
Volume: 12
Issue: 5
Pages: 278
•
•
•
•
•
Publication
22114281 | -
First Author: Sun Y
Year: 2011
Journal: J Neurosci
Title: β-Pix modulates actin-mediated recruitment of synaptic vesicles to synapses.
Volume: 31
Issue: 47
Pages: 17123-33
•
•
•
•
•
Publication
22087847 | -
First Author: Koh SH
Year: 2012
Journal: Stem Cells Dev
Title: β-PIX is critical for transplanted mesenchymal stromal cell migration.
Volume: 21
Issue: 11
Pages: 1989-99
•
•
•
•
•
Protein Coding Gene
MGI:95787 | Gng7
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:893584 | Gngt2
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:102703 | Gng4
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:102705 | Gng2
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:1925616 | Gng13
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom