| Type |
Details |
Score |
| Publication |
| First Author: |
Lavado A |
| Year: |
2013 |
| Journal: |
Development |
| Title: |
Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators. |
| Volume: |
140 |
| Issue: |
16 |
| Pages: |
3323-34 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shi Y |
| Year: |
2017 |
| Journal: |
Elife |
| Title: |
Hedgehog signaling via Gli2 prevents obesity induced by high-fat diet in adult mice. |
| Volume: |
6 |
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Saadane A |
| Year: |
2014 |
| Journal: |
Am J Pathol |
| Title: |
Retinal and nonocular abnormalities in Cyp27a1(-/-)Cyp46a1(-/-) mice with dysfunctional metabolism of cholesterol. |
| Volume: |
184 |
| Issue: |
9 |
| Pages: |
2403-19 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sun L |
| Year: |
2013 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Genetic confirmation for a central role for TNFα in the direct action of thyroid stimulating hormone on the skeleton. |
| Volume: |
110 |
| Issue: |
24 |
| Pages: |
9891-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kowalska E |
| Year: |
2013 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
NONO couples the circadian clock to the cell cycle. |
| Volume: |
110 |
| Issue: |
5 |
| Pages: |
1592-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Otipoby KL |
| Year: |
2008 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells. |
| Volume: |
105 |
| Issue: |
34 |
| Pages: |
12435-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fejza A |
| Year: |
2023 |
| Journal: |
Matrix Biol |
| Title: |
Emilin2 fosters vascular stability by promoting pericyte recruitment. |
| Volume: |
122 |
|
| Pages: |
18-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yoshida A |
| Year: |
2017 |
| Journal: |
Oncotarget |
| Title: |
MicroRNA-140 mediates RB tumor suppressor function to control stem cell-like activity through interleukin-6. |
| Volume: |
8 |
| Issue: |
8 |
| Pages: |
13872-13885 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Davies CC |
| Year: |
2014 |
| Journal: |
Cancer Res |
| Title: |
Impaired JNK signaling cooperates with KrasG12D expression to accelerate pancreatic ductal adenocarcinoma. |
| Volume: |
74 |
| Issue: |
12 |
| Pages: |
3344-56 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hong KH |
| Year: |
2001 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Deletion of cytosolic phospholipase A(2) suppresses Apc(Min)-induced tumorigenesis. |
| Volume: |
98 |
| Issue: |
7 |
| Pages: |
3935-9 |
|
•
•
•
•
•
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| Publication |
| First Author: |
Yamamoto M |
| Year: |
2004 |
| Journal: |
Genes Cells |
| Title: |
ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules. |
| Volume: |
9 |
| Issue: |
11 |
| Pages: |
1055-67 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Werninghaus K |
| Year: |
2009 |
| Journal: |
J Exp Med |
| Title: |
Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation. |
| Volume: |
206 |
| Issue: |
1 |
| Pages: |
89-97 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Florea A |
| Year: |
2021 |
| Journal: |
Cells |
| Title: |
Sodium [18F]Fluoride PET Can Efficiently Monitor In Vivo Atherosclerotic Plaque Calcification Progression and Treatment. |
| Volume: |
10 |
| Issue: |
2 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hon A |
| Year: |
2023 |
| Journal: |
Atherosclerosis |
| Title: |
Effects of activity levels on aortic calcification in hyperlipidemic mice as measured by microPETmicroCT. |
| Volume: |
380 |
|
| Pages: |
117198 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Saadane A |
| Year: |
2018 |
| Journal: |
J Lipid Res |
| Title: |
Mechanisms that minimize retinal impact of apolipoprotein E absence. |
| Volume: |
59 |
| Issue: |
12 |
| Pages: |
2368-2382 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Advani A |
| Year: |
2011 |
| Journal: |
Am J Pathol |
| Title: |
Long-term administration of the histone deacetylase inhibitor vorinostat attenuates renal injury in experimental diabetes through an endothelial nitric oxide synthase-dependent mechanism. |
| Volume: |
178 |
| Issue: |
5 |
| Pages: |
2205-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lelli A |
| Year: |
2013 |
| Journal: |
Glia |
| Title: |
The NADPH oxidase Nox2 regulates VEGFR1/CSF-1R-mediated microglial chemotaxis and promotes early postnatal infiltration of phagocytes in the subventricular zone of the mouse cerebral cortex. |
| Volume: |
61 |
| Issue: |
9 |
| Pages: |
1542-55 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Guellich A |
| Year: |
2007 |
| Journal: |
Am J Physiol Heart Circ Physiol |
