|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 301 to 400 out of 568 for Adam17

<< First    < Previous  |  Next >    Last >>
0.029s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
GXD Expression
GXD Expression
Probe: MGI:3580786
Assay Type: Immunohistochemistry
Annotation Date: 2005-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750325
Pattern: Non-Uniform
Stage: TS25
Assay Id: MGI:3580820
Age: embryonic day 17.5
Image: 2R
Note: Expression was reduced in the exocrine compartment relative to the endocrine compartment.
Specimen Label: 2R
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:3580786
Assay Type: Immunohistochemistry
Annotation Date: 2005-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3580820
Age: postnatal week 8
Image: 4D
Note: Expression was detected in all three endocrine subpopulations investigated.
Specimen Label: 4D
Detected: true
Specimen Num: 11
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:3580786
Assay Type: Immunohistochemistry
Annotation Date: 2005-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3580820
Age: postnatal week 8
Image: 4E
Note: Expression was detected in all three endocrine subpopulations investigated.
Specimen Label: 4E
Detected: true
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:3580786
Assay Type: Immunohistochemistry
Annotation Date: 2005-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3580820
Age: postnatal week 8
Image: 4F
Note: Expression was detected in all three endocrine subpopulations investigated.
Specimen Label: 4F
Detected: true
Specimen Num: 13
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:3580786
Assay Type: Immunohistochemistry
Annotation Date: 2005-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:3580820
Age: embryonic day 15.5
Image: 6G, 6I
Note: Expression was detected in pancreatic ductal cells.
Specimen Label: 6G, 6I
Detected: true
Specimen Num: 15
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3580786
Assay Type: Immunohistochemistry
Annotation Date: 2005-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750322
Pattern: Uniform
Stage: TS22
Assay Id: MGI:3580820
Age: embryonic day 14.5
Note: Expression was uniformly distributed throughout the pancreas.
Specimen Label: Table 1
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3580786
Assay Type: Immunohistochemistry
Annotation Date: 2005-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750324
Pattern: Uniform
Stage: TS24
Assay Id: MGI:3580820
Age: embryonic day 16.5
Note: Expression was uniformly distributed throughout the pancreas.
Specimen Label: Table 1
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6860347
Assay Type: RNA in situ
Annotation Date: 2022-01-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6860349
Age: postnatal day 4
Specimen Label: P4 (medial)
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6860347
Assay Type: RNA in situ
Annotation Date: 2022-01-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6860349
Age: postnatal day 4
Specimen Label: P4 (lateral)
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:7412838
Assay Type: RNA in situ
Annotation Date: 2022-12-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609219
Pattern: Widespread
Stage: TS19
Assay Id: MGI:7412908
Age: embryonic day 11.5
Image: 6F
Note: Broadly in spinal cord and dorsal root ganglion, in expressed regions including motor column and floor plate. and along commissural axon tracts.
Specimen Label: 6F
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:7587722
Assay Type: Immunohistochemistry
Annotation Date: 2024-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3574224
Pattern: Ubiquitous
Stage: TS24
Assay Id: MGI:7587741
Age: embryonic day 16.5
Image: 1D
Note: Ubiquitous expression in ganglion cell and neuroblastic layers.
Specimen Label: 1D
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:3580786
Assay Type: Immunohistochemistry
Annotation Date: 2005-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3292728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3580820
Age: postnatal adult
Image: 5G, 5I
Note: Expression was detected in the cell cytoplasm but was not detectable in the outer cell membrane of the islets. Expression did not colocalize with Cdh1 (E-Cadherin).
Specimen Label: 5G, 5I
Detected: true
Specimen Num: 14
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:7587722
Assay Type: Immunohistochemistry
Annotation Date: 2024-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3573927
Pattern: Ubiquitous
Stage: TS27
Assay Id: MGI:7587741
Age: postnatal day 0.5
Image: 1F
Note: Ubiquitous expression in ganglion cell layer.
Specimen Label: 1F
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:7587722
Assay Type: Immunohistochemistry
Annotation Date: 2024-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3573928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7587741
Age: postnatal day 7
Image: 1H
Specimen Label: 1H
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:7587722
Assay Type: Immunohistochemistry
Annotation Date: 2024-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3573928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7587741
Age: postnatal day 28
Image: 1J
Specimen Label: 1J
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:5505838
Assay Type: Immunohistochemistry
Annotation Date: 2013-09-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1862624
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:5505870
Age: embryonic day 16.5
Image: 1D
Note: More intense expression in ventricular septum and trabeculae.
Specimen Label: 1D
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6860347
Assay Type: RNA in situ
Annotation Date: 2022-01-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6860349
Age: postnatal day 4
Specimen Label: P4 (medial)
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6860347
Assay Type: RNA in situ
Annotation Date: 2022-01-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6860349
Age: postnatal day 4
Specimen Label: P4 (lateral)
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:3580786
Assay Type: Immunohistochemistry
Annotation Date: 2005-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706616
Pattern: Not Specified
Stage: TS16
Assay Id: MGI:3580820
Age: embryonic day 10.0
Image: 1E, 1K
Note: Expression was detected in both the dorsal and ventral pancreatic buds, as well as in the intervening gut endoderm. Expression was detected in the majority of the pancreatic primordial cells, including the early glucagon-producing cells.
Specimen Label: 1E, 1K
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3580786
Assay Type: Immunohistochemistry
Annotation Date: 2005-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706615
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:3580820
Age: embryonic day 9.5
Note: Expression is present in the pancreatic epithelium as well as in pancreas-associated mesenchyme.
Specimen Label: Table 1
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5505838
Assay Type: Immunohistochemistry
Annotation Date: 2013-09-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1668824
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:5505870
Age: embryonic day 16.5
Image: 1C
Specimen Label: 1C
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6860347
Assay Type: RNA in situ
Annotation Date: 2022-01-27
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6860349
Age: embryonic day 13.0
Specimen Label: E13
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6860347
Assay Type: RNA in situ
Annotation Date: 2022-01-27
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689425
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:6860349
Age: embryonic day 17.0
Specimen Label: E17
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6860347
Assay Type: RNA in situ
Annotation Date: 2022-01-27
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6860349
Age: postnatal day 4
Specimen Label: P4 (medial)
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6860347
Assay Type: RNA in situ
Annotation Date: 2022-01-27
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6860349
Age: postnatal day 4
Specimen Label: P4 (lateral)
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:7587722
Assay Type: Immunohistochemistry
Annotation Date: 2024-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1717121
Pattern: Ubiquitous
Stage: TS21
Assay Id: MGI:7587741
Age: embryonic day 13.5
Image: 1B
Note: Ubiquitous expression in ganglion cell and neuroblastic layers.
Specimen Label: 1B
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6860347
Assay Type: RNA in situ
Annotation Date: 2022-01-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1881228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6860349
Age: postnatal day 4
Specimen Label: P4 (medial)
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6860347
Assay Type: RNA in situ
Annotation Date: 2022-01-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1881228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6860349
Age: postnatal day 4
Specimen Label: P4 (lateral)
Detected: true
Specimen Num: 4
•
•
•
•
•
Publication
15215246 | J:93344
First Author: Budagian V
Year: 2004
Journal: J Biol Chem
Title: Natural soluble interleukin-15Ralpha is generated by cleavage that involves the tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17).
Volume: 279
Issue: 39
Pages: 40368-75
•
•
•
•
•
Publication
17709479 | J:139846
First Author: Horiuchi K
Year: 2007
Journal: J Immunol
Title: Cutting edge: TNF-alpha-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock.
Volume: 179
Issue: 5
Pages: 2686-9
•
•
•
•
•
Publication
22009748 | J:178716
First Author: Lamour NF
Year: 2011
Journal: J Biol Chem
Title: Ceramide kinase regulates the production of tumor necrosis factor α (TNFα) via inhibition of TNFα-converting enzyme.
Volume: 286
Issue: 50
Pages: 42808-17
•
•
•
•
•
Publication
29045841 | J:254204
First Author: Cavadas M
Year: 2017
Journal: Cell Rep
Title: Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE.
