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Details |
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| First Author: |
Gunton JE |
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2005 |
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Cell |
| Title: |
Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. |
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| First Author: |
Lee EY |
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2010 |
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Proc Natl Acad Sci U S A |
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Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis. |
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•
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Barakat A |
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2001 |
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Plant Physiol |
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The organization of cytoplasmic ribosomal protein genes in the Arabidopsis genome. |
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127 |
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2 |
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•
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•
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
432
 |
| Fragment?: |
false |
|
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•
•
•
•
|
| Publication |
| First Author: |
Koopman P |
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Zfy gene expression patterns are not compatible with a primary role in mouse sex determination. |
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Mossa A |
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2021 |
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Mol Psychiatry |
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26 |
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6 |
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•
•
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| First Author: |
Zembrzycki A |
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2015 |
| Journal: |
Elife |
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Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas. |
| Volume: |
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Bracamonte-Baran W |
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2017 |
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Proc Natl Acad Sci U S A |
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Modification of host dendritic cells by microchimerism-derived extracellular vesicles generates split tolerance. |
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| First Author: |
DeZwaan-McCabe D |
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PLoS Genet |
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•
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Sönmez A |
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Nucleolar stress controls mutant Huntington toxicity and monitors Huntington's disease progression. |
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12 |
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•
•
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| First Author: |
Alt A |
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2004 |
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Biochem Biophys Res Commun |
| Title: |
Differential regulation of alpha6beta4 integrin by PKC isoforms in murine skin keratinocytes. |
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Chaturvedi A |
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Nat Immunol |
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| Volume: |
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11 |
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•
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| First Author: |
Krebs P |
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Proc Natl Acad Sci U S A |
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Sathyamurthy A |
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Antonson P |
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2015 |
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Biochem Biophys Res Commun |
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Identification of proteins highly expressed in uterine fluid from mice with hydrometra. |
| Volume: |
466 |
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4 |
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650-5 |
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•
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| First Author: |
Zhang Y |
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2018 |
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J Exp Med |
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Plasma cell output from germinal centers is regulated by signals from Tfh and stromal cells. |
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215 |
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Ozawa A |
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2015 |
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J Neurosci |
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Knock-In Mice with NOP-eGFP Receptors Identify Receptor Cellular and Regional Localization. |
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33 |
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Konishi A |
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J Biol Chem |
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Greenfield A |
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Genomics |
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The Sry-related gene Sox18 maps to distal mouse chromosome 2. |
| Volume: |
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Pedram A |
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Mol Biol Cell |
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Functional estrogen receptors in the mitochondria of breast cancer cells. |
| Volume: |
17 |
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Mahadevan A |
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2014 |
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Dev Cell |
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The left-right Pitx2 pathway drives organ-specific arterial and lymphatic development in the intestine. |
| Volume: |
31 |
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6 |
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Sankoda A |
| Year: |
2017 |
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Endocrinology |
| Title: |
Long-Chain Free Fatty Acid Receptor GPR120 Mediates Oil-Induced GIP Secretion Through CCK in Male Mice. |
| Volume: |
158 |
| Issue: |
5 |
| Pages: |
1172-1180 |
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Cho SJ |
| Year: |
2006 |
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J Biol Chem |
| Title: |
