|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 301 to 400 out of 552 for Bace1

<< First    < Previous  |  Next >    Last >>
0.031s

Categories

Hits by Category

Hits by Strain

Type Details Score
Publication
11740561 | J:73257
First Author: Kamal A
Year: 2001
Journal: Nature
Title: Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP.
Volume: 414
Issue: 6864
Pages: 643-8
•
•
•
•
•
Publication
17573534 | J:122497
First Author: Parkin ET
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein.
Volume: 104
Issue: 26
Pages: 11062-7
•
•
•
•
•
Publication
24630972 | J:216265
 
First Author: Pajoohesh-Ganji A
Year: 2014
Journal: Brain Res
Title: Inhibition of amyloid precursor protein secretases reduces recovery after spinal cord injury.
Volume: 1560
Pages: 73-82
•
•
•
•
•
Publication
28739891 | J:244685
First Author: Keskin AD
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: BACE inhibition-dependent repair of Alzheimer's pathophysiology.
Volume: 114
Issue: 32
Pages: 8631-8636
•
•
•
•
•
Publication
15123597 | J:91545
First Author: Rossner S
Year: 2004
Journal: J Biol Chem
Title: Munc13-1-mediated vesicle priming contributes to secretory amyloid precursor protein processing.
Volume: 279
Issue: 27
Pages: 27841-4
•
•
•
•
•
Publication
18845544 | J:144412
First Author: Saito Y
Year: 2008
Journal: J Biol Chem
Title: X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain.
Volume: 283
Issue: 51
Pages: 35763-71
•
•
•
•
•
Publication
19737556 | J:153764
First Author: Bloch L
Year: 2009
Journal: FEBS Lett
Title: Klotho is a substrate for alpha-, beta- and gamma-secretase.
Volume: 583
Issue: 19
Pages: 3221-4
•
•
•
•
•
Publication
19118188 | J:239203
First Author: Puzzo D
Year: 2008
Journal: J Neurosci
Title: Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus.
Volume: 28
Issue: 53
Pages: 14537-45
•
•
•
•
•
Publication
20212127 | J:158688
First Author: Seshadri S
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Disrupted-in-Schizophrenia-1 expression is regulated by beta-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade.
Volume: 107
Issue: 12
Pages: 5622-7
•
•
•
•
•
Publication
17920016 | J:126954
First Author: Liu Q
Year: 2007
Journal: Neuron
Title: Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1.
Volume: 56
Issue: 1
Pages: 66-78
•
•
•
•
•
Publication
23274884 | J:199052
First Author: Niedowicz DM
Year: 2013
Journal: Biochim Biophys Acta
Title: Leptin regulates amyloid β production via the γ-secretase complex.
Volume: 1832
Issue: 3
Pages: 439-44
•
•
•
•
•
Publication
11032903 | J:65205
First Author: Marcinkiewicz M
Year: 2000
Journal: J Neurochem
Title: Coordinated expression of beta-amyloid precursor protein and the putative beta-secretase BACE and alpha-secretase ADAM10 in mouse and human brain.
Volume: 75
Issue: 5
Pages: 2133-43
•
•
•
•
•
Publication
14717705 | J:97674
First Author: Culvenor JG
Year: 2004
Journal: Eur J Biochem
Title: Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations.
Volume: 271
Issue: 2
Pages: 375-85
•
•
•
•
•
Publication
19357271 | J:147429
First Author: Hoey SE
Year: 2009
Journal: J Neurosci
Title: Synaptic NMDA receptor activation stimulates alpha-secretase amyloid precursor protein processing and inhibits amyloid-beta production.
Volume: 29
Issue: 14
Pages: 4442-60
•
•
•
•
•
Publication
15886206 | J:100835
First Author: Vetrivel KS
Year: 2005
Journal: J Biol Chem
Title: Spatial segregation of gamma-secretase and substrates in distinct membrane domains.
Volume: 280
Issue: 27
Pages: 25892-900
•
•
•
•
•
Publication
19935654 | J:155532
First Author: Ohno M
Year: 2009
Journal: Nat Neurosci
Title: Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system.
Volume: 12
Issue: 12
Pages: 1506-13
•
•
•
•
•
Publication
34613632 | J:317051
First Author: Tüshaus J
Year: 2021
Journal: FASEB J
Title: The pseudoprotease iRhom1 controls ectodomain shedding of membrane proteins in the nervous system.
Volume: 35
Issue: 11
Pages: e21962
•
•
•
•
•
Publication
27707970 | J:235934
First Author: Fleming MS
Year: 2016
Journal: J Neurosci
Title: A RET-ER81-NRG1 Signaling Pathway Drives the Development of Pacinian Corpuscles.
Volume: 36
Issue: 40
Pages: 10337-10355
•
•
•
•
•
Publication
36765071 | J:333392
First Author: Cao R
Year: 2023
Journal: Nat Commun
Title: Intrafusal-fiber LRP4 for muscle spindle formation and maintenance in adult and aged animals.
Volume: 14
Issue: 1
Pages: 744
•
•
•
•
•
Publication
- | J:147112
     
First Author: Taconic
Year: 2006
Journal: MGI Direct Data Submission
Title: Information obtained from Taconic website.
•
•
•
•
•
Publication
32290105 | J:282558
 
First Author: Collin GB
Year: 2020
Journal: Cells
Title: Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.
Volume: 9
Issue: 4
•
•
•
•
•
Publication
- | J:94338
     
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
•
•
•
•
•
Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
•
•
•
•
•
Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
•
•
•
•
•
Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
•
•
•
•
•
Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
•
•
•
•
•
Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
•
•
•
•
•
Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
•
•
•
•
•
Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
•
•
•
•
•
Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
•
•
•
•
•
Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
•
•
•
•
•
Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
•
•
•
•
•
Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
•
•
•
•
•
Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
•
•
•
•
•
Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
•
•
•
•
•
Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
•
•
•
•
•
Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
•
•
•
•
•
Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
•
•
•
•
•
Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
•
•
•
•
•
Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
•
•
•
•
•
Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
•
•
•
•
•
Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
HT Experiment
GSE217960 | Postnatal neuronal Bace1 deletion impairs neuroblast and oligodendrocyte maturation
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
•
•
•
•
•
Publication
27138913 | J:236062
First Author: Plucińska K
Year: 2016
Journal: Diabetologia
Title: Neuronal human BACE1 knockin induces systemic diabetes in mice.
Volume: 59
Issue: 7
Pages: 1513-1523
•
•
•
•
•
Publication
21565331 | J:172500
 
First Author: Zong Y
Year: 2011
Journal: Brain Res
Title: miR-29c regulates BACE1 protein expression.
Volume: 1395
Pages: 108-15
•
•
•
•
•
Publication
33892080 | J:320451
First Author: Dekeryte R
Year: 2021
Journal: Biochim Biophys Acta Mol Basis Dis
Title: The BACE1 inhibitor LY2886721 improves diabetic phenotypes of BACE1 knock-in mice.
Volume: 1867
Issue: 7
Pages: 166149
•
•
•
•
•
Publication
22975420 | J:194511
First Author: Yun SM
Year: 2013
Journal: Neurobiol Aging
Title: SUMO1 modulates Aβ generation via BACE1 accumulation.
Volume: 34
Issue: 3
Pages: 650-62
•
•
•
•
•
HT Experiment
GSE230116 | BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of beta-amyloid peptides
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
•
•
•
•
•
Publication
25100603 | J:215577
First Author: Plucińska K
Year: 2014
Journal: J Neurosci
Title: Knock-in of human BACE1 cleaves murine APP and reiterates Alzheimer-like phenotypes.
Volume: 34
Issue: 32
Pages: 10710-28
•
•
•
•
•
Publication
19508864 | J:150654
First Author: Cho HJ
Year: 2009
Journal: Biochem Biophys Res Commun
Title: Constitutive JAK2/STAT1 activation regulates endogenous BACE1 expression in neurons.
Volume: 386
Issue: 1
Pages: 175-80
•
•
•
•
•
Publication
37239217 | J:348317
 
First Author: Liu Y
Year: 2023
Journal: Brain Sci
Title: DEAD-Box Helicase 17 Promotes Amyloidogenesis by Regulating BACE1 Translation.
Volume: 13
Issue: 5
•
•
•
•
•
Publication
32920833 | J:308589
First Author: Li KY
Year: 2021
Journal: J Neurochem
Title: Mitochondrial TXN2 attenuates amyloidogenesis via selective inhibition of BACE1 expression.
Volume: 157
Issue: 4
Pages: 1351-1365
•
•
•
•
•
Publication
17596707 | J:162531
First Author: Herzig MC
Year: 2007
Journal: Neurodegener Dis
Title: BACE1 and mutated presenilin-1 differently modulate Abeta40 and Abeta42 levels and cerebral amyloidosis in APPDutch transgenic mice.
Volume: 4
Issue: 2-3
Pages: 127-35
•
•
•
•
•
Publication
17121991 | J:118288
First Author: Sun X
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression.
Volume: 103
Issue: 49
Pages: 18727-32
•
•
•
•
•
Publication
16136043 | J:101700
First Author: Singer O
Year: 2005
Journal: Nat Neurosci
Title: Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model.
Volume: 8
Issue: 10
Pages: 1343-9
•
•
•
•
•
Publication
22212137 | J:183721
First Author: Zhang M
Year: 2012
Journal: J Neurochem
Title: Control of BACE1 degradation and APP processing by ubiquitin carboxyl-terminal hydrolase L1.
Volume: 120
Issue: 6
Pages: 1129-38
•
•
•
•
•
Publication
30411846 | J:273257
First Author: Kim HJ
Year: 2019
Journal: Aging Cell
Title: Carbon monoxide attenuates amyloidogenesis via down-regulation of NF-κB-mediated BACE1 gene expression.
Volume: 18
Issue: 1
Pages: e12864
•
•
•
•
•
Publication
34118085 | J:310781
First Author: Schnöder L
Year: 2021
Journal: FASEB J
Title: P38α-MAPK phosphorylates Snapin and reduces Snapin-mediated BACE1 transportation in APP-transgenic mice.
Volume: 35
Issue: 7
Pages: e21691
•
•
•
•
•
Publication
25319692 | J:217161
First Author: Shi Q
Year: 2014
Journal: J Neurosci
Title: Impact of RTN3 deficiency on expression of BACE1 and amyloid deposition.
Volume: 34
Issue: 42
Pages: 13954-62
•
•
•
•
•
Publication
17331621 | J:140920
First Author: Kobayashi D
Year: 2008
Journal: Neurobiol Aging
Title: BACE1 gene deletion: impact on behavioral function in a model of Alzheimer's disease.
Volume: 29
Issue: 6
Pages: 861-73
•
•
•
•
•
Publication
31422108 | J:291336
 
First Author: Saadipour K
Year: 2019
Journal: Mol Cell Neurosci
Title: Regulation of BACE1 expression after injury is linked to the p75 neurotrophin receptor.
Volume: 99
Pages: 103395
•
•
•
•
•
Publication
22306812 | J:185010
First Author: Mouton-Liger F
Year: 2012
Journal: Biochim Biophys Acta
Title: Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2α pathway.
Volume: 1822
Issue: 6
Pages: 885-96
•
•
•
•
•
Publication
38971310 | J:353398
First Author: Pu Y
Year: 2024
Journal: J Biol Chem
Title: MGST3 regulates BACE1 protein translation and amyloidogenesis by controlling the RGS4-mediated AKT signaling pathway.
Volume: 300
Issue: 8
Pages: 107530
•
•
•
•
•
Publication
20089133 | J:174832
First Author: Kimura R
Year: 2010
Journal: J Neurochem
Title: Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer's disease transgenic mice.
Volume: 113
Issue: 1
Pages: 248-61
•
•
•
•
•
Publication
21329555 | J:287036
First Author: Chen CH
Year: 2012
Journal: Int J Neuropsychopharmacol
Title: Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease.
Volume: 15
Issue: 1
Pages: 77-90
•
•
•
•
•
Publication
29315574 | J:260623
First Author: Marwarha G
Year: 2018
Journal: J Neurochem
Title: Palmitate-induced C/EBP homologous protein activation leads to NF-κB-mediated increase in BACE1 activity and amyloid beta genesis.
Volume: 144
Issue: 6
Pages: 761-779
•
•
•
•
•
Publication
24462621 | J:215369
 
First Author: Adwan L
Year: 2014
Journal: Neuropharmacology
Title: Tolfenamic acid downregulates BACE1 and protects against lead-induced upregulation of Alzheimer's disease related biomarkers.
Volume: 79
Pages: 596-602
•
•
•
•
•
Publication
37569661 | J:355321
 
First Author: Pratsch K
Year: 2023
Journal: Int J Mol Sci
Title: New Highly Selective BACE1 Inhibitors and Their Effects on Dendritic Spine Density In Vivo.
Volume: 24
Issue: 15
•
•
•
•
•
Publication
24373968 | J:207508
First Author: Ye X
Year: 2014
Journal: Cell Rep
Title: Snapin-mediated BACE1 retrograde transport is essential for its degradation in lysosomes and regulation of APP processing in neurons.
Volume: 6
Issue: 1
Pages: 24-31
•
•
•
•
•
Publication
32973454 | J:311250
 
First Author: Guan Z
Year: 2020
Journal: Front Cell Neurosci
Title: Progranulin Administration Attenuates β-Amyloid Deposition in the Hippocampus of 5xFAD Mice Through Modulating BACE1 Expression and Microglial Phagocytosis.
Volume: 14
Pages: 260
•
•
•
•
•
Publication
31701556 | J:286014
First Author: Peters F
Year: 2019
Journal: EMBO J
Title: Tau deletion reduces plaque-associated BACE1 accumulation and decelerates plaque formation in a mouse model of Alzheimer's disease.
Volume: 38
Issue: 23
Pages: e102345
•
•
•
•
•
Publication
23637177 | J:325503
First Author: Fleck D
Year: 2013
Journal: J Neurosci
Title: Dual cleavage of neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling.
Volume: 33
Issue: 18
Pages: 7856-69
•
•
•
•
•
Publication
29743204 | J:263678
First Author: Dafnis I
Year: 2018
Journal: Biochem J
Title: ApoE isoforms and carboxyl-terminal-truncated apoE4 forms affect neuronal BACE1 levels and Aβ production independently of their cholesterol efflux capacity.
Volume: 475
Issue: 10
Pages: 1839-1859
•
•
•
•
•
Publication
37420104 | J:359082
First Author: Wang MD
Year: 2023
Journal: Acta Pharmacol Sin
Title: Salvianolic acid B ameliorates retinal deficits in an early-stage Alzheimer's disease mouse model through downregulating BACE1 and Aβ generation.
Volume: 44
Issue: 11
Pages: 2151-2168
•
•
•
•
•
Publication
29078331 | J:254186
First Author: Andrew RJ
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease.
Volume: 114
Issue: 45
Pages: E9665-E9674
•
•
•
•
•
Publication
17098871 | J:117130
First Author: Majercak J
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease.
Volume: 103
Issue: 47
Pages: 17967-72
•
•
•
•
•
Interaction Experiment
Gong B (2010)
Description: SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimers disease amyloidosis and improves synaptic function.
•
•
•
•
•
Interaction Experiment
Lakshmana MK (2009)
Description: Novel role of RanBP9 in BACE1 processing of amyloid precursor protein and amyloid beta peptide generation.
•
•
•
•
•
Interaction Experiment
Perdigao C (2021)
Description: Alzheimers disease BIN1 coding variants increase intracellular A? levels by interfering with BACE1 recycling.
•
•
•
•
•
Publication
26582141 | J:290046
 
First Author: Hou X
Year: 2015
Journal: Front Aging Neurosci
Title: Differential contributions of ApoE4 and female sex to BACE1 activity and expression mediate Aβ deposition and learning and memory in mouse models of Alzheimer's disease.
Volume: 7
Pages: 207
•
•
•
•
•
Publication
29391027 | J:264995
First Author: Kim W
Year: 2018
Journal: Mol Neurodegener
Title: BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice.
Volume: 13
Issue: 1
Pages: 6
•
•
•
•
•
Publication
24992504 | J:218929
First Author: Sadleir KR
Year: 2014
Journal: PLoS One
Title: Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease.
Volume: 9
Issue: 7
Pages: e101643
•
•
•
•
•
Publication
22492996 | J:184612
First Author: Mao P
Year: 2012
Journal: Hum Mol Genet
Title: Mitochondria-targeted catalase reduces abnormal APP processing, amyloid β production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension.
Volume: 21
Issue: 13
Pages: 2973-90
•
•
•
•
•
Publication
36939283 | J:350959
First Author: Kumro J
Year: 2023
Journal: Cereb Cortex
Title: Chronic basal forebrain activation improves spatial memory, boosts neurotrophin receptor expression, and lowers BACE1 and Aβ42 levels in the cerebral cortex in mice.
Volume: 33
Issue: 12
Pages: 7627-7641
•
•
•
•
•
Allele
Tg(CAG-BACE1)2Rbrc | MGI:7496012
Name: transgene insertion 2, RIKEN BioResource Center
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
•
•
•
•
•
Allele
Tg(Thy1-BACE1)54/4Ppa | MGI:4819402
Name: transgene insertion 54/4, Paolo Paganetti
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
•
•
•
•
•
Allele
Tg(Thy1-BACE1)54/11Ppa | MGI:4819403
Name: transgene insertion 54/11, Paolo Paganetti
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom