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Search results 301 to 368 out of 368 for Apobec3

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Type Details Score
GXD Expression
GXD Expression
   
Probe: MGI:5829704
Assay Type: RNA in situ
Annotation Date: 2017-03-28
Strength: Absent
Sex: Female
Emaps: EMAPS:3273522
Stage: TS22
Assay Id: MGI:5829752
Age: embryonic day 14.5
Note: No staining was detected in the neural crest derivatives of the pelvic urethra.
Specimen Label: Supplemental Table E14.5 female
Detected: false
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:5829704
Assay Type: RNA in situ
Annotation Date: 2017-03-28
Strength: Moderate
Sex: Female
Emaps: EMAPS:3610525
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:5829752
Age: embryonic day 17.5
Specimen Label: Supplemental Table E17.5 female
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
   
Probe: MGI:5829704
Assay Type: RNA in situ
Annotation Date: 2017-03-28
Strength: Moderate
Sex: Female
Emaps: EMAPS:3610528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5829752
Age: postnatal day 5
Specimen Label: Supplemental Table P5 female
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:3724949
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1756322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421600
Age: embryonic day 14.5
Image: MH1599; Specimen C1124
Specimen Label: MH1599; Specimen C1124
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5829704
Assay Type: RNA in situ
Annotation Date: 2017-03-28
Strength: Absent
Sex: Female
Emaps: EMAPS:3100328
Stage: TS28
Assay Id: MGI:5829752
Age: postnatal day 5
Specimen Label: Supplemental Table P5 female
Detected: false
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:3724949
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1668822
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421600
Age: embryonic day 14.5
Image: MH1599; Specimen C1124
Specimen Label: MH1599; Specimen C1124
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3724949
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1757722
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421600
Age: embryonic day 14.5
Image: MH1599; Specimen C1124
Specimen Label: MH1599; Specimen C1124
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3724949
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1757522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421600
Age: embryonic day 14.5
Image: MH1599; Specimen C1124
Specimen Label: MH1599; Specimen C1124
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3724949
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1738322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421600
Age: embryonic day 14.5
Image: MH1599; Specimen C1124
Specimen Label: MH1599; Specimen C1124
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3724949
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1802422
Stage: TS22
Assay Id: MGI:5421600
Age: embryonic day 14.5
Specimen Label: MH1599; Specimen C1124
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5829704
Assay Type: RNA in situ
Annotation Date: 2017-03-28
Strength: Moderate
Sex: Male
Emaps: EMAPS:3090322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5829752
Age: embryonic day 14.5
Note: Medium expression was detected in the lamina propria and the muscularis propria. No staining was detected in the muscularis mucosa or submucosa.
Specimen Label: Supplemental Table E14.5 male
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:5829704
Assay Type: RNA in situ
Annotation Date: 2017-03-28
Strength: Moderate
Sex: Female
Emaps: EMAPS:3090322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5829752
Age: embryonic day 14.5
Note: Medium expression was detected in the lamina propria and the muscularis propria. No staining was detected in the muscularis mucosa or submucosa.
Specimen Label: Supplemental Table E14.5 female
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:5829704
Assay Type: RNA in situ
Annotation Date: 2017-03-28
Strength: Moderate
Sex: Male
Emaps: EMAPS:2978625
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:5829752
Age: embryonic day 17.5
Specimen Label: Supplemental Table E17.5 male
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
   
Probe: MGI:5829704
Assay Type: RNA in situ
Annotation Date: 2017-03-28
Strength: Moderate
Sex: Male
Emaps: EMAPS:2978628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5829752
Age: postnatal day 5
Specimen Label: Supplemental Table P5 male
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
     
Probe: MGI:5829704
Assay Type: RNA in situ
Annotation Date: 2017-03-28
Strength: Absent
Sex: Male
Emaps: EMAPS:3226225
Stage: TS25
Assay Id: MGI:5829752
Age: embryonic day 17.5
Specimen Label: Supplemental Table E17.5 male
Detected: false
Specimen Num: 9
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GXD Expression
GXD Expression
     
Probe: MGI:5829704
Assay Type: RNA in situ
Annotation Date: 2017-03-28
Strength: Absent
Sex: Male
Emaps: EMAPS:3226228
Stage: TS28
Assay Id: MGI:5829752
Age: postnatal day 5
Specimen Label: Supplemental Table P5 male
Detected: false
Specimen Num: 11
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GXD Expression
GXD Expression
   
Probe: MGI:3724949
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1768022
Stage: TS22
Assay Id: MGI:5421600
Age: embryonic day 14.5
Note: Expression was not detected in the skull (base and vault).
Specimen Label: MH1599; Specimen C1124
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5829704
Assay Type: RNA in situ
Annotation Date: 2017-03-28
Strength: Absent
Sex: Male
Emaps: EMAPS:3612625
Stage: TS25
Assay Id: MGI:5829752
Age: embryonic day 17.5
Specimen Label: Supplemental Table E17.5 male
Detected: false
Specimen Num: 9
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GXD Expression
GXD Expression
     
