Type |
Details |
Score |
UniProt Feature |
Begin: |
1203 |
Description: |
Essential for CALM1 interaction |
Type: |
site |
End: |
1203 |
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•
•
•
•
•
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Allele |
Name: |
calmodulin 1; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Not Specified |
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•
•
•
•
•
|
Allele |
Name: |
calmodulin 1; endonuclease-mediated mutation 3, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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•
•
•
•
•
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Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
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•
•
•
•
•
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DO Term |
|
•
•
•
•
•
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Allele |
Name: |
calmodulin 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
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Allele |
Name: |
calmodulin 1; targeted mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Targeted |
Attribute String: |
Not Specified |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen Z |
Year: |
2017 |
Journal: |
Diabetes |
Title: |
Hepatic Activation of the FAM3C-HSF1-CaM Pathway Attenuates Hyperglycemia of Obese Diabetic Mice. |
Volume: |
66 |
Issue: |
5 |
Pages: |
1185-1197 |
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•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhao X |
Year: |
2018 |
Journal: |
Cell Biochem Funct |
Title: |
ILEI is an important intermediate participating in the formation of TGF-β1-induced renal tubular EMT. |
Volume: |
36 |
Issue: |
2 |
Pages: |
46-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen Z |
Year: |
2017 |
Journal: |
Oncotarget |
Title: |
FAM3C activates HSF1 to suppress hepatic gluconeogenesis and attenuate hyperglycemia of type 1 diabetic mice. |
Volume: |
8 |
Issue: |
62 |
Pages: |
106038-106049 |
|
•
•
•
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•
|
Protein Domain |
Type: |
Family |
Description: |
Protein FAM3C, also known as interleukin-like EMT inducer (ILEI), participates in the formation of TGF-beta1-induced renal tubular epithelial-to-mesenchymal transition (EMT) and has been linked to EMT in some diseases []. It is a hepatokine that suppresses hepatic gluconeogenic gene expression and insulin-independent gluconeogenesis by activating the HSF1-CaM-Akt pathway. It activates transcriptor heat shock factor 1 (HSF1) to induce CALM1 gene expression and increase calmodulin (CaM) protein level. An increase in CaM protein level suppresses glucose production by inducing Akt activation [, ]. |
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•
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
110
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
99
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
227
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
303
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
247
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
197
 |
Fragment?: |
false |
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•
•
•
•
|