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Search results 2901 to 3000 out of 3113 for Rac1

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Type Details Score
Publication
8643598 | -
First Author: Debant A
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains.
Volume: 93
Issue: 11
Pages: 5466-71
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Publication
17391702 | -
First Author: Chhatriwala MK
Year: 2007
Journal: J Mol Biol
Title: The DH and PH domains of Trio coordinately engage Rho GTPases for their efficient activation.
Volume: 368
Issue: 5
Pages: 1307-20
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Publication
9139723 | -
First Author: Alam MR
Year: 1997
Journal: J Biol Chem
Title: Kalirin, a cytosolic protein with spectrin-like and GDP/GTP exchange factor-like domains that interacts with peptidylglycine alpha-amidating monooxygenase, an integral membrane peptide-processing enzyme.
Volume: 272
Issue: 19
Pages: 12667-75
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Publication
11606631 | -
First Author: Penzes P
Year: 2001
Journal: J Neurosci
Title: Distinct roles for the two Rho GDP/GTP exchange factor domains of kalirin in regulation of neurite growth and neuronal morphology.
Volume: 21
Issue: 21
Pages: 8426-34
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Publication
18057561 | -
First Author: Youn H
Year: 2007
Journal: J Alzheimers Dis
Title: Under-expression of Kalirin-7 Increases iNOS activity in cultured cells and correlates to elevated iNOS activity in Alzheimer's disease hippocampus.
Volume: 12
Issue: 3
Pages: 271-81
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Publication
22548195 | -
 
First Author: Mandela P
Year: 2012
Journal: Neural Plast
Title: Kalirin, a key player in synapse formation, is implicated in human diseases.
Volume: 2012
Pages: 728161
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Publication
15215162 | -
First Author: Zheng M
Year: 2004
Journal: Am J Pathol
Title: TRIO amplification and abundant mRNA expression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer.
Volume: 165
Issue: 1
Pages: 63-9
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Publication
30407917 | -
     
First Author: Dufurrena Q
Year: 2018
Journal: J Mol Endocrinol
Title: Kalirin/Trio Rho GDP/GTP exchange factors regulate proinsulin and insulin secretion.
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Publication
17881726 | -
First Author: Ferraro F
Year: 2007
Journal: Mol Biol Cell
Title: Kalirin/Trio Rho guanine nucleotide exchange factors regulate a novel step in secretory granule maturation.
Volume: 18
Issue: 12
Pages: 4813-25
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Publication
12832783 | -
First Author: Skowronek K
Year: 2003
Journal: Acta Crystallogr D Biol Crystallogr
Title: Crystallization and initial crystal characterization of the N-terminal DH/PH domain of Trio.
Volume: 59
Issue: Pt 7
Pages: 1273-5
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Protein Domain
IPR028570 | Kalirin/TRIO
Type: Family
Description: This entry includes a group of RhoGEFs, including Kalirin and TRIO from mammals. Kalirin and TRIO are encoded by separate genes in mammals and by a single one in invertebrates. Kalirin and TRIO share the same complex multidomain structure and display several splice variants. They are implicated in secretory granule (SG) maturation and exocytosis [, ]. The longest Kalirin and TRIO proteins have a Sec14 domain, a stretch of spectrin repeats, a RhoGEF(DH)/PH cassette (also called GEF1), an SH3 domain, a second RhoGEF(DH)/PH cassette (also called GEF2), a second SH3 domain, Ig/FNIII domains, and a kinase domain. The first RhoGEF(DH)/PH cassette catalyzes exchange on Rac1 and RhoG while the second RhoGEF(DH)/PH cassette is specific for RhoA. Kalirin and TRIO are closely related to p63RhoGEF and have PH domains of similar function. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner [, ].Triple functional domain protein (TRIO) contains a protein kinase domain and two guanine nucleotide exchange factor (GEF) domains []. These functional domains suggest that it may play a role in signalling pathways controlling cell proliferation []. TRIO may form a complex with LAR transmembrane protein tyrosine phosphatase (PT-Pase), which localises to the ends of focal adhesions and plays an important part in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration []. Its expression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer [].Kalirin () promotes the exchange of GDP by GTP and stimulates the activity of specific Rho GTPases []. There are several Kalirin isoforms in humans and mice. Each Kalirin isoform is composed of a unique collection of domains and may have different functions []. In rat, isoforms 1 and 7 are necessary for neuronal development and axonal outgrowth, while isoform 6 is required for dendritic spine formation []. In humans, the major isoform of Kalirin in the adult brain is Kalirin-7, which plays a critical role in spine formation/synaptic plasticity. Kalirin-7 has been linked to neuropsychiatric and neurological diseases such as Alzheimer's, Huntingtin's, ischemic stroke, schizophrenia, depression, and cocaine addiction [, , ].
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Protein
Q3TV50
Organism: Mus musculus/domesticus
Length: 282  
Fragment?: false
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Protein
J3QQ55
Organism: Mus musculus/domesticus
Length: 168  
Fragment?: true
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Protein
H3BKQ0
Organism: Mus musculus/domesticus
Length: 250  
Fragment?: true
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Protein
Q6P1D6
Organism: Mus musculus/domesticus
Length: 900  
Fragment?: false
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Publication
22427969 | J:186916
First Author: Hart SP
Year: 2012
Journal: PLoS One
Title: Characterization of the effects of cross-linking of macrophage CD44 associated with increased phagocytosis of apoptotic PMN.
Volume: 7
Issue: 3
Pages: e33142
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Publication
17825562 | J:145112
First Author: Pegtel DM
Year: 2007
Journal: Curr Biol
Title: The Par-Tiam1 complex controls persistent migration by stabilizing microtubule-dependent front-rear polarity.
Volume: 17
Issue: 19
Pages: 1623-34
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Publication
9128250 | J:39768
First Author: Michiels F
Year: 1997
Journal: J Cell Biol
Title: Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activation.
Volume: 137
Issue: 2
Pages: 387-98
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Protein Coding Gene
MGI:1194899 | Inpp5k
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:97846 | Rac2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1343098 | Aif1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1354184 | Nox4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
B1AZ46
Organism: Mus musculus/domesticus
Length: 521  
Fragment?: false
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Protein
Q3UKP6
Organism: Mus musculus/domesticus
Length: 522  
Fragment?: false
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Publication
26180209 | J:225814
First Author: Lin WJ
Year: 2015
Journal: J Neurosci
Title: VGF and Its C-Terminal Peptide TLQP-62 Regulate Memory Formation in Hippocampus via a BDNF-TrkB-Dependent Mechanism.
Volume: 35
Issue: 28
Pages: 10343-56
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Publication
29980568 | J:292253
First Author: Issa Bhaloo S
Year: 2018
Journal: Circ Res
Title: Binding of Dickkopf-3 to CXCR7 Enhances Vascular Progenitor Cell Migration and Degradable Graft Regeneration.
Volume: 123
Issue: 4
Pages: 451-466
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Publication
20860838 | J:183958
First Author: McHenry PR
Year: 2010
Journal: Breast Cancer Res
Title: P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis.
Volume: 12
Issue: 5
Pages: R73
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Publication
19929439 | J:183371
First Author: Leung R
Year: 2010
Journal: J Bone Miner Res
Title: Filamin A regulates monocyte migration through Rho small GTPases during osteoclastogenesis.
Volume: 25
Issue: 5
Pages: 1077-91
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Publication
37821230 | J:358535
First Author: Long RM
Year: 2023
Journal: J Neurosci
Title: The Role of Protocadherin γ in Adult Sensory Neurons and Skin Reinnervation.
Volume: 43
Issue: 49
Pages: 8348-8366
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Publication
30791960 | J:295232
First Author: Joseph GA
Year: 2019
Journal: Skelet Muscle
Title: Late-onset megaconial myopathy in mice lacking group I Paks.
Volume: 9
Issue: 1
Pages: 5
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Publication
20603213 | J:165694
First Author: Roselli S
Year: 2010
Journal: Cell Signal
Title: The SH2 domain protein Shep1 regulates the in vivo signaling function of the scaffolding protein Cas.
Volume: 22
Issue: 11
Pages: 1745-52
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Protein
Q60631-1
 
Organism: Mus musculus/domesticus
Length:  
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Protein
A2AB70
Organism: Mus musculus/domesticus
Length: 123  
Fragment?: true
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Protein
F7AI27
Organism: Mus musculus/domesticus
Length: 932  
Fragment?: true
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Protein
A0A2I3BRK3
Organism: Mus musculus/domesticus
Length: 178  
Fragment?: true
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Publication
12134158 | -
First Author: Brugnera E
Year: 2002
Journal: Nat Cell Biol
Title: Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex.