Probe: MGI:5829704
Assay Type: RNA in situ
Annotation Date: 2017-03-28
Strength: Absent
Sex: Male
Emaps: EMAPS:3612628
Stage: TS28
Assay Id: MGI:5829752
Age: postnatal day 5
Specimen Label: Supplemental Table P5 male
Detected: false
Specimen Num: 11
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GXD Expression
GXD Expression
   
Probe: MGI:3724949
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2672022
Stage: TS22
Assay Id: MGI:5421600
Age: embryonic day 14.5
Note: Expression was not detected in whisker follicle.
Specimen Label: MH1599; Specimen C1124
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:5829704
Assay Type: RNA in situ
Annotation Date: 2017-03-28
Strength: Present
Sex: Female
Emaps: EMAPS:3815322
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:5829752
Age: embryonic day 14.5
Image: 4V
Note: There were no noteworthy sex differences in staining within the lower urinary tract.
Specimen Label: 4V
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:5829704
Assay Type: RNA in situ
Annotation Date: 2017-03-28
Strength: Present
Sex: Female
Emaps: EMAPS:3816125
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:5829752
Age: embryonic day 17.5
Image: 4W
Note: There were no noteworthy sex differences in staining within the lower urinary tract.
Specimen Label: 4W
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:5829704
Assay Type: RNA in situ
Annotation Date: 2017-03-28
Strength: Ambiguous
Sex: Female
Emaps: EMAPS:3816128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5829752
Age: postnatal day 5
Image: 4X
Note: There were no noteworthy sex differences in staining within the lower urinary tract.
Specimen Label: 4X
Specimen Num: 6
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Publication
- | J:15839
       
First Author: International Committee on Standardized Genetic Nomenclature for Mice
Year: 1993
Title: Nomenclature rule change to delete hyphens and parentheses from mouse locus symbols
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
- | J:68300
   
First Author: Strausberg R
Year: 2001
Journal: GenBank Submission
Title: Mus musculus, clone MGC: 7002, mRNA, complete cds
Pages: BC003314
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Protein
B5T0J0
Organism: Mus musculus/domesticus
Length: 373  
Fragment?: false
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Protein
B5T0I8
Organism: Mus musculus/domesticus
Length: 373  
Fragment?: false
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Publication
33947663 | J:310822
First Author: Venkatesan S
Year: 2021
Journal: Cancer Discov
Title: Induction of APOBEC3 Exacerbates DNA Replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution.
Volume: 11
Issue: 10
Pages: 2456-2473
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Publication
19153233 | J:244402
First Author: Okeoma CM
Year: 2009
Journal: J Virol
Title: Expression of murine APOBEC3 alleles in different mouse strains and their effect on mouse mammary tumor virus infection.
Volume: 83
Issue: 7
Pages: 3029-38
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Publication
25408426 | -
First Author: Kim DY
Year: 2015
Journal: Arch Pharm Res
Title: The assembly of Vif ubiquitin E3 ligase for APOBEC3 degradation.
Volume: 38
Issue: 4
Pages: 435-45
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Allele
Apobec3<em2Smoc> | MGI:7288300
Name: apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6474782 | C57BL/6JSmoc-Apobec3<em2Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Apobec3<em1Smoc> | MGI:7288299
Name: apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Publication
18304004 | -
 
First Author: Chiu YL
Year: 2008
Journal: Annu Rev Immunol
Title: The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements.
Volume: 26
Pages: 317-53
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Publication
22915799 | -
First Author: Phalora PK
Year: 2012
Journal: J Virol
Title: HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies.
Volume: 86
Issue: 21
Pages: 11712-24
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Strain
MGI:7623298 | C57BL/6JSmoc-Apobec3<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
26091828 | J:227235
First Author: Swanton C
Year: 2015
Journal: Cancer Discov
Title: APOBEC Enzymes: Mutagenic Fuel for Cancer Evolution and Heterogeneity.
Volume: 5
Issue: 7
Pages: 704-12
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Publication
32870257 | J:298716
 
First Author: Law EK
Year: 2020
Journal: J Exp Med
Title: APOBEC3A catalyzes mutation and drives carcinogenesis in vivo.
Volume: 217
Issue: 12
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Publication
1995946 | -
First Author: Guy B
Year: 1991
Journal: J Virol
Title: A specific inhibitor of cysteine proteases impairs a Vif-dependent modification of human immunodeficiency virus type 1 Env protein.
Volume: 65
Issue: 3
Pages: 1325-31
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Publication
1357189 | -
First Author: Gabuzda DH
Year: 1992
Journal: J Virol
Title: Role of vif in replication of human immunodeficiency virus type 1 in CD4+ T lymphocytes.
Volume: 66
Issue: 11
Pages: 6489-95
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Publication
3497453 | -
First Author: Fisher AG
Year: 1987
Journal: Science
Title: The sor gene of HIV-1 is required for efficient virus transmission in vitro.
Volume: 237
Issue: 4817
Pages: 888-93
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Publication
14618252 | -
First Author: Pomerantz RJ
Year: 2003
Journal: Cell Mol Life Sci
Title: The HIV-1 Vif protein: a paradigm for viral:cell interactions.
Volume: 60
Issue: 10
Pages: 2017-9
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Publication
24586532 | -
First Author: da Costa KS
Year: 2014
Journal: PLoS One
Title: Structural analysis of viral infectivity factor of HIV type 1 and its interaction with A3G, EloC and EloB.
Volume: 9
Issue: 2
Pages: e89116
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Publication
30961890 | -
First Author: Ball KA
Year: 2019
Journal: Biophys J
Title: Conformational Dynamics of the HIV-Vif Protein Complex.
Volume: 116
Issue: 8
Pages: 1432-1445
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Publication
30941116 | -
 
First Author: Zhao Z
Year: 2019
Journal: Front Microbiol
Title: CAEV Vif Hijacks ElonginB/C, CYPA and Cullin5 to Assemble the E3 Ubiquitin Ligase Complex Stepwise to Degrade oaA3Z2-Z3.
Volume: 10
Pages: 565
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Protein Domain
IPR000475 | Vif
Type: Family
Description: The virion infectivity factor (vif) is an accessory protein, which is essential for HIV replication in host cells. Vif of Human immunodeficiency virus 1 (HIV-1) affects the infectivity of virus particles []to T lymphocytes and macrophages (in some casesincreasing the infectivity of HIV-1 particles by 100- to 1000-fold), but has no direct effect on transcription, translation or virus release. Vif antibodies are found in the sera of patients at all levels of HIV-1 infection, indicating that vif is expressed in natural infections in vivo. Other lentiviruses, including Simian immunodeficiency virus (SIV-cpz), Visna/Maedi virus, and Feline immunodeficiency virus (FIV), have vif open reading frames, suggestingvif plays an essential role during natural infections [].The expression of vif in BHK-21 cells has been shown to be linked to amodification of the C terminus of gp41env, which modification is inhibited by trans-epoxysuccinyl-L-leucylamido-(4-guanidio)butane (E64), a specific inhibitor of cysteine proteases []. Coupled with sequence analysis and the effects of point mutations in vif, it has been suggested that vif could be a cysteine protease. Virions produced in the absence of Vif have abnormal core morphology and those produced in primary T cells carry immature core proteins and low levels of mature capsid [].In humans, HIV-1 Vif hijacks cellular E3 ligase components containing CUL5, RBX2, ELOB, ELOC and CBFbeta, to poly-ubiquitinate antiviral cellular factors, APOBEC3 proteins [, , ]. In sheep and goats, Caprine arthritis encephalitis virus (CAEV) Vif is responsible for degradation of oaA3Z2-Z3 [].
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Publication
19188259 | J:173040
First Author: MacDuff DA
Year: 2009
Journal: Nucleic Acids Res
Title: AID can restrict L1 retrotransposition suggesting a dual role in innate and adaptive immunity.
Volume: 37
Issue: 6
Pages: 1854-67
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Publication
21398638 | J:173831
First Author: Ikeda T
Year: 2011
Journal: Nucleic Acids Res
Title: Intrinsic restriction activity by apolipoprotein B mRNA editing enzyme APOBEC1 against the mobility of autonomous retrotransposons.
Volume: 39
Issue: 13
Pages: 5538-54
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Publication
21084477 | J:193385
First Author: Sakuma T
Year: 2011
Journal: J Virol
Title: Early events in retrovirus XMRV infection of the wild-derived mouse Mus pahari.
Volume: 85
Issue: 3
Pages: 1205-13
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Publication
27758855 | J:237629
First Author: Matsui Y
Year: 2016
Journal: J Biol Chem
Title: Core Binding Factor β Protects HIV, Type 1 Accessory Protein Viral Infectivity Factor from MDM2-mediated Degradation.
Volume: 291
Issue: 48
Pages: 24892-24899
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Publication
31726973 | J:281668
First Author: Caval V
Year: 2019
Journal: BMC Genomics
Title: Mouse APOBEC1 cytidine deaminase can induce somatic mutations in chromosomal DNA.
Volume: 20
Issue: 1
Pages: 858
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Publication
33351847 | J:299494
First Author: Wei Y
Year: 2020
Journal: PLoS One
Title: Coronavirus genomes carry the signatures of their habitats.
Volume: 15
Issue: 12
Pages: e0244025
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Publication
31409681 | J:292356
 
First Author: Singh GB
Year: 2019
Journal: mBio
Title: A Protein Antagonist of Activation-Induced Cytidine Deaminase Encoded by a Complex Mouse Retrovirus.
Volume: 10
Issue: 4
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Publication
28794032 | J:256423
 
First Author: Bamunusinghe D
Year: 2017
Journal: J Virol
Title: Recombinant Origins of Pathogenic and Nonpathogenic Mouse Gammaretroviruses with Polytropic Host Range.
Volume: 91
Issue: 21
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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