Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:3506292 |
Assay Type: |
RNA in situ |
Annotation Date: |
2004-12-03 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3267927 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3507815 |
Age: |
postnatal newborn |
Image: |
2 |
|
Specimen Label: |
2 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506292 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:2852723 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5539311 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:5612 |
|
Specimen Label: |
GUDMAP:5612 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506292 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:2852723 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5539311 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:12590 |
|
Specimen Label: |
GUDMAP:12590 |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506292 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:2852723 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5539311 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:12591 |
|
Specimen Label: |
GUDMAP:12591 |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506292 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:2852723 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5539311 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:13617 |
|
Specimen Label: |
GUDMAP:13617 |
Detected: |
false |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506292 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:2874723 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5539311 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:12591 |
|
Specimen Label: |
GUDMAP:12591 |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506292 |
Assay Type: |
RNA in situ |
Annotation Date: |
2004-12-03 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757721 |
|
Stage: |
TS21 |
Assay Id: |
MGI:3507815 |
Age: |
embryonic day 13.5 |
Image: |
1 |
|
Specimen Label: |
1 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506292 |
Assay Type: |
RNA in situ |
Annotation Date: |
2004-12-03 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757727 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3507815 |
Age: |
postnatal newborn |
Image: |
2 |
|
Specimen Label: |
2 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506292 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:2776423 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5539311 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:13617 |
|
Specimen Label: |
GUDMAP:13617 |
Detected: |
false |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506292 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:2850023 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5539311 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:5612 |
|
Specimen Label: |
GUDMAP:5612 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506292 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:2850023 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5539311 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:12590 |
|
Specimen Label: |
GUDMAP:12590 |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506292 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:2850023 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5539311 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:12591 |
|
Specimen Label: |
GUDMAP:12591 |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506292 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:2850023 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5539311 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:13617 |
|
Specimen Label: |
GUDMAP:13617 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506292 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:2860123 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5539311 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:12249 |
|
Specimen Label: |
GUDMAP:12249 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506292 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:1796223 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5539311 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:12591 |
|
Specimen Label: |
GUDMAP:12591 |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506292 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:2772123 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5539311 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:13617 |
|
Specimen Label: |
GUDMAP:13617 |
Detected: |
false |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3506292 |
Assay Type: |
RNA in situ |
Annotation Date: |
2021-03-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3817723 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:6513160 |
Age: |
embryonic day 15.5 |
|
Note: |
Both sexes were examined; no reproducible differences were detected between them. |
Specimen Label: |
Table 3 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ito N |
Year: |
2009 |
Journal: |
Genes Cells |
Title: |
Crystal structure of the Bach1 BTB domain and its regulation of homodimerization. |
Volume: |
14 |
Issue: |
2 |
Pages: |
167-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Russ BE |
Year: |
2023 |
Journal: |
Cell Rep |
Title: |
Active maintenance of CD8(+) TÂ cell naivety through regulation of global genome architecture. |
Volume: |
42 |
Issue: |
10 |
Pages: |
113301 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kurotaki D |
Year: |
2018 |
Journal: |
Cell Rep |
Title: |
Transcription Factor IRF8 Governs Enhancer Landscape Dynamics in Mononuclear Phagocyte Progenitors. |
Volume: |
22 |
Issue: |
10 |
Pages: |
2628-2641 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
1 |
Description: |
Transcription regulator protein BACH2 |
Type: |
chain |
End: |
839 |
|
•
•
•
•
•
|
Publication |
First Author: |
Katsuoka F |
Year: |
2003 |
Journal: |
Mol Cell Biol |
Title: |
Small Maf compound mutants display central nervous system neuronal degeneration, aberrant transcription, and Bach protein mislocalization coincident with myoclonus and abnormal startle response. |
Volume: |
23 |
Issue: |
4 |
Pages: |
1163-74 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
132
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Khor B |
Year: |
2015 |
Journal: |
Elife |
Title: |
The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells. |
Volume: |
4 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Gu Y |
Year: |
2022 |
Journal: |
Cell Rep |
Title: |
Multi-omics profiling visualizes dynamics of cardiac development and functions. |
Volume: |
41 |