Volume: 4
Issue: 8
Pages: 574-82
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Publication
22331897 | -
First Author: Hanawa-Suetsugu K
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms.
Volume: 109
Issue: 9
Pages: 3305-10
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Protein
Q3UVX2
Organism: Mus musculus/domesticus
Length: 622  
Fragment?: false
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Protein
E9Q1R7
Organism: Mus musculus/domesticus
Length: 622  
Fragment?: false
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Publication
16249175 | J:105716
First Author: Malliri A
Year: 2006
Journal: J Biol Chem
Title: The rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development.
Volume: 281
Issue: 1
Pages: 543-8
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Publication
9204476 | J:41286
First Author: Ehler E
Year: 1997
Journal: Mol Cell Neurosci
Title: Expression of Tiam-1 in the developing brain suggests a role for the Tiam-1-Rac signaling pathway in cell migration and neurite outgrowth.
Volume: 9
Issue: 1
Pages: 1-12
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Publication
28416184 | J:242489
First Author: Diamantopoulou Z
Year: 2017
Journal: Cancer Cell
Title: TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells.
Volume: 31
Issue: 5
Pages: 621-634.e6
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Publication
17521720 | J:128628
First Author: Strumane K
Year: 2008
Journal: Leuk Res
Title: Increased Rac activity is required for the progression of T-lymphomas induced by Pten-deficiency.
Volume: 32
Issue: 1
Pages: 113-20
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Protein Coding Gene
MGI:99435 | Arf6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1333787 | Inppl1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
D3Z0V2
Organism: Mus musculus/domesticus
Length: 636  
Fragment?: true
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Protein
A0A0R4J0X8
Organism: Mus musculus/domesticus
Length: 646  
Fragment?: false
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Protein
Q06649
Organism: Mus musculus/domesticus
Length: 559  
Fragment?: false
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Protein
Q8CHC4
Organism: Mus musculus/domesticus
Length: 1574  
Fragment?: false
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Protein
Q3U1H0
Organism: Mus musculus/domesticus
Length: 603  
Fragment?: false
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Protein
Q91Z52
Organism: Mus musculus/domesticus
Length: 559  
Fragment?: false
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Protein
Q6A0A3
Organism: Mus musculus/domesticus
Length: 1567  
Fragment?: true
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Protein
A2AFJ8
Organism: Mus musculus/domesticus
Length: 483  
Fragment?: false
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Protein
Q3TRA4
Organism: Mus musculus/domesticus
Length: 743  
Fragment?: true
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Protein
D3Z656
Organism: Mus musculus/domesticus
Length: 1607  
Fragment?: false
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Protein
E9Q7S0
Organism: Mus musculus/domesticus
Length: 1309  
Fragment?: false
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Protein
Q8C220
Organism: Mus musculus/domesticus
Length: 559  
Fragment?: false
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Protein
E9QJU7
Organism: Mus musculus/domesticus
Length: 615  
Fragment?: false
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Protein
F7BQW7
Organism: Mus musculus/domesticus
Length: 1324  
Fragment?: true
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Protein
Q3UD40
Organism: Mus musculus/domesticus
Length: 603  
Fragment?: false
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Protein
Q5U3L0
Organism: Mus musculus/domesticus
Length: 559  
Fragment?: false
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Publication
14607270 | -
First Author: Hornstein I
Year: 2004
Journal: Cell Signal
Title: Vav proteins, masters of the world of cytoskeleton organization.
