| Type |
Details |
Score |
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Absent |
| Sex: |
Male |
| Emaps: |
EMAPS:1868128 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:6691526 |
| Age: |
postnatal adult |
| Image: |
HMGU_692925 |
| Note: |
vas deferens |
| Specimen Label: |
HMGU_692925 |
| Detected: |
false |
| Specimen Num: |
14 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:1610528 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6691526 |
| Age: |
postnatal adult |
| Image: |
HMGU_1366714 |
|
| Specimen Label: |
HMGU_1366714 |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1610528 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6691526 |
| Age: |
postnatal adult |
| Image: |
HMGU_692927 |
|
| Specimen Label: |
HMGU_692927 |
| Detected: |
true |
| Specimen Num: |
15 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1797228 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6691526 |
| Age: |
postnatal adult |
| Image: |
HMGU_692917 |
|
| Specimen Label: |
HMGU_692917 |
| Detected: |
true |
| Specimen Num: |
10 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Absent |
| Sex: |
Female |
| Emaps: |
EMAPS:1832128 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:6691526 |
| Age: |
postnatal adult |
| Image: |
HMGU_1366711 |
|
| Specimen Label: |
HMGU_1366711 |
| Detected: |
false |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Absent |
| Sex: |
Male |
| Emaps: |
EMAPS:1832128 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:6691526 |
| Age: |
postnatal adult |
| Image: |
HMGU_692925 |
|
| Specimen Label: |
HMGU_692925 |
| Detected: |
false |
| Specimen Num: |
14 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1510754 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2009-08-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1754722 |
| Pattern: |
Not Specified |
| Stage: |
TS22 |
| Assay Id: |
MGI:4354920 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
Table S5 - Siva |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1510754 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2023-09-18 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1754722 |
| Pattern: |
Not Specified |
| Stage: |
TS22 |
| Assay Id: |
MGI:7526629 |
| Age: |
embryonic day 14.5 |
|
| Note: |
Ventricular zone expression was greater than in the cortical plate. |
| Specimen Label: |
Supplementary table 2 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:3599828 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6691526 |
| Age: |
postnatal adult |
| Image: |
HMGU_1366712 |
|
| Specimen Label: |
HMGU_1366712 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:3599828 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6691526 |
| Age: |
postnatal adult |
| Image: |
HMGU_692921 |
|
| Specimen Label: |
HMGU_692921 |
| Detected: |
true |
| Specimen Num: |
12 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:1702128 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6691526 |
| Age: |
postnatal adult |
| Image: |
HMGU_1366717 |
|
| Specimen Label: |
HMGU_1366717 |
| Detected: |
true |
| Specimen Num: |
8 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1702128 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6691526 |
| Age: |
postnatal adult |
| Image: |
HMGU_692933 |
|
| Specimen Label: |
HMGU_692933 |
| Detected: |
true |
| Specimen Num: |
18 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:3592628 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6691526 |
| Age: |
postnatal adult |
| Image: |
HMGU_692915 |
|
| Specimen Label: |
HMGU_692915 |
| Detected: |
true |
| Specimen Num: |
9 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:1757728 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6691526 |
| Age: |
postnatal adult |
| Image: |
HMGU_1366715 |
|
| Specimen Label: |
HMGU_1366715 |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1757728 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6691526 |
| Age: |
postnatal adult |
| Image: |
HMGU_692929 |
|
| Specimen Label: |
HMGU_692929 |
| Detected: |
true |
| Specimen Num: |
16 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:1689428 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6691526 |
| Age: |
postnatal adult |
| Image: |
HMGU_1366713 |
|
| Specimen Label: |
HMGU_1366713 |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689428 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6691526 |
| Age: |
postnatal adult |
| Image: |
HMGU_692923 |
|
| Specimen Label: |
HMGU_692923 |
| Detected: |
true |
| Specimen Num: |
13 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1881228 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6691526 |
| Age: |
postnatal adult |
| Image: |
HMGU_692935 |
|
| Specimen Label: |
HMGU_692935 |
| Detected: |
true |
| Specimen Num: |
19 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Taghon T |
| Year: |
2006 |
| Journal: |
Immunity |
| Title: |
Developmental and molecular characterization of emerging beta- and gammadelta-selected pre-T cells in the adult mouse thymus. |
| Volume: |
24 |
| Issue: |
1 |
| Pages: |
