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Search results 2801 to 2900 out of 3029 for Pdx1

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Type Details Score
Publication
23071091 | J:192859
First Author: Gao Y
Year: 2012
Journal: Mol Cell Biol
Title: PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis.
Volume: 32
Issue: 24
Pages: 5129-39
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Publication
24613355 | J:211832
First Author: Chen YJ
Year: 2014
Journal: Cell Rep
Title: De novo formation of insulin-producing "neo-β cell islets" from intestinal crypts.
Volume: 6
Issue: 6
Pages: 1046-1058
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Strain
MGI:5604889 | B6.Cg-Gt(ROSA)26Sor<tm1(Neurog3*S183A*S187A)Axbe> Tg(Pdx1-cre)6Tuv
Attribute String: congenic, mutant strain, targeted mutation, transgenic
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Publication
30303066 | J:269819
   
First Author: Ceasrine AM
Year: 2018
Journal: Elife
Title: Adrb2 controls glucose homeostasis by developmental regulation of pancreatic islet vasculature.
Volume: 7
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Publication
34345920 | J:339816
 
First Author: Altman MK
Year: 2021
Journal: Development
Title: TRPM7 is a crucial regulator of pancreatic endocrine development and high-fat-diet-induced β-cell proliferation.
Volume: 148
Issue: 16
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Publication
25105579 | J:215154
First Author: Sancho R
Year: 2014
Journal: Cell Stem Cell
Title: Loss of Fbw7 reprograms adult pancreatic ductal cells into α, δ, and β cells.
Volume: 15
Issue: 2
Pages: 139-53
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Publication
26512112 | J:227471
First Author: Antonucci L
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress.
Volume: 112
Issue: 45
Pages: E6166-74
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Publication
38905124 | J:353482
First Author: Ortiz JA
Year: 2024
Journal: Diabetes
Title: Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar Cells Is Required for the Development of Islets and for β-Cell Function During Aging.
Volume: 73
Issue: 9
Pages: 1447-1461
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Publication
31187215 | J:282554
First Author: Mandelbaum AD
Year: 2019
Journal: Diabetologia
Title: miR-17-92 and miR-106b-25 clusters regulate beta cell mitotic checkpoint and insulin secretion in mice.
Volume: 62
Issue: 9
Pages: 1653-1666
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Publication
28801621 | J:287496
First Author: Horii T
Year: 2017
Journal: Sci Rep
Title: Efficient generation of conditional knockout mice via sequential introduction of lox sites.
Volume: 7
Issue: 1
Pages: 7891
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Publication
23648841 | J:232009
First Author: Snyder CS
Year: 2013
Journal: Pancreas
Title: A dual-color genetically engineered mouse model for multispectral imaging of the pancreatic microenvironment.
Volume: 42
Issue: 6
Pages: 952-8
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Publication
31447265 | J:284132
First Author: Murakami S
Year: 2019
Journal: Dev Cell
Title: A Yap-Myc-Sox2-p53 Regulatory Network Dictates Metabolic Homeostasis and Differentiation in Kras-Driven Pancreatic Ductal Adenocarcinomas.
Volume: 51
Issue: 1
Pages: 113-128.e9
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Strain
MGI:5810713 | C57BL/6-Tg(Pdx1-itTA)#Fto/Orl
Attribute String: coisogenic, mutant strain, transgenic
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Genotype
Genotype
Symbol: Myt1/Myt1 Tg(Pdx1-cre)89.1Dam/?
Background: involves: 129 * C57BL/6 * CBA * CD-1 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Brca2/Brca2 Kras/Kras<+> Trp53/Trp53<+> Tg(Pdx1-cre)6Tuv/?
Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Brca2/Brca2 Kras/Kras<+> Tg(Pdx1-cre)6Tuv/?
Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kras/Kras<+> Pten/Pten<+> Tg(Pdx1-cre)89.1Dam/?
Background: involves: 129S4/SvJae * BALB/c * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kras/Kras<+> Pten/Pten Tg(Pdx1-cre)89.1Dam/?
Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdkn2a/Cdkn2a<+> Kras/Kras<+> Trp53/Trp53 Tg(Pdx1-cre)89.1Dam/?
