Type |
Details |
Score |
Publication |
First Author: |
Byrd AE |
Year: |
2012 |
Journal: |
J Cell Biol |
Title: |
MicroRNA-30c-2* limits expression of proadaptive factor XBP1 in the unfolded protein response. |
Volume: |
196 |
Issue: |
6 |
Pages: |
689-98 |
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•
•
•
•
•
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Publication |
First Author: |
Bray ER |
Year: |
2019 |
Journal: |
Neuron |
Title: |
Thrombospondin-1 Mediates Axon Regeneration in Retinal Ganglion Cells. |
Volume: |
103 |
Issue: |
4 |
Pages: |
642-657.e7 |
|
•
•
•
•
•
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Publication |
First Author: |
Bilger A |
Year: |
2004 |
Journal: |
Genetics |
Title: |
A potent modifier of liver cancer risk on distal mouse chromosome 1: linkage analysis and characterization of congenic lines. |
Volume: |
167 |
Issue: |
2 |
Pages: |
859-66 |
|
•
•
•
•
•
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Publication |
First Author: |
Kanekura K |
Year: |
2015 |
Journal: |
Sci Signal |
Title: |
IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions. |
Volume: |
8 |
Issue: |
382 |
Pages: |
ra62 |
|
•
•
•
•
•
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Publication |
First Author: |
Tang X |
Year: |
2023 |
Journal: |
iScience |
Title: |
EMC3 regulates mesenchymal cell survival via control of the mitotic spindle assembly. |
Volume: |
26 |
Issue: |
1 |
Pages: |
105667 |
|
•
•
•
•
•
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Publication |
First Author: |
Firtina Z |
Year: |
2011 |
Journal: |
Gene Expr Patterns |
Title: |
Unfolded Protein Response (UPR) is activated during normal lens development. |
Volume: |
11 |
Issue: |
1-2 |
Pages: |
135-43 |
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•
•
•
•
•
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Publication |
First Author: |
Upton JP |
Year: |
2012 |
Journal: |
Science |
Title: |
IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. |
Volume: |
338 |
Issue: |
6108 |
Pages: |
818-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vanhoutte D |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy. |
Volume: |
12 |
Issue: |
1 |
Pages: |
3928 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kalish BT |
Year: |
2021 |
Journal: |
Nat Neurosci |
Title: |
Maternal immune activation in mice disrupts proteostasis in the fetal brain. |
Volume: |
24 |
Issue: |
2 |
Pages: |
204-213 |
|
•
•
•
•
•
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Publication |
First Author: |
Zhang X |
Year: |
2007 |
Journal: |
Int J Dev Neurosci |
Title: |
Endoplasmic reticulum stress during the embryonic development of the central nervous system in the mouse. |
Volume: |
25 |
Issue: |
7 |
Pages: |
455-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tan YY |
Year: |
2021 |
Journal: |
Front Cell Dev Biol |
Title: |
PERK Signaling Controls Myoblast Differentiation by Regulating MicroRNA Networks. |
Volume: |
9 |
|
Pages: |
670435 |
|
•
•
•
•
•
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Publication |
First Author: |
Iwawaki T |
Year: |
2009 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. |
Volume: |
106 |
Issue: |
39 |
Pages: |
16657-62 |
|
•
•
•
•
•
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Publication |
First Author: |
Mao M |
Year: |
2017 |
Journal: |
Dis Model Mech |
Title: |
Genetic dissection of anterior segment dysgenesis caused by a Col4a1 mutation in mouse. |
Volume: |
10 |
Issue: |
4 |
Pages: |
475-485 |
|
•
•
•
•
•
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Publication |
First Author: |
Yamaguchi H |
Year: |
2022 |
Journal: |
Dev Dyn |
Title: |
Disruption of Trip11 in cranial neural crest cells is associated with increased ER and Golgi stress contributing to skull defects in mice. |
Volume: |
251 |
Issue: |
7 |
Pages: |
1209-1222 |
|
•
•
•
•
•
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Publication |
First Author: |
Liang G |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Endoplasmic reticulum stress-unfolding protein response-apoptosis cascade causes chondrodysplasia in a col2a1 p.Gly1170Ser mutated mouse model. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e86894 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhao Z |
Year: |
2017 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Formation of neurodegenerative aggresome and death-inducing signaling complex in maternal diabetes-induced neural tube defects. |
Volume: |
114 |
Issue: |
17 |
Pages: |
4489-4494 |
|
•
•
•
•
•
|
Publication |
First Author: |
Park S |
Year: |
2020 |
Journal: |
Nat Commun |
Title: |
The endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonates. |
Volume: |
11 |
Issue: |
1 |
Pages: |
1914 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lindahl M |
Year: |
2014 |
Journal: |
Cell Rep |
Title: |
MANF is indispensable for the proliferation and survival of pancreatic β cells. |
Volume: |
7 |
Issue: |
2 |
Pages: |
366-75 |
|
•
•
•
•
•
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Publication |
First Author: |
Pakarinen E |
Year: |
2020 |
Journal: |
eNeuro |
Title: |
MANF Ablation Causes Prolonged Activation of the UPR without Neurodegeneration in the Mouse Midbrain Dopamine System. |
Volume: |
7 |
Issue: |
1 |
|
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•
•
•
•
•
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Publication |
First Author: |
Guo CG |
Year: |
2023 |
Journal: |
Mol Metab |
Title: |
Intestinal SURF4 is essential for apolipoprotein transport and lipoprotein secretion. |
Volume: |
79 |
|
Pages: |
101847 |
|
•
•
•
•
•
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Publication |
First Author: |
Aryal YP |
Year: |
2019 |
Journal: |
J Cell Physiol |
Title: |
An endoplasmic reticulum stress regulator, Tmbim6, modulates secretory stage of mice molar. |
Volume: |
234 |
Issue: |
11 |
Pages: |
20354-20365 |
|
•
•
•
•
•
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Publication |
First Author: |
Cao X |
Year: |
2021 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
EMC3 Is Essential for Retinal Organization and Neurogenesis During Mouse Retinal Development. |
Volume: |
62 |
Issue: |
2 |
Pages: |
31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Firtina Z |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
Abnormal expression of collagen IV in lens activates unfolded protein response resulting in cataract. |
Volume: |
284 |
Issue: |
51 |
Pages: |
35872-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang R |
Year: |
2019 |
Journal: |
Development |
Title: |
CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development. |
Volume: |
146 |
Issue: |
2 |
|
|
•
•
•
•
•
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Publication |
First Author: |
Bojanic DD |
Year: |
2010 |
Journal: |
J Lipid Res |
Title: |
Differential expression and function of ABCG1 and ABCG4 during development and aging. |
Volume: |
51 |
Issue: |
1 |
Pages: |
169-81 |
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•
•
•
•
•
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Publication |
First Author: |
Pakarinen E |
Year: |
2022 |
Journal: |
Cell Mol Life Sci |
Title: |
CDNF and MANF regulate ER stress in a tissue-specific manner. |
Volume: |
79 |
Issue: |
2 |
Pages: |
124 |
|
•
•
•
•
•
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Publication |
First Author: |
Jiang M |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
Regulation of PERK-eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes. |
Volume: |
7 |
|
Pages: |
12185 |
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•
•
•
•
•
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Publication |
First Author: |
Guo M |
Year: |
2019 |
Journal: |
Nat Commun |
Title: |
Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth. |
Volume: |
10 |
Issue: |
1 |
Pages: |
37 |
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•
•
•
•
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Publication |
First Author: |
Borisova E |
Year: |
2024 |
Journal: |
Nat Commun |
Title: |
Protein translation rate determines neocortical neuron fate. |
Volume: |
15 |
Issue: |
1 |
Pages: |
4879 |
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•
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•
•
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Publication |
First Author: |
Wang X |
Year: |
2009 |
Journal: |
J Cell Biol |
Title: |
Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice. |
Volume: |
184 |
Issue: |
1 |
Pages: |
143-58 |
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•
•
•
•
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Publication |
First Author: |
Wang DY |
Year: |
2014 |
Journal: |
J Am Heart Assoc |
Title: |
Endoplasmic reticulum resident protein 44 (ERp44) deficiency in mice and zebrafish leads to cardiac developmental and functional defects. |
Volume: |
3 |
Issue: |
5 |
Pages: |
e001018 |
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Publication |
First Author: |
Danilova T |
Year: |
2019 |
Journal: |
Front Endocrinol (Lausanne) |
Title: |
Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Is Highly Expressed in Mouse Tissues With Metabolic Function. |
Volume: |
10 |
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Pages: |
765 |
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Publication |
First Author: |
Yan W |
Year: |
2024 |
Journal: |
Commun Biol |
Title: |
Loss of Mptx2 alters bacteria composition and intestinal homeostasis potentially by impairing autophagy. |
Volume: |
7 |
Issue: |
1 |
Pages: |
94 |
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Publication |
First Author: |
Jazwiec PA |
Year: |
2022 |
Journal: |
Biol Reprod |
Title: |
Paternal obesity induces placental hypoxia and sex-specific impairments in placental vascularization and offspring metabolism†. |
Volume: |
107 |
Issue: |
2 |
Pages: |
574-589 |
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Publication |
First Author: |
Eddleston J |
Year: |
1999 |
Journal: |
Genomics |
Title: |
Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). |
Volume: |
56 |
Issue: |
2 |
Pages: |
149-59 |
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Publication |
First Author: |
Neupane S |
Year: |
2022 |
Journal: |
Matrix Biol |
Title: |
O-fucosylation of thrombospondin type 1 repeats is essential for ECM remodeling and signaling during bone development. |
Volume: |
107 |
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Pages: |
77-96 |
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Publication |
First Author: |
Xu L |
Year: |
2024 |
Journal: |
Cell Stem Cell |
Title: |
Context-dependent roles of mitochondrial LONP1 in orchestrating the balance between airway progenitor versus progeny cells. |
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Publication |
First Author: |
Flodby P |
Year: |
2016 |
Journal: |
Am J Respir Cell Mol Biol |
Title: |
The 78-kD Glucose-Regulated Protein Regulates Endoplasmic Reticulum Homeostasis and Distal Epithelial Cell Survival during Lung Development. |
Volume: |
55 |
Issue: |
1 |
Pages: |
135-49 |
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Publication |
First Author: |
Tian E |
Year: |
2012 |
Journal: |
Nat Commun |
Title: |
O-glycosylation modulates integrin and FGF signalling by influencing the secretion of basement membrane components. |
Volume: |
3 |
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Pages: |
869 |
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Publication |
First Author: |
Muñoz-Gallardo MDM |
Year: |
2024 |
Journal: |
Sci Rep |
Title: |
miR-195b is required for proper cellular homeostasis in the elderly. |
Volume: |
14 |
Issue: |
1 |
Pages: |
810 |
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Publication |
First Author: |
Wang N |
Year: |
2022 |
Journal: |
Neuron |
Title: |
Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures. |
Volume: |
110 |
Issue: |
20 |
Pages: |
3318-3338.e9 |
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First Author: |
Park EJ |
Year: |
2023 |
Journal: |
Nat Commun |
Title: |
Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation. |
Volume: |
14 |
Issue: |
1 |
Pages: |
1097 |
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Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
Journal: |
Database Download |
Title: |
Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
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Title: |
FANTOM2 Data Curation in Mouse Genome Informatics |
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Publication |
First Author: |
Hansen J |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
Volume: |
100 |
Issue: |
17 |
Pages: |
9918-22 |
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First Author: |
Friedel RH |
Year: |
2007 |
Journal: |
Brief Funct Genomic Proteomic |
Title: |
EUCOMM--the European conditional mouse mutagenesis program. |
Volume: |
6 |
Issue: |
3 |
Pages: |
180-5 |
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First Author: |
Gray PA |
Year: |
2004 |
Journal: |
Science |
Title: |
Mouse brain organization revealed through direct genome-scale TF expression analysis. |
Volume: |
306 |
Issue: |
5705 |
Pages: |
2255-7 |
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First Author: |
Visel A |
Year: |
2004 |
Journal: |
Nucleic Acids Res |
Title: |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
Volume: |
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Pages: |
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First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
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First Author: |
Lennon G |
Year: |
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Journal: |
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Title: |
WashU-HHMI Mouse EST Project |
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First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
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Issue: |
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First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
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Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
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First Author: |
UniProt-GOA |
Year: |
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Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
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First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
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Title: |
MGI Sequence Curation Reference |
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First Author: |
Kawai J |
Year: |
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Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
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MGD Nomenclature Committee |
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Year: |
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Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
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Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
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Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
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Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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UniProt-GOA |
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Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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Mouse Genome Informatics Scientific Curators |
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Mouse Genome Informatics Computational Sequence to Gene Associations |
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Mouse Genome Informatics Scientific Curators |
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Database Download |
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MGI-UniGene Interconnection Effort |
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2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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Mouse Genome Database and National Center for Biotechnology Information |
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Allen Institute for Brain Science |
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Allen Brain Atlas: mouse riboprobes |
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Mouse Genome Informatics Scientific Curators |
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
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First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Pathway |
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Publication |
First Author: |
Gonzalo-Gobernado R |
Year: |
2023 |
Journal: |
Int J Mol Sci |
Title: |
Repaglinide Induces ATF6 Processing and Neuroprotection in Transgenic SOD1G93A Mice. |
Volume: |
24 |
Issue: |
21 |
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Publication |
First Author: |
Wang Q |
Year: |
2021 |
Journal: |
Cell Immunol |
Title: |
ATF6 promotes liver fibrogenesis by regulating macrophage-derived interleukin-1α expression. |
Volume: |
367 |
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Pages: |
104401 |
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HT Experiment |
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Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
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Allele |
Name: |
activating transcription factor 6; targeted mutation 1, Gokhan S Hotamisligil |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change |
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Publication |
First Author: |
Coleman OI |
Year: |
2018 |
Journal: |
Gastroenterology |
Title: |
Activated ATF6 Induces Intestinal Dysbiosis and Innate Immune Response to Promote Colorectal Tumorigenesis. |
Volume: |
155 |
Issue: |
5 |
Pages: |
1539-1552.e12 |
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Publication |
First Author: |
Schindler AJ |
Year: |
2009 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles. |
Volume: |
106 |
Issue: |
42 |
Pages: |
17775-80 |
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Publication |
First Author: |
Lee K |
Year: |
2002 |
Journal: |
Genes Dev |
Title: |
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. |
Volume: |
16 |
Issue: |
4 |
Pages: |
452-66 |
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Publication |
First Author: |
Shen Y |
Year: |
2021 |
Journal: |
J Am Heart Assoc |
Title: |
Activation of the ATF6 (Activating Transcription Factor 6) Signaling Pathway in Neurons Improves Outcome After Cardiac Arrest in Mice. |
Volume: |
10 |
Issue: |
12 |
Pages: |
e020216 |
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GO Term |
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Publication |
First Author: |
Nozaki Ji |
Year: |
2004 |
Journal: |
Genes Cells |
Title: |
The endoplasmic reticulum stress response is stimulated through the continuous activation of transcription factors ATF6 and XBP1 in Ins2+/Akita pancreatic beta cells. |
Volume: |
9 |
Issue: |
3 |
Pages: |
261-70 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
656
 |
Fragment?: |
false |
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Publication |
First Author: |
Hong M |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
Underglycosylation of ATF6 as a novel sensing mechanism for activation of the unfolded protein response. |
Volume: |
279 |
Issue: |
12 |
Pages: |
11354-63 |
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Allele |
Name: |
activating transcription factor 6; targeted mutation 1.1, Randal J Kaufman |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
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Genotype |
Symbol: |
Atf6/Atf6 |
Background: |
involves: C57BL/6 * C57BL/6J |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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DO Term |
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Publication |
First Author: |
Thuerauf DJ |
Year: |
2007 |
Journal: |
J Biol Chem |
Title: |
Effects of the isoform-specific characteristics of ATF6 alpha and ATF6 beta on endoplasmic reticulum stress response gene expression and cell viability. |
Volume: |
282 |
Issue: |
31 |
Pages: |
22865-78 |
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Allele |
Name: |
activating transcription factor 6; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
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Publication |
First Author: |
Ranjan K |
Year: |
2021 |
Journal: |
J Clin Invest |
Title: |
Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response. |
Volume: |
131 |
Issue: |
17 |
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