| Title: |
Role of oxidative stress in cardiac dysfunction of PPARalpha-/- mice. |
| Volume: |
293 |
| Issue: |
1 |
| Pages: |
H93-H102 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Langford-Smith A |
| Year: |
2011 |
| Journal: |
Genes Brain Behav |
| Title: |
Hyperactive behaviour in the mouse model of mucopolysaccharidosis IIIB in the open field and home cage environments. |
| Volume: |
10 |
| Issue: |
6 |
| Pages: |
673-82 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hasib A |
| Year: |
2019 |
| Journal: |
Am J Physiol Endocrinol Metab |
| Title: |
CD44 contributes to hyaluronan-mediated insulin resistance in skeletal muscle of high-fat-fed C57BL/6 mice. |
| Volume: |
317 |
| Issue: |
6 |
| Pages: |
E973-E983 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Caraux A |
| Year: |
2006 |
| Journal: |
Blood |
| Title: |
Phospholipase C-gamma2 is essential for NK cell cytotoxicity and innate immunity to malignant and virally infected cells. |
| Volume: |
107 |
| Issue: |
3 |
| Pages: |
994-1002 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sharma A |
| Year: |
2014 |
| Journal: |
Carcinogenesis |
| Title: |
Targeted deletion of RasGRP1 impairs skin tumorigenesis. |
| Volume: |
35 |
| Issue: |
5 |
| Pages: |
1084-91 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Daroszewska A |
| Year: |
2018 |
| Journal: |
Dis Model Mech |
| Title: |
Zoledronic acid prevents pagetic-like lesions and accelerated bone loss in the p62P394L mouse model of Paget's disease. |
| Volume: |
11 |
| Issue: |
9 |
|
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•
•
•
•
•
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| Publication |
| First Author: |
Riccio A |
| Year: |
2014 |
| Journal: |
J Neurosci |
| Title: |
Decreased anxiety-like behavior and Gαq/11-dependent responses in the amygdala of mice lacking TRPC4 channels. |
| Volume: |
34 |
| Issue: |
10 |
| Pages: |
3653-67 |
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•
•
•
•
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| Publication |
| First Author: |
Jannasch A |
| Year: |
2021 |
| Journal: |
Sci Rep |
| Title: |
Optical coherence tomography and multiphoton microscopy offer new options for the quantification of fibrotic aortic valve disease in ApoE-/- mice. |
| Volume: |
11 |
| Issue: |
1 |
| Pages: |
5834 |
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•
•
•
•
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| Publication |
| First Author: |
Hirayama A |
| Year: |
2003 |
| Journal: |
Free Radic Biol Med |
| Title: |
EPR imaging of reducing activity in Nrf2 transcriptional factor-deficient mice. |
| Volume: |
34 |
| Issue: |
10 |
| Pages: |
1236-42 |
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•
•
•
•
•
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| Publication |
| First Author: |
Solovey A |
| Year: |
2004 |
| Journal: |
Blood |
| Title: |
Endothelial cell expression of tissue factor in sickle mice is augmented by hypoxia/reoxygenation and inhibited by lovastatin. |
| Volume: |
104 |
| Issue: |
3 |
| Pages: |
840-6 |
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•
•
•
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| Publication |
| First Author: |
Longatti A |
| Year: |
2021 |
| Journal: |
Mol Neurobiol |
| Title: |
Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting Hippocampal Glutamatergic Synapses and Cognition in Mice. |
| Volume: |
58 |
| Issue: |
12 |
| Pages: |
6092-6110 |
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•
•
•
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| First Author: |
Corradi A |
| Year: |
2003 |
| Journal: |
Development |
| Title: |
Hypogonadotropic hypogonadism and peripheral neuropathy in Ebf2-null mice. |
| Volume: |
130 |
| Issue: |
2 |
| Pages: |
401-10 |
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•
•
•
•
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| First Author: |
Ademi H |
| Year: |
2022 |
| Journal: |
Cell Rep |
| Title: |
Deciphering the origins and fates of steroidogenic lineages in the mouse testis. |
| Volume: |
39 |
| Issue: |
11 |
| Pages: |
110935 |
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•
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•
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| First Author: |
Lyons A |
| Year: |
2009 |
| Journal: |
Brain Behav Immun |
| Title: |
Decreased neuronal CD200 expression in IL-4-deficient mice results in increased neuroinflammation in response to lipopolysaccharide. |
| Volume: |
23 |
| Issue: |
7 |
| Pages: |
1020-7 |
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•
•