Background: involves: 129 * C57BL/6 * CBA * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdkn2a/Cdkn2a Kras/Kras<+> Trp53/Trp53 Tg(Pdx1-cre)89.1Dam/?
Background: involves: 129 * C57BL/6 * CBA * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdkn2a/Cdkn2a<+> Kras/Kras<+> Trp53/Trp53<+> Tg(Pdx1-cre)89.1Dam/?
Background: involves: 129 * C57BL/6 * CBA * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdkn2a/Cdkn2a Kras/Kras<+> Trp53/Trp53<+> Tg(Pdx1-cre)89.1Dam/?
Background: involves: 129 * C57BL/6 * CBA * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kras/Kras<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Pdx1-cre)6Tuv/? TgTn(sb-T2/Onc)#Dla/?
Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Brca1/Brca1 Kras/Kras<+> Trp53/Trp53 Tg(Pdx1-cre)6Tuv/?
Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Brca1/Brca1 Kras/Kras<+> Trp53/Trp53 Tg(Pdx1-cre)6Tuv/?
Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(CAG-Bgeo,-tTA,-EGFP)2A11Kuw/? Tg(Pdx1-cre)6Tuv/? Tg(tetO-MYC)36Bop/?
Background: involves: 129P2/OlaHsd * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdkn2a/Cdkn2a<+> Tg(CAG-Bgeo,-tTA,-EGFP)2A11Kuw/? Tg(Pdx1-cre)6Tuv/? Tg(tetO-MYC)36Bop/?
Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cish/Cish Tg(Ins1-EGFP)1Hara/? Tg(Pdx1-cre)89.1Dam/?
Background: involves: C57BL/6 * CBA * CD-1
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kras/Kras<+> Tg(CAG-Bgeo,-tsA58T)T26Ichi/? Tg(Pdx1-cre)6Tuv/?
Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/? Tg(Pdx1-cre)6Tuv/?
Background: B6.Cg-Gt(ROSA)26Sor Tg(Pdx1-cre)6Tuv
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kras/Kras<+> Tg(Pdx1-cre)6Tuv/? Trp53/Trp53
Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kras/Kras<+> Rab11fip1/Rab11fip1 Tg(Pdx1-cre)6Tuv/? Trp53/Trp53<+>
Background: involves: 129S4/SvJae * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Epha2/Epha2 Kras/Kras<+> Trp53/Trp53<+> Tg(Pdx1-cre)6Tuv/?
Background: involves: 129S/SvEv * 129S4/SvJae * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Kras/Kras<+> Prdm1/Prdm1 Tg(Pdx1-cre)6Tuv/? Trp53/Trp53<+>
Background: involves: 129 * C57BL/6NCrl * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Kras/Kras<+> Tg(Pdx1-cre)6Tuv/? Trp53/Trp53<+>
Background: involves: 129 * C57BL/6NCrl * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd9/Cd9<+> Kras/Kras<+> Tg(Pdx1-cre)6Tuv/? Trp53/Trp53<+>
Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6N * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Kras/Kras<+> Tg(Pdx1-cre)6Tuv/? Trp53/Trp53<+>
Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129X1/SvJ * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Kras/Kras<+> Tg(Pdx1-cre)6Tuv/? Trp53/Trp53
Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129X1/SvJ * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdk8/Cdk8 Tg(Pdx1-cre)6Tuv/?
Background: involves: C57BL/6N * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kras/Kras<+> Tg(Pdx1-cre)6Tuv/? Trp53/Trp53<+>
Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Trim29/Trim29 Tg(Pdx1-cre)6Tuv/?
Background: involves: C57BL/6N * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Pdx1-cre)89.1Dam/? Trim29/Trim29
Background: involves: 129 * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gata4/Gata4 Gata6/Gata6 Tg(Pdx1-cre)6Tuv/?
Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dpy30/Dpy30 Tg(Pdx1-cre)89.1Dam/?
Background: involves: C57BL/6 * C57BL/6N * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Pdx1-flpo)#Ybi/?
Background: involves: 129S6/SvEvTac
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Myt1/Myt1 Myt1l/Myt1l St18/St18 Tg(Ins1-EGFP)1Hara/? Tg(Pdx1-cre)89.1Dam/?
Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * CD-1
Zygosity: cn
Has Mutant Allele: true
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Publication
18288891 | J:135659
First Author: Tanabe K
Year: 2008
Journal: PLoS Biol
Title: Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance.
Volume: 6
Issue: 2
Pages: e37
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Publication
32712220 | J:350351
 
First Author: Wei R
Year: 2020
Journal: Metabolism
Title: Dapagliflozin promotes beta cell regeneration by inducing pancreatic endocrine cell phenotype conversion in type 2 diabetic mice.
Volume: 111
Pages: 154324
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Publication
31055616 | J:282688
First Author: Obata A
Year: 2019
Journal: Diabetologia
Title: Vascular endothelial PDPK1 plays a pivotal role in the maintenance of pancreatic beta cell mass and function in adult male mice.
Volume: 62
Issue: 7
Pages: 1225-1236
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Publication
35802167 | J:331554
First Author: Habibe JJ
Year: 2022
Journal: Diabetologia
Title: Glucose-mediated insulin secretion is improved in FHL2-deficient mice and elevated FHL2 expression in humans is associated with type 2 diabetes.
Volume: 65
Issue: 10
Pages: 1721-1733
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Publication
31116975 | J:284493
First Author: Sharon N
Year: 2019
Journal: Cell Rep
Title: Wnt Signaling Separates the Progenitor and Endocrine Compartments during Pancreas Development.
Volume: 27
Issue: 8
Pages: 2281-2291.e5
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Publication
29017057 | J:243744
First Author: Mello SS
Year: 2017
Journal: Cancer Cell
Title: A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer.
Volume: 32
Issue: 4
Pages: 460-473.e6
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Publication
29249692 | J:253745
First Author: Renz BW
Year: 2018
Journal: Cancer Cell
Title: β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer.
Volume: 33
Issue: 1
Pages: 75-90.e7
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Publication
24097820 | J:205411
First Author: Zhang Y
Year: 2013
Journal: Cancer Res
Title: Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistance.
Volume: 73
Issue: 20
Pages: 6359-74
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Publication
33307028 | J:308020
First Author: Peran I
Year: 2021
Journal: Gastroenterology
Title: Cadherin 11 Promotes Immunosuppression and Extracellular Matrix Deposition to Support Growth of Pancreatic Tumors and Resistance to Gemcitabine in Mice.
Volume: 160
Issue: 4
Pages: 1359-1372.e13
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Publication
26567136 | J:237566
First Author: Baird JR
Year: 2016
Journal: Cancer Res
Title: Radiotherapy Combined with Novel STING-Targeting Oligonucleotides Results in Regression of Established Tumors.
Volume: 76
Issue: 1
Pages: 50-61
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Publication
28790031 | J:245611
First Author: Chiou SH
Year: 2017
Journal: Cancer Discov
Title: BLIMP1 Induces Transient Metastatic Heterogeneity in Pancreatic Cancer.
Volume: 7
Issue: 10
Pages: 1184-1199
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Publication
30858608 | J:285667
First Author: Liko D
Year: 2019
Journal: Cell Death Differ
Title: Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas.
Volume: 26
Issue: 12
Pages: 2535-2550
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Publication
22699621 | J:186717
First Author: Pérez-Mancera PA
Year: 2012
Journal: Nature
Title: The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma.
Volume: 486
Issue: 7402
Pages: 266-70
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Publication
25024225 | J:212242
First Author: Lee JJ
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Stromal response to Hedgehog signaling restrains pancreatic cancer progression.
Volume: 111
Issue: 30
Pages: E3091-100
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Publication
24216479 | J:204180
First Author: Court H
Year: 2013
Journal: J Clin Invest
Title: Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression.
Volume: 123
Issue: 11
Pages: 4681-94
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Publication
23361300 | J:196881
First Author: Khalaileh A
Year: 2013
Journal: Cancer Res
Title: Phosphorylation of ribosomal protein S6 attenuates DNA damage and tumor suppression during development of pancreatic cancer.
Volume: 73
Issue: 6
Pages: 1811-20
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Publication
25127677 | J:314626
First Author: Hermann PC
Year: 2014
Journal: Gastroenterology
Title: Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice.
