Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Allele |
Name: |
attractin; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Recombinase |
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Allele |
Name: |
attractin; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
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Allele |
Name: |
attractin; mahogany 3 Jackson |
Allele Type: |
Spontaneous |
Attribute String: |
Null/knockout |
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Strain |
Attribute String: |
mutant strain, spontaneous mutation |
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Strain |
Attribute String: |
spontaneous mutation, mutant strain, coisogenic |
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Strain |
Attribute String: |
coisogenic, mutant strain, spontaneous mutation |
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Allele |
Name: |
attractin; mahogany 6 Jackson |
Allele Type: |
Spontaneous |
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Genotype |
Symbol: |
Atrn/Atrn |
Background: |
C3HeB/FeJ-Atrn/J |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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•
•
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•
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Genotype |
Symbol: |
Atrn/Atrn |
Background: |
C3HeB/FeJ-Atrn |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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•
•
•
•
•
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Genotype |
Symbol: |
Atrn/Atrn |
Background: |
involves: C3H/HeJ * C3HeB/FeJ * CBA/J |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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Publication |
First Author: |
Haqq AM |
Year: |
2003 |
Journal: |
Biochem J |
Title: |
Characterization of a novel binding partner of the melanocortin-4 receptor: attractin-like protein. |
Volume: |
376 |
Issue: |
Pt 3 |
Pages: |
595-605 |
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Publication |
First Author: |
Duke-Cohan JS |
Year: |
1998 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions. |
Volume: |
95 |
Issue: |
19 |
Pages: |
11336-41 |
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Publication |
First Author: |
Duke-Cohan JS |
Year: |
2000 |
Journal: |
Adv Exp Med Biol |
Title: |
Attractin: a cub-family protease involved in T cell-monocyte/macrophage interactions. |
Volume: |
477 |
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Pages: |
173-85 |
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Publication |
First Author: |
Yeo GS |
Year: |
2003 |
Journal: |
Biochem J |
Title: |
Attractin' more attention - new pieces in the obesity puzzle? |
Volume: |
376 |
Issue: |
Pt 3 |
Pages: |
e7-8 |
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Publication |
First Author: |
Pozzi N |
Year: |
2001 |
Journal: |
Clin Exp Immunol |
Title: |
Defective surface expression of attractin on T cells in patients with common variable immunodeficiency (CVID). |
Volume: |
123 |
Issue: |
1 |
Pages: |
99-104 |
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Publication |
First Author: |
Muto Y |
Year: |
2003 |
Journal: |
Brain Res Mol Brain Res |
Title: |
Pivotal role of attractin in cell survival under oxidative stress in the zitter rat brain with genetic spongiform encephalopathy. |
Volume: |
111 |
Issue: |
1-2 |
Pages: |
111-22 |
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Protein Domain |
Type: |
Domain |
Description: |
This C-type lectin-like domain (CTLD) is found in human and mouse attractin (AtrN) and attractin-like protein (ALP). CTLD refers to a domain homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins. Mouse AtrN (the product of the mahogany gene) has been shown to bind Agouti protein and to function in agouti-induced pigmentation and obesity []. Mutations in AtrN have also been shown to cause spongiform encephalopathy and hypomyelination in rats and hamsters [, , ]. The cytoplasmic region of mouse ALP has been shown to bind to melanocortin receptor (MCR4) []. Signaling through MCR4 plays a role in appetite suppression. Attractin may have therapeutic potential in the treatment of obesity []. Human attractin (hAtrN) has been shown to be expressed on activated T cells and released extracellularly. The circulating serum attractin induces the spreading of monocytes that become the focus of the clustering of non-proliferating T cells [, , ]. |
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Allele |
Name: |
attractin; mahogany |
Allele Type: |
Spontaneous |
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Strain |
Attribute String: |
mutant stock |
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Strain |
Attribute String: |
congenic, mutant strain, spontaneous mutation |
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Strain |
Attribute String: |
inbred strain |
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Strain |
Attribute String: |
congenic, mutant strain |
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Genotype |
Symbol: |
Atrn/Atrn |
Background: |
LDJ/Le |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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•
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Genotype |
Symbol: |
Atrn/Atrn |
Background: |
CAST/Ei-Atrn |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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Genotype |
Symbol: |
Atrn/Atrn |
Background: |
involves: C3H/HeSnJ * CAST/Ei |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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Genotype |
Symbol: |
Atrn/Atrn |
Background: |
C3H/HeJ.Cg-Atrn |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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Genotype |
Symbol: |
Atrn/Atrn Tg(ACTB-Atrnl1)B4Tmg/? |
Background: |
involves: C3HeB/FeJ * C57BL/6 * DBA/2 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
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Genotype |
Symbol: |
Atrn/Atrn Atrnl1/Atrnl1 |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C3H * C3HeB/FeJ |
Zygosity: |
cx |
Has Mutant Allele: |
true |
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Strain |
Attribute String: |
mutant stock |
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Strain |
Attribute String: |
mutant stock |
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Genotype |
Symbol: |
Atrn/Atrn<+> Pepd/Pepd |
Background: |
involves: C3H/HeJ * C3HeB/FeJ * CBA/J |
Zygosity: |
cx |
Has Mutant Allele: |
true |
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•
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Genotype |
Symbol: |
Atrn/Atrn<+> Pepd/Pepd<+> |
Background: |
involves: C3H/HeJ * C3HeB/FeJ * CBA/J |
Zygosity: |
cx |
Has Mutant Allele: |
true |
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Strain |
Attribute String: |
mutant stock |
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Strain |
Attribute String: |
congenic, mutant strain, spontaneous mutation |
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Strain |
Attribute String: |
inbred strain, spontaneous mutation |
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Publication |
First Author: |
Yi R |
Year: |
2024 |
Journal: |
CNS Neurosci Ther |
Title: |
GABAergic neurons of anterior thalamic reticular nucleus regulate states of consciousness in propofol- and isoflurane-mediated general anesthesia. |
Volume: |
30 |
Issue: |
6 |
Pages: |
e14782 |
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Strain |
Attribute String: |
mutant strain |
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Strain |
Attribute String: |
mutant stock, spontaneous mutation |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1378
 |
Fragment?: |
false |
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