Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:3714011 |
Assay Type: |
RNA in situ |
Annotation Date: |
2007-07-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757721 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:3714289 |
Age: |
embryonic day 13.5 |
Image: |
4E |
|
Specimen Label: |
4E |
Detected: |
true |
Specimen Num: |
16 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3714011 |
Assay Type: |
RNA in situ |
Annotation Date: |
2007-07-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757721 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:3714289 |
Age: |
embryonic day 13.5 |
Image: |
4H |
|
Specimen Label: |
4H |
Detected: |
true |
Specimen Num: |
18 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3714011 |
Assay Type: |
RNA in situ |
Annotation Date: |
2007-07-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1738819 |
Pattern: |
Regionally restricted |
Stage: |
TS19 |
Assay Id: |
MGI:3714289 |
Age: |
embryonic day 11.5 |
Image: |
4A |
Note: |
Expression is in the right and left bronchi and connected lung buds. |
Specimen Label: |
4A |
Detected: |
true |
Specimen Num: |
13 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3714011 |
Assay Type: |
RNA in situ |
Annotation Date: |
2007-07-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1738819 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:3714289 |
Age: |
embryonic day 11.5 |
Image: |
4C |
Note: |
Expression is in the right and left bronchi and connected lung buds. |
Specimen Label: |
4C |
Detected: |
true |
Specimen Num: |
14 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3714011 |
Assay Type: |
RNA in situ |
Annotation Date: |
2007-07-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3287323 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:3714289 |
Age: |
embryonic day 15.5 |
Image: |
5E |
|
Specimen Label: |
5E |
Detected: |
true |
Specimen Num: |
22 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3714011 |
Assay Type: |
RNA in situ |
Annotation Date: |
2007-07-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3287323 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:3714289 |
Age: |
embryonic day 15.5 |
Image: |
5H |
|
Specimen Label: |
5H |
Detected: |
true |
Specimen Num: |
24 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4424994 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1791823 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4823455 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_013800_11 |
|
Specimen Label: |
euxassay_013800_11 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4424994 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1791823 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4823455 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_013800_12 |
|
Specimen Label: |
euxassay_013800_12 |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4424994 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1791823 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4823455 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_013800_15 |
|
Specimen Label: |
euxassay_013800_15 |
Detected: |
true |
Specimen Num: |
11 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4424994 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1791823 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4823455 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_013800_16 |
|
Specimen Label: |
euxassay_013800_16 |
Detected: |
true |
Specimen Num: |
12 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4424994 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1791823 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4823455 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_013800_17 |
|
Specimen Label: |
euxassay_013800_17 |
Detected: |
true |
Specimen Num: |
13 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3714011 |
Assay Type: |
RNA in situ |
Annotation Date: |
2007-07-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:2513523 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:3714289 |
Age: |
embryonic day 15.5 |
Image: |
5E |
|
Specimen Label: |
5E |
Detected: |
true |
Specimen Num: |
22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takano J |
Year: |
2022 |
Journal: |
Nat Commun |
Title: |
PCGF1-PRC1 links chromatin repression with DNA replication during hematopoietic cell lineage commitment. |
Volume: |
13 |
Issue: |
1 |
Pages: |
7159 |
|
•
•
•
•
•
|
Publication |
First Author: |
Béguelin W |
Year: |
2016 |
Journal: |
Cancer Cell |
Title: |
EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis. |
Volume: |
30 |
Issue: |
2 |
Pages: |
197-213 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hasegawa N |
Year: |
2017 |
Journal: |
Leukemia |
Title: |
Impact of combinatorial dysfunctions of Tet2 and Ezh2 on the epigenome in the pathogenesis of myelodysplastic syndrome. |
Volume: |
31 |
Issue: |
4 |
Pages: |
861-871 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jeon BN |
Year: |
2012 |
Journal: |
Cancer Res |
Title: |
KR-POK interacts with p53 and represses its ability to activate transcription of p21WAF1/CDKN1A. |
Volume: |
72 |
Issue: |
5 |
Pages: |
1137-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rose NR |
Year: |
2016 |
Journal: |
Elife |
Title: |
RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes. |
Volume: |
5 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Tomsig JL |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif. |
Volume: |
278 |
Issue: |
12 |
Pages: |
10048-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cui W |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. |
Volume: |
6 |
|
Pages: |
37396 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cox BJ |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Phenotypic annotation of the mouse X chromosome |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Shimogori T |
Year: |
2010 |
Journal: |
Nat Neurosci |
Title: |
A genomic atlas of mouse hypothalamic development. |
Volume: |
13 |
Issue: |
6 |
Pages: |
767-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki N |
Year: |
2003 |
Journal: |
DNA Res |
Title: |
Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. |
Volume: |
10 |
Issue: |
4 |
Pages: |
167-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yokoyama S |
Year: |
2009 |
Journal: |
Dev Cell |
Title: |
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. |
Volume: |
17 |
Issue: |
6 |
Pages: |
836-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
FANTOM2 Data Curation in Mouse Genome Informatics |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen J |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
Volume: |
100 |
Issue: |
17 |
Pages: |
9918-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thompson CL |
Year: |
2014 |
Journal: |
Neuron |
Title: |
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. |
Volume: |
83 |
Issue: |
2 |
Pages: |
309-323 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bedogni F |
Year: |
2021 |
Journal: |
Front Mol Neurosci |
Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
Volume: |
14 |
|
Pages: |
686034 |
|
•
•
•
•
•
|
Publication |
First Author: |
Velocigene |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Tian L |
Year: |
2021 |
Journal: |
Immunity |
Title: |
Clonal multi-omics reveals Bcor as a negative regulator of emergency dendritic cell development. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Junco SE |
Year: |
2013 |
Journal: |
Structure |
Title: |
Structure of the polycomb group protein PCGF1 in complex with BCOR reveals basis for binding selectivity of PCGF homologs. |
Volume: |
21 |
Issue: |
4 |
Pages: |
665-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gearhart MD |
Year: |
2006 |
Journal: |
Mol Cell Biol |
Title: |
Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. |
Volume: |
26 |
Issue: |
18 |
Pages: |
6880-9 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1741
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1725
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1707
 |
Fragment?: |
false |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Allele |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Vivian J Bardwell |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
BCL6 interacting corepressor; targeted mutation 1.1, Vivian J Bardwell |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Bcor/Bcor<+> Tmem163/Tmem163<+> |
Background: |
involves: 129S1/Sv * C57BL/6N * FVB/N |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, mutant stock |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor |
Background: |
involves: 129S1/Sv |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
158
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
The RAWUL domain is found at the C terminus of poly-comb group RING finger proteins. It contains a variant ubiquitin-like fold with a distinct conserved surface region. The conserved surface found in this domain is responsible for interaction with Cbx members of the PRC1 (polycomb repression complex 1) and homodimer formation []. The RAWUL domain binds directly to PUFD, a domain on BCOR proteins (BCL6 corepressor). BCOR has emerged as an important player in development and health []. |
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•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the minimal domain at the C terminus of BCOR (BCL6 corepressor) that is needed for binding specifically to some of the PCGF proteins (polycomb-group RING finger homologues). Because of the selective binding, this domain has been named PCGF Ub-like fold discriminator (PUFD). PUFD binds to the RAWUL (RING finger- and WD40-associated ubiquitin-like) domain of the particular PCGF, PCGF1. Polycomb group proteins form repressive complexes (PRC) that mediate epigenetic modifications of histones. In humans there are many different PCGF homologues whose functions all vary, but the direct binding partner of PCGF1 is BCOR. BCOR has emerged as an important player in development and health []. |
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•
•
•
•
•
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Publication |
First Author: |
Wong SJ |
Year: |
2016 |
Journal: |
Structure |
Title: |
KDM2B Recruitment of the Polycomb Group Complex, PRC1.1, Requires Cooperation between PCGF1 and BCORL1. |
Volume: |
24 |
Issue: |
10 |
Pages: |
1795-1801 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pagan JK |
Year: |
2007 |
Journal: |
J Biol Chem |
Title: |
A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP. |
Volume: |
282 |
Issue: |
20 |
Pages: |
15248-57 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
E3 ubiquitin-protein ligase RING2 () mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub) [], which is a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals []. RING2 is a component of the PRC1 complex [], and other chromatin-associated Polycomb (PcG) complexes such as BCOR []. It is also a component of the MLL1/MLL complex []. |
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•
•
•
•
|
Protein Domain |
Type: |
Homologous_superfamily |
Description: |
The PUFD (PCGF Ub-like fold discriminator) domain is found at the C terminus of BCOR (BCL6 corepressor), and binds to the RAWUL (RING finger- and WD40-associated ubiquitin-like) domain of the polycomb-group protein PCGF1 []. This domain is also found in BCORL1 (BCL6 corepressor-like), which also binds PCGF1 through its PUFD domain []. Like BCOR, BCORL1 functions as a corepressor []. |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
211
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tmem163/Tmem163<+> |
Background: |
involves: 129S1/Sv * FVB/N |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Cao R |
Year: |
2005 |
Journal: |
Mol Cell |
Title: |
Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. |
Volume: |
20 |
Issue: |
6 |
Pages: |
845-54 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
108
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
E3 ubiquitin-protein ligase RING1 () is one of the three E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, which is a specific tag for repression of epigenetic transcription and particularly for inactivation of chromosome X of female mammals [, ]. RING1 is a component of the Polycomb group (PcG) multiprotein PRC1-like complex, the repressive BCOR complex [], and the the E2F6.com-1 complex in G0 phase []. RING1 has a RING-type zinc finger.E3 ubiquitin-protein ligase RING2 () mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub) [], which is a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals []. RING2 is a component of the PRC1 complex [], and other chromatin-associated Polycomb (PcG) complexes such as BCOR []. It is also a component of the MLL1/MLL complex [].This entry includes E3 ubiquitin-protein ligase RING1/RING2. |
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•
•
•
•
|
Publication |
First Author: |
Li Z |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex. |
Volume: |
281 |
Issue: |
29 |
Pages: |
20643-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang H |
Year: |
2004 |
Journal: |
Nature |
Title: |
Role of histone H2A ubiquitination in Polycomb silencing. |
Volume: |
431 |
Issue: |
7010 |
Pages: |
873-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang L |
Year: |
2024 |
Journal: |
J Exp Med |
Title: |
Induction of immortal-like and functional CAR T cells by defined factors. |
Volume: |
221 |
Issue: |
5 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Slavotinek AM |
Year: |
2011 |
Journal: |
Mol Genet Metab |
Title: |
Eye development genes and known syndromes. |
Volume: |
104 |
Issue: |
4 |
Pages: |
448-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bezsonova I |
Year: |
2009 |
Journal: |
Biochemistry |
Title: |
Ring1B contains a ubiquitin-like docking module for interaction with Cbx proteins. |
Volume: |
48 |
Issue: |
44 |
Pages: |
10542-8 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1781
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
73
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1693
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakajima-Takagi Y |
Year: |
2023 |
Journal: |
Elife |
Title: |
Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis. |
Volume: |
12 |
|
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
176
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Lapthanasupkul P |
Year: |
2012 |
Journal: |
Dev Biol |
Title: |
Ring1a/b polycomb proteins regulate the mesenchymal stem cell niche in continuously growing incisors. |
Volume: |
367 |
Issue: |
2 |
Pages: |
140-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sánchez C |
Year: |
2007 |
Journal: |
Mol Cell Proteomics |
Title: |
Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor. |
Volume: |
6 |
Issue: |
5 |
Pages: |
820-34 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
336
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
264
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
406
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
406
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
de Napoles M |
Year: |
2004 |
Journal: |
Dev Cell |
Title: |
Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation. |
Volume: |
7 |
Issue: |
5 |
Pages: |
663-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ogawa H |
Year: |
2002 |
Journal: |
Science |
Title: |
A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. |
Volume: |
296 |
Issue: |
5570 |
Pages: |
1132-6 |
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•
•
•
•
•
|