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Search results 301 to 400 out of 832 for C4b

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Hits by Strain

Type Details Score
Allele
C4b<em1Peng> | MGI:7450929
Name: complement C4B (Chido blood group); endonuclease-mediated mutation 1, Bo Peng
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6428278 | C57BL/6JSmoc-C4b<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
9013975 | J:38369
First Author: Hillarp A
Year: 1997
Journal: J Immunol
Title: Molecular cloning of rat C4b binding protein alpha- and beta-chains: structural and functional relationships among human, bovine, rabbit, mouse, and rat proteins.
Volume: 158
Issue: 3
Pages: 1315-23
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Publication
9169428 | J:40948
First Author: Linse S
Year: 1997
Journal: J Biol Chem
Title: A region of vitamin K-dependent protein S that binds to C4b binding protein (C4BP) identified using bacteriophage peptide display libraries.
Volume: 272
Issue: 23
Pages: 14658-65
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Allele
C4b<+> | MGI:2430204
   
Name: complement C4B (Chido blood group); wild type
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DO Term
DOID:0060298 | complement component 4b deficiency
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Protein Coding Gene
MGI:1330832 | Masp2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
9339368 | J:43498
First Author: Yang Z
Year: 1997
Journal: Genomics
Title: Identification, partial characterization, and genetic mapping of kinesin-like protein genes in mouse.
Volume: 45
Issue: 1
Pages: 123-31
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Publication
9727007 | J:49745
First Author: Wright MB
Year: 1998
Journal: J Biol Chem
Title: Proliferating and migrating mesangial cells responding to injury express a novel receptor protein-tyrosine phosphatase in experimental mesangial proliferative glomerulonephritis.
Volume: 273
Issue: 37
Pages: 23929-37
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Allele
C4b<em1(IMPC)H> | MGI:6144264
Name: complement C4B (Chido blood group); endonuclease-mediated mutation 1, Harwell
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
C4b<em2(IMPC)H> | MGI:6153867
Name: complement C4B (Chido blood group); endonuclease-mediated mutation 2, Harwell
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
C4b<tm1Crr> | MGI:1889070
Name: complement C4B (Chido blood group); targeted mutation 1, Michael C Carroll
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
C4b<tm1(NCOM)Mfgc> | MGI:4880486
Name: complement C4B (Chido blood group); targeted mutation 1, Mammalian Functional Genomics Centre
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Strain
MGI:6123003 | C57BL/6NTac-C4b<em1(IMPC)H>/H
Attribute String: mutant strain, coisogenic, endonuclease-mediated mutation
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Strain
MGI:6866699 | C57BL/6NTac-C4b<em1(IMPC)H>/Mmucd
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
C4b<em1Crr> | MGI:6505588
Name: complement C4B (Chido blood group); endonuclease-mediated mutation 1, Michael C Carroll
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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Allele
C4b<em2Smoc> | MGI:7750407
Name: complement C4B (Chido blood group); endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Genotype
Genotype
Symbol: C4b/C4b
Background: C57BL/6NTac-C4b/H
Zygosity: hm
Has Mutant Allele: true
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Protein Coding Gene
MGI:88513 | Cr1l
Type: protein_coding_gene
Organism: mouse, laboratory
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Strain
MGI:2165045 | B6.129S4-C4b<tm1Crr>/J
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:3047108 | B6.129S4 C4b<tm1Crr>/J-Cal6/GrsrJ
Attribute String: congenic, mutant strain, spontaneous mutation, targeted mutation
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Strain
MGI:7751624 | C57BL/6JSmoc-C4b<em2Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: C4b/C4b
Background: involves: 129S4/SvJae * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: C4b/C4b
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: C4b/C4b
Background: involves: 129S4/SvJae
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: C4b/C4b Fas/Fas
Background: involves: 129S4/SvJae * C57BL/6 * MRL
Zygosity: cx
Has Mutant Allele: true
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HT Experiment
E-GEOD-33372 | Transcription profiling by array of mouse hypothalamus mutant for WFS1
Series Id: GSE33372
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Genotype
Genotype
Symbol: C3/C3 C4b/C4b Fas/Fas
Background: involves: 129S4/SvJae * C57BL/6 * MRL
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: C4b/C4b Cr1l/Cr1l
Background: involves: 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Protein
V9GZK7
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: true
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Publication
7868903 | -
First Author: Ogata RT
Year: 1995
Journal: J Immunol
Title: Substrate specificities of the protease of mouse serum Ra-reactive factor.