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| First Author: |
Chini A |
| Year: |
2007 |
| Journal: |
Nature |
| Title: |
The JAZ family of repressors is the missing link in jasmonate signalling. |
| Volume: |
448 |
| Issue: |
7154 |
| Pages: |
666-71 |
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•
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| First Author: |
Wei A |
| Year: |
1990 |
| Journal: |
Science |
| Title: |
K+ current diversity is produced by an extended gene family conserved in Drosophila and mouse. |
| Volume: |
248 |
| Issue: |
4955 |
| Pages: |
599-603 |
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•
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| First Author: |
Yoshimura K |
| Year: |
2009 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Distinct function of 2 chromatin remodeling complexes that share a common subunit, Williams syndrome transcription factor (WSTF). |
| Volume: |
106 |
| Issue: |
23 |
| Pages: |
9280-5 |
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•
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| First Author: |
Madaan A |
| Year: |
2019 |
| Journal: |
Am J Pathol |
| Title: |
Müller Cell-Localized G-Protein-Coupled Receptor 81 (Hydroxycarboxylic Acid Receptor 1) Regulates Inner Retinal Vasculature via Norrin/Wnt Pathways. |
| Volume: |
189 |
| Issue: |
9 |
| Pages: |
1878-1896 |
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| First Author: |
Varfolomeev E |
| Year: |
2012 |
| Journal: |
Biochem J |
| Title: |
Characterization of ML-IAP protein stability and physiological role in vivo. |
| Volume: |
447 |
| Issue: |
3 |
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427-36 |
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| First Author: |
Meek TH |
| Year: |
2016 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Functional identification of a neurocircuit regulating blood glucose. |
| Volume: |
113 |
| Issue: |
14 |
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E2073-82 |
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| First Author: |
CÇŽlin A |
| Year: |
2018 |
| Journal: |
Front Cell Neurosci |
| Title: |
Chemogenetic Recruitment of Specific Interneurons Suppresses Seizure Activity. |
| Volume: |
12 |
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293 |
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•
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| First Author: |
Guo Z |
| Year: |
2014 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Dysfunction of dendritic cells in aged C57BL/6 mice leads to failure of natural killer cell activation and of tumor eradication. |
| Volume: |
111 |
| Issue: |
39 |
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14199-204 |
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| First Author: |
Leiva A |
| Year: |
2017 |
| Journal: |
PLoS One |
| Title: |
Gugulipid causes hypercholesterolemia leading to endothelial dysfunction, increased atherosclerosis, and premature death by ischemic heart disease in male mice. |
| Volume: |
12 |
| Issue: |
9 |
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e0184280 |
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| First Author: |
Barnett A |
| Year: |
2022 |
| Journal: |
Front Pharmacol |
| Title: |
Adolescent Binge Alcohol Enhances Early Alzheimer's Disease Pathology in Adulthood Through Proinflammatory Neuroimmune Activation. |
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| First Author: |
Zwijsen A |
| Year: |
2001 |
| Journal: |
Mol Cell Endocrinol |
| Title: |
Transforming growth factor beta signalling in vitro and in vivo: activin ligand-receptor interaction, Smad5 in vasculogenesis, and repression of target genes by the deltaEF1/ZEB-related SIP1 in the vertebrate embryo. |
| Volume: |
180 |
| Issue: |
1-2 |
| Pages: |
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| First Author: |
Nakajima A |
| Year: |
2001 |
| Journal: |
Gastroenterology |
| Title: |
Endogenous PPAR gamma mediates anti-inflammatory activity in murine ischemia-reperfusion injury. |
| Volume: |
120 |
| Issue: |
2 |
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460-9 |
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| First Author: |
Lancha A |
| Year: |
2014 |
| Journal: |
PLoS One |
| Title: |
Osteopontin deletion prevents the development of obesity and hepatic steatosis via impaired adipose tissue matrix remodeling and reduced inflammation and fibrosis in adipose tissue and liver in mice. |
| Volume: |
9 |
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e98398 |
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| First Author: |
