| Type |
Details |
Score |
| Publication |
| First Author: |
Mayers JR |
| Year: |
2014 |
| Journal: |
Nat Med |
| Title: |
Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development. |
| Volume: |
20 |
| Issue: |
10 |
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1193-1198 |
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| First Author: |
Bolhuis A |
| Year: |
1999 |
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J Biol Chem |
| Title: |
Signal peptide peptidase- and ClpP-like proteins of Bacillus subtilis required for efficient translocation and processing of secretory proteins. |
| Volume: |
274 |
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35 |
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| Publication |
| First Author: |
Cuervo A |
| Year: |
2013 |
| Journal: |
J Biol Chem |
| Title: |
Structural characterization of the bacteriophage T7 tail machinery. |
| Volume: |
288 |
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36 |
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| First Author: |
Boboila C |
| Year: |
2010 |
| Journal: |
J Exp Med |
| Title: |
Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4. |
| Volume: |
207 |
| Issue: |
2 |
| Pages: |
417-27 |
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| Protein Domain |
| Type: |
Family |
| Description: |
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands, allowing rapid transmission of signals at chemical synapses [, ]. Five of these ion channel receptor families have been shown to form a sequence-related superfamily:Nicotinic acetylcholine receptor (AchR), an excitatory cation channel in vertebrates and invertebrates; in vertebrate motor endplates it is composed of alpha, beta, gamma and delta/epsilon subunits; in neurons it is composed of alpha and non-alpha (or beta) subunits [].Glycine receptor, an inhibitory chloride ion channel composed of alpha and beta subunits [].Gamma-aminobutyric acid (GABA) receptor, an inhibitory chloride ion channel; at least four types of subunits (alpha, beta, gamma and delta) are known [].Serotonin 5HT3 receptor, of which there are seven major types (5HT3-5HT7) [].Glutamate receptor, an excitatory cation channel of which at least three types have been described (kainate, N-methyl-D-aspartate (NMDA) and quisqualate) [].These receptors possess a pentameric structure (made up of varying subunits), surrounding a central pore. All known sequences of subunits from neurotransmitter-gated ion-channels are structurally related. They are composed of a large extracellular glycosylated N-terminal ligand-binding domain, followed by three hydrophobic transmembrane regions which form the ionic channel, followed by an intracellular region of variable length. A fourth hydrophobic region is found at the C-terminal of the sequence [, ].Gamma-aminobutyric acid type A (GABAA) receptors are members of the neurotransmitter ligand-gated ion channels: they mediate neuronal inhibition on binding GABA. The effects of GABA on GABAA receptors are modulated by a range of therapeutically important drugs, including barbiturates, anaesthetics and benzodiazepines (BZs) []. The BZs are a diverse range of compounds, including widely prescribed drugs, such as librium and valium, and their interaction with GABAA receptors provides the most potent pharmacological means of distinguishing different GABAA receptor subtypes.GABAA receptors are pentameric membrane proteins that operate GABA-gated chloride channels []. Eight types of receptor subunit have been cloned, with multiple subtypes within some classes: alpha 1-6, beta 1-4, gamma 1-4, delta, epsilon, pi, rho 1-3 and theta [, ]. Subunits are typically 50-60kDa in size and comprise a long N-terminal extracellular domain, containing a putative signal peptide and a disulphide-bonded beta structural loop; 4 putative transmembrane (TM) domains; and a large cytoplasmic loop connecting the third and fourth TM domains. Amongst family members, the large cytoplasmic loop displays the most divergence in terms of primary structure, the TM domains showing the highest level of sequence conservation [].Most GABAA receptors contain one type of alpha and beta subunit, and a single gamma polypeptide in a ratio of 2:2:1 [], though in some cases other subunits such as epsilon or delta may replace gamma. The BZ binding site is located at the interface of adjacent alpha and gamma subunits; therefore, the type of alpha and gamma subunits present is instrumental in determining BZ selectivity and sensitivity. Receptors can be categorised into 3 groups based on their alpha subunit content and, hence, sensitivity to BZs: alpha 1-containing receptors have greatest sensitivity towards BZs (type I); alpha 2, 3 and 5-containing receptors have similar but distinguishable properties (type II); and alpha 4- and 6-containing assemblies have very low BZ affinity []. A conserved histidine residue in the alpha subunit of type I and II receptors is believed to be responsible for BZ affinity []. A cDNA encoding the human GABAA receptor beta 2 subunit has been cloned andsequenced []. Expression of recombinant human GABAA receptors containingdifferent beta subunits (beta 1, beta 2 or beta 3) in both transfectedcells and Xenopus laevis oocytes, has revealed the influence of the beta subunit onthe pharmacology of the receptor. For a number of benzodiazepine bindingsite compounds, a barbiturate, and several neurosteroids, neither theaffinity nor the efficacy of the compounds is influenced by the type ofbeta subunit present in the receptor molecule []. These observationssuggest that the beta subunit does not significantly influence thebenzodiazepine, barbiturate, or steroid site pharmacologies of human GABAAreceptor subtypes []. |
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| Publication |
| First Author: |
Vural A |
| Year: |
2016 |
| Journal: |
J Immunol |
| Title: |
Activator of G-Protein Signaling 3-Induced Lysosomal Biogenesis Limits Macrophage Intracellular Bacterial Infection. |
| Volume: |
196 |
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2 |
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| First Author: |
Schröder A |
| Year: |
2019 |
| Journal: |
JCI Insight |
| Title: |
Osteoprotective action of low-salt diet requires myeloid cell-derived NFAT5. |
| Volume: |
4 |
| Issue: |
23 |
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•
•
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| Publication |
| First Author: |
McCampbell A |
| Year: |
2005 |
| Journal: |
Hum Mol Genet |
| Title: |
Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy. |
| Volume: |
14 |
| Issue: |
22 |
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3507-21 |
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•
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| First Author: |
Upadhyay A |
| Year: |
2019 |
| Journal: |
Front Mol Neurosci |
| Title: |
Neurocalcin Delta Knockout Impairs Adult Neurogenesis Whereas Half Reduction Is Not Pathological. |
| Volume: |
12 |
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19 |
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| First Author: |
Nakajima A |
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2017 |
| Journal: |
J Immunol |
| Title: |
Maternal High Fiber Diet during Pregnancy and Lactation Influences Regulatory T Cell Differentiation in Offspring in Mice. |
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10 |
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Valença A |
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2021 |
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Exp Eye Res |
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Neels JG |
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2006 |
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Am J Pathol |
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DeSimone JC |
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Neurobiol Dis |
| Title: |
In vivo imaging reveals impaired connectivity across cortical and subcortical networks in a mouse model of DYT1 dystonia. |
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Tomlinson RE |
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2017 |
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Proc Natl Acad Sci U S A |
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NGF-TrkA signaling in sensory nerves is required for skeletal adaptation to mechanical loads in mice. |
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18 |
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Teufel R |
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Proc Natl Acad Sci U S A |
| Title: |
Bacterial phenylalanine and phenylacetate catabolic pathway revealed. |
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Dawe CE |
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Dev Dyn |
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Ekonomou A |
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PLoS Biol |
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Neuron |
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A Sensorimotor Circuit in Mouse Cortex for Visual Flow Predictions. |
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Wehbe Z |
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Biochim Biophys Acta Mol Cell Biol Lipids |
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The fate of medium-chain fatty acids in very long-chain acyl‑CoA dehydrogenase deficiency (VLCADD): A matter of sex? |
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J Cell Biol |
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21 |
| Pages: |
3059-3066 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
143
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dupuy AJ |
| Year: |
2005 |
| Journal: |
Nature |
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Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system. |
| Volume: |
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7048 |
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•
•
•
•
|
| Publication |
| First Author: |
Naetar N |
| Year: |
2008 |
| Journal: |
Nat Cell Biol |
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Loss of nucleoplasmic LAP2alpha-lamin A complexes causes erythroid and epidermal progenitor hyperproliferation. |
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•
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| Publication |
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Fioriti L |
| Year: |
2005 |
| Journal: |
Mol Cell Neurosci |
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| Volume: |
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| Publication |
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| Year: |
2018 |
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Sci Rep |
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Y1 receptor deficiency in β-cells leads to increased adiposity and impaired glucose metabolism. |
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•
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| Publication |
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iScience |
| Title: |
Core circadian transcription factor Bmal1 mediates β cell response and recovery from pro-inflammatory injury. |
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27 |
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11 |
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2021 |
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Cell Rep |
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Defining the fetal origin of MLL-AF4 infant leukemia highlights specific fatty acid requirements. |
| Volume: |
37 |
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•
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| Publication |
| First Author: |
Dey A |
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2004 |
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Endocrinology |
| Title: |
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Proteau A |
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J Mol Biol |
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| Publication |
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Magenta A |
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2003 |
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Mol Cell Biol |
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MyoD stimulates RB promoter activity via the CREB/p300 nuclear transduction pathway. |
| Volume: |
23 |
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8 |
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•
•
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Pachikara A |
| Year: |
2007 |
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| Title: |
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305 |
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•
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Kakarougkas A |
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2013 |
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Nucleic Acids Res |
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•
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Imai M |
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2020 |
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Proc Natl Acad Sci U S A |
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Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development. |
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117 |
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•
•
•
|
| Publication |
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Housley GD |
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2013 |
| Journal: |
Proc Natl Acad Sci U S A |
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ATP-gated ion channels mediate adaptation to elevated sound levels. |
| Volume: |
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•
•
•
•
|
| Publication |
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Lacroix M |
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2021 |
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Nat Commun |
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The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes. |
| Volume: |
12 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Lee CG |
| Year: |
2004 |
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J Exp Med |
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Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis. |
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200 |
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•
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Giammanco A |
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•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ma Y |
| Year: |
2020 |
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Gastroenterology |
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Combination of PD-1 Inhibitor and OX40 Agonist Induces Tumor Rejection and Immune Memory in Mouse Models of Pancreatic Cancer. |
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159 |
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1 |
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306-319.e12 |
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•
•
|
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Maestrini E |
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Proc Natl Acad Sci U S A |
| Title: |
A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor. |
| Volume: |
93 |
| Issue: |
2 |
| Pages: |
674-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chiu AP |
| Year: |
2019 |
| Journal: |
Mol Cancer Res |
| Title: |
HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism. |
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7 |
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•
|
| Publication |
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Azizoglu DB |
| Year: |
2017 |
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Genes Dev |
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Afadin and RhoA control pancreatic endocrine mass via lumen morphogenesis. |
| Volume: |
31 |
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23-24 |
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2376-2390 |
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•
•
|
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| First Author: |
Morohoshi A |
| Year: |
2020 |
| Journal: |
PLoS Genet |
| Title: |
Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is required for sperm flagellum formation and male fertility in mice. |
| Volume: |
16 |
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•
|
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Kumazawa A |
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Mol Cell Neurosci |
| Title: |
Cyclin-dependent kinase 5 is required for normal cerebellar development. |
| Volume: |
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97-105 |
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•
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| Publication |
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Moon JH |
| Year: |
2020 |
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Sci Transl Med |
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Lactation improves pancreatic β cell mass and function through serotonin production. |
| Volume: |
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•
|
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Satoh K |
| Year: |
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Circulation |
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Cyclophilin A mediates vascular remodeling by promoting inflammation and vascular smooth muscle cell proliferation. |
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Kashiwa A |
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Anat Rec A Discov Mol Cell Evol Biol |
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VEGF modulates early heart valve formation. |
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| Protein Coding Gene |
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protein_coding_gene |
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mouse, laboratory |
|
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•
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