Volume: 21
Issue: 3
Pages: 745-757
•
•
•
•
•
Publication
10224132 | J:54896
First Author: Lum L
Year: 1999
Journal: J Biol Chem
Title: Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival.
Volume: 274
Issue: 19
Pages: 13613-8
•
•
•
•
•
Publication
23868980 | J:210400
First Author: Niu A
Year: 2013
Journal: J Cell Sci
Title: Src mediates the mechanical activation of myogenesis by activating TNFα-converting enzyme.
Volume: 126
Issue: Pt 19
Pages: 4349-57
•
•
•
•
•
Publication
19482949 | J:172489
First Author: Brill A
Year: 2009
Journal: Cardiovasc Res
Title: Oxidative stress activates ADAM17/TACE and induces its target receptor shedding in platelets in a p38-dependent fashion.
Volume: 84
Issue: 1
Pages: 137-44
•
•
•
•
•
Publication
19965619 | J:157780
First Author: Canault M
Year: 2010
Journal: Blood
Title: p38 mitogen-activated protein kinase activation during platelet storage: consequences for platelet recovery and hemostatic function in vivo.
Volume: 115
Issue: 9
Pages: 1835-42
•
•
•
•
•
Publication
19494263 | J:149303
First Author: Horiuchi K
Year: 2009
Journal: J Immunol
Title: Ectodomain shedding of FLT3 ligand is mediated by TNF-alpha converting enzyme.
Volume: 182
Issue: 12
Pages: 7408-14
•
•
•
•
•
Publication
31655089 | J:292303
 
First Author: Rhee M
Year: 2019
Journal: Metabolism
Title: Preadipocyte factor 1 regulates adipose tissue browning via TNF-α-converting enzyme-mediated cleavage.
Volume: 101
Pages: 153977
•
•
•
•
•
Publication
28823868 | J:248696
First Author: Leite Dantas R
Year: 2017
Journal: Am J Pathol
Title: The LIM-Only Protein Four and a Half LIM Domain Protein 2 Attenuates Development of Psoriatic Arthritis by Blocking Adam17-Mediated Tumor Necrosis Factor Release.
Volume: 187
Issue: 11
Pages: 2388-2398
•
•
•
•
•
Publication
29751002 | J:266381
First Author: Woodring T
Year: 2018
Journal: J Invest Dermatol
Title: ADAM17-Deficient Mice Model the Transcriptional Signature of Human Atopic Dermatitis.
Volume: 138
Issue: 10
Pages: 2283-2286
•
•
•
•
•
Publication
25384035 | J:225309
First Author: Sato K
Year: 2014
Journal: PLoS One
Title: Involvement of TNF-α converting enzyme in the development of psoriasis-like lesions in a mouse model.
Volume: 9
Issue: 11
Pages: e112408
•
•
•
•
•
Publication
23817563 | J:205319
First Author: Martin P
Year: 2013
Journal: J Leukoc Biol
Title: Mouse neutrophils express the decoy type 2 interleukin-1 receptor (IL-1R2) constitutively and in acute inflammatory conditions.
Volume: 94
Issue: 4
Pages: 791-802
•
•
•
•
•
Publication
18625725 | J:143805
First Author: Wang SE
Year: 2008
Journal: Mol Cell Biol
Title: Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab.
Volume: 28
Issue: 18
Pages: 5605-20
•
•
•
•
•
Publication
10187843 | J:54367
First Author: Sadhukhan R
Year: 1999
Journal: J Biol Chem
Title: Unaltered cleavage and secretion of angiotensin-converting enzyme in tumor necrosis factor-alpha-converting enzyme-deficient mice.
Volume: 274
Issue: 15
Pages: 10511-6
•
•
•
•
•
Publication
14638693 | J:124510
First Author: Weskamp G
Year: 2004
Journal: J Biol Chem
Title: Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR).
Volume: 279
Issue: 6
Pages: 4241-9
•
•
•
•
•
Publication
20800622 | J:170223
First Author: Lizama C
Year: 2011
Journal: Biochim Biophys Acta
Title: Etoposide induces apoptosis and upregulation of TACE/ADAM17 and ADAM10 in an in vitro male germ cell line model.
Volume: 1813
Issue: 1
Pages: 120-8
•
•
•
•
•
Publication
25795784 | J:222585
First Author: Wong E
Year: 2015
Journal: J Biol Chem
Title: The Functional Maturation of A Disintegrin and Metalloproteinase (ADAM) 9, 10, and 17 Requires Processing at a Newly Identified Proprotein Convertase (PC) Cleavage Site.
Volume: 290
Issue: 19
Pages: 12135-46
•
•
•
•
•
Publication
29897333 | J:264179
   
First Author: Oikonomidi I
Year: 2018
Journal: Elife
Title: iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE.
Volume: 7
•
•
•
•
•
Publication
11823465 | J:75887
First Author: Sunnarborg SW
Year: 2002
Journal: J Biol Chem
Title: Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability.
Volume: 277
Issue: 15
Pages: 12838-45
•
•
•
•
•
Publication
26338334 | J:226162
First Author: Palazuelos J
Year: 2015
Journal: J Neurosci
Title: Oligodendrocyte Regeneration and CNS Remyelination Require TACE/ADAM17.
Volume: 35
Issue: 35
Pages: 12241-7
•
•
•
•
•
Publication
25186737 | J:216135
First Author: Palazuelos J
Year: 2014
Journal: J Neurosci
Title: TACE/ADAM17 is essential for oligodendrocyte development and CNS myelination.
Volume: 34
Issue: 36
Pages: 11884-96
•
•
•
•
•
Publication
23349978 | J:195804
First Author: Saito K
Year: 2013
Journal: PLoS One
Title: Conditional inactivation of TNFα-converting enzyme in chondrocytes results in an elongated growth plate and shorter long bones.
Volume: 8
Issue: 1
Pages: e54853
•
•
•
•
•
Publication
19027012 | J:145876
First Author: Menghini R
Year: 2009
Journal: Gastroenterology
Title: Tissue inhibitor of metalloproteinase 3 deficiency causes hepatic steatosis and adipose tissue inflammation in mice.
Volume: 136
Issue: 2
Pages: 663-72.e4
•
•
•
•
•
Publication
9034190 | J:38527
First Author: Black RA
Year: 1997
Journal: Nature
Title: A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells.
Volume: 385
Issue: 6618
Pages: 729-33
•
•
•
•
•
Publication
19426283 | J:340116
First Author: Duerschmied D
Year: 2009
Journal: J Thromb Haemost
Title: Serotonin stimulates platelet receptor shedding by tumor necrosis factor-alpha-converting enzyme (ADAM17).
Volume: 7
Issue: 7
Pages: 1163-71
•
•
•
•
•
Publication
14625290 | J:143688
First Author: Cruz AC
Year: 2004
Journal: J Biol Chem
Title: Tumor necrosis factor-alpha-converting enzyme controls surface expression of c-Kit and survival of embryonic stem cell-derived mast cells.
Volume: 279
Issue: 7
Pages: 5612-20
•
•
•
•
•
Publication
31366620 | J:281999
First Author: Cappenberg A
Year: 2019
Journal: Blood
Title: L-selectin shedding affects bacterial clearance in the lung: a new regulatory pathway for integrin outside-in signaling.
Volume: 134
Issue: 17
Pages: 1445-1457
•
•
•
•
•
Publication
21097655 | J:186821
First Author: Shiomi T
Year: 2011
Journal: Am J Respir Cell Mol Biol
Title: TNF-α-converting enzyme/a disintegrin and metalloprotease-17 mediates mechanotransduction in murine tracheal epithelial cells.
Volume: 45
Issue: 2
Pages: 376-85
•
•
•
•
•
Publication
23348744 | J:194483
First Author: Issuree PD
Year: 2013
Journal: J Clin Invest
Title: iRHOM2 is a critical pathogenic mediator of inflammatory arthritis.