Pérez-Bosque A |
| Year: |
2016 |
| Journal: |
PLoS One |
| Title: |
Oral Serum-Derived Bovine Immunoglobulin/Protein Isolate Has Immunomodulatory Effects on the Colon of Mice that Spontaneously Develop Colitis. |
| Volume: |
11 |
| Issue: |
5 |
| Pages: |
e0154823 |
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•
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| First Author: |
Honda A |
| Year: |
2001 |
| Journal: |
J Lipid Res |
| Title: |
Differences in hepatic levels of intermediates in bile acid biosynthesis between Cyp27(-/-) mice and CTX. |
| Volume: |
42 |
| Issue: |
2 |
| Pages: |
291-300 |
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•
•
•
•
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| First Author: |
Reifler A |
| Year: |
2013 |
| Journal: |
Skelet Muscle |
| Title: |
Murine Fig4 is dispensable for muscle development but required for muscle function. |
| Volume: |
3 |
| Issue: |
1 |
| Pages: |
21 |
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•
•
•
•
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| First Author: |
Miletich I |
| Year: |
2011 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Developmental stalling and organ-autonomous regulation of morphogenesis. |
| Volume: |
108 |
| Issue: |
48 |
| Pages: |
19270-5 |
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•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
130
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cogné M |
| Year: |
1994 |
| Journal: |
Cell |
| Title: |
A class switch control region at the 3' end of the immunoglobulin heavy chain locus. |
| Volume: |
77 |
| Issue: |
5 |
| Pages: |
737-47 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
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| First Author: |
Rivella S |
| Year: |
2003 |
| Journal: |
Blood |
| Title: |
A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human beta-globin gene transfer. |
| Volume: |
101 |
| Issue: |
8 |
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2932-9 |
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•
•
•
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| First Author: |
Umiker BR |
| Year: |
2014 |
| Journal: |
Eur J Immunol |
| Title: |
Production of IgG autoantibody requires expression of activation-induced deaminase in early-developing B cells in a mouse model of SLE. |
| Volume: |
44 |
| Issue: |
10 |
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•
•
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Mijalski T |
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Proc Natl Acad Sci U S A |
| Title: |
Identification of coexpressed gene clusters in a comparative analysis of transcriptome and proteome in mouse tissues. |
| Volume: |
102 |
| Issue: |
24 |
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8621-6 |
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•
•
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| First Author: |
Egashira A |
| Year: |
2002 |
| Journal: |
DNA Repair (Amst) |
| Title: |
Mutational specificity of mice defective in the MTH1 and/or the MSH2 genes. |
| Volume: |
1 |
| Issue: |
11 |
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Masuda S |
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Proc Natl Acad Sci U S A |
| Title: |
Mutation of a PER2 phosphodegron perturbs the circadian phosphoswitch. |
| Volume: |
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20 |
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| First Author: |
Li M |
| Year: |
2010 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis. |
| Volume: |
107 |
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32 |
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•
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| First Author: |
Das A |
| Year: |
2003 |
| Journal: |
Nutr Cancer |
| Title: |
Comparison of the chemopreventive efficacies of 1,4-phenylenebis(methylene)selenocyanate and selenium-enriched yeast on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced lung tumorigenesis in A/J mouse. |
| Volume: |
46 |
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2 |
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179-85 |
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•
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| First Author: |
Kelly A |
| Year: |
2002 |
| Journal: |
Diabetes |
| Title: |
Glutaminolysis and insulin secretion: from bedside to bench and back. |
| Volume: |
51 Suppl 3 |
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S421-6 |
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•
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Ghahary A |
