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Search results 2801 to 2900 out of 3144 for Gli1

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Type Details Score
Publication
30389913 | J:268349
First Author: Kim HT
Year: 2018
Journal: Nat Commun
Title: Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease.
Volume: 9
Issue: 1
Pages: 4600
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Publication
32747435 | J:295894
 
First Author: Wei G
Year: 2020
Journal: Development
Title: Erk and MAPK signaling is essential for intestinal development through Wnt pathway modulation.
Volume: 147
Issue: 17
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Publication
38466355 | J:347414
 
First Author: Yang J
Year: 2024
Journal: J Clin Invest
Title: A BMP-controlled metabolic/epigenetic signaling cascade directs midfacial morphogenesis.
Volume: 134
Issue: 8
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Publication
35377797 | J:325356
First Author: Su-Feher L
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: Single cell enhancer activity distinguishes GABAergic and cholinergic lineages in embryonic mouse basal ganglia.
Volume: 119
Issue: 15
Pages: e2108760119
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Publication
8570653 | J:31191
First Author: Sullivan SL
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: The chromosomal distribution of mouse odorant receptor genes.
Volume: 93
Issue: 2
Pages: 884-8
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Publication
30352686 | J:270543
First Author: Tanahashi H
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Deletion of Lrp4 increases the incidence of microphthalmia.
Volume: 506
Issue: 3
Pages: 478-484
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Publication
38653356 | J:347984
First Author: Naillat F
Year: 2024
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Calcium signaling induces partial EMT and renal fibrosis in a Wnt4(mCherry) knock-in mouse model.
Volume: 1870
Issue: 5
Pages: 167180
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Publication
32001436 | J:291486
 
First Author: Daniel E
Year: 2020
Journal: Development
Title: Cyp26b1 is an essential regulator of distal airway epithelial differentiation during lung development.
Volume: 147
Issue: 4
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Publication
30728831 | J:304253
 
First Author: Jones MR
Year: 2018
Journal: Front Genet
Title: A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis.
Volume: 9
Pages: 746
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Publication
20516124 | J:161624
First Author: Ayrault O
Year: 2010
Journal: Cancer Res
Title: Atoh1 inhibits neuronal differentiation and collaborates with Gli1 to generate medulloblastoma-initiating cells.
Volume: 70
Issue: 13
Pages: 5618-27
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Publication
19030180 | J:173287
First Author: Long JE
Year: 2009
Journal: J Comp Neurol
Title: Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways.
Volume: 512
Issue: 4
Pages: 556-72
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Publication
19386638 | J:173286
 
First Author: Long JE
Year: 2009
Journal: Cereb Cortex
Title: Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways.
Volume: 19 Suppl 1
Pages: i96-106
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Publication
26930384 | J:231595
First Author: Gurdziel K
Year: 2016
Journal: Dev Dyn
Title: Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun.
Volume: 245
Issue: 5
Pages: 614-26
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Publication
31867038 | J:311090
 
First Author: Pyczek J
Year: 2019
Journal: Front Genet
Title: Regulation and Role of GLI1 in Cutaneous Squamous Cell Carcinoma Pathogenesis.
Volume: 10
Pages: 1185
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Publication
26238476 | J:226028
First Author: Lewandowski JP
Year: 2015
Journal: Dev Biol
Title: Spatiotemporal regulation of GLI target genes in the mammalian limb bud.
Volume: 406
Issue: 1
Pages: 92-103
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Publication
24146773 | J:209112
First Author: Shimizu H
Year: 2013
Journal: PLoS One
Title: The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo.
Volume: 8
Issue: 10
Pages: e75754
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Publication
21731673 | J:174767
First Author: Tang F
Year: 2011
Journal: PLoS One
Title: Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
Volume: 6
Issue: 6
Pages: e21208
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Publication
- | J:15839
       
First Author: International Committee on Standardized Genetic Nomenclature for Mice
Year: 1993
Title: Nomenclature rule change to delete hyphens and parentheses from mouse locus symbols
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
22988430 | J:190636
 
First Author: Wiese CB
Year: 2012
Journal: Front Neurosci
Title: A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.
Volume: 6
Pages: 130
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Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
15618518 | J:91257
First Author: Gray PA
Year: 2004
Journal: Science
Title: Mouse brain organization revealed through direct genome-scale TF expression analysis.
Volume: 306
Issue: 5705
Pages: 2255-7
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
16158046 | J:186380
First Author: Li X
Year: 2006
Journal: Oncogene
Title: Snail induction is an early response to Gli1 that determines the efficiency of epithelial transformation.
Volume: 25
Issue: 4
Pages: 609-21
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Publication
20818436 | J:175332
First Author: Di Marcotullio L
Year: 2011
Journal: Oncogene
Title: Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal.
Volume: 30
Issue: 1
Pages: 65-76
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Publication
25632159 | J:223840
First Author: Deng W
Year: 2015
Journal: J Cell Sci
Title: SOX9 inhibits β-TrCP-mediated protein degradation to promote nuclear GLI1 expression and cancer stem cell properties.
Volume: 128
Issue: 6
Pages: 1123-38
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Publication
34052323 | J:306525
 