Volume: 123
Issue: 2
Pages: 928-32
•
•
•
•
•
Publication
31640947 | J:291057
 
First Author: Lian G
Year: 2019
Journal: EBioMedicine
Title: Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1α-ADAM17 pathway✰.
Volume: 49
Pages: 291-304
•
•
•
•
•
Publication
21722904 | J:286492
First Author: Kaneko H
Year: 2011
Journal: Atherosclerosis
Title: Tumor necrosis factor-α converting enzyme is a key mediator of abdominal aortic aneurysm development.
Volume: 218
Issue: 2
Pages: 470-8
•
•
•
•
•
Publication
21900081 | J:189364
First Author: Carnevale D
Year: 2011
Journal: Circulation
Title: Placental growth factor regulates cardiac inflammation through the tissue inhibitor of metalloproteinases-3/tumor necrosis factor-α-converting enzyme axis: crucial role for adaptive cardiac remodeling during cardiac pressure overload.
Volume: 124
Issue: 12
Pages: 1337-50
•
•
•
•
•
Publication
29166602 | J:254707
First Author: Wichert R
Year: 2017
Journal: Cell Rep
Title: Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB.
Volume: 21
Issue: 8
Pages: 2090-2103
•
•
•
•
•
Publication
18713734 | J:309067
First Author: Chow JP
Year: 2008
Journal: J Biol Chem
Title: Metalloproteinase- and gamma-secretase-mediated cleavage of protein-tyrosine phosphatase receptor type Z.
Volume: 283
Issue: 45
Pages: 30879-89
•
•
•
•
•
Publication
10393218 | J:56090
First Author: Mu JL
Year: 1999
Journal: J Lipid Res
Title: Quantitative trait loci analysis for the differences in susceptibility to atherosclerosis and diabetes between inbred mouse strains C57BL/6J and C57BLKS/J.
Volume: 40
Issue: 7
Pages: 1328-35
•
•
•
•
•
Publication
26183206 | J:226074
First Author: Ali M
Year: 2015
Journal: FEBS Lett
Title: LPS-mediated septic shock is augmented in ceramide synthase 2 null mice due to elevated activity of TNFα-converting enzyme.
Volume: 589
Issue: 17
Pages: 2213-7
•
•
•
•
•
Publication
28432785 | J:259889
   
First Author: Grieve AG
Year: 2017
Journal: Elife
Title: Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling.
Volume: 6
•
•
•
•
•
Publication
9034191 | J:38526
First Author: Moss ML
Year: 1997
Journal: Nature
Title: Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha.
Volume: 385
Issue: 6618
Pages: 733-6
•
•
•
•
•
Publication
10523497 | J:58532
 
First Author: Schlöndorff J
Year: 1999
Journal: J Cell Sci
Title: Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding.
Volume: 112 ( Pt 21)
Pages: 3603-17
•
•
•
•
•
Publication
18355445 | J:134275
First Author: Hiraoka Y
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation of ADAM proteases.
Volume: 370
Issue: 1
Pages: 154-8
•
•
•
•
•
Publication
25245289 | J:220081
First Author: Lee HS
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Shedding of epithin/PRSS14 is induced by TGF-β and mediated by tumor necrosis factor-α converting enzyme.
Volume: 452
Issue: 4
Pages: 1084-90
•
•
•
•
•
Publication
26815118 | J:248776
First Author: Moreno-Càceres J
Year: 2016
Journal: FEBS J
Title: Caveolin-1-dependent activation of the metalloprotease TACE/ADAM17 by TGF-β in hepatocytes requires activation of Src and the NADPH oxidase NOX1.
Volume: 283
Issue: 7
Pages: 1300-10
•
•
•
•
•
Publication
14761956 | J:89492
First Author: Naus S
Year: 2004
Journal: J Biol Chem
Title: Ectodomain shedding of the neural recognition molecule CHL1 by the metalloprotease-disintegrin ADAM8 promotes neurite outgrowth and suppresses neuronal cell death.
