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Search results 301 to 400 out of 2034 for Bcr

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Hits by Pathway

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Hits by Strain

Type Details Score
Allele
Bcr<em2Smoc> | MGI:7750383
Name: BCR activator of RhoGEF and GTPase; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Genotype
Genotype
Symbol: Bcr/Bcr<+> Tg(CMV-cre)1Cgn/?
Background: involves: BALB/c * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Publication
15879100 | J:98984
First Author: Mizuno T
Year: 2005
Journal: J Immunol
Title: B cell receptor (BCR) cross-talk: CD40 engagement creates an alternate pathway for BCR signaling that activates I kappa B kinase/I kappa B alpha/NF-kappa B without the need for PI3K and phospholipase C gamma.
Volume: 174
Issue: 10
Pages: 6062-70
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Genotype
Genotype
Symbol: Bcr/Bcr<+> Tg(Mx1-cre)1Cgn/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bcr/Bcr<+> Tg(Vav1-cre)#Cgp/?
Background: involves: C57BL/6
Zygosity: cn
Has Mutant Allele: true
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GO Term
GO:0032598 | B cell receptor transport into immunological synapse
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GO Term
GO:1901245 | positive regulation of toll-like receptor 9 signaling pathway by B cell receptor internalization
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Pathway
R-MMU-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling
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Publication
17090304 | -
 
First Author: Zheng X
Year: 2006
Journal: BMC Cancer
Title: BCR and its mutants, the reciprocal t(9;22)-associated ABL/BCR fusion proteins, differentially regulate the cytoskeleton and cell motility.
Volume: 6
Pages: 262
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Strain
MGI:2165445 | STOCK Bcr<tm1Hkp>/J
Attribute String: mutant stock, targeted mutation
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Strain
MGI:5605985 | FVB.129S2(B6)-Bcr<tm1Hkp>/J
Attribute String: targeted mutation, mutant strain, congenic
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Allele
Bcr<Gt(IST10404F5)Tigm> | MGI:4016264
 
Name: BCR activator of RhoGEF and GTPase; gene trap IST10404F5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Strain
MGI:7751665 | C57BL/6JSmoc-Bcr<em2Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Bcr/Bcr
Background: involves: 129S2/SvPas
Zygosity: hm
Has Mutant Allele: true
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GO Term
GO:1990117 | B cell receptor apoptotic signaling pathway
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GO Term
GO:0019815 | B cell receptor complex
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GO Term
GO:0032597 | B cell receptor transport into membrane raft
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DO Term
DOID:0080643 | B-lymphoblastic leukemia/lymphoma with BCR-ABL1
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Allele
Tg(IghelMD4)4Ccg | MGI:2384162
Name: transgene insertion 4, Christopher C Goodnow
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Transgene
MGI:3053738 | Tg(IghelMD4)4Ccg
Type: transgene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Abr/Abr Bcr/Bcr
Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Black Swiss * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Allele
Tg(Tec-BCR/ABL1)3Hhi | MGI:3039032
Name: transgene insertion 3, Hisamaru Hirai
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(Tec-BCR/ABL1)5Hhi | MGI:3039034
Name: transgene insertion 5, Hisamaru Hirai
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(Tec-BCR/ABL1)#Hhi | MGI:3527269
Name: transgene insertion, Hisamaru Hirai
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Tec-BCR/ABL1)1Hhi | MGI:7507535
Name: transgene insertion 1, Hisamaru Hirai
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
7665185 | -
First Author: Chissoe SL
Year: 1995
Journal: Genomics
Title: Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation.
Volume: 27
Issue: 1
Pages: 67-82
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Publication
12356683 | -
First Author: Li C
Year: 2002
Journal: Int Immunol
Title: Cooperative interaction of Ig(alpha) and Ig(beta) of the BCR regulates the kinetics and specificity of antigen targeting.
Volume: 14
Issue: 10
Pages: 1179-91
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Publication
12805216 | -
First Author: Saeki K
Year: 2003
Journal: EMBO J
Title: The B cell-specific major raft protein, Raftlin, is necessary for the integrity of lipid raft and BCR signal transduction.
Volume: 22
Issue: 12
Pages: 3015-26
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Genotype
Genotype
Symbol: Bcr/Bcr<+> Runx1/Runx1<+> Tg(Vav1-cre)#Cgp/?
Background: involves: C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Protein Coding Gene
MGI:101774 | Cd79a
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
19234145 | J:148525
First Author: Miyazaki K
Year: 2009
Journal: Blood
Title: Enhanced expression of p210BCR/ABL and aberrant expression of Zfp423/ZNF423 induce blast crisis of chronic myelogenous leukemia.
Volume: 113
Issue: 19
Pages: 4702-10
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Publication
30167087 | J:346826
First Author: Takita M
Year: 2018
Journal: Oncotarget
Title: Paradoxical counteraction by imatinib against cell death in myeloid progenitor 32D cells expressing p210BCR-ABL.
Volume: 9
Issue: 60
Pages: 31682-31696
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Publication
18193087 | J:135601
First Author: Mizuno T
Year: 2008
Journal: Oncogene
Title: Overexpression/enhanced kinase activity of BCR/ABL and altered expression of Notch1 induced acute leukemia in p210BCR/ABL transgenic mice.
Volume: 27
Issue: 24
Pages: 3465-74
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Strain
MGI:6145075 | B6.Cg-Tg(Tec-BCR/ABL1)1Hhi/HomyRbrc
Attribute String: mutant strain, congenic, transgenic
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Publication
24833663 | J:258718
First Author: Sánchez-Sánchez B
Year: 2014
Journal: Clin Cancer Res
Title: NADPH oxidases as therapeutic targets in chronic myelogenous leukemia.
Volume: 20
Issue: 15
Pages: 4014-25
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Publication
1565462 | -
First Author: Adams JM
Year: 1992
Journal: Oncogene
Title: The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization.
Volume: 7
Issue: 4
Pages: 611-8
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CL Term
CL:0000960 | T3 B cell
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Publication
2179728 | J:91174
First Author: Heisterkamp N
Year: 1990
Journal: Nature
Title: Acute leukaemia in bcr/abl transgenic mice.
Volume: 344
Issue: 6263
Pages: 251-3
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Protein Domain
IPR011955 | Benzoyl_CoA_Rdtase_B
Type: Family
Description: This entry describes describes the B, or beta, subunit of the bcr type of benzoyl-CoA reductase, a 4-subunit enzyme. Many aromatic compounds are metabolized by way of benzoyl-CoA.
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Protein Coding Gene
MGI:96431 | Cd79b
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene Segment
MGI:96447 | Ighd
Type: gene_segment
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1916507 | Elf2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:97489 | Pax5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P11911
Organism: Mus musculus/domesticus
Length: 220  
Fragment?: false
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Protein
P15530
Organism: Mus musculus/domesticus
Length: 228  
Fragment?: false
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Protein
Q02650
Organism: Mus musculus/domesticus
Length: 391  
Fragment?: false
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Protein
Q9JHC9
Organism: Mus musculus/domesticus
Length: 593  
Fragment?: false
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Protein
A0A0A6YW14
Organism: Mus musculus/domesticus
Length: 291  
Fragment?: true
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Publication
16249387 | J:129312
First Author: Ahn E
Year: 2006
Journal: Blood
Title: LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation.
Volume: 107
Issue: 4
Pages: 1521-7
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Publication
11222386 | J:67477
First Author: Reichert A
Year: 2001
Journal: Blood
Title: Treatment of Bcr/Abl-positive acute lymphoblastic leukemia in P190 transgenic mice with the farnesyl transferase inhibitor SCH66336.
Volume: 97
Issue: 5
Pages: 1399-403
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Protein
H3BL84
Organism: Mus musculus/domesticus
Length: 91  
Fragment?: true
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Publication
19840940 | -
First Author: Yi SJ
Year: 2009
Journal: J Biol Chem
Title: Transglutaminase 2 regulates the GTPase-activating activity of Bcr.
Volume: 284
Issue: 51
Pages: 35645-51
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Publication
21295482 | -
First Author: Vaughan EM
Year: 2011
Journal: Curr Biol
Title: Control of local Rho GTPase crosstalk by Abr.
Volume: 21
Issue: 4
Pages: 270-7
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Publication
9376659 | -
First Author: Groffen J
Year: 1997
Journal: Baillieres Clin Haematol
Title: The chimeric BCR-ABL gene.
Volume: 10
Issue: 2
Pages: 187-201
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Protein Domain
IPR037769 | Abr/Bcr
Type: Family
Description: Abr (active breakpoint cluster region-related protein) and Bcr (breakpoint cluster region protein) are homologous proteins containing a C-terminal domain with GTPase-activating protein (GAP) activity specific for Rac. They control multiple cellular functions of murine macrophages []. They contain several domains, including tandem DH-PH, C2 and GAP domains. Bcr has an extra N-terminal oligomerization domain []. Bcr has been shown to fused to Abl tyrosine kinase in leukemia. The fusion of Bcr to Abl deregulates the tyrosine kinase activity of Abl []. The N-terminal oligomerization domain is thought to be the most critical component that allows the formation of homo-tetramer Bcr/Abl complexes and deregulates the Abl tyrosine kinase [, ]. The GTPase-activating activity of Bcr has been shown to be regulated by transglutaminase 2 (TG2), a multifunctional protein that has been implicated in numerous pathologies including that of neurodegeneration and celiac disease [, ].Abr is a critical regulator of Rho and Cdc42 during the single cell wound healing [].
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Publication
10640270 | J:95641
First Author: Yamanashi Y
Year: 2000
Journal: Genes Dev
Title: Role of the rasGAP-associated docking protein p62(dok) in negative regulation of B cell receptor-mediated signaling.
Volume: 14
Issue: 1
Pages: 11-6
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MP Term
MP:0010228 | decreased transitional stage T3 B cell number
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MP Term
MP:0010229 | increased transitional stage T3 B cell number
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MP Term
MP:0009921 | abnormal transitional stage T3 B cell morphology
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MP Term
MP:0010230 | absent transitional stage T3 B cells
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Protein Coding Gene
MGI:88322 | Cd22
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P35329
Organism: Mus musculus/domesticus
Length: 868  
Fragment?: false
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Protein
P01872
Organism: Mus musculus/domesticus
Length: 454  
Fragment?: false
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GO Term
GO:0002315 | marginal zone B cell differentiation
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Publication
19620960 | J:151543
First Author: Sanada M
Year: 2009
Journal: Nature
Title: Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.
Volume: 460
Issue: 7257
Pages: 904-8
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Publication
11489947 | J:95640
First Author: Di Cristofano A
Year: 2001
Journal: J Exp Med
Title: p62(dok), a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl).
Volume: 194
Issue: 3
Pages: 275-84
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Allele
Tg(MSCV-BCR/ABL*P230)22Kti | MGI:3527198
Name: transgene insertion 22, Koiti Inokuchi
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(MSCV-BCR/ABL*P230)13Kti | MGI:3527200
Name: transgene insertion 13, Koiti Inokuchi
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
21848808 | J:309066
First Author: Seo S
Year: 2011
Journal: Cancer Sci
Title: Crk-associated substrate lymphocyte type regulates myeloid cell motility and suppresses the progression of leukemia induced by p210Bcr/Abl.
Volume: 102
Issue: 12
Pages: 2109-17
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Allele
Tg(BCR/ABL)623Hkp | MGI:3582388
Name: transgene insertion 623, Nora Heisterkamp
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Strain
MGI:5654351 | B6;CBA-Tg(BCR/ABL)623Hkp/Nci
Attribute String: mutant stock, transgenic
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Strain
MGI:5305965 | B6.Cg-Tg(BCR/ABL)623Hkp/J
Attribute String: congenic, mutant strain, transgenic
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Publication
10980612 | J:64601
First Author: Salloukh HF
Year: 2000
Journal: Oncogene
Title: Early events in leukemogenesis in P190Bcr-abl transgenic mice.
Volume: 19
Issue: 38
Pages: 4362-74
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Publication
28190000 | J:241218
First Author: Witkowski MT
Year: 2017
Journal: J Exp Med
Title: Conserved IKAROS-regulated genes associated with B-progenitor acute lymphoblastic leukemia outcome.
Volume: 214
Issue: 3
Pages: 773-791
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Publication
1643646 | J:89786
First Author: Voncken JW
Year: 1992
Journal: Cancer Res
Title: Restricted oncogenicity of BCR/ABL p190 in transgenic mice.
Volume: 52
Issue: 16
Pages: 4534-9
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Publication
26097891 | J:260531
First Author: Uckun FM
Year: 2015
Journal: EBioMedicine
Title: Low Dose Total Body Irradiation Combined With Recombinant CD19-Ligand × Soluble TRAIL Fusion Protein is Highly Effective Against Radiation-Resistant B-Precursor Acute Lymphoblastic Leukemia in Mice.
Volume: 2
Issue: 4
Pages: 306-316
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Publication
15982636 | J:99259
First Author: Cho YJ
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Interaction of Bcr/Abl with C3G, an exchange factor for the small GTPase Rap1, through the adapter protein Crkl.
Volume: 333
Issue: 4
Pages: 1276-83
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Publication
1737087 | J:90937
First Author: Voncken JW
Year: 1992
Journal: Blood
Title: Clonal development and karyotype evolution during leukemogenesis of BCR/ABL transgenic mice.
Volume: 79
Issue: 4
Pages: 1029-36
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Publication
8541551 | J:90914
First Author: Voncken JW
Year: 1995
Journal: Blood
Title: BCR/ABL P210 and P190 cause distinct leukemia in transgenic mice.
Volume: 86
Issue: 12
Pages: 4603-11
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Genotype
Genotype
Symbol: Dok1/Dok1 Tg(Tec-BCR/ABL1)5Hhi/?
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dok2/Dok2 Tg(Tec-BCR/ABL1)5Hhi/?
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dok1/Dok1<+> Tg(Tec-BCR/ABL1)5Hhi/?
Background: involves: 129S1/Sv
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dok2/Dok2<+> Tg(Tec-BCR/ABL1)5Hhi/?
Background: involves: 129S1/Sv
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dok1/Dok1 Tg(Tec-BCR/ABL1)5Hhi/?
Background: involves: 129S1/Sv
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dok2/Dok2 Tg(Tec-BCR/ABL1)5Hhi/?
Background: involves: 129S1/Sv
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(BCR/ABL)623Hkp/?
Background: involves: C57BL/6 * CBA
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(BCR/ABL)623Hkp/?
Background: involves: C57BL/6 * C57BL/6J * CBA
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(BCR/ABL)623Hkp/?
Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * CBA
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cbl/Cbl<+> Tg(Tec-BCR/ABL1)5Hhi/?
Background: involves: C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cbl/Cbl Tg(Tec-BCR/ABL1)5Hhi/?
Background: involves: C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
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Publication
14610044 | -
First Author: Hur EM
Year: 2003
Journal: J Exp Med
Title: LIME, a novel transmembrane adaptor protein, associates with p56lck and mediates T cell activation.
Volume: 198
Issue: 10
Pages: 1463-73
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Protein
Q9EQR5
Organism: Mus musculus/domesticus
Length: 269  
Fragment?: false
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Protein
Q3T9B9
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: false
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Protein
A2AU24
Organism: Mus musculus/domesticus
Length: 87  
Fragment?: false
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Protein
F6QX71
Organism: Mus musculus/domesticus
Length: 249  
Fragment?: true
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Protein
F6ZRC5
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: true
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Publication
8486276 | -
First Author: Bentley J
Year: 1993
Journal: Gene
Title: Cloning and sequence analysis of an Escherichia coli gene conferring bicyclomycin resistance.
Volume: 127
Issue: 1
Pages: 117-20
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Publication
1648560 | -
First Author: Bissonnette L
Year: 1991
Journal: J Bacteriol
Title: Characterization of the nonenzymatic chloramphenicol resistance (cmlA) gene of the In4 integron of Tn1696: similarity of the product to transmembrane transport proteins.
Volume: 173
Issue: 14
Pages: 4493-502
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Publication
15980376 | -
First Author: Braibant M
Year: 2005
Journal: Antimicrob Agents Chemother
Title: Structural and functional study of the phenicol-specific efflux pump FloR belonging to the major facilitator superfamily.
Volume: 49
Issue: 7
Pages: 2965-71
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Publication
19261606 | -
First Author: Cummings CM
Year: 2009
Journal: J Biol Chem
Title: The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells.
Volume: 284
Issue: 17
Pages: 11663-75
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