Volume: 154
Issue: 5
Pages: 2351-7
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Protein Domain
IPR037569 | Complement_C4A
Type: Family
Description: This entry represents complement component C4-A. C4-A is proteolytically processed to generate subcomponents C4a and C4b by complement component activated C1s (classical pathway) []or mannan-binding lectin-associated serine peptidases (lectin pathway) [, ]. C4a is an anaphylatoxin, whereas C4b forms a complex with complement subcomponent C2a to form the C3/C5 convertase, which is stabilized by Mg2+[, ]. The C3/C5 convertase has trypsin-like specificity [].
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Protein Coding Gene
MGI:98320 | C4a
Type: protein_coding_gene
Organism: mouse, laboratory
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ncRNA Gene
MGP_CAROLIEiJ_G0013483 | -
Type: ncRNA_gene
Organism: Mus caroli
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ncRNA Gene
MGP_129S1SvImJ_G0015350 | -
Type: ncRNA_gene
Organism: mouse, laboratory
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ncRNA Gene
MGP_AKRJ_G0015288 | -
Type: ncRNA_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_98320 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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ncRNA Gene
MGP_LPJ_G0015266 | -
Type: ncRNA_gene
Organism: mouse, laboratory
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ncRNA Gene
MGP_NODShiLtJ_G0015219 | -
Type: ncRNA_gene
Organism: mouse, laboratory
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ncRNA Gene
MGP_WSBEiJ_G0014770 | -
Type: ncRNA_gene
Organism: mouse, laboratory
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ncRNA Gene
MGP_PahariEiJ_G0012230 | -
Type: ncRNA_gene
Organism: Mus pahari
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Publication
7409861 | J:84442
First Author: Brown LJ
Year: 1980
Journal: Immunogenetics
Title: Female expression of the H-2-linked sex-limited protein (Slp) due to non-H-2 genes.
Volume: 10
Issue: 1
Pages: 19-29
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Publication
8570659 | J:31190
First Author: Jiang PP
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: Localization of the mouse gene releasing sex-limited expression of Slp.
Volume: 93
Issue: 2
Pages: 913-7
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Publication
8133084 | J:18023
First Author: Van den Berg CW
Year: 1994
Journal: J Immunol Methods
Title: Rapid, activity-guided isolation of sex-limited protein (Slp) from mouse serum by fractionated precipitation and high-performance liquid chromatography.
Volume: 169
Issue: 2
Pages: 251-6
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Publication
4991029 | J:5181
First Author: Passmore HC
Year: 1970
Journal: Biochem Genet
Title: A sex-limited serum protein variant in the mouse: inheritance and association with the H-2 region.
Volume: 4
Issue: 3
Pages: 351-65
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Publication
4998129 | J:23660
First Author: Passmore HC
Year: 1971
Journal: Biochem Genet
Title: A sex-limited serum protein variant in the mouse: hormonal control of phenotypic expression.
Volume: 5
Issue: 2
Pages: 201-9
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Publication
2050390 | J:11251
First Author: Huang ZM
Year: 1991
Journal: Immunogenetics
Title: Differential expression of the five C4-related genes of H-2w7 mice.
Volume: 33
Issue: 5-6
Pages: 361-6
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Publication
6242884 | J:12658
First Author: Ferreira A
Year: 1980
Journal: Immunogenetics
Title: H-2-controlled polymorphism of the gamma chain of Slp (sex-limited protein).
Volume: 11
Issue: 5
Pages: 491-7
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Publication
1400503 | J:3166
First Author: Milstone DS
Year: 1992
Journal: J Biol Chem
Title: An element regulating adrenal-specific steroid 21-hydroxylase expression is located within the slp gene.
Volume: 267
Issue: 30
Pages: 21924-7
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Publication
1281802 | J:3236
First Author: Robins DM
Year: 1992
Journal: Genetica
Title: Retrotransposons and the evolution of mammalian gene expression.
Volume: 86
Issue: 1-3
Pages: 191-201
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Publication
8475111 | J:4928
First Author: Georgatsou E
Year: 1993
Journal: Proc Natl Acad Sci U S A
Title: Male-specific expression of mouse sex-limited protein requires growth hormone, not testosterone.
Volume: 90
Issue: 8
Pages: 3626-30
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Publication
7877972 | J:23330
First Author: Yokomori N
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: Sexually dimorphic DNA demethylation in the promoter of the Slp (sex-limited protein) gene in mouse liver.
Volume: 92
Issue: 5
Pages: 1302-6
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Publication
9022044 | J:38277
First Author: Scarlett CO
Year: 1997
Journal: DNA Cell Biol
Title: Involvement of an octamer-like sequence within a crucial region of the androgen-dependent Slp enhancer.
Volume: 16
Issue: 1
Pages: 45-57
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Publication
9671750 | J:49342
First Author: Varin-Blank N
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Male-specific transcription initiation of the C4-Slp gene in mouse liver follows activation of STAT5.
Volume: 95
Issue: 15
Pages: 8750-5
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Publication
10361225 | J:56578
First Author: Beurskens FJ
Year: 1999
Journal: Clin Exp Immunol
Title: Sex-limited protein: in vitro and in vivo functions.
Volume: 116
Issue: 3
Pages: 395-400
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Publication
- | J:68221
   
First Author: Matsumoto K
Year: 2000
Journal: GenBank Submission
Title: Mus musculus Cyp21 and Slp genes for steroid 21-hydroxylase and sex-limited protein, complete and partial cds
Pages: AB015623
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Publication
14748705 | -
First Author: Sim RB
Year: 2004
Journal: Biochem Soc Trans
Title: Proteases of the complement system.
Volume: 32
Issue: Pt 1
Pages: 21-7
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Publication
10843656 | -
First Author: Astier A
Year: 2000
Journal: J Immunol
Title: Cutting edge: CD46, a new costimulatory molecule for T cells, that induces p120CBL and LAT phosphorylation.
Volume: 164
Issue: 12
Pages: 6091-5
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Publication
15215199 | -
First Author: Mizuno M
Year: 2004
Journal: Biol Reprod
Title: Rat membrane cofactor protein (MCP; CD46) is expressed only in the acrosome of developing and mature spermatozoa and mediates binding to immobilized activated C3.
Volume: 71
Issue: 4
Pages: 1374-83
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Protein Domain
IPR017341 | CD46
Type: Family
Description: This entry represents a group of membrane cofactor proteins (also known as CD46 or TLX). Human CD46 acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue []. Rat CD46 may be involved in the fusion of the spermatozoa with the oocyte during fertilization [].
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Publication
- | J:24194
     
First Author: The Jackson Laboratory Backcross DNA Panel Mapping Resource
Year: 1999
Journal: Database Release
Title: JAX BSS Panel Mapping Data
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Publication
36973281 | J:334938
First Author: Hu S
Year: 2023
Journal: Nat Commun
Title: Helicobacter pylori initiates successful gastric colonization by utilizing L-lactate to promote complement resistance.
Volume: 14
Issue: 1
Pages: 1695
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Publication
33258449 | J:300697
   
First Author: Griffin P
Year: 2020
Journal: Elife
Title: REV-ERBα mediates complement expression and diurnal regulation of microglial synaptic phagocytosis.
Volume: 9
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Publication
12055630 | J:324333
First Author: Marie JC
Year: 2002
Journal: Nat Immunol
Title: Linking innate and acquired immunity: divergent role of CD46 cytoplasmic domains in T cell induced inflammation.
Volume: 3
Issue: 7
Pages: 659-66
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Publication
6919506 | J:6780
First Author: Roos MH
Year: 1982
Journal: Immunogenetics
Title: Murine complement factor B (BF): sexual dimorphism and H-2-linked polymorphism.
Volume: 15
Issue: 1
Pages: 23-30
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Publication
11341920 | -
First Author: Laich A
Year: 2001
Journal: Biochim Biophys Acta
Title: Complement C4bC2 complex formation: an investigation by surface plasmon resonance.
Volume: 1544
Issue: 1-2
Pages: 96-112
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Publication
9642242 | -
First Author: Rawal N
Year: 1998
Journal: J Biol Chem
Title: C5 convertase of the alternative pathway of complement. Kinetic analysis of the free and surface-bound forms of the enzyme.
Volume: 273
Issue: 27
Pages: 16828-35
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Publication
3546307 | -
First Author: Kam CM
Year: 1987
Journal: J Biol Chem
Title: Human complement proteins D, C2, and B. Active site mapping with peptide thioester substrates.
Volume: 262
Issue: 8
Pages: 3444-51
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Publication
12922167 | -
First Author: Smith SA
Year: 2003
Journal: Biochim Biophys Acta
Title: Mapping of regions within the vaccinia virus complement control protein involved in dose-dependent binding to key complement components and heparin using surface plasmon resonance.
Volume: 1650
Issue: 1-2
Pages: 30-9
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Publication
20218853 | -
First Author: Paran N
Year: 2010
Journal: Expert Rev Vaccines
Title: Complement-bound human antibodies to vaccinia virus B5 antigen protect mice from virus challenge.