Volume: 147
Issue: 5
Pages: 1119-33.e4
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Publication
35418690 | J:324774
First Author: Kidger AM
Year: 2022
Journal: Oncogene
Title: Suppression of mutant Kirsten-RAS (KRASG12D)-driven pancreatic carcinogenesis by dual-specificity MAP kinase phosphatases 5 and 6.
Volume: 41
Issue: 20
Pages: 2811-2823
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Publication
35120601 | J:320538
First Author: Alam A
Year: 2022
Journal: Cancer Cell
Title: Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer.
Volume: 40
Issue: 2
Pages: 153-167.e11
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Publication
24794439 | J:211801
First Author: Kinsey C
Year: 2014
Journal: Cell Rep
Title: Plac8 links oncogenic mutations to regulation of autophagy and is critical to pancreatic cancer progression.
Volume: 7
Issue: 4
Pages: 1143-55
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Publication
31983610 | J:285699
First Author: Cheung EC
Year: 2020
Journal: Cancer Cell
Title: Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer.
Volume: 37
Issue: 2
Pages: 168-182.e4
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Publication
32234521 | J:336882
First Author: Ruscetti M
Year: 2020
Journal: Cell
Title: Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer.
Volume: 181
Issue: 2
Pages: 424-441.e21
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Publication
29364867 | J:257934
First Author: Mueller S
Year: 2018
Journal: Nature
Title: Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes.
Volume: 554
Issue: 7690
Pages: 62-68
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Publication
34907344 | J:321218
First Author: Klimovich B
Year: 2022
Journal: Oncogene
Title: p53 partial loss-of-function mutations sensitize to chemotherapy.
Volume: 41
Issue: 7
Pages: 1011-1023
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Publication
36653361 | J:332636
First Author: Ferguson LP
Year: 2023
Journal: Nat Commun
Title: Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinoma.
Volume: 14
Issue: 1
Pages: 292
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Publication
30228296 | J:283080
First Author: Chiou SH
Year: 2018
Journal: Sci Rep
Title: Hmga2 is dispensable for pancreatic cancer development, metastasis, and therapy resistance.
Volume: 8
Issue: 1
Pages: 14008
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Publication
25119024 | J:217085
First Author: Viale A
Year: 2014
Journal: Nature
Title: Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function.
Volume: 514
Issue: 7524
Pages: 628-32
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Publication
33839689 | J:308176
First Author: Kim MP
Year: 2021
Journal: Cancer Discov
Title: Oncogenic KRAS Recruits an Expansive Transcriptional Network through Mutant p53 to Drive Pancreatic Cancer Metastasis.
Volume: 11
Issue: 8
Pages: 2094-2111
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Publication
20624967 | J:162569
First Author: Mazur PK
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma.
Volume: 107
Issue: 30
Pages: 13438-43
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Publication
24721715 | J:213751
First Author: Baumgartner BK
Year: 2014
Journal: Dev Biol
Title: Distinct requirements for beta-catenin in pancreatic epithelial growth and patterning.
Volume: 391
Issue: 1
Pages: 89-98
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Publication
20614471 | J:164701
First Author: Carpenter AC
Year: 2010
Journal: Genesis
Title: Generation of mice with a conditional null allele for Wntless.
Volume: 48
Issue: 9
Pages: 554-8
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Publication
21747171 | J:176160
First Author: Tiano JP
Year: 2011
Journal: J Clin Invest
Title: Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents β cell failure in rodent models of type 2 diabetes.
Volume: 121
Issue: 8
Pages: 3331-42
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Publication
30456390 | J:287931
First Author: Pitarresi JR
Year: 2018
Journal: Life Sci Alliance
Title: Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth.
Volume: 1
Issue: 5
Pages: e201800190
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Publication
25716832 | J:219852
First Author: Wu Z
Year: 2015
Journal: J Neurosci
Title: GABAergic projections from lateral hypothalamus to paraventricular hypothalamic nucleus promote feeding.
Volume: 35
Issue: 8
Pages: 3312-8
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Publication
25133424 | J:215828
First Author: Chamberlain CE
Year: 2014
Journal: J Clin Invest
Title: Menin determines K-RAS proliferative outputs in endocrine cells.
Volume: 124
Issue: 9
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