Role of early growth response-1 (Egr-1) in interleukin-13-induced inflammation and remodeling. |
| Volume: |
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8161-8 |
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Hu JH |
| Year: |
2010 |
| Journal: |
Circulation |
| Title: |
Overexpression of urokinase by plaque macrophages causes histological features of plaque rupture and increases vascular matrix metalloproteinase activity in aged apolipoprotein e-null mice. |
| Volume: |
121 |
| Issue: |
14 |
| Pages: |
1637-44 |
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Vallejo M |
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Proc Natl Acad Sci U S A |
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C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements. |
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SWI/SNF chromatin remodeling subunit Smarca4/BRG1 is essential for female fertility†. |
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KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma. |
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Chronic toxicity of a mixture of chlorinated alkanes and alkenes in ICR mice. |
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Exp Dermatol |
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PDGF signalling in the dermis and in dermal condensates is dispensable for hair follicle induction and formation. |
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Cdk4 promotes adipogenesis through PPARgamma activation. |
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Endothelial deletion of Sag/Rbx2/Roc2 E3 ubiquitin ligase causes embryonic lethality and blocks tumor angiogenesis. |
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Boutet A |
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Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney. |
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| Allele |
| Name: |
Casitas B-lineage lymphoma; targeted mutation 2, Wallace Y Langdon |
| Allele Type: |
Targeted |
| Attribute String: |
Inserted expressed sequence |
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| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
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•
•
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| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
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•
•
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| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
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| Protein Domain |
| Type: |
Family |
| Description: |
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands, allowing rapid transmission of signals at chemical synapses [, ]. Five of these ion channel receptor families have been shown to form a sequence-related superfamily:Nicotinic acetylcholine receptor (AchR), an excitatory cation channel in vertebrates and invertebrates; in vertebrate motor endplates it is composed of alpha, beta, gamma and delta/epsilon subunits; in neurons it is composed of alpha and non-alpha (or beta) subunits [].Glycine receptor, an inhibitory chloride ion channel composed of alpha and beta subunits [].Gamma-aminobutyric acid (GABA) receptor, an inhibitory chloride ion channel; at least four types of subunits (alpha, beta, gamma and delta) are known [].Serotonin 5HT3 receptor, of which there are seven major types (5HT3-5HT7) [].Glutamate receptor, an excitatory cation channel of which at least three types have been described (kainate, N-methyl-D-aspartate (NMDA) and quisqualate) [].These receptors possess a pentameric structure (made up of varying subunits), surrounding a central pore. All known sequences of subunits from neurotransmitter-gated ion-channels are structurally related. They are composed of a large extracellular glycosylated N-terminal ligand-binding domain, followed by three hydrophobic transmembrane regions which form the ionic channel, followed by an intracellular region of variable length. A fourth hydrophobic region is found at the C-terminal of the sequence [, ].Gamma-aminobutyric acid type A (GABAA) receptors are members of the neurotransmitter ligand-gated ion channels: they mediate neuronal inhibition on binding GABA. The effects of GABA on GABAA receptors are modulated by a range of therapeutically important drugs, including barbiturates, anaesthetics and benzodiazepines (BZs) []. The BZs are a diverse range of compounds, including widely prescribed drugs, such as librium and valium, and their interaction with GABAA receptors provides the most potent pharmacological means of distinguishing different GABAA receptor subtypes.GABAA receptors are pentameric membrane proteins that operate GABA-gated chloride channels []. Eight types of receptor subunit have been cloned, with multiple subtypes within some classes: alpha 1-6, beta 1-4, gamma 1-4, delta, epsilon, pi, rho 1-3 and theta [, ]. Subunits are typically 50-60kDa in size and comprise a long N-terminal extracellular domain, containing a putative signal peptide and a disulphide-bonded beta structural loop; 4 putative transmembrane (TM) domains; and a large cytoplasmic loop connecting the third and fourth TM domains. Amongst family members, the large cytoplasmic loop displays the most divergence in terms of primary structure, the TM domains showing the highest level of sequence conservation [].Most GABAA receptors contain one type of alpha and beta subunit, and a single gamma polypeptide in a ratio of 2:2:1 [], though in some cases other subunits such as epsilon or delta may replace gamma. The BZ binding site is located at the interface of adjacent alpha and gamma subunits; therefore, the type of alpha and gamma subunits present is instrumental in determining BZ selectivity and sensitivity. Receptors can be categorised into 3 groups based on their alpha subunit content and, hence, sensitivity to BZs: alpha 1-containing receptors have greatest sensitivity towards BZs (type I); alpha 2, 3 and 5-containing receptors have similar but distinguishable properties (type II); and alpha 4- and 6-containing assemblies have very low BZ affinity []. A conserved histidine residue in the alpha subunit of type I and II receptors is believed to be responsible for BZ affinity []. Identification and characterisation of the theta subunit was first reportedin 1999 []. Cloning of the full-length cDNA was performed using a humanwhole-brain library, yielding a deduced open reading frame of 627 aminoacids. This polypeptide was found to be most similar to the beta 1 subunitwith regard to sequence identity, and was able to co-assemble with alpha 2,beta 1 and gamma 1 subunits, yielding heteromeric assemblies with a 4-foldincrease in sensitivity towards GABA. Furthermore, theta mRNA was found to have a unique spatial distribution, with significant expression withinmonoaminergic neurons of both human and monkey brain. |
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