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Search results 2801 to 2900 out of 3068 for Ret

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Hits by Strain

Type Details Score
Protein
I6L993
Organism: Mus musculus/domesticus
Length: 179  
Fragment?: false
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Protein
D3YUD5
Organism: Mus musculus/domesticus
Length: 54  
Fragment?: true
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Protein
D3Z3C9
Organism: Mus musculus/domesticus
Length: 48  
Fragment?: true
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Publication
8846787 | -
First Author: Borden KL
Year: 1995
Journal: EMBO J
Title: Novel topology of a zinc-binding domain from a protein involved in regulating early Xenopus development.
Volume: 14
Issue: 23
Pages: 5947-56
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Publication
9923704 | -
First Author: Borden KL
Year: 1998
Journal: Biochem Cell Biol
Title: RING fingers and B-boxes: zinc-binding protein-protein interaction domains.
Volume: 76
Issue: 2-3
Pages: 351-8
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Protein Domain
IPR017372 | Glial_neurotroph_fac_rcpt_a1/2
Type: Family
Description: Glial cell line-derived neurotrophic factor (GDNF) and its related factorsneurturin (NTN), artemin (ART) and persephin (PSP), are members of the GDNFfamily of neurotrophic factors. They form a sub-group in the transforming growth factor-beta (TGF-beta) superfamily. These factors are involved inthe promotion of neurone survival, exerting their effects through specific receptors.The GDNF family receptors (GFRs) are glycosyl-phosphatidylinositol-linked,cell surface receptors []. Four receptor subtypes, termed GFRalpha-1 to 4, are currently recognised. GFRalpha-1 and 2 are activated by GDNF and NTN respectively, although some degree of ligand promiscuity is thought to occur []. Homologues for these receptor subtypes have been cloned from mammalian and avian tissue. The principal ligand for GFRalpha-3 is artemin. This receptor subtype is currently described only in mammals []. GFRalpha-4 is activated by persephin and has so far only been found in chicken []. This entry is general for types 1 to 3.Activation of GFR family members triggers their interaction with the membrane-bound receptor kinase Ret. This induces Ret homo-dimerisation, triggering a cascade of intracellular signalling events such as the activation of the Ras-mitogen-activated protein kinase (MAPK), phosphoinositol-3-kinase (PI3K), Jun N-terminal kinase (JNK) and phospholipase C gamma (PLC gamma) dependent pathways [].
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Protein Domain
IPR003438 | GDNF_rcpt
Type: Family
Description: Glial cell line-derived neurotrophic factor (GDNF) and its related factorsneurturin (NTN), artemin (ART) and persephin (PSP), are members of the GDNFfamily of neurotrophic factors. They form a sub-group in the transforming growth factor-beta (TGF-beta) superfamily. These factors are involved inthe promotion of neurone survival, exerting their effects through specific receptors.The GDNF family receptors (GFRs) are glycosyl-phosphatidylinositol-linked,cell surface receptors []. Four receptor subtypes, termed GFRalpha-1 to 4, are currently recognised. GFRalpha-1 and 2 are activated by GDNF and NTN respectively, although some degree of ligand promiscuity is thought to occur []. Homologues for these receptor subtypes have been cloned from mammalian and avian tissue. The principal ligand for GFRalpha-3 is artemin. This receptor subtype is currently described only in mammals []. GFRalpha-4 is activated by persephin and has so far only been found in chicken []. This entry is general for types 1 to 3.Activation of GFR family members triggers their interaction with the membrane-bound receptor kinase Ret. This induces Ret homo-dimerisation, triggering a cascade of intracellular signalling events such as the activation of the Ras-mitogen-activated protein kinase (MAPK), phosphoinositol-3-kinase (PI3K), Jun N-terminal kinase (JNK) and phospholipase C gamma (PLC gamma)dependent pathways [].
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Protein Domain
IPR003879 | Butyrophylin_SPRY
Type: Domain
Description: Several proteins that contain RING fingers also contain a well-conserved40-residue cysteine-rich domain termed a B-box zinc finger. Often, one or two copies of the B-box are associated with a coiled coil domain in additionto the ring finger, forming a tripartite motif. The tripartite motif is found in transcription factors, ribonucleoproteins and proto-oncoproteins,but no function has yet been ascribed to the domain [].The solution structure of the B-box motif has been determined by NMR. The protein is a monomer, with 2 β-strands, 2 helical turns and 3extended loop regions packed in a novel topology []. Of 7 potential zincligands, only 4 are used, binding a single zinc atom in a C2-H2 tetrahedral arrangement. The B-box structure differs in tertiary fold from allother known zinc-binding motifs.A group of proteins that contain the B-box motif also host a well conserveddomain of unknown function. Proteins that include this domain are,e.g.: butyrophilin, the RET finger protein, the 52kDa Ro protein and theXenopus nuclear factor protein. The C-terminal portion of this region hasbeen termed the SPRY domain (after SPla and the RYanodine Receptor) [].
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Publication
14871802 | J:88074
First Author: Kato M
Year: 2004
Journal: Cancer Res
Title: c-Kit-targeting immunotherapy for hereditary melanoma in a mouse model.
Volume: 64
Issue: 3
Pages: 801-6
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Publication
38875504 | J:353755
First Author: Farrokhi A
Year: 2024
Journal: Blood
Title: Early-life infection depletes preleukemic cells in a mouse model of hyperdiploid B-cell acute lymphoblastic leukemia.
Volume: 144
Issue: 8
Pages: 809-821
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Publication
23045606 | J:190913
First Author: Hansen W
Year: 2012
Journal: J Exp Med
Title: Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth.
Volume: 209
Issue: 11
Pages: 2001-16
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Publication
17369397 | J:119483
First Author: Tang F
Year: 2007
Journal: Genes Dev
Title: Maternal microRNAs are essential for mouse zygotic development.
Volume: 21
Issue: 6
Pages: 644-8
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Publication
31657143 | J:282136
First Author: Kato Y
Year: 2019
Journal: EMBO Rep
Title: ELAVL2-directed RNA regulatory network drives the formation of quiescent primordial follicles.
Volume: 20
Issue: 12
Pages: e48251
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Publication
15256250 | J:91900
 
First Author: Yan KP
Year: 2004
Journal: Gene
Title: Molecular cloning, genomic structure, and expression analysis of the mouse transcriptional intermediary factor 1 gamma gene.
Volume: 334
Pages: 3-13
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Publication
1630810 | J:1682
First Author: Dumont DJ
Year: 1992
Journal: Oncogene
Title: tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors.
Volume: 7
Issue: 8
Pages: 1471-80
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Publication
10679935 | J:59241
First Author: Rice J
Year: 2000
Journal: Dev Dyn
Title: Transgenic rescue of aganglionosis and piebaldism in lethal spotted mice.
Volume: 217
Issue: 1
Pages: 120-32
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Publication
37125774 | J:335532
     
First Author: Som R
Year: 2023
Journal: Am J Physiol Cell Physiol
Title: Oxaloacetate regulates complex II respiration in brown fat: dependence on UCP1 expression.
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Publication
12669066 | J:85322
First Author: Paw BH
Year: 2003
Journal: Nat Genet
Title: Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency.
Volume: 34
Issue: 1
Pages: 59-64
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Publication
20702564 | J:168364
First Author: Kiefer SM
Year: 2010
Journal: Development
Title: Sall1-dependent signals affect Wnt signaling and ureter tip fate to initiate kidney development.
Volume: 137
Issue: 18
Pages: 3099-106
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Publication
23152559 | J:190855
First Author: Schlecker E
Year: 2012
Journal: J Immunol
Title: Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth.
Volume: 189
Issue: 12
Pages: 5602-11
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Publication
20107080 | J:157942
First Author: Wang H
Year: 2010
Journal: J Neurosci
Title: The timing and location of glial cell line-derived neurotrophic factor expression determine enteric nervous system structure and function.
Volume: 30
Issue: 4
Pages: 1523-38
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Publication
15245503 | J:100259
First Author: Võikar V
Year: 2004
Journal: Eur J Neurosci
Title: Impaired behavioural flexibility and memory in mice lacking GDNF family receptor alpha2.
Volume: 20
Issue: 1
Pages: 308-12
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Publication
25111710 | J:221012
First Author: Kupari J
Year: 2014
Journal: PLoS One
Title: Different requirements for GFRα2-signaling in three populations of cutaneous sensory neurons.
Volume: 9
Issue: 8
Pages: e104764
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Publication
24169552 | J:207714
First Author: Lu N
Year: 2013
Journal: Endocrinology
Title: Loss of vascular endothelial growth factor A (VEGFA) isoforms in the testes of male mice causes subfertility, reduces sperm numbers, and alters expression of genes that regulate undifferentiated spermatogonia.
Volume: 154
Issue: 12
Pages: 4790-802
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Publication
9697851 | J:68750
First Author: Cacalano G
Year: 1998
Journal: Neuron
Title: GFRalpha1 is an essential receptor component for GDNF in the developing nervous system and kidney.
Volume: 21
Issue: 1
Pages: 53-62
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Publication
22615490 | J:186652
First Author: Gonzales ML
Year: 2012
Journal: Mol Cell Biol