53-64 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ballesteros-Tato A |
| Year: |
2014 |
| Journal: |
Immunity |
| Title: |
Epitope-specific regulation of memory programming by differential duration of antigen presentation to influenza-specific CD8(+) T cells. |
| Volume: |
41 |
| Issue: |
1 |
| Pages: |
127-40 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Muranski P |
| Year: |
2011 |
| Journal: |
Immunity |
| Title: |
Th17 cells are long lived and retain a stem cell-like molecular signature. |
| Volume: |
35 |
| Issue: |
6 |
| Pages: |
972-85 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Klein F |
| Year: |
2019 |
| Journal: |
J Exp Med |
| Title: |
The transcription factor Duxbl mediates elimination of pre-T cells that fail β-selection. |
| Volume: |
216 |
| Issue: |
3 |
| Pages: |
638-655 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shin HM |
| Year: |
2013 |
| Journal: |
Immunity |
| Title: |
Epigenetic modifications induced by Blimp-1 Regulate CD8⁺ T cell memory progression during acute virus infection. |
| Volume: |
39 |
| Issue: |
4 |
| Pages: |
661-75 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schmolka N |
| Year: |
2018 |
| Journal: |
Sci Immunol |
| Title: |
MicroRNA-146a controls functional plasticity in γδ T cells by targeting NOD1. |
| Volume: |
3 |
| Issue: |
23 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
García P |
| Year: |
2004 |
| Journal: |
J Leukoc Biol |
| Title: |
Signalling via CD70, a member of the TNF family, regulates T cell functions. |
| Volume: |
76 |
| Issue: |
1 |
| Pages: |
263-70 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Johansson SE |
| Year: |
2011 |
| Journal: |
Cell Immunol |
| Title: |
Accumulation and activation of natural killer cells in local intraperitoneal HIV-1/MuLV infection results in early control of virus infected cells. |
| Volume: |
272 |
| Issue: |
1 |
| Pages: |
71-8 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more than 20 type-I transmembrane proteins. Family members are defined based on similarity in their extracellular domain -a region that contains many cysteine residues arranged in a specific repetitive pattern []. The cysteines allow formation of an extended rod-like structure, responsible for ligand binding []. Upon receptor activation, different intracellular signalling complexes are assembled for different members of the TNFR superfamily, depending on their intracellular domains and sequences []. Activation of TNFRs can therefore induce a range of disparate effects, including cell proliferation, differentiation, survival, or apoptotic cell death, depending upon the receptor involved [, ]. TNFRs are widely distributed and play important roles in many crucial biological processes, such as lymphoid and neuronal development, innate and adaptive immunity, and maintenance of cellular homeostasis []. Drugs that manipulate their signalling have potential roles in the prevention and treatment of many diseases, such as viral infections, coronary heart disease, transplant rejection, and immune disease []. TNF receptor 7, otherwise known as CD27 antigen, is expressed on discrete subpopulations of T-and B-cells []. The receptor plays a vital role in the generation and long-term maintenance of T-cell immunity []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nocentini G |
| Year: |
1997 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. |
| Volume: |
94 |
| Issue: |
12 |
| Pages: |
6216-21 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Teng MS |
| Year: |
2002 |
| Journal: |
Eur J Immunol |
| Title: |
A human TAPBP (TAPASIN)-related gene, TAPBP-R. |
| Volume: |
32 |
| Issue: |
4 |
| Pages: |
1059-68 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Harms RZ |
| Year: |
2017 |
| Journal: |
Front Immunol |
| Title: |
Interleukin (IL)-18 Binding Protein Deficiency Disrupts Natural Killer Cell Maturation and Diminishes Circulating IL-18. |
| Volume: |
8 |
|
| Pages: |
1020 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ballas ZK |
| Year: |
2013 |
| Journal: |
PLoS One |
| Title: |
Role of NK cell subsets in organ-specific murine melanoma metastasis. |
| Volume: |
8 |
| Issue: |
6 |
| Pages: |
e65599 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Demirci G |
| Year: |
2004 |
| Journal: |
J Immunol |
| Title: |
Critical role of OX40 in CD28 and CD154-independent rejection. |
| Volume: |
172 |
| Issue: |
3 |
| Pages: |
1691-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kemball CC |
| Year: |
2006 |
| Journal: |
J Immunol |
| Title: |
Costimulation requirements for antiviral CD8+ T cells differ for acute and persistent phases of polyoma virus infection. |
| Volume: |
176 |
| Issue: |
3 |
| Pages: |
1814-24 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fuse S |
| Year: |
2008 |
| Journal: |
J Immunol |
| Title: |
Control of memory CD8+ T cell differentiation by CD80/CD86-CD28 costimulation and restoration by IL-2 during the recall response. |
| Volume: |
180 |
| Issue: |
2 |
| Pages: |
1148-57 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
van Olffen RW |
| Year: |
2010 |
| Journal: |
J Innate Immun |
| Title: |
CD70-driven chronic immune activation is protective against atherosclerosis. |
| Volume: |
2 |
| Issue: |
4 |
| Pages: |
344-52 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ong S |
| Year: |
2015 |
| Journal: |
Am J Pathol |
| Title: |
Natural killer cells limit cardiac inflammation and fibrosis by halting eosinophil infiltration. |
| Volume: |
185 |
| Issue: |
3 |
| Pages: |
847-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mikkelsen M |
| Year: |
2011 |
| Journal: |
J Immunol |
| Title: |
Enhanced and sustained CD8+ T cell responses with an adenoviral vector-based hepatitis C virus vaccine encoding NS3 linked to the MHC class II chaperone protein invariant chain. |
| Volume: |
186 |
| Issue: |
4 |
| Pages: |
2355-64 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dong H |
| Year: |
2015 |
| Journal: |
Eur J Immunol |
| Title: |
CD70 and IFN-1 selectively induce eomesodermin or T-bet and synergize to promote CD8+ T-cell responses. |
| Volume: |
45 |
| Issue: |
12 |
| Pages: |
3289-301 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Beyranvand Nejad E |
| Year: |
2016 |
| Journal: |
Cancer Res |
| Title: |
Tumor Eradication by Cisplatin Is Sustained by CD80/86-Mediated Costimulation of CD8+ T Cells. |
| Volume: |
76 |
| Issue: |
20 |
| Pages: |
6017-6029 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Sandau MM |
| Year: |
2010 |
| Journal: |
J Immunol |
| Title: |
IL-15 regulates both quantitative and qualitative features of the memory CD8 T cell pool. |
| Volume: |
184 |
| Issue: |
1 |
| Pages: |
35-44 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Munitic I |
| Year: |
2013 |
| Journal: |
J Immunol |
| Title: |
CD70 deficiency impairs effector CD8 T cell generation and viral clearance but is dispensable for the recall response to lymphocytic choriomeningitis virus. |
| Volume: |
190 |
| Issue: |
3 |
| Pages: |
1169-79 |
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•
•
•
•
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| Publication |
| First Author: |
Fogel LA |
| Year: |
2013 |
| Journal: |
J Immunol |
| Title: |
Markers of nonselective and specific NK cell activation. |
| Volume: |
190 |
| Issue: |
12 |
| Pages: |
6269-76 |
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•
•
•
•
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| Publication |
| First Author: |
Maillard I |
| Year: |
2006 |
| Journal: |
J Exp Med |
| Title: |
The requirement for Notch signaling at the beta-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor. |
| Volume: |
203 |
| Issue: |
10 |
| Pages: |
2239-45 |
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•
•
•
•
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| Publication |
| First Author: |
Redmond WL |
| Year: |
2007 |
| Journal: |
J Immunol |
| Title: |
Defects in the acquisition of CD8 T cell effector function after priming with tumor or soluble antigen can be overcome by the addition of an OX40 agonist. |
| Volume: |
179 |
| Issue: |
11 |
| Pages: |
7244-53 |
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•
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| Publication |
| First Author: |
Wang Y |
| Year: |
2017 |
| Journal: |
J Immunol |
| Title: |
Involvement of NK Cells in IL-28B-Mediated Immunity against Influenza Virus Infection. |
| Volume: |
199 |
| Issue: |
3 |
| Pages: |
1012-1020 |
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•
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| Publication |
| First Author: |
Leigh ND |
| Year: |
2017 |
| Journal: |
J Immunol |
| Title: |
Host-Derived CD70 Suppresses Murine Graft-versus-Host Disease by Limiting Donor T Cell Expansion and Effector Function. |
| Volume: |
199 |
| Issue: |
1 |
| Pages: |
336-347 |
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•
•
•
•
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| Publication |
| First Author: |
O'Neill RE |
| Year: |
2017 |
| Journal: |
J Immunol |
| Title: |
T Cell-Derived CD70 Delivers an Immune Checkpoint Function in Inflammatory T Cell Responses. |
| Volume: |
199 |
| Issue: |
10 |
| Pages: |
3700-3710 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tangye SG |
| Year: |
2002 |
| Journal: |
Eur J Immunol |
| Title: |
CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2. |
| Volume: |
32 |
| Issue: |
6 |
| Pages: |
1640-9 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Patra AK |
| Year: |
2006 |
| Journal: |
J Immunol |
| Title: |
PKB rescues calcineurin/NFAT-induced arrest of Rag expression and pre-T cell differentiation. |
| Volume: |
177 |
| Issue: |
7 |
| Pages: |
4567-76 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Despoix N |
| Year: |
2008 |
| Journal: |
Eur J Immunol |
| Title: |
Mouse CD146/MCAM is a marker of natural killer cell maturation. |
| Volume: |
38 |
| Issue: |
10 |
| Pages: |
2855-64 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kawamura T |
| Year: |
2011 |
| Journal: |
J Invest Dermatol |
| Title: |
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