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Search results 301 to 363 out of 363 for Bbox1

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Type Details Score
Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Bbox1<em1Smoc> | MGI:7288440
Name: gamma-butyrobetaine hydroxylase 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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GXD Expression
GXD Expression
Probe: MGI:6473350
Assay Type: Immunohistochemistry
Annotation Date: 2020-11-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3573928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6474273
Age: postnatal week 14
Image: 6c
Note: Expressed in astrocytes (9 ± 1%). Gfap-positive cells did not express Bbox1 (96 ± 0.1%).
Specimen Label: 6c
Detected: true
Specimen Num: 1
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Strain
MGI:6428218 | C57BL/6JSmoc-Bbox1<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
10207104 | J:54633
First Author: Harada H
Year: 1999
Journal: Mol Cell Biol
Title: HERF1, a novel hematopoiesis-specific RING finger protein, is required for terminal differentiation of erythroid cells.
Volume: 19
Issue: 5
Pages: 3808-15
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Publication
18560381 | -
First Author: Blaybel R
Year: 2008
Journal: Cell Res
Title: Downregulation of the Spi-1/PU.1 oncogene induces the expression of TRIM10/HERF1, a key factor required for terminal erythroid cell differentiation and survival.
Volume: 18
Issue: 8
Pages: 834-45
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Protein Domain
IPR042784 | TRIM10_RING-HC
Type: Domain
Description: TRIM10 (also known as HERF1) is a hematopoiesis-specific RING finger protein required for terminal differentiation of erythroid cells [, ]. TRIM10 belongs to the C-IV subclass of TRIM (tripartite motif) family of proteins that are defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, Bbox1 and Bbox2, and a coiled coil region, as well as a B30.2/SPRY (SplA and ryanodine receptor) domain positioned C-terminal to the RBCC domain.
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Publication
23791107 | -
First Author: Guo Y
Year: 2013
Journal: Am J Hum Genet
Title: Dissecting disease inheritance modes in a three-dimensional protein network challenges the "guilt-by-association" principle.
Volume: 93
Issue: 1
Pages: 78-89
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Publication
24814515 | -
First Author: Thoresen SB
Year: 2014
Journal: Nat Cell Biol
Title: ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4.
Volume: 16
Issue: 6
Pages: 550-60
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Protein Domain
IPR044553 | Bbox1_ANCHR
Type: Domain
Description: Abscission/NoCut checkpoint regulator (ANCHR), also known as MLL partner containing FYVE domain or zinc finger FYVE domain-containing protein 19, is a key regulator of the abscission step in cytokinesis as it is part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. ANCHR acts in an Aurora-B-dependent manner and associates with VPS4 at the midbody ring [].This entry represents the B-box motif found in ANCHR, it shows high sequence similarity with B-Box-type 1 (Bbox1) zinc finger found in tripartite motif-containing proteins (TRIMs). Bbox1 zinc finger is characterised by a C6H2 zinc-binding consensus motif.
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Protein Domain
IPR042699 | TRIM58_RING-HC
Type: Domain
Description: TRIM58, also known as protein BIA2, is an erythroid E3 ubiquitin-protein ligase induced during late erythropoiesis. It binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. It may participate in the erythroblast enucleation process through regulation of nuclear polarization. TRIM58 belongs to the C-IV subclass of TRIM (tripartite motif) family of proteins that are defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, Bbox1 and Bbox2, and a coiled coil region, as well as a B30.2/SPRY (SplA and ryanodine receptor) domain positioned C-terminal to the RBCC domain [].
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Protein Domain
IPR042765 | TRIM42_RING-HC
Type: Domain
Description: Tripartite motif-containing protein 42 (TRIM42) belongs to the C-III subclass of TRIM (tripartite motif) family of proteins that are defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, Bbox1 and Bbox2, and a coiled coil domain. It also has a novel cysteine-rich motif N-terminal to the RBCC domain, as well as a COS (carboxyl-terminal subgroup one signature) box and a fibronectin type-III (FN3) domain positioned C-terminal to the RBCC domain. TRIM42 can interact with TRIM27, a known cancer-associated protein. Its precise biological function remains unclear [, ].
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Publication
25241935 | J:243477
First Author: Thom CS
Year: 2014
Journal: Dev Cell
Title: Trim58 degrades Dynein and regulates terminal erythropoiesis.
Volume: 30
Issue: 6
Pages: 688-700
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Protein Domain
IPR042713 | TIF1beta_RING-HC
Type: Domain
Description: TIF1-beta, also known as Kruppel-associated Box (KRAB)-associated protein 1 (KAP-1), belongs to the C-VI subclass of TRIM (tripartite motif) family of proteins that are defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, Bbox1 and Bbox2, and a coiled coil region, as well as a plant homeodomain (PHD), and a bromodomain (Bromo) positioned C-terminal to the RBCC domain. It acts as a nuclear co-repressor that plays a role in transcription and in the DNA damage response [, , ]. Upon DNA damage, the phosphorylation of KAP-1 on serine 824 by the ataxia telangiectasia-mutated (ATM) kinase enhances cell survival and facilitates chromatin relaxation and heterochromatic DNA repair []. It also regulates CHD3 nucleosome remodelling during the DNA double-strand break (DSB) response []. Meanwhile, KAP-1 can be dephosphorylated by protein phosphatase PP4C in the DNA damage response []. Moreover, KAP-1 is a co-activator of the orphan nuclear receptor NGFI-B (or Nur77) and is involved in NGFI-B-dependent transcription []. It is also a coiled-coil binding partner, substrate and activator of the c-Fes protein tyrosine kinase []. The N-terminal RBCC domains of TIF1-beta are responsible for the interaction with KRAB zinc finger proteins (KRAB-ZFPs), MDM2, MM1, C/EBPbeta, and the regulation of homo- and heterodimerization []. The C-terminal PHD/Bromo domains are involved in interacting with SETDB1, Mi-2alpha and other proteins to form complexes with histone deacetylase or methyltransferase activity [, ].This entry represents the RING-HC finger found in TIF1-beta.
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Protein Domain
IPR037373 | KAP1
Type: Family
Description: TIF1-beta, also known as Kruppel-associated Box (KRAB)-associated protein 1 (KAP-1), belongs to the C-VI subclass of TRIM (tripartite motif) family of proteins that are defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, Bbox1 and Bbox2, and a coiled coil region, as well as a plant homeodomain (PHD), and a bromodomain (Bromo) positioned C-terminal to the RBCC domain. It acts as a nuclear co-repressor that plays a role in transcription and in the DNA damage response [, , ]. Upon DNA damage, the phosphorylation of KAP-1 on serine 824 by the ataxia telangiectasia-mutated (ATM) kinase enhances cell survival and facilitates chromatin relaxation and heterochromatic DNA repair []. It also regulates CHD3 nucleosome remodelling during the DNA double-strand break (DSB) response []. Meanwhile, KAP-1 can be dephosphorylated by protein phosphatase PP4C in the DNA damage response []. Moreover, KAP-1 is a co-activator of the orphan nuclear receptor NGFI-B (or Nur77) and is involved in NGFI-B-dependent transcription []. It is also a coiled-coil binding partner, substrate and activator of the c-Fes protein tyrosine kinase []. The N-terminal RBCC domains of TIF1-beta are responsible for the interaction with KRAB zinc finger proteins (KRAB-ZFPs), MDM2, MM1, C/EBPbeta, and the regulation of homo- and heterodimerization []. The C-terminal PHD/Bromo domains are involved in interacting with SETDB1, Mi-2alpha and other proteins to form complexes with histone deacetylase or methyltransferase activity [, ].
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Publication
19321449 | J:222151
First Author: Rambaud J
Year: 2009
Journal: J Biol Chem
Title: TIF1beta/KAP-1 is a coactivator of the orphan nuclear receptor NGFI-B/Nur77.
Volume: 284
Issue: 21
Pages: 14147-56
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Publication
8769649 | -
First Author: Friedman JR
Year: 1996
Journal: Genes Dev
Title: KAP-1, a novel corepressor for the highly conserved KRAB repression domain.
Volume: 10
Issue: 16
Pages: 2067-78
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Publication
11226167 | -
First Author: Capili AD
Year: 2001
Journal: EMBO J
Title: Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains.
Volume: 20
Issue: 1-2
Pages: 165-77
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Publication
9016654 | -
First Author: Moosmann P
Year: 1996
Journal: Nucleic Acids Res
Title: Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1.
Volume: 24
Issue: 24
Pages: 4859-67
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Publication
16792528 | -
First Author: Delfino FJ
Year: 2006
Journal: Biochem J
Title: The KRAB-associated co-repressor KAP-1 is a coiled-coil binding partner, substrate and activator of the c-Fes protein tyrosine kinase.
Volume: 399
Issue: 1
Pages: 141-50
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Publication
21642969 | -
First Author: Goodarzi AA
Year: 2011
Journal: Nat Struct Mol Biol
Title: KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response.
Volume: 18
Issue: 7
Pages: 831-9
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Publication
1610787 | -
First Author: Simon E
Year: 1992
Journal: Physiol Res
Title: Osmoreception in the duck's brain identified by neurophysiological methods and phylogenetic structural cues.
Volume: 41
Issue: 1
Pages: 93-4
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Publication
16862143 | -
First Author: Ziv Y
Year: 2006
Journal: Nat Cell Biol
Title: Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway.
Volume: 8
Issue: 8
Pages: 870-6
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Publication
11959841 | -
First Author: Schultz DC
Year: 2002
Journal: Genes Dev
Title: SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.
Volume: 16
Issue: 8
Pages: 919-32
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Publication
11230151 | -
First Author: Schultz DC
Year: 2001
Journal: Genes Dev
Title: Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD.
Volume: 15
Issue: 4
Pages: 428-43
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Publication
22491012 | -
First Author: Lee DH
Year: 2012
Journal: EMBO J
Title: Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response.
Volume: 31
Issue: 10
Pages: 2403-15
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Publication
16434393 | -
First Author: Short KM
Year: 2006
Journal: J Biol Chem
Title: Subclassification of the RBCC/TRIM superfamily reveals a novel motif necessary for microtubule binding.
Volume: 281
Issue: 13
Pages: 8970-80
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Protein
Q9DAZ9
Organism: Mus musculus/domesticus
Length: 389  
Fragment?: false
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Protein
Q62318
Organism: Mus musculus/domesticus
Length: 834  
Fragment?: false
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Protein
Q5EBP9
Organism: Mus musculus/domesticus
Length: 834  
Fragment?: false
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Protein
Q9D2H5
Organism: Mus musculus/domesticus
Length: 723  
Fragment?: false
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Protein
Q3UDN8
Organism: Mus musculus/domesticus
Length: 631  
Fragment?: true
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Protein
Q9WUH5
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: false
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Protein
Q5NCC9
Organism: Mus musculus/domesticus
Length: 485  
Fragment?: false
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Protein
B9EK29
Organism: Mus musculus/domesticus
Length: 485  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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