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Search results 301 to 400 out of 543 for Bad

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Type Details Score
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
8589709 | J:32057
First Author: Bedell MA
Year: 1996
Journal: Nat Genet
Title: Good genes in bad neighbourhoods.
Volume: 12
Issue: 3
Pages: 229-32
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Strain
MGI:3765457 | B6(V)-Bhrd/GrsrJ
Attribute String: mutant strain, spontaneous mutation
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Allele
Bhrd<+> | MGI:3765349
 
Name: bad hair day; wild type
Allele Type: Not Specified
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Genotype
Genotype
Symbol: Bhrd/?
Background: B6(V)-Bhrd/GrsrJ
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bhrd/Bhrd
Background: B6(V)-Bhrd/GrsrJ
Zygosity: hm
Has Mutant Allele: true
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Publication
29175460 | J:253761
 
First Author: Bui NL
Year: 2018
Journal: Cancer Lett
Title: Bad phosphorylation as a target of inhibition in oncology.
Volume: 415
Pages: 177-186
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Publication
10485701 | J:57348
First Author: Khwaja A
Year: 1999
Journal: Nature
Title: Akt is more than just a Bad kinase.
Volume: 401
Issue: 6748
Pages: 33-4
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Interaction Experiment
Han EK (2005)
Description: Chkl binds and phosphorylates BAD protein.
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Publication
17613432 | J:122851
First Author: Settleman J
Year: 2007
Journal: Cancer Cell
Title: Drugging the bad "AKT-TOR" to overcome TKI-resistant lung cancer.
Volume: 12
Issue: 1
Pages: 6-8
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Publication
17974948 | J:127149
First Author: Kitamura T
Year: 2007
Journal: Cancer Res
Title: Keeping out the bad guys: gateway to cellular target therapy.
Volume: 67
Issue: 21
Pages: 10099-102
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Publication
27728799 | J:236717
First Author: Hu Z
Year: 2016
Journal: Cancer Cell
Title: p62 in Liver Disease: Good Guy or Bad Guy?
Volume: 30
Issue: 4
Pages: 509-510
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Publication
- | J:213765
     
First Author: Karst SY
Year: 2014
Journal: MGI Direct Data Submission
Title: X-linked hair loss, a spontaneous mutation similar to bad hair day
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Publication
10837473 | J:63926
First Author: Zhou XM
Year: 2000
Journal: J Biol Chem
Title: Growth factors inactivate the cell death promoter BAD by phosphorylation of its BH3 domain on Ser155.
Volume: 275
Issue: 32
Pages: 25046-51
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Publication
15280015 | J:91967
First Author: Aho TL
Year: 2004
Journal: FEBS Lett
Title: Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site.
Volume: 571
Issue: 1-3
Pages: 43-9
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Publication
8756343 | J:34767
First Author: Lowell CA
Year: 1996
Journal: Genes Dev
Title: Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories.
Volume: 10
Issue: 15
Pages: 1845-57
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Publication
38446877 | J:360646
First Author: Zhang Y
Year: 2024
Journal: Sci Adv
Title: Arresting the bad seed: HDAC3 regulates proliferation of different microglia after ischemic stroke.
Volume: 10
Issue: 10
Pages: eade6900
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Publication
8912006 | J:36632
First Author: Barbara JA
Year: 1996
Journal: Immunol Cell Biol
Title: Tumour necrosis factor-alpha (TNF-alpha): the good, the bad and potentially very effective.
Volume: 74
Issue: 5
Pages: 434-43
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Publication
22810811 | J:186229
First Author: Sporn MB
Year: 2012
Journal: Nat Rev Cancer
Title: NRF2 and cancer: the good, the bad and the importance of context.
Volume: 12
Issue: 8
Pages: 564-71
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Publication
27411579 | J:233527
First Author: Watanabe T
Year: 2016
Journal: Cancer Cell
Title: Context, Context, Context: New Gene Programs Linked to Bad Behavior in MLL-AF9-Initiated Leukemia.
Volume: 30
Issue: 1
Pages: 3-5
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Publication
25765936 | J:258758
First Author: Abdurrachim D
Year: 2015
Journal: Cardiovasc Res
Title: Good and bad consequences of altered fatty acid metabolism in heart failure: evidence from mouse models.
Volume: 106
Issue: 2
Pages: 194-205
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Pathway
R-MMU-111447 | Activation of BAD and translocation to mitochondria
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Publication
31377403 | J:353191
 
First Author: LaSarge CL
Year: 2019
Journal: Exp Neurol
Title: Impact of mTOR hyperactive neurons on the morphology and physiology of adjacent neurons: Do PTEN KO cells make bad neighbors?
Volume: 321
Pages: 113029
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Genotype
Genotype
Symbol: Bhrd/Bhrd<+>
Background: B6(V)-Bhrd/GrsrJ
Zygosity: ht
Has Mutant Allele: true
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Publication
36520045 | J:335399
First Author: Basavarajappa D
Year: 2023
Journal: FASEB J
Title: S1PR1 signaling attenuates apoptosis of retinal ganglion cells via modulation of cJun/Bim cascade and Bad phosphorylation in a mouse model of glaucoma.
Volume: 37
Issue: 1
Pages: e22710
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Publication
15736430 | -
First Author: Han EK
Year: 2004
Journal: Anticancer Res
Title: Chkl binds and phosphorylates BAD protein.
Volume: 24
Issue: 6
Pages: 3907-10
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Allele
Bad<em1Smoc> | MGI:7288427
Name: BCL2-associated agonist of cell death; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Interaction Experiment
Danial NN (2003)
Description: BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis.
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Interaction Experiment
Schuermann A (2000)
Description: p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis.
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Publication
20596645 | -
First Author: Co NN
Year: 2010
Journal: Oncol Rep
Title: AF1q enhancement of gamma irradiation-induced apoptosis by up-regulation of BAD expression via NF-kappaB in human squamous carcinoma A431 cells.
Volume: 24
Issue: 2
Pages: 547-54
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Publication
9381178 | -
First Author: del Peso L
Year: 1997
Journal: Science
Title: Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt.
Volume: 278
Issue: 5338
Pages: 687-9
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Publication
22377282 | -
First Author: Heitzeneder S
Year: 2012
Journal: Clin Immunol
Title: Mannan-binding lectin deficiency - Good news, bad news, doesn't matter?
Volume: 143
Issue: 1
Pages: 22-38
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GO Term
GO:0097138 | BAD-BCL-2 complex
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GO Term
GO:0097137 | BAD-BCL-xl complex
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Strain
MGI:6428215 | C57BL/6JSmoc-Bad<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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MP Term
MP:0000120 | malocclusion
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Publication
10949026 | -
First Author: Datta SR
Year: 2000
Journal: Mol Cell
Title: 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation.
Volume: 6
Issue: 1
Pages: 41-51
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Publication
10611223 | -
First Author: Schürmann A
Year: 2000
Journal: Mol Cell Biol
Title: p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis.
Volume: 20
Issue: 2
Pages: 453-61
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Publication
24421315 | -
First Author: Son D
Year: 2014
Journal: J Biol Chem
Title: Platelet-derived growth factor-C (PDGF-C) induces anti-apoptotic effects on macrophages through Akt and Bad phosphorylation.
Volume: 289
Issue: 9
Pages: 6225-35
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Publication
26353933 | -
First Author: Katzav S
Year: 2015
Journal: Oncotarget
Title: Vav1: A Dr. Jekyll and Mr. Hyde protein--good for the hematopoietic system, bad for cancer.
Volume: 6
Issue: 30
Pages: 28731-42
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Publication
16403219 | -
 
First Author: Macdonald A
Year: 2006
Journal: BMC Cell Biol
Title: Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL.
Volume: 7
Pages: 1
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Protein Coding Gene
MGI:107162 | Ppp3cc
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P48455
Organism: Mus musculus/domesticus
Length: 513  
Fragment?: false
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DO Term
DOID:6088 | acute stress disorder
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Allele
Bcl2l11<tm1.1Boui> | MGI:4366749
 
Name: BCL2 like 11; targeted mutation 1.1, Philippe Bouillet
Allele Type: Targeted
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Protein Coding Gene
MGI:88138 | Bcl2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
11050396 | J:76180
First Author: Liu D
Year: 2000
Journal: Curr Biol
Title: Identification of CISK, a new member of the SGK kinase family that promotes IL-3-dependent survival.
Volume: 10
Issue: 19
Pages: 1233-6
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Strain
MGI:4366971 | C57BL/6-Bcl2l11<tm1.1Boui>
Attribute String: targeted mutation, mutant strain, coisogenic
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Genotype
Genotype
Symbol: Bcl2l11/Bcl2l11
Background: C57BL/6-Bcl2l11
Zygosity: hm
Has Mutant Allele: true
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Protein Coding Gene
MGI:108093 | Bid
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P10417
Organism: Mus musculus/domesticus
Length: 236  
Fragment?: false
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Protein
P70444
Organism: Mus musculus/domesticus
Length: 195  
Fragment?: false
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Protein
P68254
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: false
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Strain
MGI:4366975 | B6.Cg-Bcl2<tm1Dlo> Bcl2l11<tm1.1Boui>
Attribute String: targeted mutation, mutant strain, congenic
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Genotype
Genotype
Symbol: Bcl2/Bcl2 Bcl2l11/Bcl2l11
Background: B6.Cg-Bcl2 Bcl2l11
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bcl2l11/Bcl2l11<+> Tg(IghMyc)22Bri/?
Background: involves: C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bcl2l11/Bcl2l11 Tg(IghMyc)22Bri/?
Background: involves: C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
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Protein Coding Gene
MGI:107172 | Ppp3r1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:109194 | Ywhah
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P68510
Organism: Mus musculus/domesticus
Length: 246  
Fragment?: false
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Protein
Q63810
Organism: Mus musculus/domesticus
Length: 170  
Fragment?: false
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Strain
MGI:4366978 | B6.Cg-Bcl2<tm1Dlo> Bcl2l11<tm1.1Boui>/Bcl2l11<tm2.1Boui>
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:4366974 | C57BL/6-Bcl2l11<tm1.1Boui>/Bcl2l11<tm2.1Boui>
Attribute String: coisogenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Bcl2/Bcl2 Bcl2l11/Bcl2l11
Background: B6.Cg-Bcl2 Bcl2l11/Bcl2l11
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bcl2l11/Bcl2l11
Background: C57BL/6-Bcl2l11/Bcl2l11
Zygosity: ht
Has Mutant Allele: true
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Protein Coding Gene
MGI:891963 | Ywhaq
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1891831 | Sfn
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
O70456
Organism: Mus musculus/domesticus
Length: 248  
Fragment?: false
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Publication
15530661 | -
First Author: Lin HJ
Year: 2004
Journal: Brain Res Mol Brain Res
Title: AF1q, a differentially expressed gene during neuronal differentiation, transforms HEK cells into neuron-like cells.
Volume: 131
Issue: 1-2
Pages: 126-30
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Publication
11514587 | -
First Author: Xu J
Year: 2001
Journal: J Cell Biol
Title: Regulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositides.
Volume: 154
Issue: 4
Pages: 699-705
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Publication
7833468 | -
First Author: Tse W
Year: 1995
Journal: Blood
Title: A novel gene, AF1q, fused to MLL in t(1;11) (q21;q23), is specifically expressed in leukemic and immature hematopoietic cells.
Volume: 85
Issue: 3
Pages: 650-6
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Publication
22854283 | -
First Author: Lee SG
Year: 2012
Journal: Acta Haematol
Title: Molecular identification of a new splicing variant of the MLL - MLLT11 fusion transcript in an adult with acute myeloid leukemia and t(1;11)(q21;q23).
Volume: 128
Issue: 3
Pages: 131-8
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Publication
21715312 | -
First Author: Parcelier A
Year: 2011
Journal: Blood
Title: AF1q/MLLT11 regulates the emergence of human prothymocytes through cooperative interaction with the Notch signaling pathway.
Volume: 118
Issue: 7
Pages: 1784-96
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Publication
15126499 | J:91618
First Author: Xing Y
Year: 2004
Journal: J Biol Chem
Title: Structural basis of membrane targeting by the Phox homology domain of cytokine-independent survival kinase (CISK-PX).
Volume: 279
Issue: 29
Pages: 30662-9
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Publication
15240817 | J:94650
First Author: McCormick JA
Year: 2004
Journal: Mol Biol Cell
Title: Targeted disruption of the protein kinase SGK3/CISK impairs postnatal hair follicle development.
Volume: 15
Issue: 9
Pages: 4278-88
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Publication
21673735 | -
First Author: Trepiccione F
Year: 2011
Journal: Kidney Int
Title: SGK3: a novel regulator of renal phosphate transport?
Volume: 80
Issue: 1
Pages: 13-5
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Protein Domain
IPR026778 | MLLT11_fam
Type: Family
Description: This entry represents AF1q, encoded by the MLLT11 gene, which is a fusion partner of the MLL (mixed lineage leukemia) gene. The MLL-MLLT11 fusion is linked to the acute leukemias [].At the protein level, AF1q/MLLT11 is highly expressed in thymus and all leukemic cell lines, and is differentially expressed during neuronal differentiation [, ]. It interacts with the Notch signalling pathway to regulate the emergence of human prothymocytes []. It has also been shown that AF1q increases radiation-induced apoptosis through up-regulation of BAD (BCL-2 antagonist of cell death) in human squamous carcinoma via NF-kappaB [].
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Protein Domain
IPR037900 | CISK_PX
Type: Domain
Description: Cytokine-independent survival kinase (CISK also called SGK3) is a serine/threonine-protein kinase involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration []. It phosphorylates and inhibits the proapoptotic proteins, Bad and FKHRL1 []. CISK/SGK3 also regulates many transporters, ion channels, and receptors []. It plays a critical role in hair follicle morphogenesis and hair cycling []. N-terminal to a catalytic kinase domain, CISK contains a PX domain which binds highly phosphorylated PIs, directs membrane localization, and regulates the enzyme's activity [, ].This entry represents the PX domain of CISK.
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Publication
22081075 | J:186117
First Author: Mérino D
Year: 2012
Journal: Oncogene
Title: Bim must be able to engage all pro-survival Bcl-2 family members for efficient tumor suppression.
Volume: 31
Issue: 28
Pages: 3392-6
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Protein Coding Gene
MGI:108109 | Ywhag
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P61982
Organism: Mus musculus/domesticus
Length: 247  
Fragment?: false
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Publication
17015487 | -
First Author: Lang F
Year: 2006
Journal: Physiol Rev
Title: (Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms.
Volume: 86
Issue: 4
Pages: 1151-78
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Publication
8798343 | J:35815
First Author: Wang W
Year: 1996
Journal: J Mol Evol
Title: Molecular evolution of the 14-3-3 protein family.
Volume: 43
Issue: 4
Pages: 384-98
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Publication
16103198 | -
First Author: Surjit M
Year: 2005
Journal: J Virol
Title: The severe acute respiratory syndrome coronavirus nucleocapsid protein is phosphorylated and localizes in the cytoplasm by 14-3-3-mediated translocation.
Volume: 79
Issue: 17
Pages: 11476-86
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Publication
11080204 | -
First Author: Malaspina A
Year: 2000
Journal: J Neurochem
Title: A 14-3-3 mRNA is up-regulated in amyotrophic lateral sclerosis spinal cord.
Volume: 75
Issue: 6
Pages: 2511-20
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Publication
12527748 | -
First Author: Martin D
Year: 2003
Journal: J Cell Biol
Title: Tenascin-C signaling through induction of 14-3-3 tau.
Volume: 160
Issue: 2
Pages: 171-5
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Protein Domain
IPR042584 | 14-3-3_theta
Type: Family
Description: 14-3-3 tau/theta (tau in humans, theta in mice) isoform is encoded by the YWHAQ gene in humans and plays an important role in controlling apoptosis through interactions with ASK1, c-jun NH-terminal kinase, and p38 mitogen-activated protein kinase (MAPK). Its interaction with CDC25c regulates entry into the cell cycle and subsequent interaction with Bad prevents apoptosis. 14-3-3 theta protein expression is induced in patients with amyotrophic lateral sclerosis []. 14-3-3 tau is often overexpressed in breast cancer, which is associated with the downregulation of p21, a p53 target gene, and thus leads to tamoxifen resistance in MCF7 breast cancer cells and shorter patientsurvival. Therefore, 14-3-3 tau may be a potential therapeutic target in breast cancer []. Additionally, 14-3-3 theta mediates nucleocytoplasmic shuttling of the coronavirus nucleocapsid protein which causes severe acute respiratory syndrome []. 14-3-3 domain is an essential part of 14-3-3 proteins, a ubiquitous class of regulatory, phosphoserine/threonine-binding proteins found in all eukaryotic cells, including yeast, protozoa and mammalian cells [].
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Publication
11493700 | J:161036
First Author: Harada H
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD.
Volume: 98
Issue: 17
Pages: 9666-70
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Publication
10843388 | J:111999
First Author: Yang FC
Year: 2000
Journal: Immunity
Title: Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells.
Volume: 12
Issue: 5
Pages: 557-68
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Publication
1791302 | J:642
First Author: Schön M
Year: 1991
Journal: J Hirnforsch
Title: Quantitative morphological analysis of hippocampal structures in DBA1 and DBA2 inbred mice strains with genetically determined different shuttle box behavior: the mossy fiber system with reference data to the C3H strain.
Volume: 32
Issue: 2
Pages: 225-30
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Publication
25565426 | J:237326
First Author: Doerflinger M
Year: 2015
Journal: FEBS J
Title: BH3-only proteins: a 20-year stock-take.
Volume: 282
Issue: 6
Pages: 1006-16
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Publication
19651893 | J:153846
First Author: Mérino D
Year: 2009
Journal: J Cell Biol
Title: The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins.
Volume: 186
Issue: 3
Pages: 355-62
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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