First Author: Viswakarma N
Year: 2021
Journal: Cancer Lett
Title: Mixed Lineage Kinase 3 phosphorylates prolyl-isomerase PIN1 and potentiates GLI1 signaling in pancreatic cancer development.
Volume: 515
Pages: 1-13
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Publication
29463581 | J:262302
First Author: Rahman MM
Year: 2018
Journal: Cancer Res
Title: A Novel Mechanism for Activation of GLI1 by Nuclear SMO That Escapes Anti-SMO Inhibitors.
Volume: 78
Issue: 10
Pages: 2577-2588
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Publication
26868908 | J:259865
First Author: Falkenberg KJ
Year: 2016
Journal: Cell Death Differ
Title: A genome scale RNAi screen identifies GLI1 as a novel gene regulating vorinostat sensitivity.
Volume: 23
Issue: 7
Pages: 1209-18
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Publication
17638910 | J:123164
First Author: Dennler S
Year: 2007
Journal: Cancer Res
Title: Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo.
Volume: 67
Issue: 14
Pages: 6981-6
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Publication
30291846 | J:294443
First Author: Brennan-Crispi DM
Year: 2019
Journal: J Invest Dermatol
Title: Overexpression of Desmoglein 2 in a Mouse Model of Gorlin Syndrome Enhances Spontaneous Basal Cell Carcinoma Formation through STAT3-Mediated Gli1 Expression.
Volume: 139
Issue: 2
Pages: 300-307
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Publication
20433698 | -
 
First Author: Palaniswamy R
Year: 2010
Journal: BMC Mol Biol
Title: Genetic variations regulate alternative splicing in the 5' untranslated regions of the mouse glioma-associated oncogene 1, Gli1.
Volume: 11
Pages: 32
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Interaction Experiment
Barnfield PC (2005)
Description: Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms.
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Interaction Experiment
Abe Y (2019)
Description: MEP50/PRMT5-mediated methylation activates GLI1 in Hedgehog signalling through inhibition of ubiquitination by the ITCH/NUMB complex.
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Pathway
R-MMU-5610780 | Degradation of GLI1 by the proteasome
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GXD Expression
GXD Expression
Probe: MGI:23359
Assay Type: RNA in situ
Annotation Date: 2012-11-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689519
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:5441098
Age: embryonic day 11.5
Image: 4G
Note: Expression flanked the midline and extended to abut the hypothalamic border of Gli1 expression.
Specimen Label: 4G
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6382995
Assay Type: RNA in situ
Annotation Date: 2020-01-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716823
Pattern: Widespread
Stage: TS23
Assay Id: MGI:6383014
Age: embryonic day 15.5
Image: 2G
Note: Authors report expression comparable to that of Gli1 and Ptch1 in wild type retina.
Specimen Label: 2G
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:7664629
Assay Type: RNA in situ
Annotation Date: 2024-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1859223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7664634
Age: embryonic day 15.5
Image: 2BB
Note: Expression overlapping with that of Gli1 in neuroblast layer of neural retina
Specimen Label: 2BB
Detected: true
Specimen Num: 8
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Allele
Gli1<tm4Alj> | MGI:4838602
Name: GLI-Kruppel family member GLI1; targeted mutation 4, Alexandra L Joyner
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Gli1<em1(cre/ERT2)Smoc> | MGI:6724555
Name: GLI-Kruppel family member GLI1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Inducible, Recombinase
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Publication
30675521 | -
 