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J Invest Dermatol |
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Genetically modified dermal keratinocytes express high levels of transforming growth factor-beta1. |
| Volume: |
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5 |
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800-5 |
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Gu A |
| Year: |
2009 |
| Journal: |
Exp Cell Res |
| Title: |
Role of Ceacam1 in VEGF induced vasculogenesis of murine embryonic stem cell-derived embryoid bodies in 3D culture. |
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Alawieh A |
| Year: |
2018 |
| Journal: |
J Neurosci |
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Identifying the role of complement in triggering neuroinflammation after traumatic brain injury. |
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Swift-Gallant A |
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Horm Behav |
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Non-neural androgen receptor promotes androphilic odor preference in mice. |
| Volume: |
83 |
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Wang A |
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2023 |
| Journal: |
Int Immunopharmacol |
| Title: |
IFIH1/IRF1/STAT1 promotes sepsis associated inflammatory lung injury via activating macrophage M1 polarization. |
| Volume: |
114 |
|
| Pages: |
109478 |
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•
•
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| Publication |
| First Author: |
Ratchatasunthorn A |
| Year: |
2024 |
| Journal: |
J Anat |
| Title: |
Temporal involvement of phosphatidylinositol 4-phosphate 5-kinase γ in differentiation of Z-bands and myofilament bundles as well as intercalated discs in mouse heart at mid-gestation. |
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| Publication |
| First Author: |
Wal A |
| Year: |
2021 |
| Journal: |
J Neurosci |
| Title: |
Evaluating Visual Cues Modulates Their Representation in Mouse Visual and Cingulate Cortex. |
| Volume: |
41 |
| Issue: |
15 |
| Pages: |
3531-3544 |
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•
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| Publication |
| First Author: |
Orazi A |
| Year: |
1996 |
| Journal: |
Lab Invest |
| Title: |
Interleukin-11 prevents apoptosis and accelerates recovery of small intestinal mucosa in mice treated with combined chemotherapy and radiation. |
| Volume: |
75 |
| Issue: |
1 |
| Pages: |
33-42 |
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•
•
•
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| Publication |
| First Author: |
Rabinovitch A |
| Year: |
1997 |
| Journal: |
Transplantation |
| Title: |
Combination therapy with cyclosporine and interleukin-4 or interleukin-10 prolongs survival of synergeneic pancreatic islet grafts in nonobese diabetic mice: islet graft survival does not correlate with mRNA levels of type 1 or type 2 cytokines, or transforming growth factor-beta in the islet grafts. |
| Volume: |
64 |
| Issue: |
11 |
| Pages: |
1525-31 |
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•
•
•
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| Publication |
| First Author: |
Milatovich A |
| Year: |
1991 |
| Journal: |
Am J Hum Genet |
| Title: |
The gene for LEF-1, lymphoid enhancer-binding factor 1, mapped to human chromosome 4 (q23-q25) and mouse chromosome 3 by Southern blot analysis and fluorescent in situ hybridization |
| Volume: |
49 |
| Issue: |
4 Suppl |
| Pages: |
334 (Abstr.) |
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•
•
•
•
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| Publication |
| First Author: |
Chen J |
| Year: |
2018 |
| Journal: |
Front Immunol |
| Title: |
Interleukin-33 Contributes to the Induction of Th9 Cells and Antitumor Efficacy by Dectin-1-Activated Dendritic Cells. |
| Volume: |
9 |
|
| Pages: |
1787 |
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•
•
•
•
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| Publication |
| First Author: |
Brull A |
| Year: |
2015 |
| Journal: |
J Physiol |
| Title: |
Phenotype consequences of myophosphorylase dysfunction: insights from the McArdle mouse model. |
| Volume: |
593 |
| Issue: |
12 |
| Pages: |
2693-706 |
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•
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•
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| Publication |
| First Author: |
Artuso I |
| Year: |
2018 |
| Journal: |
Blood |
| Title: |
Transferrin receptor 2 is a potential novel therapeutic target for β-thalassemia: evidence from a murine model. |
| Volume: |
132 |
| Issue: |
21 |
| Pages: |
2286-2297 |
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•
•
•
|
| Publication |
| First Author: |
Schumann G |
| Year: |
2016 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference. |
| Volume: |
113 |
| Issue: |
50 |
| Pages: |
14372-14377 |
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•
•
•
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| Publication |
| First Author: |
Zimmerman MA |
| Year: |
2013 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Signaling through hepatocellular A2B adenosine receptors dampens ischemia and reperfusion injury of the liver. |
| Volume: |
110 |
| Issue: |
29 |
| Pages: |
12012-7 |
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•
•
•
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| Publication |
| First Author: |
Wade A |
| Year: |
2013 |
| Journal: |
FEBS J |
| Title: |
Proteoglycans and their roles in brain cancer. |
| Volume: |
280 |
| Issue: |
10 |
| Pages: |
2399-417 |
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•
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| Protein Domain |
| Type: |
Family |
| Description: |
This entry represents Spo11, a meiotic recombination protein found in eukaryotes, and subunit A of topoisomerase VI, a type IIB topoisomerase found predominantly in archaea [, , , ]. These two types of proteins share structural homology.DNA topoisomerases regulate the number of topological links between two DNA strands (i.e. change the number of superhelical turns) by catalysing transient single- or double-strand breaks, crossing the strands through one another, then resealing the breaks. They can be divided into two classes: type I enzymes (, topoisomerases I, III and V) break single-strand DNA, and type II enzymes (, topoisomerases II, IV and VI) break double-strand DNA []. Topoisomerase VI is a type IIB enzymes that assembles as a heterotetramer, consisting of two A subunits required for DNA cleavage and two B subunits required for ATP hydrolysis. The B subunit is structurally similar to the ATPase domain of type IIA topoisomerases, but the A subunit is distinct, and instead shares homology with the Spo11 protein. Spo11 is a meiosis-specific protein that is responsible for the initiation of recombination through the formation of DNA double-strand breaks by a type II DNA topoisomerase-like activity. Spo11 acts in conjunction with several other proteins, including Rec102 in yeast, to bring about meiotic recombination []. |
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•
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| Protein Domain |
| Type: |
Active_site |
| Description: |
Coenzyme A (CoA) transferases belong to an evolutionary conserved [, ]family of enzymes catalyzing the reversible transfer of CoA from one carboxylic acid to another. They have been identified in many prokaryotes and in mammalian tissues. The bacterial enzymes are heterodimers of two subunits (A and B) of about 25 Kd each while eukaryotic SCOT consists of a single chain which is colinear with the two bacterial subunits. This signature corresponds to a region in the N terminus of the B subunit which contains a glutamate that is involved in the catalytic mechanism. |
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•
•
•
•
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| Protein Domain |
| Type: |
Binding_site |
| Description: |
Coenzyme A (CoA) transferases belong to an evolutionary conserved [, ]family of enzymes catalyzing the reversible transfer of CoA from one carboxylic acid to another. They have been identified in many prokaryotes and in mammalian tissues. The bacterial enzymes are heterodimer of two subunits (A and B) of about 25 Kd each while eukaryotic SCOT consist of a single chain which is colinear with the two bacterial subunits. This entry corresponds to a region in the N-terminal of the A subunit that may be implicated in the binding of CoA to the enzyme. |
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•
•
•
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| Protein Domain |
| Type: |
Family |
| Description: |
The highly conserved and essential protein Ssu72 has intrinsic phosphatase activity and plays an essential role in the transcription cycle. Ssu72 was originally identified in a yeast genetic screen as enhancer of a defect caused by a mutation in the transcription initiation factor TFIIB []. It binds to TFIIB and is also involved in mRNA elongation. Ssu72 is further involved in both poly(A) dependent and independent termination. It is a subunit of the yeast cleavage and polyadenylation factor (CPF), which is part of the machinery for mRNA 3'-end formation. Ssu72 is also essential for transcription termination of snRNAs []. |
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•
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| Protein Domain |
| Type: |
Domain |
| Description: |
This domain is found at the N terminus of many acetyl-coenzyme A synthetase enzymes. The function of this domain is not clear. |
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•
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| Protein Domain |
| Type: |
Family |
| Description: |
This family consists of several bacterial Na+-translocating NADH-quinone reductase subunit A (NQRA) proteins. The Na+-translocating NADH: ubiquinone oxidoreductase (Na+-NQR) generates an electrochemical Na+potential driven by aerobic respiration []. |
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•
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| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
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•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
214
 |
| Fragment?: |
false |
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•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
208
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
368
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
392
 |
| Fragment?: |
false |
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•
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•
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| Publication |
| First Author: |
Blake DJ |
| Year: |
1998 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
beta-dystrobrevin, a member of the dystrophin-related protein family. |
| Volume: |
95 |
| Issue: |
1 |
| Pages: |
241-6 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Karunaratne A |
| Year: |
2012 |
| Journal: |
J Bone Miner Res |
| Title: |
Significant deterioration in nanomechanical quality occurs through incomplete extrafibrillar mineralization in rachitic bone: evidence from in-situ synchrotron X-ray scattering and backscattered electron imaging. |
| Volume: |
27 |
| Issue: |
4 |
| Pages: |
876-90 |
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•
•
•
•
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| Publication |
| First Author: |
Vouilloz A |
| Year: |
2025 |
| Journal: |
Metabolism |
| Title: |
Impaired unsaturated fatty acid elongation alters mitochondrial function and accelerates metabolic dysfunction-associated steatohepatitis progression. |
| Volume: |
162 |
|
| Pages: |
156051 |
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•
•
•
•
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| Publication |
| First Author: |
Means CK |
| Year: |
2011 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria. |
| Volume: |
108 |
| Issue: |
48 |
| Pages: |
E1227-35 |
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•
•
•
|
| Publication |
| First Author: |
Messerschmidt A |
| Year: |
2005 |
| Journal: |
J Mol Biol |
| Title: |
Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif. |
| Volume: |
352 |
| Issue: |
4 |
| Pages: |
918-31 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Yurdagul A Jr |
| Year: |
2016 |
| Journal: |
J Cell Sci |
| Title: |
Oxidized LDL induces FAK-dependent RSK signaling to drive NF-κB activation and VCAM-1 expression. |
| Volume: |
129 |
| Issue: |
8 |
| Pages: |
1580-91 |
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•
•
•
•
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| Publication |
| First Author: |
Doyonnas R |
| Year: |
2004 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Hematopoietic contribution to skeletal muscle regeneration by myelomonocytic precursors. |
| Volume: |
101 |
| Issue: |
37 |
| Pages: |
13507-12 |
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•
•
•
•
|
| Publication |
| First Author: |
Valluet A |
| Year: |
2012 |
| Journal: |
Cell Rep |
| Title: |
B-Raf and C-Raf are required for melanocyte stem cell self-maintenance. |
| Volume: |
2 |
| Issue: |
4 |
| Pages: |
774-80 |
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•
•
•
•
|
| Publication |
| First Author: |
Bonnert TP |
| Year: |
1999 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
theta, a novel gamma-aminobutyric acid type A receptor subunit. |
| Volume: |
96 |
| Issue: |
17 |
| Pages: |
9891-6 |
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•
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•
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