Volume: 279
Issue: 16
Pages: 16083-90
•
•
•
•
•
Publication
30022999 | J:275895
 
First Author: Hosur V
Year: 2018
Journal: Front Genet
Title: RHBDF2-Regulated Growth Factor Signaling in a Rare Human Disease, Tylosis With Esophageal Cancer: What Can We Learn From Murine Models?
Volume: 9
Pages: 233
•
•
•
•
•
Publication
12773386 | J:83820
First Author: Jackson LF
Year: 2003
Journal: EMBO J
Title: Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling.
Volume: 22
Issue: 11
Pages: 2704-16
•
•
•
•
•
Publication
24140644 | J:207027
First Author: Burghardt S
Year: 2013
Journal: J Immunol
Title: Hepatocytes contribute to immune regulation in the liver by activation of the Notch signaling pathway in T cells.
Volume: 191
Issue: 11
Pages: 5574-82
•
•
•
•
•
Publication
17982061 | J:153864
First Author: Horiuchi K
Year: 2007
Journal: J Immunol
Title: Cell surface colony-stimulating factor 1 can be cleaved by TNF-alpha converting enzyme or endocytosed in a clathrin-dependent manner.
Volume: 179
Issue: 10
Pages: 6715-24
•
•
•
•
•
Publication
22101895 | J:181795
First Author: Jansen AJ
Year: 2012
Journal: Blood
Title: Desialylation accelerates platelet clearance after refrigeration and initiates GPIbα metalloproteinase-mediated cleavage in mice.
Volume: 119
Issue: 5
Pages: 1263-73
•
•
•
•
•
Publication
27929373 | J:269688
   
First Author: Ku AW
Year: 2016
Journal: Elife
Title: Tumor-induced MDSC act via remote control to inhibit L-selectin-dependent adaptive immunity in lymph nodes.
Volume: 5
•
•
•
•
•
Publication
22357929 | J:182742
First Author: Triolo D
Year: 2012
Journal: Development
Title: Vimentin regulates peripheral nerve myelination.
Volume: 139
Issue: 7
Pages: 1359-67
•
•
•
•
•
Publication
21666671 | J:174007
First Author: La Marca R
Year: 2011
Journal: Nat Neurosci
Title: TACE (ADAM17) inhibits Schwann cell myelination.
Volume: 14
Issue: 7
Pages: 857-65
•
•
•
•
•
Publication
23955714 | J:202038
First Author: Pietri M
Year: 2013
Journal: Nat Med
Title: PDK1 decreases TACE-mediated α-secretase activity and promotes disease progression in prion and Alzheimer's diseases.
Volume: 19
Issue: 9
Pages: 1124-31
•
•
•
•
•
Publication
28814605 | J:251129
First Author: Lownik JC
Year: 2017
Journal: J Immunol
Title: ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses.
Volume: 199
Issue: 7
Pages: 2305-2315
•
•
•
•
•
Publication
24142516 | J:210193
First Author: Xu W
Year: 2013
Journal: Am J Physiol Lung Cell Mol Physiol
Title: TACE in perinatal mouse lung epithelial cells promotes lung saccular formation.
Volume: 305
Issue: 12
Pages: L953-63
•
•
•
•
•
Publication
31262819 | J:278204
First Author: Fujita K
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Cell-autonomous FLT3L shedding via ADAM10 mediates conventional dendritic cell development in mouse spleen.
Volume: 116
Issue: 29
Pages: 14714-14723
•
•
•
•
•
Publication
22696231 | J:197586
First Author: Nagao K
Year: 2012
Journal: Stem Cells
Title: Brief report: requirement of TACE/ADAM17 for hair follicle bulge niche establishment.
Volume: 30
Issue: 8
Pages: 1781-5
•
•
•
•
•
Publication
19201862 | J:144795
First Author: Horiuchi K
Year: 2009
Journal: J Immunol
Title: Conditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF.
Volume: 182
Issue: 4
Pages: 2093-101
•
•
•
•
•
Publication
24574341 | J:213674
First Author: Guinea-Viniegra J
Year: 2014
Journal: Sci Transl Med
Title: Targeting miR-21 to treat psoriasis.
