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Search results 301 to 396 out of 396 for Aff4

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:3724459
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3557722
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421119
Age: embryonic day 14.5
Image: MH575; Specimen C1266
Specimen Label: MH575; Specimen C1266
Detected: true
Specimen Num: 1
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:4428259
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3557722
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422583
Age: embryonic day 14.5
Image: MH3058; Specimen C4155
Specimen Label: MH3058; Specimen C4155
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724459
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1702122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421119
Age: embryonic day 14.5
Image: MH575; Specimen C1266
Specimen Label: MH575; Specimen C1266
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4428259
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1702122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422583
Age: embryonic day 14.5
Image: MH3058; Specimen C4155
Specimen Label: MH3058; Specimen C4155
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5002016
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2852723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542570
Age: embryonic day 15.5
Image: GUDMAP:12943
Specimen Label: GUDMAP:12943
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5002016
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2852723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542570
Age: embryonic day 15.5
Image: GUDMAP:12944
Specimen Label: GUDMAP:12944
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5002016
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2874723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542570
Age: embryonic day 15.5
Image: GUDMAP:12944
Specimen Label: GUDMAP:12944
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724459
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1756322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421119
Age: embryonic day 14.5
Image: MH575; Specimen C1266
Specimen Label: MH575; Specimen C1266
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4428259
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1756322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422583
Age: embryonic day 14.5
Image: MH3058; Specimen C4155
Specimen Label: MH3058; Specimen C4155
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724459
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1668822
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421119
Age: embryonic day 14.5
Image: MH575; Specimen C1266
Specimen Label: MH575; Specimen C1266
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4428259
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1668822
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422583
Age: embryonic day 14.5
Image: MH3058; Specimen C4155
Specimen Label: MH3058; Specimen C4155
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3724459
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1757722
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421119
Age: embryonic day 14.5
Specimen Label: MH575; Specimen C1266
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4428259
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1757722
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422583
Age: embryonic day 14.5
Image: MH3058; Specimen C4155
Specimen Label: MH3058; Specimen C4155
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724459
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1757522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421119
Age: embryonic day 14.5
Image: MH575; Specimen C1266
Specimen Label: MH575; Specimen C1266
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4428259
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757522
Stage: TS22
Assay Id: MGI:5422583
Age: embryonic day 14.5
Specimen Label: MH3058; Specimen C4155
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5002016
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2850023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542570
Age: embryonic day 15.5
Image: GUDMAP:12943
Specimen Label: GUDMAP:12943
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5002016
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2850023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542570
Age: embryonic day 15.5
Image: GUDMAP:12944
Specimen Label: GUDMAP:12944
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724459
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1738322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421119
Age: embryonic day 14.5
Image: MH575; Specimen C1266
Specimen Label: MH575; Specimen C1266
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4428259
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1738322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422583
Age: embryonic day 14.5
Image: MH3058; Specimen C4155
Specimen Label: MH3058; Specimen C4155
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3724459
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1802422
Stage: TS22
Assay Id: MGI:5421119
Age: embryonic day 14.5
Specimen Label: MH575; Specimen C1266
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4428259
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1802422
Stage: TS22
Assay Id: MGI:5422583
Age: embryonic day 14.5
Specimen Label: MH3058; Specimen C4155
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5002016
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:1796223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542570
Age: embryonic day 15.5
Image: GUDMAP:12944
Specimen Label: GUDMAP:12944
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3724459
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1768022
Stage: TS22
Assay Id: MGI:5421119
Age: embryonic day 14.5
Note: Expression was not detected in the skull (base and vault).
Specimen Label: MH575; Specimen C1266
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4428259
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1768022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422583
Age: embryonic day 14.5
Image: MH3058; Specimen C4155
Note: Expression was weak in the skull (base and vault).
Specimen Label: MH3058; Specimen C4155
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3724459
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2826626
Stage: TS26
Assay Id: MGI:5540399
Age: embryonic day 17.5
Image: GUDMAP:15514
Specimen Label: GUDMAP:15514
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3724459
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2772126
Stage: TS26
Assay Id: MGI:5540399
Age: embryonic day 17.5
Image: GUDMAP:15514
Specimen Label: GUDMAP:15514
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:3724459
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:2672022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421119
Age: embryonic day 14.5
Image: MH575; Specimen C1266
Note: Expression was weak in whisker follicle.
Specimen Label: MH575; Specimen C1266
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:4428259
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2672022
Stage: TS22
Assay Id: MGI:5422583
Age: embryonic day 14.5
Note: Expression was not detected in whisker follicle.
Specimen Label: MH3058; Specimen C4155
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:6693331
Assay Type: Immunohistochemistry
Annotation Date: 2021-04-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3801427
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6693339
Age: postnatal day 0
Image: 3E/EV2D'
Note: Virtually all Foxn1+ cells expressed Aff4, as there were Aff4+ only cells.
Specimen Label: 3E/EV2D'
Detected: true
Specimen Num: 3
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•
•
•
GXD Expression
GXD Expression
Probe: MGI:6693331
Assay Type: Immunohistochemistry
Annotation Date: 2021-04-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3801527
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6693339
Age: postnatal day 0
Image: 3E/EV2D'
Note: Virtually all Foxn1+ cells expressed Aff4, as there were Aff4+ only cells.
Specimen Label: 3E/EV2D'
Detected: true
Specimen Num: 3
•
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Publication
- | J:70086
   
First Author: Wenderfer SE
Year: 2000
Journal: GenBank Submission
Title: Mus musculus putative transcription factor ALF-4 (Alf4) mRNA, complete cds
Pages: AF190449
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Publication
- | J:70087
   
First Author: Birren B
Year: 1999
Journal: GenBank Submission
Title: Mus musculus Chromosome 11, clone RP23-218N2, complete sequence
Pages: AC011013
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Publication
23273992 | J:190435
First Author: Lin C
Year: 2013
Journal: Cell
Title: The RNA Pol II elongation factor Ell3 marks enhancers in ES cells and primes future gene activation.
Volume: 152
Issue: 1-2
Pages: 144-56
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Publication
22195968 | J:212787
First Author: Smith ER
Year: 2011
Journal: Mol Cell
Title: The little elongation complex regulates small nuclear RNA transcription.
Volume: 44
Issue: 6
Pages: 954-65
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Publication
15459319 | J:93546
First Author: Oliver PL
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Mediation of Af4 protein function in the cerebellum by Siah proteins.
Volume: 101
Issue: 41
Pages: 14901-6
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Publication
11923441 | J:76005
First Author: Gu Y
Year: 2002
Journal: J Neurosci
Title: Impaired conditioned fear and enhanced long-term potentiation in Fmr2 knock-out mice.
Volume: 22
Issue: 7
Pages: 2753-63
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Publication
18039856 | J:130394
First Author: Jiang H
Year: 2008
Journal: Mol Cell Biol
Title: Differential chromatin looping regulates CD4 expression in immature thymocytes.
Volume: 28
Issue: 3
Pages: 907-12
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Publication
10704283 | J:60872
First Author: Wenderfer SE
Year: 2000
Journal: Genomics
Title: Identification of 40 genes on a 1-Mb contig around the IL-4 cytokine family gene cluster on mouse chromosome 11.
Volume: 63
Issue: 3
Pages: 354-73
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Publication
16024815 | J:100030
First Author: Urano A
Year: 2005
Journal: Mol Cell Biol
Title: Infertility with defective spermiogenesis in mice lacking AF5q31, the target of chromosomal translocation in human infant leukemia.
Volume: 25
Issue: 15
Pages: 6834-45
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Publication
- | J:94077
     
First Author: Mutant Mouse Regional Resource Centers
Year: 2004
Journal: Unpublished
Title: Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC)
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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•
•
•
Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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HT Experiment
GSE152247 | Effects of FOXN1 or AFF4 deficiency on gene expression in the skin
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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GXD Expression
GXD Expression
Probe: MGI:5660521
Assay Type: Immunohistochemistry
Annotation Date: 2021-04-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752824
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6693349
Age: embryonic day 16.5
Image: 3C/EV2B
Note: Coexpressed with Aff4 in the differentiating layers.
Specimen Label: 3C/EV2B
Detected: true
Specimen Num: 2
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Publication
31147444 | -
First Author: Chen Y
Year: 2019
Journal: J Biol Chem
Title: Structure of the super-elongation complex subunit AFF4 C-terminal homology domain reveals requirements for AFF homo- and heterodimerization.
