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Search results 301 to 400 out of 530 for Cd22

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Hits by Pathway

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Hits by Strain

Type Details Score
Allele
Cd22<tm1b(EUCOMM)Wtsi> | MGI:5696933
Name: CD22 antigen; targeted mutation 1b, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Strain
MGI:6113422 | C57BL/6J-Cd22<m5Btlr>
Attribute String: mutant strain, chemically induced mutation, coisogenic
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Allele
Cd22<tm1d(EUCOMM)Wtsi> | MGI:7256947
Name: CD22 antigen; targeted mutation 1d, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Cd22<em3Gpt> | MGI:7296545
Name: CD22 antigen; endonuclease-mediated mutation 3, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Cd22<em1(CD22)Gpt> | MGI:7462058
Name: CD22 antigen; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Cd22<tm1c(EUCOMM)Wtsi> | MGI:7514185
Name: CD22 antigen; targeted mutation 1c, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready
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Strain
MGI:7577225 | BALB/cJGpt-Cd22<em2(CD22)Gpt>/Gpt
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7590954 | C57BL/6J-Cd22<em1Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Cd22<em3(CD22)Smoc> | MGI:7750455
Name: CD22 antigen; endonuclease-mediated mutation 3, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Inserted expressed sequence
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Genotype
Genotype
Symbol: Cd22/Cd22
Background: C57BL/6JAnu-Cd22/AnuApb
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd22/Cd22
Background: C57BL/6J-Cd22
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd22/Cd22
Background: involves: C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd22/Cd22
Background: involves: 129S4/SvJae
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd22/Cd22
Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd22/Cd22
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd22/Cd22
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd22/Cd22
Background: C57BL/6J-Cd22
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd22/Cd22
Background: C57BL/6J-Cd22
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd22/Cd22
Background: C57BL/6J-Cd22
Zygosity: hm
Has Mutant Allele: true
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Publication
9344866 | -
First Author: Sawzdargo M
Year: 1997
Journal: Biochem Biophys Res Commun
Title: A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1.
Volume: 239
Issue: 2
Pages: 543-7
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Strain
MGI:3772695 | C57BL/6-Cd22<tm1Lam>/J
Attribute String: coisogenic, mutant strain, targeted mutation
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Strain
MGI:6756388 | B6.129-Cd22<tm2Tft>/Tft
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:6756387 | B6;129-Cd22<tm2Tft>/Tft
Attribute String: mutant stock, targeted mutation
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Strain
MGI:6343626 | B6(Cg)-Cd22<tm2.1Tft>/Mmnc
Attribute String: mutant strain, congenic, targeted mutation
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Strain
MGI:6334730 | C57BL/6N-Cd22<tm1a(EUCOMM)Wtsi>/Tcp
Attribute String: coisogenic, mutant strain, targeted mutation
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Strain
MGI:6261483 | C57BL/6N-Cd22<tm1b(EUCOMM)Wtsi>/Tcp
Attribute String: coisogenic, targeted mutation
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Strain
MGI:7258046 | C57BL/6NCrl-Cd22<tm1d(EUCOMM)Wtsi>/Tcp
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7469101 | C57BL/6JGpt-Cd22<em1(CD22)Gpt>/Gpt
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7764225 | BALB/cAnSmoc-Cd22<em3(CD22)Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Cd22/Cd22
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd22/Cd22
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd22/Cd22
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd22/Cd22
Background: involves: 129 * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd22/Cd22
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd22/Cd22
Background: either: (involves: 129S/SvEv * BALB/c) or (involves: 129S/SvEv * C57BL/6J)
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd22/Cd22
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd22/Cd22
Background: C57BL/6N-Cd22/Tcp
Zygosity: hm
Has Mutant Allele: true
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Publication
18925876 | -
First Author: Toda M
Year: 2009
Journal: Biochem J
Title: Ligation of tumour-produced mucins to CD22 dramatically impairs splenic marginal zone B-cells.
Volume: 417
Issue: 3
Pages: 673-83
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Publication
- | J:676
First Author: Law CL
Year: 1992
Journal: FASEB J
Title: cDNA and genomic organization of the murine B cell associated adhesion protein CD22
Volume: 6
Issue: 4
Pages: A1131 (Abstr.)
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Strain
MGI:4941833 | B6;129P2-Cd22<tm1Eac> Tg(IghelMD4)4Ccg/AnuApb
Attribute String: targeted mutation, transgenic, mutant stock
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Strain
MGI:6343944 | C57BL/6N-A<tm1Brd> Cd22<tm1b(EUCOMM)Wtsi>/TcpMmucd
Attribute String: mutant strain, coisogenic, targeted mutation
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Strain
MGI:6343943 | C57BL/6N-A<tm1Brd> Cd22<tm1a(EUCOMM)Wtsi>/TcpMmucd
Attribute String: mutant strain, coisogenic, targeted mutation
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Strain
MGI:7577319 | BALB/cJGpt-Cd22<em2(CD22)Gpt> Is(9CD3E-CD3G)1Gpt/Gpt
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Cd22/Cd22 Endou/Endou
Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd22/Cd22<+>
Background: C57BL/6N-Cd22/Tcp
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd22/Cd22 Igh/Igh
Background: involves: 129 * BALB/c * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd22/Cd22<+> Tg(IghelMD4)4Ccg/?
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Protein Coding Gene
MGI:96431 | Cd79b
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene Segment
MGI:96447 | Ighd
Type: gene_segment
Organism: mouse, laboratory
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Protein Coding Gene
MGI:101774 | Cd79a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P11911
Organism: Mus musculus/domesticus
Length: 220  
Fragment?: false
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Protein
P15530
Organism: Mus musculus/domesticus
Length: 228  
Fragment?: false
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Protein
A0A0A6YW14
Organism: Mus musculus/domesticus
Length: 291  
Fragment?: true
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Genotype
Genotype
Symbol: Cd22/Cd22 Igh/Igh<+>
Background: involves: 129 * BALB/c * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Gene Segment
MGI:96448 | Ighm
Type: gene_segment
Organism: mouse, laboratory
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Protein
P01872
Organism: Mus musculus/domesticus
Length: 454  
Fragment?: false
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Genotype
Genotype
Symbol: Cd22/Cd22<+> Ptpn6/Ptpn6<+> Tg(IghelMD4)4Ccg/?
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd22/Cd22<+> Lyn/Lyn<+> Tg(IghelMD4)4Ccg/?
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd22/Cd22<+> Lyn/Lyn<+> Ptpn6/Ptpn6<+> Tg(IghelMD4)4Ccg/?
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Protein
P25911
Organism: Mus musculus/domesticus
Length: 512  
Fragment?: false
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Publication
9547345 | J:110932
First Author: Nishizumi H
Year: 1998
Journal: J Exp Med
Title: A double-edged kinase Lyn: a positive and negative regulator for antigen receptor-mediated signals.
Volume: 187
Issue: 8
Pages: 1343-8
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Publication
16054613 | J:100560
First Author: Mattsson N
Year: 2005
Journal: Cell Immunol
Title: Expansion of CD22lo B cells in the spleen of autoimmune-prone flaky skin mice.
Volume: 234
Issue: 2
Pages: 124-32
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Publication
9539767 | J:79166
First Author: Hennet T
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Immune regulation by the ST6Gal sialyltransferase.
Volume: 95
Issue: 8
Pages: 4504-9
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Publication
20181615 | J:161568
First Author: Chen WC
Year: 2010
Journal: Blood
Title: In vivo targeting of B-cell lymphoma with glycan ligands of CD22.
Volume: 115
Issue: 23
Pages: 4778-86
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Publication
11007759 | -
First Author: Ochi H
Year: 2000
Journal: Int Immunol
Title: Negative regulation of B cell receptor-mediated signaling in B-1 cells through CD5 and Ly49 co-receptors via Lyn kinase activity.
Volume: 12
Issue: 10
Pages: 1417-23
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Publication
15664155 | J:96277
First Author: Xu Y
Year: 2005
Journal: Immunity
Title: Lyn tyrosine kinase: accentuating the positive and the negative.
Volume: 22
Issue: 1
Pages: 9-18
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Publication
17127394 | -
 
First Author: Sampson M
Year: 2007
Journal: Front Biosci
Title: Src kinases in G-CSF receptor signaling.
Volume: 12
Pages: 1463-74
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Protein Domain
IPR013312 | GPR40-rel_orph
Type: Family
Description: G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions (including various autocrine, para-crine and endocrine processes). They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include the rhodopsin-like GPCRs, the secretin-like GPCRs, the cAMP receptors, the fungal mating pheromone receptors, and the metabotropic glutamate receptor family. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone, neurotransmitter and light receptors, all of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character, the amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7 transmembrane (TM) helices [, , ]. A cluster of four intronless GPCR genes, sharing significant sequence similarity with one another, have been identified on human chromosome 19q13.1, downstream from the CD22 gene []. The receptors have been named GPR40, GPR41, GPR42 and GPR43. The GPR42 protein sequence shares more than 98% amino acid identity with GPR41 and is located on a possible polymorphic insert[].
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Protein Domain
IPR035748 | Lyn_SH3
Type: Domain
Description: Lyn is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Lyn is expressed in B lymphocytes and myeloid cells. It exhibits both positive and negative regulatory roles in B cell receptor (BCR) signaling. Lyn, as well as Fyn and Blk, promotes B cell activation by phosphorylating ITAMs (immunoreceptor tyr activation motifs) in CD19 and in Ig components of BCR []. It negatively regulates signaling by its unique ability to phosphorylate ITIMs (immunoreceptor tyr inhibition motifs) in cell surface receptors like CD22 and CD5 []. Lyn also plays an important role in G-CSF receptor signaling by phosphorylating a variety of adaptor molecules []. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The SH3 domain of Src kinases contributes to substrate recruitment by binding adaptor proteins/substrates, and regulation of kinase activity through an intramolecular interaction [, ].
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Gene Segment
MGI:4439556 | Ighv5-16
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3645977 | Ighv5-12-4
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:4439873 | Ighv5-9
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:4439895 | Ighv5-4
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:4439533 | Ighv5-17
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3643949 | Ighv3-3
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3644034 | Ighv3-4
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3648045 | Ighv3-5
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:4439856 | Ighv3-6
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3645298 | Ighv3-8
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3705861 | Ighv13-2
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3646760 | Ighv12-3
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:4439854 | Ighv6-3
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3704120 | Ighv6-4
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:4439619 | Ighv6-6
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3644477 | Ighv6-7
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3647474 | Ighv8-2
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3646040 | Ighv8-4
Type: gene_segment
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96529 | Igll1
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene Segment
MGI:99546 | Iglc1
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3642338 | Igkv11-125
Type: gene_segment
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96055 | Ptpn6
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene Segment
MGI:4439534 | Ighv3-1
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:99886 | Iglc3
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:99547 | Iglc2
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:4439879 | Igkv2-137
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3647671 | Igkv17-121
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3648380 | Igkv1-133
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3648800 | Igkv1-132
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:3645551 | Igkv1-131
Type: gene_segment
Organism: mouse, laboratory
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Gene Segment
MGI:4439721 | Igkv1-117
Type: gene_segment
Organism: mouse, laboratory
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