Volume: 6
Issue: 225
Pages: 225re1
•
•
•
•
•
Publication
28004780 | J:253846
 
First Author: Wolf C
Year: 2016
Journal: Sci Rep
Title: ADAM17/EGFR axis promotes transglutaminase-dependent skin barrier formation through phosholipase C γ1 and protein kinase C pathways.
Volume: 6
Pages: 39780
•
•
•
•
•
Publication
30354220 | J:285069
First Author: Carnevale D
Year: 2018
Journal: Arterioscler Thromb Vasc Biol
Title: Loss of EMILIN-1 Enhances Arteriolar Myogenic Tone Through TGF-β (Transforming Growth Factor-β)-Dependent Transactivation of EGFR (Epidermal Growth Factor Receptor) and Is Relevant for Hypertension in Mice and Humans.
Volume: 38
Issue: 10
Pages: 2484-2497
•
•
•
•
•
Publication
27330189 | J:259991
First Author: Cataisson C
Year: 2016
Journal: Sci Signal
Title: MET signaling in keratinocytes activates EGFR and initiates squamous carcinogenesis.
Volume: 9
Issue: 433
Pages: ra62
•
•
•
•
•
Publication
22246778 | J:179653
First Author: McIlwain DR
Year: 2012
Journal: Science
Title: iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS.
Volume: 335
Issue: 6065
Pages: 229-32
•
•
•
•
•
Publication
15985531 | J:99632
First Author: Pietri M
Year: 2005
Journal: FASEB J
Title: Reactive oxygen species-dependent TNF-alpha converting enzyme activation through stimulation of 5-HT2B and alpha1D autoreceptors in neuronal cells.
Volume: 19
Issue: 9
Pages: 1078-87
•
•
•
•
•
Publication
17884817 | J:128341
First Author: Charbonneau M
Year: 2007
Journal: J Biol Chem
Title: Hypoxia-inducible factor mediates hypoxic and tumor necrosis factor alpha-induced increases in tumor necrosis factor-alpha converting enzyme/ADAM17 expression by synovial cells.
Volume: 282
Issue: 46
Pages: 33714-24
•
•
•
•
•
Publication
18367087 | J:136046
First Author: Cho RW
Year: 2008
Journal: Neuron
Title: mGluR1/5-dependent long-term depression requires the regulated ectodomain cleavage of neuronal pentraxin NPR by TACE.
Volume: 57
Issue: 6
Pages: 858-71
•
•
•
•
•
Publication
19737556 | J:153764
First Author: Bloch L
Year: 2009
Journal: FEBS Lett
Title: Klotho is a substrate for alpha-, beta- and gamma-secretase.
Volume: 583
Issue: 19
Pages: 3221-4
•
•
•
•
•
Publication
21273553 | J:183600
First Author: Leksa V
Year: 2011
Journal: Circ Res
Title: Soluble M6P/IGF2R released by TACE controls angiogenesis via blocking plasminogen activation.
Volume: 108
Issue: 6
Pages: 676-85
•
•
•
•
•
Publication
24462774 | J:210843
First Author: Fiaturi N
Year: 2014
Journal: Biochim Biophys Acta
Title: Dissociated presenilin-1 and TACE processing of ErbB4 in lung alveolar type II cell differentiation.
Volume: 1843
Issue: 4
Pages: 797-805
•
•
•
•
•
Publication
10656920 | J:59904
First Author: Wagener R
Year: 2000
Journal: Mamm Genome
Title: Structure and mapping of the mouse matrilin-3 gene (Matn3), a member of a gene family containing a U12-type AT-AC intron.
Volume: 11
Issue: 2
Pages: 85-90
•
•
•
•
•
Publication
22772468 | J:190075
First Author: Guinea-Viniegra J
Year: 2012
Journal: J Clin Invest
Title: Differentiation-induced skin cancer suppression by FOS, p53, and TACE/ADAM17.
Volume: 122
Issue: 8
Pages: 2898-910
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom