Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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|
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•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Allele |
Name: |
CD164 antigen; wild type |
|
|
|
•
•
•
•
•
|
Allele |
Name: |
CD164 sialomucin-like 2; wild type |
Allele Type: |
Not Specified |
|
|
•
•
•
•
•
|
Allele |
Name: |
CD164 antigen; gene trap OST33912, Lexicon Genetics |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
CD164 antigen; endonuclease-mediated mutation 1, Cyagen Biosciences |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Publication |
First Author: |
Zannettino AC |
Year: |
1998 |
Journal: |
Blood |
Title: |
The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis. |
Volume: |
92 |
Issue: |
8 |
Pages: |
2613-28 |
|
•
•
•
•
•
|
Allele |
Name: |
CD164 antigen; gene trap D157G01, German Gene Trap Consortium |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
CD164 sialomucin-like 2; gene trap OST14023, Lexicon Genetics |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
CD164 sialomucin-like 2; targeted mutation 1, Lexicon Pharmaceuticals |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
CD164 antigen; targeted mutation 1a, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Null/knockout, Reporter |
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•
•
•
•
•
|
Allele |
Name: |
CD164 antigen; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Allele |
Name: |
CD164 antigen; endonuclease-mediated mutation 2, GemPharmatech Co., Ltd |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
CD164 sialomucin-like 2; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Allele |
Name: |
CD164 sialomucin-like 2; endonuclease-mediated mutation 2, GemPharmatech Co., Ltd |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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•
•
•
•
•
|
Allele |
Name: |
CD164 antigen; endonuclease-mediated mutation 1, Baylor College of Medicine |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6455044 |
Assay Type: |
RNA in situ |
Annotation Date: |
2020-09-14 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1760027 |
Pattern: |
Regionally restricted |
Stage: |
TS27 |
Assay Id: |
MGI:6455074 |
Age: |
postnatal day 1 |
Image: |
2c |
Note: |
Expression is restricted to the hair cells (inner and outer). |
Specimen Label: |
2c |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Allele |
Name: |
CD164 sialomucin-like 2; targeted mutation 1, Mouse Biology Program, UC Davis |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
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•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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•
•
•
•
•
|
Publication |
First Author: |
Nyegaard M |
Year: |
2015 |
Journal: |
PLoS Genet |
Title: |
A Novel Locus Harbouring a Functional CD164 Nonsense Mutation Identified in a Large Danish Family with Nonsyndromic Hearing Impairment. |
Volume: |
11 |
Issue: |
7 |
Pages: |
e1005386 |
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•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Endo Y |
Year: |
2004 |
Journal: |
Genomics |
Title: |
Identification of the mouse H-ficolin gene as a pseudogene and orthology between mouse ficolins A/B and human L-/M-ficolins. |
Volume: |
84 |
Issue: |
4 |
Pages: |
737-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chan JY |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
Relationship between novel isoforms, functionally important domains, and subcellular distribution of CD164/endolyn. |
Volume: |
276 |
Issue: |
3 |
Pages: |
2139-52 |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
197
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
195
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
162
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
24
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
197
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
161
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
CD164 is a mucin-like receptor, or sialomucin, with specificity inreceptor/ligand interactions that depends on the structural characteristics of themucin-like receptor. Its functions include mediating, or regulating,haematopoietic progenitor cell adhesion and the negative regulation of theirgrowth and/or-differentiation. It exists in the native state as adisulphide-linked homodimer of two 80-85kDa subunits. It is usually expressed by CD34+and CD341o/- haematopoietic stem cells and associated microenvironmentalcells. It contains, in its extracellular region, two mucin domains (I andII)linked by a non-mucin domain, which has been predicted to contain intra-disulphide bridges. This receptor may play a key role in haematopoiesisby facilitating the adhesion of human CD34+ cells to bone marrow stroma andby negatively regulating CD34+ CD341o/- haematopoietic progenitor cellproliferation. These effects involve the CD164 class I and/or II epitopesrecognised by the monoclonal antibodies (mAbs) 105A5 and 103B2/9E10. Theseepitopes are carbohydrate-dependent and are located on the N-terminalmucin domain I [, ].It has been found that murine MGC-24v and rat endolyn share significantsequence similarities with human CD164. However, CD164 lacks the consensusglycosaminoglycan (GAG)-attachment site found in MGC-24; it is possiblethat GAG-association is responsible for the high molecular weight of theepithelial-derived MGC-24 glycoprotein [].Genomic structure studies have placed CD164 within the mucin-subgroupthatcomprises multiple exons, and demonstrate the diverse chromosomaldistribution of this family of molecules. Molecules with such multipleexons may have sophisticated regulatory mechanisms that involve not onlypost-translational modifications of the oligosaccharide side chains, butalso differential exon usage. Although differences in the intron and exonsizes are seen between the mouse and human genes, the predicted proteinsare similar in size and structure, maintaining functionally importantmotifs that regulate cell proliferation or subcellular distribution [].CD164 is a gene whose expression depends on differential usage of poly-adenylation sites within the 3'-UTR. The conserved distribution of the3.2- and 1.2-kb CD164 transcripts between mouse and human suggests that(i) a mechanism may exist to regulate tissue-specific polyadenylation, and(ii) differences in polyadenylation are important for the expression andfunction of CD164 in different tissues. Two other aspects of the structureof CD164 are of particular interest. First, it shares one of severalconserved features of a cytokine-binding pocket - in this respect, it isnotable that evidence exists for a class of cell-surface sialomucinmodulators that directly interact with growth factor receptors to regulatetheir response to physiological ligands. Second, its cytoplasmic tailcontains a C-terminal YHTL motif found in many endocytic membrane proteinsor receptors. These Tyr-based motifs bind to adaptor proteins, which mediatethe sorting of membrane proteins into transport vesicles from the plasmamembrane to the endosomes, and between intracellular compartments. |
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•
•
•
•
•
|
Publication |
First Author: |
Kolla L |
Year: |
2020 |
Journal: |
Nat Commun |
Title: |
Characterization of the development of the mouse cochlear epithelium at the single cell level. |
Volume: |
11 |
Issue: |
1 |
Pages: |
2389 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tang T |
Year: |
2010 |
Journal: |
Nat Biotechnol |
Title: |
A mouse knockout library for secreted and transmembrane proteins. |
Volume: |
28 |
Issue: |
7 |
Pages: |
749-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lexicon Genetics, Inc |
Year: |
2011 |
Journal: |
Database Download |
Title: |
MGI download of Lexicon knockout data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
University of California, Davis |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the University of California, Davis |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
Journal: |
Database Download |
Title: |
Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Function or Process or Component Unknown following Literature Review |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
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•
•
•
•
•
|
Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
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•
•
•
•
|