Volume: 16
Issue: 1
Pages: 1-11
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Protein
Q99JW5
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: false
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Protein
Q6EDY6
Organism: Mus musculus/domesticus
Length: 1374  
Fragment?: false
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Protein
Q8R1S4
Organism: Mus musculus/domesticus
Length: 759  
Fragment?: false
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Protein
Q8BGV3
Organism: Mus musculus/domesticus
Length: 317  
Fragment?: false
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Protein
B2RR95
Organism: Mus musculus/domesticus
Length: 264  
Fragment?: false
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Protein
Q3U806
Organism: Mus musculus/domesticus
Length: 581  
Fragment?: true
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Protein
A2AKN5
Organism: Mus musculus/domesticus
Length: 243  
Fragment?: false
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Protein
Q7TPP0
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: true
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Protein
G3X9H7
Organism: Mus musculus/domesticus
Length: 759  
Fragment?: false
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Protein
Q05D34
Organism: Mus musculus/domesticus
Length: 590  
Fragment?: false
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Protein
F6UKC6
Organism: Mus musculus/domesticus
Length: 188  
Fragment?: true
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Protein
Q3TZG4
Organism: Mus musculus/domesticus
Length: 506  
Fragment?: false
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Protein
A0A3Q4EHR5
Organism: Mus musculus/domesticus
Length: 111  
Fragment?: true
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Protein
A0A087WS26
Organism: Mus musculus/domesticus
Length: 564  
Fragment?: true
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Protein
Q3U0G0
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: false
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Protein
Q6ZQB7
Organism: Mus musculus/domesticus
Length: 773  
Fragment?: true
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Protein
Q3UYH1
Organism: Mus musculus/domesticus
Length: 279  
Fragment?: true
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Protein
F6YXR3
Organism: Mus musculus/domesticus
Length: 290  
Fragment?: true
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Protein
Q8BT62
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: false
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Protein
A0A2I3BPM9
Organism: Mus musculus/domesticus
Length: 204  
Fragment?: true
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Protein
D3Z560
Organism: Mus musculus/domesticus
Length: 823  
Fragment?: false
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Protein
A2AF65
Organism: Mus musculus/domesticus
Length: 527  
Fragment?: false
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Protein
D3Z030
Organism: Mus musculus/domesticus
Length: 1332  
Fragment?: false
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Protein
Q8C9Y7
Organism: Mus musculus/domesticus
Length: 692  
Fragment?: false
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Publication
21613211 | -
First Author: Kulkarni K
Year: 2011
Journal: J Biol Chem
Title: Multiple factors confer specific Cdc42 and Rac protein activation by dedicator of cytokinesis (DOCK) nucleotide exchange factors.
Volume: 286
Issue: 28
Pages: 25341-51
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Publication
30853411 | -
First Author: Kukimoto-Niino M
Year: 2019
Journal: Structure
Title: Structural Basis for the Dual Substrate Specificity of DOCK7 Guanine Nucleotide Exchange Factor.
Volume: 27
Issue: 5
Pages: 741-748.e3
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Publication
32651375 | -
First Author: Chang L
Year: 2020
Journal: Nat Commun
Title: Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state.
Volume: 11
Issue: 1
Pages: 3464
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Publication
12829596 | -
First Author: Sanui T
Year: 2003
Journal: Blood
Title: DOCK2 regulates Rac activation and cytoskeletal reorganization through interaction with ELMO1.
Volume: 102
Issue: 8
Pages: 2948-50
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Publication
9070862 | J:38630
First Author: Song WJ
Year: 1997
Journal: Biochem Biophys Res Commun
Title: The murine Dyrk protein maps to chromosome 16, localizes to the nucleus, and can form multimers.
Volume: 231
Issue: 3
Pages: 640-4
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Publication
10662544 | J:60651
First Author: Gardner HP
Year: 2000
Journal: Genomics
Title: Cloning and characterization of Hunk, a novel mammalian SNF1-related protein kinase.
Volume: 63
Issue: 1
Pages: 46-59
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Publication
34566971 | J:311199
 
First Author: Thelen F
Year: 2021
Journal: Front Immunol
Title: The Tec Kinase Itk Integrates Naïve T Cell Migration and In Vivo Homeostasis.
Volume: 12
Pages: 716405
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Publication
37383235 | J:346951
 
First Author: Machin PA
Year: 2023
Journal: Front Immunol
Title: Dock2 generates characteristic spatiotemporal patterns of Rac activity to regulate neutrophil polarisation, migration and phagocytosis.
Volume: 14
Pages: 1180886
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Publication
7736788 | J:26602
First Author: Habets GG
Year: 1995
Journal: Cytogenet Cell Genet
Title: The invasion-inducing TIAM1 gene maps to human chromosome band 21q22 and mouse chromosome 16.
Volume: 70
Issue: 1-2
Pages: 48-51
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Protein
Q8C120
Organism: Mus musculus/domesticus
Length: 878  
Fragment?: false
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Protein
G3UWG2
Organism: Mus musculus/domesticus
Length: 1591  
Fragment?: false
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Protein
Q003U3
Organism: Mus musculus/domesticus
Length: 1097  
Fragment?: false
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Protein
E9PY12
Organism: Mus musculus/domesticus
Length: 1101  
Fragment?: false
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Protein
E9PXE2
Organism: Mus musculus/domesticus
Length: 1175  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom