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Search results 301 to 400 out of 529 for Cd68

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Hits by Strain

Type Details Score
Publication
27908893 | J:262648
First Author: McNeill E
Year: 2017
Journal: Arterioscler Thromb Vasc Biol
Title: Tracking Monocyte Recruitment and Macrophage Accumulation in Atherosclerotic Plaque Progression Using a Novel hCD68GFP/ApoE-/- Reporter Mouse-Brief Report.
Volume: 37
Issue: 2
Pages: 258-263
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Publication
27572261 | J:269693
   
First Author: Iqbal AJ
Year: 2016
Journal: Elife
Title: Acute exposure to apolipoprotein A1 inhibits macrophage chemotaxis in vitro and monocyte recruitment in vivo.
Volume: 5
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Allele
Tg(CD68-rtTA2S*M2)3Mpil | MGI:4418488
Name: transgene insertion 3, Manoj M Pillai
Allele Type: Transgenic
Attribute String: Transactivator
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Allele
Tg(CD68-icre)1Bwlx | MGI:5474196
Name: transgene insertion 1, Ben Wielockx
Allele Type: Transgenic
Attribute String: Recombinase
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Strain
MGI:5576385 | B6.Cg-Tg(Cd68-BCL2)535Medz/Biat
Attribute String: mutant strain, transgenic
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Strain
MGI:5750313 | B10.Cg-H2<p> Tg(CD68-H2-Ab1<q>)#Rhd/RhdKctt
Attribute String: congenic, major histocompatibility congenic, mutant strain, transgenic
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Allele
Tg(CD68-Prkaa1*T172D)1Dbrh | MGI:5752355
Name: transgene insertion 1, DeBroski R Herbert
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:7562291 | B6(Cg)-Gt(ROSA)26Sor<tm1(CD68-cre/ERT2)Drg>/J
Attribute String: mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Tg(Cd68-BCL2)535Medz/?
Background: involves: 129 * C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Publication
28850249 | J:269228
First Author: McCubbrey AL
Year: 2018
Journal: Am J Respir Cell Mol Biol
Title: Deletion of c-FLIP from CD11bhi Macrophages Prevents Development of Bleomycin-induced Lung Fibrosis.
Volume: 58
Issue: 1
Pages: 66-78
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Strain
MGI:5796548 | NOD.Cg-Tg(CD68-EGFP)1Drg Prkdc<scid> Il2rg<tm1Wjl>/J
Attribute String: congenic, mutant strain, spontaneous mutation, targeted mutation, transgenic
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Strain
MGI:4418964 | B6.Cg-Tg(CD68-rtTA2S*M2)3Mpil/Mmjax
Attribute String: congenic, mutant strain, transgenic
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Publication
19772887 | J:154457
First Author: Pillai MM
Year: 2009
Journal: Exp Hematol
Title: Inducible transgenes under the control of the hCD68 promoter identifies mouse macrophages with a distribution that differs from the F4/80 - and CSF-1R-expressing populations.
Volume: 37
Issue: 12
Pages: 1387-92
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Publication
19307478 | J:166498
First Author: Gautier EL
Year: 2009
Journal: Circulation
Title: Macrophage apoptosis exerts divergent effects on atherogenesis as a function of lesion stage.
Volume: 119
Issue: 13
Pages: 1795-804
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Strain
MGI:5752363 | C57BL/6N-Tg(CD68-Prkaa1*T172D)1Dbrh/J
Attribute String: coisogenic, mutant strain, transgenic
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HT Experiment
GSE180274 | PLCG2 regulates endocannabinoid and eicosanoid networks in innate immune cells
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
33052099 | J:353224
   
First Author: Joseph A
Year: 2020
Journal: Elife
Title: Label-free imaging of immune cell dynamics in the living retina using adaptive optics.
Volume: 9
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Allele
Hprt1<tm100(Ple31-EGFP)Ems> | MGI:5303182
Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 100, Elizabeth M Simpson
Allele Type: Targeted
Attribute String: Reporter
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Allele
Hprt1<tm98(Ple30-EGFP)Ems> | MGI:5303454
Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 98, Elizabeth M Simpson
Allele Type: Targeted
Attribute String: Reporter
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Allele
Hprt1<tm99(Ple30-lacZ)Ems> | MGI:5303455
 
Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 99, Elizabeth M Simpson
Allele Type: Targeted
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Genotype
Genotype
Symbol: Egln1/Egln1 Tg(CD68-icre)1Bwlx/?
Background: involves: C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hif1a/Hif1a Tg(CD68-icre)1Bwlx/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Epas1/Epas1 Tg(CD68-icre)1Bwlx/?
Background: involves: 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Protein
P31996
Organism: Mus musculus/domesticus
Length: 326  
Fragment?: false
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Protein
P17047
Organism: Mus musculus/domesticus
Length: 415  
Fragment?: false
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Protein
P11438
Organism: Mus musculus/domesticus
Length: 406  
Fragment?: false
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Protein
Q8C5K0
Organism: Mus musculus/domesticus
Length: 416  
Fragment?: false
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Protein
Q8C876
Organism: Mus musculus/domesticus
Length: 415  
Fragment?: false
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Protein
Q3TA96
Organism: Mus musculus/domesticus
Length: 406  
Fragment?: false
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Protein
Q9DC13
Organism: Mus musculus/domesticus
Length: 407  
Fragment?: false
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Protein
Q3TWE1
Organism: Mus musculus/domesticus
Length: 415  
Fragment?: false
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Protein
Q922T9
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: true
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Protein
Q9CZU7
Organism: Mus musculus/domesticus
Length: 415  
Fragment?: false
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Protein
Q3TX84
Organism: Mus musculus/domesticus
Length: 406  
Fragment?: false
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Protein
A2AT95
Organism: Mus musculus/domesticus
Length: 91  
Fragment?: true
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Protein
Q8VH34
Organism: Mus musculus/domesticus
Length: 406  
Fragment?: false
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Protein
Q3UIW3
Organism: Mus musculus/domesticus
Length: 415  
Fragment?: false
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Protein
A0A0R4J1C8
Organism: Mus musculus/domesticus
Length: 335  
Fragment?: false
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Publication
1939168 | -
First Author: Fukuda M
Year: 1991
Journal: J Biol Chem
Title: Lysosomal membrane glycoproteins. Structure, biosynthesis, and intracellular trafficking.
Volume: 266
Issue: 32
Pages: 21327-30
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Publication
9768752 | -
First Author: de Saint-Vis B
Year: 1998
Journal: Immunity
Title: A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment.
Volume: 9
Issue: 3
Pages: 325-36
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Publication
23798557 | J:204713
First Author: Kalucka J
Year: 2013
Journal: Mol Cell Biol
Title: Loss of epithelial hypoxia-inducible factor prolyl hydroxylase 2 accelerates skin wound healing in mice.
Volume: 33
Issue: 17
Pages: 3426-38
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Publication
23913502 | J:231998
First Author: Mamlouk S
Year: 2014
Journal: Int J Cancer
Title: Loss of prolyl hydroxylase-2 in myeloid cells and T-lymphocytes impairs tumor development.
Volume: 134
Issue: 4
Pages: 849-58
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Genotype
Genotype
Symbol: Egln1/Egln1 Hif1a/Hif1a Tg(CD68-icre)1Bwlx/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Egln1/Egln1 Epas1/Epas1 Tg(CD68-icre)1Bwlx/?
Background: involves: 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Egln1/Egln1 Egln3/Egln3 Tg(CD68-icre)1Bwlx/?
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Protein
Q7TST5
Organism: Mus musculus/domesticus
Length: 411  
Fragment?: false
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Protein
Q9D387
Organism: Mus musculus/domesticus
Length: 280  
Fragment?: false
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Protein
Q8BZW9
Organism: Mus musculus/domesticus
Length: 258  
Fragment?: false
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Protein Domain
IPR002000 | Lysosome-assoc_membr_glycop
Type: Family
Description: Lysosome-associated membrane glycoproteins (lamp) []are integral membrane proteins, specific to lysosomes, and whose exact biological function is not yet clear. Structurally, the lamp proteins consist of two internally homologous lysosome-luminal domains separated by a proline-rich hinge region; at the C-terminal extremity there is a transmembrane region (TM) followed by a very short cytoplasmic tail (C). In each of the duplicated domains, there are two conserved disulphide bonds. This structure is schematically represented in the figure below. +-----+ +-----+ +-----+ +-----+| | | | | | | |xCxxxxxCxxxxxxxxxxxxCxxxxxCxxxxxxxxxCxxxxxCxxxxxxxxxxxxCxxxxxCxxxxxxxx+--------------------------++Hinge++--------------------------++TM++C+In mammals, there are two closely related types of lamp: lamp-1 and lamp-2, which form major components of the lysosome membrane. In chicken lamp-1 is known as LEP100. Also included in this entry is the macrophage protein CD68 (or macrosialin) []is a heavily glycosylated integral membrane protein whose structure consists of a mucin-like domain followed by a proline-rich hinge; a single lamp-like domain; a transmembrane region and a short cytoplasmic tail. Similar to CD68, mammalian lamp-3, which is expressed in lymphoid organs, dendritic cells and in lung, contains all the C-terminal regions but lacks the N-terminal lamp-like region []. In a lamp-family protein from nematodes []only the part C-terminal to the hinge is conserved.
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Protein Domain
IPR018134 | LAMP_CS
Type: Conserved_site
Description: Lysosome-associated membrane glycoproteins (lamp) []are integral membrane proteins, specific to lysosomes, and whose exact biological function is not yet clear. Structurally, the lamp proteins consist of two internally homologous lysosome-luminal domains separated by a proline-rich hinge region; at the C-terminal extremity there is a transmembrane region (TM) followed by a very short cytoplasmic tail (C). In each of the duplicated domains, there are two conserved disulphide bonds. This structure is schematically represented in the figure below. +-----+ +-----+ +-----+ +-----+| | | | | | | |xCxxxxxCxxxxxxxxxxxxCxxxxxCxxxxxxxxxCxxxxxCxxxxxxxxxxxxCxxxxxCxxxxxxxx+--------------------------++Hinge++--------------------------++TM++C+In mammals, there are two closely related types of lamp: lamp-1 and lamp-2, which form major components of the lysosome membrane. In chicken lamp-1 is known as LEP100. Also included in this entry is the macrophage protein CD68 (or macrosialin) []is a heavily glycosylated integral membrane protein whose structure consists of a mucin-like domain followed by a proline-rich hinge; a single lamp-like domain; a transmembrane region and a short cytoplasmic tail. Similar to CD68, mammalian lamp-3, which is expressed in lymphoid organs, dendritic cells and in lung, contains all the C-terminal regions but lacks the N-terminal lamp-like region []. In a lamp-family protein from nematodes []only the part C-terminal to the hinge is conserved. There are two signatures in this entry, one is centred on the first conserved cysteine of the duplicated domains. The second corresponds to a region that includes the extremity of the second domain, the totality of the transmembrane region and the cytoplasmic tail.
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Publication
34505007 | J:313520
First Author: Aguilar-Pineda JA
Year: 2021
Journal: iScience
Title: Vascular smooth muscle cell dysfunction contribute to neuroinflammation and Tau hyperphosphorylation in Alzheimer disease.
Volume: 24
Issue: 9
Pages: 102993
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Publication
22001347 | J:180066
First Author: Sangaletti S
Year: 2011
Journal: Am J Pathol
Title: SPARC oppositely regulates inflammation and fibrosis in bleomycin-induced lung damage.
Volume: 179
Issue: 6
Pages: 3000-10
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Publication
23637179 | J:197150
First Author: Sorrells SF
Year: 2013
Journal: J Neurosci
Title: Glucocorticoid signaling in myeloid cells worsens acute CNS injury and inflammation.
Volume: 33
Issue: 18
Pages: 7877-89
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Publication
30392787 | J:268404
 
First Author: Deng Q
Year: 2019
Journal: Cancer Lett
Title: NLRP3 inflammasomes in macrophages drive colorectal cancer metastasis to the liver.
Volume: 442
Pages: 21-30
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Publication
18929539 | J:143579
First Author: Emanuelli B
Year: 2008
Journal: Biochem Biophys Res Commun
Title: SOCS-1 deficiency does not prevent diet-induced insulin resistance.
Volume: 377
Issue: 2
Pages: 447-452
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Publication
25130466 | J:220107
First Author: Ding Z
Year: 2014
Journal: Biochem Biophys Res Commun
Title: LOX-1 - dependent mitochondrial DNA damage and NLRP3 activation during systemic inflammation in mice.
Volume: 451
Issue: 4
Pages: 637-43
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Publication
21469118 | J:177315
First Author: Rani R
Year: 2011
Journal: Eur J Immunol
Title: TGF-β limits IL-33 production and promotes the resolution of colitis through regulation of macrophage function.
Volume: 41
Issue: 7
Pages: 2000-9
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Publication
27477458 | J:279645
First Author: Chiba T
Year: 2016
Journal: Proc Jpn Acad Ser B Phys Biol Sci
Title: Microglial phospholipase D4 deficiency influences myelination during brain development.
Volume: 92
Issue: 7
Pages: 237-54
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Publication
26092098 | J:260862
First Author: Bouchareychas L
Year: 2015
Journal: Cardiovasc Res
Title: Promoting macrophage survival delays progression of pre-existing atherosclerotic lesions through macrophage-derived apoE.
Volume: 108
Issue: 1
Pages: 111-23
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Publication
28650342 | J:248197
First Author: Rahman K
Year: 2017
Journal: J Clin Invest
Title: Inflammatory Ly6Chi monocytes and their conversion to M2 macrophages drive atherosclerosis regression.
Volume: 127
Issue: 8
Pages: 2904-2915
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Publication
24616478 | J:210231
First Author: Caro-Maldonado A
Year: 2014
Journal: J Immunol
Title: Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells.
Volume: 192
Issue: 8
Pages: 3626-36
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Publication
34854257 | J:331616
First Author: Deng R
Year: 2022
Journal: Adv Sci (Weinh)
Title: Periosteal CD68(+) F4/80(+) Macrophages Are Mechanosensitive for Cortical Bone Formation by Secretion and Activation of TGF-β1.
Volume: 9
Issue: 3
Pages: e2103343
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Publication
23974197 | J:203440
First Author: Gautier EL
Year: 2013
Journal: Blood
Title: Local apoptosis mediates clearance of macrophages from resolving inflammation in mice.
Volume: 122
Issue: 15
Pages: 2714-22
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Publication
23264599 | J:194598
First Author: Franke K
Year: 2013
Journal: Blood
Title: HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis.
Volume: 121
Issue: 8
Pages: 1436-45
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Publication
23667053 | J:200956
First Author: Singh RP
Year: 2013
Journal: Blood
Title: HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress.
Volume: 121
Issue: 26
Pages: 5158-66
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Publication
27190063 | J:236056
First Author: McCubbrey AL
Year: 2016
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Selective and inducible targeting of CD11b+ mononuclear phagocytes in the murine lung with hCD68-rtTA transgenic systems.
Volume: 311
Issue: 1
Pages: L87-L100
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Publication
38718793 | J:348845
     
First Author: Qian Q
Year: 2024
Journal: Cell Metab
Title: Obesity disrupts the pituitary-hepatic UPR communication leading to NAFLD progression.
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Publication
28624505 | J:244450
First Author: Fujikawa R
Year: 2017
Journal: Am J Pathol
Title: Deficiency in EP4 Receptor-Associated Protein Ameliorates Abnormal Anxiety-Like Behavior and Brain Inflammation in a Mouse Model of Alzheimer Disease.
Volume: 187
Issue: 8
Pages: 1848-1854
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Publication
17389330 | J:126464
First Author: Nishimura S
Year: 2007
Journal: Diabetes
Title: Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels.
Volume: 56
Issue: 6
Pages: 1517-26
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Publication
22791342 | J:188528
First Author: Kang MK
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: Purple corn anthocyanins inhibit diabetes-associated glomerular monocyte activation and macrophage infiltration.
Volume: 303
Issue: 7
Pages: F1060-9
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Publication
17327424 | J:122028
First Author: Moloney F
Year: 2007
Journal: Diabetes
Title: Antidiabetic effects of cis-9, trans-11-conjugated linoleic acid may be mediated via anti-inflammatory effects in white adipose tissue.
Volume: 56
Issue: 3
Pages: 574-82
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Publication
17573457 | J:126149
First Author: Williams IA
Year: 2007
Journal: Am J Physiol Heart Circ Physiol
Title: The role of reactive oxygen species in the hearts of dystrophin-deficient mdx mice.
Volume: 293
Issue: 3
Pages: H1969-77
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Publication
36894641 | J:334812
First Author: Thompson D
Year: 2023
Journal: Sci Rep
Title: Fenretinide inhibits obesity and fatty liver disease but induces Smpd3 to increase serum ceramides and worsen atherosclerosis in LDLR(-/-) mice.
Volume: 13
Issue: 1
Pages: 3937
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Publication
20951679 | J:166459
First Author: Sheikine Y
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Activation of VPAC1 receptors aggravates early atherosclerosis in hypercholesterolemic apolipoprotein E-deficient mice.
Volume: 402
Issue: 3
Pages: 471-6
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Publication
25750192 | J:250935
First Author: Polyzos KA
Year: 2015
Journal: Cardiovasc Res
Title: Inhibition of indoleamine 2,3-dioxygenase promotes vascular inflammation and increases atherosclerosis in Apoe-/- mice.
Volume: 106
Issue: 2
Pages: 295-302
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Publication
30576919 | J:279190
 
First Author: Vendrov AE
Year: 2019
Journal: Redox Biol
Title: NOXA1-dependent NADPH oxidase regulates redox signaling and phenotype of vascular smooth muscle cell during atherogenesis.
Volume: 21
Pages: 101063
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Publication
12829615 | J:115676
First Author: 't Hoen PA
Year: 2003
Journal: Circ Res
Title: Aorta of ApoE-deficient mice responds to atherogenic stimuli by a prelesional increase and subsequent decrease in the expression of antioxidant enzymes.
Volume: 93
Issue: 3
Pages: 262-9
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Publication
22491245 | J:188685
First Author: Pizzolla A
Year: 2012
Journal: J Immunol
Title: Reactive oxygen species produced by the NADPH oxidase 2 complex in monocytes protect mice from bacterial infections.
Volume: 188
Issue: 10
Pages: 5003-11
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Publication
32471168 | J:304398
 
First Author: Ho L
Year: 2020
Journal: Cells
Title: RELMα is Induced in Airway Epithelial Cells by Oncostatin M Without Requirement of STAT6 or IL-6 in Mouse Lungs In Vivo.
Volume: 9
Issue: 6
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Publication
29030487 | J:256363
First Author: McCurdy S
Year: 2017
Journal: J Immunol
Title: Macrophage-Specific Expression of IL-37 in Hyperlipidemic Mice Attenuates Atherosclerosis.
Volume: 199
Issue: 10
Pages: 3604-3613
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Publication
22446027 | J:312616
First Author: Beutner F
Year: 2012
Journal: Atherosclerosis
Title: Effect of everolimus on pre-existing atherosclerosis in LDL-receptor deficient mice.
Volume: 222
Issue: 2
Pages: 337-43
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Publication
17478727 | J:130794
First Author: Mehta JL
Year: 2007
Journal: Circ Res
Title: Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet.
Volume: 100
Issue: 11
Pages: 1634-42
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Publication
24036126 | J:211431
First Author: Ding Z
Year: 2013
Journal: Biochem Biophys Res Commun
Title: LOX-1 deletion and macrophage trafficking in atherosclerosis.
Volume: 440
Issue: 2
Pages: 210-4
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Publication
17925450 | J:130095
First Author: Buga GM
Year: 2008
Journal: J Lipid Res
Title: D-4F reduces EO6 immunoreactivity, SREBP-1c mRNA levels, and renal inflammation in LDL receptor-null mice fed a Western diet.
Volume: 49
Issue: 1
Pages: 192-205
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Publication
33914863 | J:332887
First Author: Wu JH
Year: 2022
Journal: Cardiovasc Res
Title: Drebrin attenuates atherosclerosis by limiting smooth muscle cell transdifferentiation.
Volume: 118
Issue: 3
Pages: 772-784
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Publication
32721081 | J:299238
First Author: Shahraz A
Year: 2021
Journal: Glia
Title: Phagocytosis-related NADPH oxidase 2 subunit gp91phox contributes to neurodegeneration after repeated systemic challenge with lipopolysaccharides.
Volume: 69
Issue: 1
Pages: 137-150
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Publication
17204585 | J:136649
First Author: Mathew B
Year: 2007
Journal: Am J Respir Cell Mol Biol
Title: Inhibitory kappaB kinase 2 activates airway epithelial cells to stimulate bone marrow macrophages.
Volume: 36
Issue: 5
Pages: 562-72
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Publication
29125588 | J:273918
 
First Author: Petrescu AD
Year: 2017
Journal: Int J Mol Sci
Title: Glucocorticoids Cause Gender-Dependent Reversal of Hepatic Fibrosis in the MDR2-Knockout Mouse Model.
Volume: 18
Issue: 11
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Publication
25892207 | J:222704
First Author: Khan AM
Year: 2015
Journal: Neurobiol Aging
Title: Telomere dysfunction reduces microglial numbers without fully inducing an aging phenotype.
Volume: 36
Issue: 6
Pages: 2164-75
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Publication
22442158 | J:191164
First Author: Miura K
Year: 2012
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2.
Volume: 302
Issue: 11
Pages: G1310-21
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Publication
29580318 | J:328398
First Author: Ehrlich L
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