First Author: Abe Y
Year: 2019
Journal: Commun Biol
Title: MEP50/PRMT5-mediated methylation activates GLI1 in Hedgehog signalling through inhibition of ubiquitination by the ITCH/NUMB complex.
Volume: 2
Pages: 23
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Strain
MGI:6428726 | C57BL/6JSmoc-Gli1<em1(cre/ERT2)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Gli1<tm1Salz> | MGI:7432317
Name: GLI-Kruppel family member GLI1; targeted mutation 1, James L Salzer
Allele Type: Targeted
Attribute String: Conditional ready
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Allele
Gli1<tm4.1Alj> | MGI:7788984
Name: GLI-Kruppel family member GLI1; targeted mutation 4.1, Alexandra L Joyner
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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DO Term
DOID:0060987 | preaxial polydactyly I
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Publication
16198329 | -
First Author: Lakiza O
Year: 2005
Journal: Dev Biol
Title: STAR proteins quaking-6 and GLD-1 regulate translation of the homologues GLI1 and tra-1 through a conserved RNA 3'UTR-based mechanism.
Volume: 287
Issue: 1
Pages: 98-110
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GXD Expression
GXD Expression
Probe: MGI:5774791
Assay Type: RNA in situ
Annotation Date: 2016-06-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1614015
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:5774798
Age: embryonic day 9.5
Image: 1B
Note: Expression expands laterally from the medial. There was some overlap between Shh and Gli1 expression at their domain boundaries (low expression).
Specimen Label: 1B
Detected: true
Specimen Num: 2
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Protein
Q9Z0P7
Organism: Mus musculus/domesticus
Length: 484  
Fragment?: false
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Strain
MGI:7788985 | STOCK Gli1<tm4.1Alj>/J
Attribute String: mutant stock, targeted mutation
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Protein Coding Gene
MGI:1345643 | Sufu
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Tg(Gli1-EGFP)DM197Gsat | MGI:3843287
Name: transgene insertion DM197, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Protein Coding Gene
MGI:107423 | Numb
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q9QZS3
Organism: Mus musculus/domesticus
Length: 653  
Fragment?: false
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HT Experiment
GSE196085 | Hedgehog signaling activates a mammalian heterochronic gene regulatory network controlling differentiation timing across lineages (Drop-Seq)
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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HT Experiment
GSE196087 | Hedgehog signaling activates a mammalian heterochronic gene regulatory network controlling differentiation timing across lineages (RNA-Seq I)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE196088 | Hedgehog signaling activates a mammalian heterochronic gene regulatory network controlling differentiation timing across lineages (RNA-Seq II)
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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GXD Expression
GXD Expression
Probe: MGI:7664631
Assay Type: RNA in situ
Annotation Date: 2024-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1792323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7664636
Age: embryonic day 15.5
Image: 2KK
Note: Expression restricted narrow band of mesenchyme surrounding molars at outer edge of Ptch1 and Gli1 expression, at a distance from Shh-expressing cells. Strong expression in narrow band of peripheral mesenchyme, including dental follicle, encompassing developing molars. Faint expression detected throughout remaining mesenchymal components.
Specimen Label: 2KK
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:7664631
Assay Type: RNA in situ
Annotation Date: 2024-07-15
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1736423
Pattern: Graded
Stage: TS23
Assay Id: MGI:7664636
Age: embryonic day 15.5
Image: 2MM
Note: Graded and robust pattern of expression, strongest in palatal mesenchyme adjacent to Shh-expressing rugae. Strong expression in palatal mesenchyme adjacent to palatal oral epithelium of palatal rugae in large region overlapping with and extending behond that of Gli1 and Ptch1 expression. Mesenchymal expression is graded, with strongest expression closest to oral epithelium.
Specimen Label: 2MM
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
Probe: MGI:7664631
Assay Type: RNA in situ
Annotation Date: 2024-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1794423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7664636
Age: embryonic day 15.5
Image: 2JJ
Note: Expression restricted narrow band of mesenchyme surrounding molars at outer edge of Ptch1 and Gli1 expression, at a distance from Shh-expressing cells. Strong expression in narrow band of peripheral mesenchyme, including dental follicle, encompassing developing molars. Faint expression detected throughout remaining mesenchymal components.
Specimen Label: 2JJ
Detected: true
Specimen Num: 2
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Strain
MGI:3843288 | STOCK Tg(Gli1-EGFP)DM197Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Allele
Gt(ROSA)26Sor<tm6(Gli1)Amc> | MGI:4460761
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 6, Andrew P McMahon
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
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Strain
MGI:4818269 | STOCK Gt(ROSA)26Sor<tm6(Gli1)Amc>/J
Attribute String: mutant stock, targeted mutation, transgenic
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/?
Background: involves: 129 * C57BL/6 * CBA * Swiss Webster
Zygosity: ot
Has Mutant Allele: true
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Publication
20460306 | J:160536
First Author: Lee EY
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis.
Volume: 107
Issue: 21
Pages: 9736-41
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Publication
24865218 | J:216312
First Author: Mesman S
Year: 2014
Journal: PLoS One
Title: Mesodiencephalic dopaminergic neuronal differentiation does not involve GLI2A-mediated SHH-signaling and is under the direct influence of canonical WNT signaling.
Volume: 9
Issue: 5
Pages: e97926
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Protein Domain
IPR032851 | GLI3
Type: Family
Description: GLI3 is a member of the GLI family of transcription factors, which also includes GLI1 and GLI2. They are central effectors of the Hedgehog (Hh) pathway in vertebrates [, ]. GLI1 is an obligatory activator, whereas GLI2 and GLI3 carry activator and repressor functions []. The full-length GLI3 form, after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while its C-terminally truncated form acts as a repressor (GLI3R). GLI3 participates in the patterning and growth of many organs, including the central nervous system (CNS) and limbs [, , , , ].
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Publication
10693759 | J:60639
First Author: Wang B
Year: 2000
Journal: Cell
Title: Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb.
Volume: 100
Issue: 4
Pages: 423-34
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Publication
20360384 | J:158961
First Author: Humke EW
Year: 2010
Journal: Genes Dev
Title: The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins.
Volume: 24
Issue: 7
Pages: 670-82
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