Volume: 294
Issue: 27
Pages: 10663-10673
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GXD Expression
GXD Expression
Probe: MGI:5660521
Assay Type: Immunohistochemistry
Annotation Date: 2021-04-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1877128
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6693349
Age: postnatal day 9
Image: 3B/EV2A
Note: Coexpressed with Aff4 in the nuclei of epithelial cells in the differentiating cortex.
Specimen Label: 3B/EV2A
Detected: true
Specimen Num: 1
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Publication
20471948 | -
First Author: He N
Year: 2010
Journal: Mol Cell
Title: HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription.
Volume: 38
Issue: 3
Pages: 428-38
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Protein Domain
IPR043640 | AF4/FMR2_CHD
Type: Domain
Description: The AFF (AF4/FMR2) family includes four members: AFF1/AF4, AFF2/FMR2, AFF3/LAF4 and AFF4/AF5q31. All AFF proteins are localized in the cell nucleus and are involved in regulation of gene expression [, ].In humans, AFF2/FMR2 is silenced in FRAXE intellectual disability, while the other three members have been reported to form fusion genes as a consequence of chromosome translocations with the myeloid/lymphoid or mixed lineage leukemia (MLL) gene in acute lymphoblastic leukemias (ALLs) [, ].This entry also includes Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila [].This entry represents the C-terminal domain homology domain (CHD) that is conserved among AF4/FMR2 family proteins, including AFF1, AFF2, AFF3, and AFF4. This domain consists of eight helices and is distantly related to tetratricopeptide repeat motifs. The CHD domain mediates the formation of an AFF4 homodimer or an AFF1-AFF4 heterodimer. []. This domain is essential for AFF4 interaction with Transcription Start Site (TSS)-associated histone H3K27 whose acetylation signals SEC to regulate transcriptional elongation of the ESR1 gene []. Depletion of AFF4 reduces expression of ESR1, and, consequently inhibits breast cancer cell growth [].
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Publication
31399344 | J:278647
First Author: Etchegaray JP
Year: 2019
Journal: Mol Cell
Title: The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing.
Volume: 75
Issue: 4
Pages: 683-699.e7
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Protein
Q8BQB7
Organism: Mus musculus/domesticus
Length: 158  
Fragment?: true
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Protein
O35233
Organism: Mus musculus/domesticus
Length: 1211  
Fragment?: true
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Publication
32265480 | -
First Author: Gao Y
Year: 2020
Journal: Commun Biol
Title: Acetylation of histone H3K27 signals the transcriptional elongation for estrogen receptor alpha.
Volume: 3
Issue: 1
Pages: 165
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Protein
O88573
Organism: Mus musculus/domesticus
Length: 1216  
Fragment?: false
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Protein
Q9ESC8
Organism: Mus musculus/domesticus
Length: 1160  
Fragment?: false
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Protein
O55112
Organism: Mus musculus/domesticus
Length: 1272  
Fragment?: false
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Protein
P51827
Organism: Mus musculus/domesticus
Length: 1254  
Fragment?: false
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Protein
E9Q921
Organism: Mus musculus/domesticus
Length: 1226  
Fragment?: false
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Protein
Q5XM34
Organism: Mus musculus/domesticus
Length: 1218  
Fragment?: false
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Protein
F8WJA7
Organism: Mus musculus/domesticus
Length: 1228  
Fragment?: false
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Protein
D3YYI6
Organism: Mus musculus/domesticus
Length: 1229  
Fragment?: false
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Protein
A3KMF4
Organism: Mus musculus/domesticus
Length: 1218  
Fragment?: false
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Publication
11171403 | -
First Author: Wittwer F
Year: 2001
Journal: Development
Title: Lilliputian: an AF4/FMR2-related protein that controls cell identity and cell growth.
Volume: 128
Issue: 5
Pages: 791-800
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Publication
11171404 | -
First Author: Tang AH
Year: 2001
Journal: Development
Title: Transcriptional regulation of cytoskeletal functions and segmentation by a novel maternal pair-rule gene, lilliputian.
Volume: 128
Issue: 5
Pages: 801-13
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Publication
21330300 | -
First Author: Melko M
Year: 2011
Journal: Hum Mol Genet
Title: Functional characterization of the AFF (AF4/FMR2) family of RNA-binding proteins: insights into the molecular pathology of FRAXE intellectual disability.
Volume: 20
Issue: 10
Pages: 1873-85
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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