Issue: |
13 |
Pages: |
111891 |
|
•
•
•
•
•
|
Publication |
First Author: |
Feng J |
Year: |
2022 |
Journal: |
Elife |
Title: |
TGF-β signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development. |
Volume: |
11 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
van der Weyden L |
Year: |
2020 |
Journal: |
G3 (Bethesda) |
Title: |
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. |
Volume: |
10 |
Issue: |
6 |
Pages: |
1869-1877 |
|
•
•
•
•
•
|
Publication |
First Author: |
Foronda M |
Year: |
2014 |
Journal: |
Cell Rep |
Title: |
Sox4 links tumor suppression to accelerated aging in mice by modulating stem cell activation. |
Volume: |
8 |
Issue: |
2 |
Pages: |
487-500 |
|
•
•
•
•
•
|
Publication |
First Author: |
MouseBookTM |
Year: |
2005 |
Journal: |
Unpublished |
Title: |
Information obtained from MouseBookTM, Medical Research Council Mammalian Genetics Unit, Harwell, UK. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Australian Phenomics Facility at The Australian National University |
Year: |
2006 |
Journal: |
MGI Direct Data Submission |
Title: |
Heritable mouse mutants from the ENU mutagenesis program at the Australian Phenomics Facility at The Australian National University |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Liu X |
Year: |
2016 |
Journal: |
BMC Immunol |
Title: |
Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. |
Volume: |
17 |
Issue: |
1 |
Pages: |
25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mutant Mouse Regional Resource Centers |
Year: |
2004 |
Journal: |
Unpublished |
Title: |
Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wiese CB |
Year: |
2012 |
Journal: |
Front Neurosci |
Title: |
A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. |
Volume: |
6 |
|
Pages: |
130 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ingham NJ |
Year: |
2019 |
Journal: |
PLoS Biol |
Title: |
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. |
Volume: |
17 |
Issue: |
4 |
Pages: |
e3000194 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guo G |
Year: |
2010 |
Journal: |
Dev Cell |
Title: |
Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. |
Volume: |
18 |
Issue: |
4 |
Pages: |
675-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
Data Curation Using Mouse Genome Assembly |
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|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory |
Year: |
2012 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by The Jackson Laboratory |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Gray PA |
Year: |
2004 |
Journal: |
Science |
Title: |
Mouse brain organization revealed through direct genome-scale TF expression analysis. |
Volume: |
306 |
Issue: |
5705 |
Pages: |
2255-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thompson CL |
Year: |
2014 |
Journal: |
Neuron |
Title: |
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. |
Volume: |
83 |
Issue: |
2 |
Pages: |
309-323 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bedogni F |
Year: |
2021 |
Journal: |
Front Mol Neurosci |
Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
Volume: |
14 |
|
Pages: |
686034 |
|
•
•
•
•
•
|
Publication |
First Author: |
International Knockout Mouse Consortium |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of modified allele data from IKMC and creation of new knockout alleles |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
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|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
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•
•
•
•
•
|
Publication |
First Author: |
GUDMAP Consortium |
Year: |
2004 |
Journal: |
www.gudmap.org |
Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
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•
•
•
•
•
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Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
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Title: |
MGI Sequence Curation Reference |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
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Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
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•
•
•
•
•
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Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
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•
•
•
•
•
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Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
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•
•
•
•
•
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Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
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Title: |
GemPharmatech Website. |
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•
•
•
•
•
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Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
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•
•
•
•
•
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Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
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Title: |
Cyagen Biosciences Website. |
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•
•
•
•
•
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Publication |
First Author: |
GOA curators |
Year: |
2016 |
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Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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•
•
•
•
•
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Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
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•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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•
•
•
•
•
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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•
•
•
•
•
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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•
•
•
•
•
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
839
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
716
 |
Fragment?: |
false |
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Publication |
First Author: |
Hoshino H |
Year: |
2000 |
Journal: |
J Biol Chem |
Title: |
Oxidative stress abolishes leptomycin B-sensitive nuclear export of transcription repressor Bach2 that counteracts activation of Maf recognition element. |
Volume: |
275 |
Issue: |
20 |
Pages: |
15370-6 |
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Allele |
Name: |
BTB and CNC homology, basic leucine zipper transcription factor 2; targeted mutation 2.1, Kazuhiko Igarashi |
Allele Type: |
Targeted |
Attribute String: |
Reporter |
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Interaction Experiment |
Description: |
Bach2 represses plasma cell gene regulatory network in B cells to promote antibody class switch. |
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Interaction Experiment |
Description: |
Plasmacytic transcription factor Blimp-1 is repressed by Bach2 in B cells. |
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Publication |
First Author: |
Ochiai K |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
Plasmacytic transcription factor Blimp-1 is repressed by Bach2 in B cells. |
Volume: |
281 |
Issue: |
50 |
Pages: |
38226-34 |
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Allele |
Name: |
BTB and CNC homology, basic leucine zipper transcription factor 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
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Allele |
Name: |
regulatory region 79; endonuclease-mediated mutation 2, Ryan Tewhey |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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DO Term |
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Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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Genotype |
Symbol: |
Rr79/Rr79 |
Background: |
C57BL/6J-Rr79/J |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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Allele |
Name: |
BTB and CNC homology, basic leucine zipper transcription factor 2; targeted mutation 2.1, Tomohiro Kurosaki |
Allele Type: |
Targeted |
Attribute String: |
Epitope tag |
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Allele |
Name: |
BTB and CNC homology, basic leucine zipper transcription factor 2; mutation 1, Bruce Beutler |
Allele Type: |
Chemically induced (ENU) |
Attribute String: |
Not Specified |
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Strain |
Attribute String: |
mutant strain, coisogenic, chemically induced mutation |
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Genotype |
Symbol: |
Bach2/Bach2 |
Background: |
C57BL/6J-Bach2 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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Publication |
First Author: |
Chen Z |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Nuclear translocation of B-cell-specific transcription factor, BACH2, modulates ROS mediated cytotoxic responses in mantle cell lymphoma. |
Volume: |
8 |
Issue: |
8 |
Pages: |
e69126 |
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Publication |
First Author: |
Okita Y |
Year: |
2013 |
Journal: |
J Biol Chem |
Title: |
Transforming growth factor-β induces transcription factors MafK and Bach1 to suppress expression of the heme oxygenase-1 gene. |
Volume: |
288 |
Issue: |
28 |
Pages: |
20658-67 |
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Publication |
First Author: |
Liang Y |
Year: |
2012 |
Journal: |
J Biol Chem |
Title: |
Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis. |
Volume: |
287 |
Issue: |
40 |
Pages: |
33533-44 |
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Protein Domain |
Type: |
Domain |
Description: |
BACH proteins are Cap'n'Collar (CNC) Basic leucine zipper (bZIP) transcription factors that are defined by a conserved 43-amino acid region (called the CNC domain) located N-terminal to the bZIP DNA-binding domain. In addition, they contain a BTB domain (Broad complex-Tramtrack-Bric-a-brac domain, also known as the POZ [poxvirus and zinc finger]domain) that is absent in other CNC proteins. Veterbrates contain two members, BACH1 and BACH2. BACH1 forms heterodimers with small Mafs such as MafK to function as a repressor of heme oxygenase-1 (HO-1) gene (Hmox-1) enhancers []. It has also been implicated as the master regulator of breast cancer bone metastasis []. The BACH1 bZIP transcription factor should not be confused with the protein originally named as BRCA1-Associated C-terminal Helicase1 (BACH1), which has been renamed BRIP1 (BRCA1 Interacting Protein C-terminal Helicase1) and also called FANCJ. BACH2 is a B-cell specific transcription factor that plays a critical role in oxidative stress-mediated apoptosis []. It plays an important role in class switching and somatic hypermutation of immunoglobulin genes []. |
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Publication |
First Author: |
Venturutti L |
Year: |
2020 |
Journal: |
Cell |
Title: |
TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate. |
Volume: |
182 |
Issue: |
2 |
Pages: |
297-316.e27 |
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Publication |
First Author: |
Verma M |
Year: |
2021 |
Journal: |
J Exp Med |
Title: |
The molecular and epigenetic mechanisms of innate lymphoid cell (ILC) memory and its relevance for asthma. |
Volume: |
218 |
Issue: |
7 |
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Publication |
First Author: |
Utzschneider DT |
Year: |
2020 |
Journal: |
Nat Immunol |
Title: |
Early precursor T cells establish and propagate T cell exhaustion in chronic infection. |
Volume: |
21 |
Issue: |
10 |
Pages: |
1256-1266 |
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Genotype |
Symbol: |
Rr79/Rr79 Tg(TcraTcrb)1100Mjb/? |
Background: |
involves: C57BL/6J |
Zygosity: |
cx |
Has Mutant Allele: |
true |
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Publication |
First Author: |
Kharabi Masouleh B |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia. |
Volume: |
111 |
Issue: |
21 |
Pages: |
E2219-28 |
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Publication |
First Author: |
Horiuchi S |
Year: |
2023 |
Journal: |
Front Immunol |
Title: |
SpiB regulates the expression of B-cell-related genes and increases the longevity of memory B cells. |
Volume: |
14 |
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Pages: |
1250719 |
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Publication |
First Author: |
Hilliard S |
Year: |
2019 |
Journal: |
Biol Open |
Title: |
Defining the dynamic chromatin landscape of mouse nephron progenitors. |
Volume: |
8 |
Issue: |
5 |
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•
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•
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Publication |
First Author: |
Suzuki H |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
Cadmium induces nuclear export of Bach1, a transcriptional repressor of heme oxygenase-1 gene. |
Volume: |
278 |
Issue: |
49 |
Pages: |
49246-53 |
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