Volume: 9
Issue: 3
Pages: 255-9
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Publication
19481265 | -
First Author: Botto M
Year: 2009
Journal: Mol Immunol
Title: Complement in human diseases: Lessons from complement deficiencies.
Volume: 46
Issue: 14
Pages: 2774-83
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Publication
26038300 | -
First Author: Truedsson L
Year: 2015
Journal: Mol Immunol
Title: Classical pathway deficiencies - A short analytical review.
Volume: 68
Issue: 1
Pages: 14-9
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Protein Domain
IPR037568 | Complement_C2
Type: Family
Description: This entry represents complement component C2, a component of the classical and lectin activation pathway of complement. C2 is cleaved by C1s (classical) or mannan-binding lectin-associated serine peptidases (lectin) into C2a and C2b []. C2a is a serine endopeptidase from family S1 (chymotrypsin family; MEROPS identifier S01.194) which complexes with C4b to form the C3/C5 convertase []. The complex is stabilized by Mg2+[, ]. The C3/C5 convertase has trypsin-like specificity []. C2 deficiency is the commonest human complement deficiency, which can result in systemic lupus erythematosus-like immune complex diseases []. The C2 gene is part of the major histocompatabaility complex [].
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Protein Domain
IPR011176 | CCP_VACV_C3/B5
Type: Family
Description: This group represents complement control proteins, vaccinia virus C3-type. The vaccinia virus complement control protein C3 is involved in modulating the host inflammatory response by blocking both classical and alternative pathways of complement activity through its ability to bind host complement components C3b and C4b (complement 3b and 4b, respectively) []. Protein B5, another member of this group, binds complement components C3 and C1q []. By blocking complement activation at multiple sites, the complement control proteins can down-regulate pro-inflammatory chemotactic factors (C3a, C4a, and C5a), resulting in reduced cellular influx and inflammation..
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Publication
8604219 | J:31869
First Author: Minta JO
Year: 1996
Journal: Mol Immunol
Title: cDNA cloning, sequencing and chromosomal assignment of the gene for mouse complement factor I (C3b/C4b inactivator): identification of a species specific divergent segment in factor I.
Volume: 33
Issue: 1
Pages: 101-12
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Publication
2940596 | J:8307
First Author: Kristensen T
Year: 1986
Journal: Proc Natl Acad Sci U S A
Title: Murine protein H is comprised of 20 repeating units, 61 amino acids in length.
Volume: 83
Issue: 11
Pages: 3963-7
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Publication
29233179 | J:271912
First Author: Nakao A
Year: 2017
Journal: Mol Brain
Title: Immature morphological properties in subcellular-scale structures in the dentate gyrus of Schnurri-2 knockout mice: a model for schizophrenia and intellectual disability.
Volume: 10
Issue: 1
Pages: 60
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Publication
22028430 | J:177710
First Author: Kõks S
Year: 2011
Journal: Physiol Genomics
Title: Hypothalamic gene expression profile indicates a reduction in G protein signaling in the Wfs1 mutant mice.
Volume: 43
Issue: 24
Pages: 1351-8
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Publication
10960475 | J:66001
First Author: Liszewski MK
Year: 2000
Journal: J Biol Chem
Title: Dissecting sites important for complement regulatory activity in membrane cofactor protein (MCP; CD46).
Volume: 275
Issue: 48
Pages: 37692-701
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Publication
8012361 | J:17371
First Author: Sargent CA
Year: 1994
Journal: Hum Mol Genet
Title: Characterisation of the novel gene G11 lying adjacent to the complement C4A gene in the human major histocompatibility complex.
Volume: 3
Issue: 3
Pages: 481-8
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Publication
27956064 | J:243049
 
First Author: Hasan M
Year: 2017
Journal: Neuroscience
Title: Novel genes in brain tissues of EAE-induced normal and obese mice: Upregulation of metal ion-binding protein genes in obese-EAE mice.
Volume: 343
Pages: 322-336
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Publication
32769120 | J:301513
First Author: Zarantonello A
Year: 2020
Journal: J Immunol
Title: An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase.
Volume: 205
Issue: 6
Pages: 1678-1694
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Publication
37943864 | J:357237
First Author: Munkhzul C
Year: 2023
Journal: PLoS One
Title: The microRNA-mediated gene regulatory network in the hippocampus and hypothalamus of the aging mouse.
Volume: 18
Issue: 11
Pages: e0291943
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Publication
1918990 | J:11498
First Author: Ogata RT
Year: 1991
Journal: J Immunol
Title: The murine Slp gene. Additional evidence that sex-limited protein has no biologic function.
Volume: 147
Issue: 8
Pages: 2756-63
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Publication
3874401 | J:7918
First Author: Amor M
Year: 1985
Journal: Proc Natl Acad Sci U S A
Title: Liver mRNA probes disclose two cytochrome P-450 genes duplicated in tandem with the complement C4 loci of the mouse H-2S region.
Volume: 82
Issue: 13
Pages: 4453-7
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Protein
O88174
Organism: Mus musculus/domesticus
Length: 365  
Fragment?: false
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Protein
A0A0R4J1X9
Organism: Mus musculus/domesticus
Length: 300  
Fragment?: false
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Protein
B2RWQ6
Organism: Mus musculus/domesticus
Length: 365  
Fragment?: false
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Publication
33183319 | J:344909
First Author: Aw E
Year: 2020
Journal: J Neuroinflammation
Title: Microglial responses to peripheral type 1 interferon.
Volume: 17
Issue: 1
Pages: 340
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Publication
33556539 | J:307704
 
First Author: Basak JM
Year: 2021
Journal: Neurobiol Dis
Title: Bacterial sepsis increases hippocampal fibrillar amyloid plaque load and neuroinflammation in a mouse model of Alzheimer's disease.
Volume: 152
Pages: 105292
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Protein
G3UXR6
Organism: Mus musculus/domesticus
Length: 177  
Fragment?: false
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Protein
I7HPW5
Organism: Mus musculus/domesticus
Length: 51  
Fragment?: true
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Protein Domain
IPR000436 | Sushi_SCR_CCP_dom
Type: Domain
Description: The extracellular sushi domain is characterised by a consensus sequence spanning ~60 residues containing four invariant cysteine residues forming two disulfide-bridges (I-III and II-IV), a highly conserved tryptophan, and conserved glycine, proline, and hydrophobic residues []. Sushi domains are known to be involved in many recognition processes, including the binding of several complement factors to fragments C3b and C4b []. The sushi domain is also known as the complement control protein (CCP) module or the short consensus repeat (SCR). Several structure of the sushi domain have been solved (see for example ) []. The sushi domain folds into a small and compact hydrophobic core enveloped by six β-strands and stabilised by two disulfide bridges. The relative structural orientation of the β-2 and β-4 strands is shared by all the sushi structures, whereas the topology of the other strands relative to this central conserved core is variable, especially at the regions that form the interfaces with the preceding and following domains [].
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Protein Domain
IPR003884 | FacI_MAC
Type: Domain
Description: This domain is found in complement component proteins, complement component factor 1 and agrin. Complement components C5b, C6, C7 C8 and C9 are the constituents of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Its assembly is initiated by protelytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9. Factor I is responsible for cleaving alpha chains of C4B and C3B in the presence of the cofactors C4-binding protein and factor H respectively. Agrin is a component of the basal lamina that causes the aggregation of acetylcholine receptors and acetylcholine-esterase on the surface of muscle fibres of the neuromuscular junction.
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Protein Domain
IPR035976 | Sushi/SCR/CCP_sf
Type: Homologous_superfamily
Description: The extracellular sushi domain is characterised by a consensus sequence spanning ~60 residues containing four invariant cysteine residues forming two disulfide-bridges (I-III and II-IV), a highly conserved tryptophan, and conserved glycine, proline, and hydrophobic residues []. Sushi domains are known to be involved in many recognition processes, including the binding of several complement factors to fragments C3b and C4b []. The sushi domain is also known as the complement control protein (CCP) module or the short consensus repeat (SCR). Several structure of the sushi domain have been solved (see for example ) []. The sushi domain folds into a small and compact hydrophobic core enveloped by six β-strands and stabilised by two disulfide bridges. The relative structural orientation of the β-2 and β-4 strands is shared by all the sushi structures, whereas the topology of the other strands relative to this central conserved core is variable, especially at the regions that form the interfaces with the preceding and following domains [].
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Protein
P19070
Organism: Mus musculus/domesticus
Length: 1025  
Fragment?: false
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Protein
P06909
Organism: Mus musculus/domesticus
Length: 1234  
Fragment?: false
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Protein
Q64735
Organism: Mus musculus/domesticus
Length: 483  
Fragment?: false
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Protein
Q61476
Organism: Mus musculus/domesticus
Length: 407  
Fragment?: false
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Protein
Q61475
Organism: Mus musculus/domesticus
Length: 390  
Fragment?: false
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