Title: Phosphorylation of distinct sites in MeCP2 modifies cofactor associations and the dynamics of transcriptional regulation.
Volume: 32
Issue: 14
Pages: 2894-903
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Publication
34903841 | J:322606
First Author: Spohr C
Year: 2022
Journal: Leukemia
Title: Gab2 deficiency prevents Flt3-ITD driven acute myeloid leukemia in vivo.
Volume: 36
Issue: 4
Pages: 970-982
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Publication
23542432 | J:199323
First Author: Keefe Davis T
Year: 2013
Journal: Mech Dev
Title: Stage specific requirement of Gfrα1 in the ureteric epithelium during kidney development.
Volume: 130
Issue: 9-10
Pages: 506-18
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Publication
21133924 | J:170428
First Author: Kholodilov N
Year: 2011
Journal: J Neurochem
Title: Glial cell line-derived neurotrophic factor receptor-α1 expressed in striatum in trans regulates development and injury response of dopamine neurons of the substantia nigra.
Volume: 116
Issue: 4
Pages: 486-98
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Publication
17540362 | J:122953
First Author: Kim D
Year: 2007
Journal: Dev Biol
Title: PTEN modulates GDNF/RET mediated chemotaxis and branching morphogenesis in the developing kidney.
Volume: 307
Issue: 2
Pages: 290-9
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Publication
22361728 | J:187487
First Author: Becker L
Year: 2012
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Divergent fate and origin of neurosphere-like bodies from different layers of the gut.
Volume: 302
Issue: 9
Pages: G958-65
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Publication
39174793 | J:353452
First Author: Altés G
Year: 2024
Journal: Sci Rep
Title: Multiple endocrine defects in adult-onset Sprouty1/2/4 triple knockout mice.
Volume: 14
Issue: 1
Pages: 19479
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Publication
22669823 | J:185503
First Author: Yu CT
Year: 2012
Journal: Development
Title: COUP-TFII is essential for metanephric mesenchyme formation and kidney precursor cell survival.
Volume: 139
Issue: 13
Pages: 2330-9
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Publication
32661391 | J:325215
First Author: Suriben R
Year: 2020
Journal: Nat Med
Title: Antibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice.
Volume: 26
Issue: 8
Pages: 1264-1270
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Publication
36794623 | J:355484
First Author: Rimal S
Year: 2023
Journal: EMBO Rep
Title: Reverse electron transfer is activated during aging and contributes to aging and age-related disease.
Volume: 24
Issue: 4
Pages: e55548
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Publication
12019325 | J:76684
First Author: Zwick M
Year: 2002
Journal: J Neurosci
Title: Glial cell line-derived neurotrophic factor is a survival factor for isolectin B4-positive, but not vanilloid receptor 1-positive, neurons in the mouse.
Volume: 22
Issue: 10
Pages: 4057-65
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Publication
16914684 | J:111687
First Author: Elitt CM
Year: 2006
Journal: J Neurosci
Title: Artemin overexpression in skin enhances expression of TRPV1 and TRPA1 in cutaneous sensory neurons and leads to behavioral sensitivity to heat and cold.
Volume: 26
Issue: 33
Pages: 8578-87
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Publication
33497358 | J:308268
 
First Author: Le TL
Year: 2021
Journal: J Clin Invest
Title: Dysregulation of the NRG1/ERBB pathway causes a developmental disorder with gastrointestinal dysmotility in humans.
Volume: 131
Issue: 6
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Publication
31015297 | J:276480
First Author: Jia Y
Year: 2019
Journal: J Exp Med
Title: Lamin B1 loss promotes lung cancer development and metastasis by epigenetic derepression of RET.
Volume: 216
Issue: 6
Pages: 1377-1395
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Publication
19351825 | J:203411
First Author: Kato T
Year: 2009
Journal: Cancer Res
Title: Characterization of the HDAC1 complex that regulates the sensitivity of cancer cells to oxidative stress.
Volume: 69
Issue: 8
Pages: 3597-604
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Publication
25064355 | J:215989
First Author: Saito M
Year: 2014
Journal: Carcinogenesis
Title: A mouse model of KIF5B-RET fusion-dependent lung tumorigenesis.
Volume: 35
Issue: 11
Pages: 2452-6
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Publication
9815134 | J:50952
First Author: Leavey SF
Year: 1998
Journal: Am J Physiol
Title: Expression of Grb7 growth factor receptor signaling protein in kidney development and in adult kidney.
Volume: 275
Issue: 5 Pt 2
Pages: F770-6
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Publication
9915833 | J:52425
First Author: Bascom RA
Year: 1999
Journal: J Biol Chem
Title: Identification and characterization of golgin-84, a novel Golgi integral membrane protein with a cytoplasmic coiled-coil domain.
Volume: 274
Issue: 5
Pages: 2953-62
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Publication
16007160 | J:102167
First Author: Bloor AJ
Year: 2005
Journal: Oncogene
Title: RFP represses transcriptional activation by bHLH transcription factors.
Volume: 24
Issue: 45
Pages: 6729-36
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Publication
7862441 | J:23625
First Author: Schuchardt A
Year: 1995
Journal: Oncogene
Title: Isolation and characterization of a chicken homolog of the c-ret proto-oncogene.
Volume: 10
Issue: 4
Pages: 641-9
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Publication
9027489 | J:37837
First Author: Pingault V
Year: 1997
Journal: Genomics
Title: Human homology and candidate genes for the Dominant megacolon locus, a mouse model of Hirschsprung disease.
Volume: 39
Issue: 1
Pages: 86-9
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Publication
9173868 | J:39505
 
First Author: Edman CF
Year: 1997
Journal: Biochem J
Title: Identification of ErbB3-stimulated genes using modified representational difference analysis.
Volume: 323 ( Pt 1)
Pages: 113-8
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Publication
9259272 | J:45375
First Author: Suvanto P
Year: 1997
Journal: Hum Mol Genet
Title: Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor beta, a homologue to GDNFR-alpha.
Volume: 6
Issue: 8
Pages: 1267-73
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Publication
9390516 | J:44327
First Author: Chen S
Year: 1997
Journal: Neuron
Title: Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes.
Volume: 19
Issue: 5
Pages: 1017-30
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Publication
9407096 | J:45366
First Author: Jing S
Year: 1997
Journal: J Biol Chem
Title: GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family.
Volume: 272
Issue: 52
Pages: 33111-7
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Publication
9545641 | J:47235
First Author: Angrist M
Year: 1998
Journal: Genomics
Title: Human GFRA1: cloning, mapping, genomic structure, and evaluation as a candidate gene for Hirschsprung disease susceptibility.
Volume: 48
Issue: 3
Pages: 354-62
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Publication
9703032 | J:48922
First Author: Golden JP
Year: 1998
Journal: J Comp Neurol
Title: Expression of neurturin, GDNF, and their receptors in the adult mouse CNS.
Volume: 398
Issue: 1
Pages: 139-50
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Publication
12444552 | J:80291
First Author: Buckwalter TL
Year: 2002
Journal: Oncogene
Title: The roles of phosphotyrosines-294, -404, and -451 in RET/PTC1-induced thyroid tumor formation.
Volume: 21
Issue: 53
Pages: 8166-72
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Publication
12752262 | J:84215
First Author: Sariola H
Year: 2003
Journal: APMIS
Title: GDNF-induced seminomatous tumours in mouse--an experimental model for human seminomas?
Volume: 111
Issue: 1
Pages: 192-6; discussion 196
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Publication
15183726 | J:125404
First Author: Young HM
Year: 2004
Journal: Dev Biol
Title: Dynamics of neural crest-derived cell migration in the embryonic mouse gut.
Volume: 270
Issue: 2
Pages: 455-73
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Publication
23365243 | J:194280
First Author: Wang T
Year: 2013
Journal: J Neurosci
Title: Neurturin overexpression in skin enhances expression of TRPM8 in cutaneous sensory neurons and leads to behavioral sensitivity to cool and menthol.
Volume: 33
Issue: 5
Pages: 2060-70
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Publication
23223128 | J:197961
First Author: Sevko A
Year: 2013
Journal: J Invest Dermatol
Title: Cyclophosphamide promotes chronic inflammation-dependent immunosuppression and prevents antitumor response in melanoma.
Volume: 133
Issue: 6
Pages: 1610-9
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Publication
24778213 | J:211075
First Author: He S
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: GFRα1 released by nerves enhances cancer cell perineural invasion through GDNF-RET signaling.
Volume: 111
Issue: 19
Pages: E2008-17
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Publication
24797128 | J:217368
First Author: Medina-Echeverz J
Year: 2014
Journal: PLoS One
Title: Harnessing high density lipoproteins to block transforming growth factor beta and to inhibit the growth of liver tumor metastases.
Volume: 9
Issue: 5
Pages: e96799
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Publication
25918373 | J:221414
First Author: Wong LE
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Artemin promotes functional long-distance axonal regeneration to the brainstem after dorsal root crush.
Volume: 112
Issue: 19
Pages: 6170-5
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Publication
27266404 | J:234994
First Author: Schriemer D
Year: 2016
Journal: Dev Biol
Title: Regulators of gene expression in Enteric Neural Crest Cells are putative Hirschsprung disease genes.
Volume: 416
Issue: 1
Pages: 255-265
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Publication
28645787 | J:252260
 
First Author: Sotoyama H
Year: 2017
Journal: Neurosci Lett
Title: Striatal hypodopamine phenotypes found in transgenic mice that overexpress glial cell line-derived neurotrophic factor.
Volume: 654
Pages: 99-106
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Publication
29229553 | J:266895
 
First Author: Rostock C
Year: 2018
Journal: Neuroscience
Title: Human vs. Mouse Nociceptors - Similarities and Differences.
Volume: 387
Pages: 13-27
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Publication
30923332 | J:275908
First Author: Li H
Year: 2019
Journal: Sci Rep
Title: Development of the urogenital system is regulated via the 3'UTR of GDNF.
Volume: 9
Issue: 1
Pages: 5302
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Publication
33672854 | J:305503
 
First Author: Meir M
Year: 2021
Journal: Int J Mol Sci
Title: Intestinal Epithelial Barrier Maturation by Enteric Glial Cells Is GDNF-Dependent.
Volume: 22
Issue: 4
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Publication
34675408 | J:317028
First Author: Liu W
Year: 2022
Journal: Oncogene
Title: OLFM4-RET fusion is an oncogenic driver in small intestine adenocarcinoma.
Volume: 41
Issue: 1
Pages: 72-82
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Publication
38400692 | J:347589
First Author: Bekkat F
Year: 2024
Journal: Eur J Immunol
Title: Upregulation of IL4-induced gene 1 enzyme by B2 cells during melanoma progression impairs their antitumor properties.
Volume: 54
Issue: 4
Pages: e2350615
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Publication
20018717 | J:356480
First Author: Wu X
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Prepubertal human spermatogonia and mouse gonocytes share conserved gene expression of germline stem cell regulatory molecules.
Volume: 106
Issue: 51
Pages: 21672-7
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Protein Coding Gene
MGI:97583 | Pik3r1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98354 | Sos1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98397 | Src
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1206581 | Pik3ca
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P26450
Organism: Mus musculus/domesticus
Length: 724  
Fragment?: false
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Protein
P05480
Organism: Mus musculus/domesticus
Length: 535  
Fragment?: false
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Protein
Q62245
Organism: Mus musculus/domesticus
Length: 1319  
Fragment?: false
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Protein
P42337
Organism: Mus musculus/domesticus
Length: 1068  
Fragment?: false
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Protein
Q3UET6
Organism: Mus musculus/domesticus
Length: 246  
Fragment?: false
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Protein
A0A2I3BQ61
Organism: Mus musculus/domesticus
Length: 309  
Fragment?: false
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Protein
Q9R2D0
Organism: Mus musculus/domesticus
Length: 385  
Fragment?: false
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Protein
D3YW40
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: true
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Protein
A1L3Q1
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: false
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Protein
A0A097BVN3
Organism: Mus musculus/domesticus
Length: 468  
Fragment?: false
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Protein
D6RDD4
Organism: Mus musculus/domesticus
Length: 419  
Fragment?: false
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Protein
A0A7R7T1T1
Organism: Mus musculus/domesticus
Length: 425  
Fragment?: false
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Protein
A0A7R7YCZ3
Organism: Mus musculus/domesticus
Length: 478  
Fragment?: false
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Protein
A0A7R7YCL1
Organism: Mus musculus/domesticus
Length: 420  
Fragment?: false
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Publication
21980263 | J:184038
First Author: Toh B
Year: 2011
Journal: PLoS Biol
Title: Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor.
Volume: 9
Issue: 9
Pages: e1001162
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Publication
34423345 | J:311931
 
First Author: Duboc V
Year: 2021
Journal: Development
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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